AU2001249348A1 - Compositions derived from modiolus modiolus and methods for making and using same - Google Patents

Compositions derived from modiolus modiolus and methods for making and using same

Info

Publication number: AU2001249348A1
Authority: AU; Australia
Prior art keywords: modiolus; soft tissue; composition; solvent; liver
Prior art date: 2000-03-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU2001249348A

Other languages

English (en)

Inventor

Thomas E. Adrian

Peter D. Collin

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Creighton University

Original Assignee

SFS Inc

Creighton University

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-03-22

Filing date

2001-03-22

Publication date

2001-10-03

2001-03-22 Application filed by SFS Inc, Creighton University filed Critical SFS Inc

2001-10-03 Publication of AU2001249348A1 publication Critical patent/AU2001249348A1/en

2003-11-27 Assigned to CREIGHTON UNIVERSITY reassignment CREIGHTON UNIVERSITY Request for Assignment Assignors: CREIGHTON UNIVERSITY, SFS, INC

Status Abandoned legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title claims description 89
238000000034 method Methods 0.000 title claims description 79
241000122161 Modiolus modiolus Species 0.000 title claims description 64
210000004872 soft tissue Anatomy 0.000 claims description 103
239000000284 extract Substances 0.000 claims description 48
239000003921 oil Substances 0.000 claims description 41
239000002904 solvent Substances 0.000 claims description 37
210000004185 liver Anatomy 0.000 claims description 35
230000000694 effects Effects 0.000 claims description 32
206010061902 Pancreatic neoplasm Diseases 0.000 claims description 30
208000009956 adenocarcinoma Diseases 0.000 claims description 30
201000002528 pancreatic cancer Diseases 0.000 claims description 28
208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 27
208000008443 pancreatic carcinoma Diseases 0.000 claims description 27
210000002784 stomach Anatomy 0.000 claims description 24
210000002683 foot Anatomy 0.000 claims description 22
210000002816 gill Anatomy 0.000 claims description 22
210000002149 gonad Anatomy 0.000 claims description 22
210000002216 heart Anatomy 0.000 claims description 22
210000003734 kidney Anatomy 0.000 claims description 22
210000000214 mouth Anatomy 0.000 claims description 22
239000000463 material Substances 0.000 claims description 19
206010009944 Colon cancer Diseases 0.000 claims description 16
102000011730 Arachidonate 12-Lipoxygenase Human genes 0.000 claims description 14
108010076676 Arachidonate 12-lipoxygenase Proteins 0.000 claims description 14
102000001381 Arachidonate 5-Lipoxygenase Human genes 0.000 claims description 14
108010093579 Arachidonate 5-lipoxygenase Proteins 0.000 claims description 14
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 14
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
206010006187 Breast cancer Diseases 0.000 claims description 13
208000026310 Breast neoplasm Diseases 0.000 claims description 13
239000000843 powder Substances 0.000 claims description 13
208000029742 colonic neoplasm Diseases 0.000 claims description 12
230000006907 apoptotic process Effects 0.000 claims description 11
229910002092 carbon dioxide Inorganic materials 0.000 claims description 10
201000010099 disease Diseases 0.000 claims description 10
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 10
230000035755 proliferation Effects 0.000 claims description 10
206010061218 Inflammation Diseases 0.000 claims description 9
230000004054 inflammatory process Effects 0.000 claims description 9
239000000546 pharmaceutical excipient Substances 0.000 claims description 9
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 8
206010058467 Lung neoplasm malignant Diseases 0.000 claims description 7
206010060862 Prostate cancer Diseases 0.000 claims description 7
208000000236 Prostatic Neoplasms Diseases 0.000 claims description 7
208000005718 Stomach Neoplasms Diseases 0.000 claims description 7
206010017758 gastric cancer Diseases 0.000 claims description 7
201000005202 lung cancer Diseases 0.000 claims description 7
208000020816 lung neoplasm Diseases 0.000 claims description 7
201000011549 stomach cancer Diseases 0.000 claims description 7
206010003246 arthritis Diseases 0.000 claims description 6
230000004069 differentiation Effects 0.000 claims description 6
230000001939 inductive effect Effects 0.000 claims description 6
238000004519 manufacturing process Methods 0.000 claims description 6
230000002401 inhibitory effect Effects 0.000 claims description 5
239000004215 Carbon black (E152) Substances 0.000 claims description 4
239000003849 aromatic solvent Substances 0.000 claims description 4
239000001569 carbon dioxide Substances 0.000 claims description 4
150000005826 halohydrocarbons Chemical class 0.000 claims description 4
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150000002430 hydrocarbons Chemical class 0.000 claims description 4
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210000004027 cell Anatomy 0.000 description 51
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 39
235000019198 oils Nutrition 0.000 description 34
238000000605 extraction Methods 0.000 description 30
239000002253 acid Substances 0.000 description 24
206010028980 Neoplasm Diseases 0.000 description 19
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 14
KGIJOOYOSFUGPC-CABOLEKPSA-N 5-HETE Natural products CCCCC\C=C/C\C=C/C\C=C/C=C/[C@H](O)CCCC(O)=O KGIJOOYOSFUGPC-CABOLEKPSA-N 0.000 description 13
KGIJOOYOSFUGPC-MSFIICATSA-N 5-Hydroxyeicosatetraenoic acid Chemical compound CCCCCC=CCC=CCC=C\C=C\[C@@H](O)CCCC(O)=O KGIJOOYOSFUGPC-MSFIICATSA-N 0.000 description 13
ZNHVWPKMFKADKW-ZYBDYUKJSA-N 12-HETE Natural products CCCCC\C=C/C[C@@H](O)\C=C\C=C/C\C=C/CCCC(O)=O ZNHVWPKMFKADKW-ZYBDYUKJSA-N 0.000 description 12
241000699800 Cricetinae Species 0.000 description 12
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 12
ZNHVWPKMFKADKW-UHFFFAOYSA-N 12-HETE Chemical compound CCCCCC=CCC(O)C=CC=CCC=CCCCC(O)=O ZNHVWPKMFKADKW-UHFFFAOYSA-N 0.000 description 10
-1 gums Substances 0.000 description 10
VNYSSYRCGWBHLG-AMOLWHMGSA-N leukotriene B4 Chemical compound CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O VNYSSYRCGWBHLG-AMOLWHMGSA-N 0.000 description 10
201000011510 cancer Diseases 0.000 description 9
239000000243 solution Substances 0.000 description 9
238000011282 treatment Methods 0.000 description 9
210000004369 blood Anatomy 0.000 description 8
239000008280 blood Substances 0.000 description 8
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241001465754 Metazoa Species 0.000 description 7
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
239000000969 carrier Substances 0.000 description 6
235000005911 diet Nutrition 0.000 description 6
238000001727 in vivo Methods 0.000 description 6
239000007788 liquid Substances 0.000 description 6
239000007787 solid Substances 0.000 description 6
239000000454 talc Substances 0.000 description 6
229910052623 talc Inorganic materials 0.000 description 6
235000012222 talc Nutrition 0.000 description 6
238000007792 addition Methods 0.000 description 5
YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 5
230000034994 death Effects 0.000 description 5
231100000517 death Toxicity 0.000 description 5
230000037213 diet Effects 0.000 description 5
238000002372 labelling Methods 0.000 description 5
150000002617 leukotrienes Chemical class 0.000 description 5
238000012545 processing Methods 0.000 description 5
239000000725 suspension Substances 0.000 description 5
VNYSSYRCGWBHLG-UKNWISKWSA-N 6-trans-leukotriene B4 Chemical compound CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C\[C@@H](O)CCCC(O)=O VNYSSYRCGWBHLG-UKNWISKWSA-N 0.000 description 4
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
208000001333 Colorectal Neoplasms Diseases 0.000 description 4
108020004414 DNA Proteins 0.000 description 4
ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 4
IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 4
230000015572 biosynthetic process Effects 0.000 description 4
238000006243 chemical reaction Methods 0.000 description 4
239000002552 dosage form Substances 0.000 description 4
238000010438 heat treatment Methods 0.000 description 4
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238000012802 pre-warming Methods 0.000 description 4
239000003755 preservative agent Substances 0.000 description 4
PRFXRIUZNKLRHM-HKVRTXJWSA-N prostaglandin B2 Chemical compound CCCCC[C@H](O)\C=C\C1=C(C\C=C/CCCC(O)=O)C(=O)CC1 PRFXRIUZNKLRHM-HKVRTXJWSA-N 0.000 description 4
108090000623 proteins and genes Proteins 0.000 description 4
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238000003786 synthesis reaction Methods 0.000 description 4
239000003643 water by type Substances 0.000 description 4
JSFATNQSLKRBCI-VAEKSGALSA-N 15-HETE Natural products CCCCC[C@H](O)\C=C\C=C/C\C=C/C\C=C/CCCC(O)=O JSFATNQSLKRBCI-VAEKSGALSA-N 0.000 description 3
JSFATNQSLKRBCI-UHFFFAOYSA-N 15-Hydroxyeicosatetraenoic acid Chemical compound CCCCCC(O)C=CC=CCC=CCC=CCCCC(O)=O JSFATNQSLKRBCI-UHFFFAOYSA-N 0.000 description 3
ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
102100033215 DNA nucleotidylexotransferase Human genes 0.000 description 3
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
239000004606 Fillers/Extenders Substances 0.000 description 3
229920002472 Starch Polymers 0.000 description 3
238000012288 TUNEL assay Methods 0.000 description 3
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
239000005456 alcohol based solvent Substances 0.000 description 3
150000001720 carbohydrates Chemical class 0.000 description 3
235000014633 carbohydrates Nutrition 0.000 description 3
239000001913 cellulose Substances 0.000 description 3
229920002678 cellulose Polymers 0.000 description 3
235000010980 cellulose Nutrition 0.000 description 3
238000005119 centrifugation Methods 0.000 description 3
239000003795 chemical substances by application Substances 0.000 description 3
238000003745 diagnosis Methods 0.000 description 3
238000010790 dilution Methods 0.000 description 3
239000012895 dilution Substances 0.000 description 3
239000002270 dispersing agent Substances 0.000 description 3
239000000945 filler Substances 0.000 description 3
235000013305 food Nutrition 0.000 description 3
239000011777 magnesium Substances 0.000 description 3
210000000440 neutrophil Anatomy 0.000 description 3
239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 3
ISYWECDDZWTKFF-UHFFFAOYSA-N nonadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCCC(O)=O ISYWECDDZWTKFF-UHFFFAOYSA-N 0.000 description 3
230000037361 pathway Effects 0.000 description 3
239000008188 pellet Substances 0.000 description 3
239000012071 phase Substances 0.000 description 3
239000008363 phosphate buffer Substances 0.000 description 3
239000002798 polar solvent Substances 0.000 description 3
239000011780 sodium chloride Substances 0.000 description 3
239000008107 starch Substances 0.000 description 3
235000019698 starch Nutrition 0.000 description 3
235000000346 sugar Nutrition 0.000 description 3
150000008163 sugars Chemical class 0.000 description 3
239000006228 supernatant Substances 0.000 description 3
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239000006188 syrup Substances 0.000 description 3
235000020357 syrup Nutrition 0.000 description 3
ZNHVWPKMFKADKW-LQWMCKPYSA-N 12(S)-HETE Chemical compound CCCCC\C=C/C[C@H](O)\C=C\C=C/C\C=C/CCCC(O)=O ZNHVWPKMFKADKW-LQWMCKPYSA-N 0.000 description 2
XKLJLHAPJBUBNL-UHFFFAOYSA-N 12-methyltetradecanoic acid Chemical compound CCC(C)CCCCCCCCCCC(O)=O XKLJLHAPJBUBNL-UHFFFAOYSA-N 0.000 description 2
HIYAVKIYRIFSCZ-CYEMHPAKSA-N 5-(methylamino)-2-[[(2S,3R,5R,6S,8R,9R)-3,5,9-trimethyl-2-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-8-yl]methyl]-1,3-benzoxazole-4-carboxylic acid Chemical compound O=C([C@@H](C)[C@H]1O[C@@]2([C@@H](C[C@H]1C)C)O[C@@H]([C@@H](CC2)C)CC=1OC2=CC=C(C(=C2N=1)C(O)=O)NC)C1=CC=CN1 HIYAVKIYRIFSCZ-CYEMHPAKSA-N 0.000 description 2
VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 2
241000416162 Astragalus gummifer Species 0.000 description 2
DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 2
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KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
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241000122159 Modiolus Species 0.000 description 2
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WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
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WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
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238000009835 boiling Methods 0.000 description 2
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239000003710 calcium ionophore Substances 0.000 description 2
239000002775 capsule Substances 0.000 description 2
MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 description 2
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CJAONIOAQZUHPN-KKLWWLSJSA-N ethyl 12-[[2-[(2r,3r)-3-[2-[(12-ethoxy-12-oxododecyl)-methylamino]-2-oxoethoxy]butan-2-yl]oxyacetyl]-methylamino]dodecanoate Chemical compound CCOC(=O)CCCCCCCCCCCN(C)C(=O)CO[C@H](C)[C@@H](C)OCC(=O)N(C)CCCCCCCCCCCC(=O)OCC CJAONIOAQZUHPN-KKLWWLSJSA-N 0.000 description 2
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AWJWCTOOIBYHON-UHFFFAOYSA-N furo[3,4-b]pyrazine-5,7-dione Chemical compound C1=CN=C2C(=O)OC(=O)C2=N1 AWJWCTOOIBYHON-UHFFFAOYSA-N 0.000 description 2
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CKDDRHZIAZRDBW-UHFFFAOYSA-N henicosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCC(O)=O CKDDRHZIAZRDBW-UHFFFAOYSA-N 0.000 description 2
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WBBQTNCISCKUMU-PDBXOOCHSA-N (13Z,16Z,19Z)-docosatrienoic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCCCCCC(O)=O WBBQTNCISCKUMU-PDBXOOCHSA-N 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Rheumatology (AREA)
Zoology (AREA)
Marine Sciences & Fisheries (AREA)
Emergency Medicine (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Obesity (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Medicines Containing Plant Substances (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AU2001249348A 2000-03-22 2001-03-22 Compositions derived from modiolus modiolus and methods for making and using same Abandoned AU2001249348A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US19096700P	2000-03-22	2000-03-22
US60190967		2000-03-22
PCT/US2001/009192 WO2001070130A2 (fr)	2000-03-22	2001-03-22	Compositions obtenues a partir de modiolus modiolus et methodes de production et d'utilisation desdites compositions

Publications (1)

Publication Number	Publication Date
AU2001249348A1 true AU2001249348A1 (en)	2001-10-03

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ID=22703534

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU2001249348A Abandoned AU2001249348A1 (en)	2000-03-22	2001-03-22	Compositions derived from modiolus modiolus and methods for making and using same

Country Status (5)

Country	Link
US (1)	US7387797B2 (fr)
AU (1)	AU2001249348A1 (fr)
CA (1)	CA2403671A1 (fr)
GB (1)	GB2378135B (fr)
WO (1)	WO2001070130A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2005538679A (ja) *	2001-10-24	2005-12-22	ザレジェンツオブザユニバーシティーオブカリフォルニアサンディエゴ	アテローム性動脈硬化症に寄与する主要遺伝子としての５−リポキシゲナーゼの同定
US20060106014A1 (en) *	2004-10-14	2006-05-18	Sekhar Boddupalli	Methods for treating diabetes
WO2008079328A2 (fr) *	2006-12-22	2008-07-03	Creighton University	Acides gras oméga-5 utiles dans l'inhibition de la 5-lipoxygénase et dans le traitement du cancer
MX2011011517A (es)	2009-04-29	2012-06-19	Amarin Corp Plc	Composiciones farmaceuticas que comprenden epa y un agente cardiovascular y metodos para utilizar el mismo.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4336247A (en) *	1978-09-05	1982-06-22	Eriksen Arthur E	Body system nutrient material
SE465516B (sv) *	1989-08-18	1991-09-23	Kurt G I Nilsson	Saett att framstaella en oligosackaridfoerening varvid glykosidas fraan en mollusk anvaendes
US6171626B1 (en) *	1996-08-29	2001-01-09	Tepual S.A.	Procedure for detoxification of shellfish, contaminated with paralytic shellfish toxins
US6127166A (en) *	1997-11-03	2000-10-03	Bayley; Hagan	Molluscan ligament polypeptides and genes encoding them
US6596303B1 (en) *	1999-03-22	2003-07-22	Mars Incorporated	Pet food for maintenance of joint health and alleviation of arthritic symptoms in companion animals

2001
- 2001-03-22 CA CA002403671A patent/CA2403671A1/fr not_active Abandoned
- 2001-03-22 AU AU2001249348A patent/AU2001249348A1/en not_active Abandoned
- 2001-03-22 US US10/239,345 patent/US7387797B2/en not_active Expired - Fee Related
- 2001-03-22 WO PCT/US2001/009192 patent/WO2001070130A2/fr not_active Ceased
- 2001-03-22 GB GB0224497A patent/GB2378135B/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
GB2378135A (en)	2003-02-05
WO2001070130A2 (fr)	2001-09-27
US7387797B2 (en)	2008-06-17
GB2378135B (en)	2004-09-29
US20030235620A1 (en)	2003-12-25
GB0224497D0 (en)	2002-11-27
CA2403671A1 (fr)	2001-09-27
WO2001070130A3 (fr)	2002-02-07

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JP2011503237A (ja)	2011-01-27	Ｓｃｕｔｅｌｌａｒｉａｂａｒｂａｔａｄ．ｄｏｎの精製抽出物を作製するためのプロセス
CN104055966A (zh)	2014-09-24	泽泻降脂浓缩丸
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AU2006202206A1 (en)	2006-06-15	Compositions derived from modiolus modiolus and methods for making and using the same
US20050129789A1 (en)	2005-06-16	Drugs including anticancer agents and immunopotentiators and health foods and drinks
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WO1998052550A1 (fr)	1998-11-26	Composition pharmaceutique et utilisation de cette composition
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