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AU2001248331A1 - Medicaments against viral diseases - Google Patents

Medicaments against viral diseases

Info

Publication number
AU2001248331A1
AU2001248331A1 AU2001248331A AU4833101A AU2001248331A1 AU 2001248331 A1 AU2001248331 A1 AU 2001248331A1 AU 2001248331 A AU2001248331 A AU 2001248331A AU 4833101 A AU4833101 A AU 4833101A AU 2001248331 A1 AU2001248331 A1 AU 2001248331A1
Authority
AU
Australia
Prior art keywords
viral diseases
against viral
medicaments against
medicaments
dihydropyrimidines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001248331A
Inventor
Karl Deres
Siegfried Goldmann
Erwin Graef
Jorg Keldenich
Ulrich Niewohner
Arnold Paessens
Karl-Heinz Schlemmer
Jurgen Stoltefuss
Olaf Weber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of AU2001248331A1 publication Critical patent/AU2001248331A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Novel dihydropyrimidines and combinations thereof with other antiviral agents, suitable for combating HBV infections.
AU2001248331A 2000-03-16 2001-03-05 Medicaments against viral diseases Abandoned AU2001248331A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10012823 2000-03-16
DE10012823A DE10012823A1 (en) 2000-03-16 2000-03-16 New alkyl-6-aminoalkyl-dihydropyrimidine-5-carboxylate derivatives, useful for the treatment of viral, especially hepatitis B, infections
PCT/EP2001/002442 WO2001068640A1 (en) 2000-03-16 2001-03-05 Medicaments against viral diseases

Publications (1)

Publication Number Publication Date
AU2001248331A1 true AU2001248331A1 (en) 2001-09-24

Family

ID=7634953

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001248331A Abandoned AU2001248331A1 (en) 2000-03-16 2001-03-05 Medicaments against viral diseases

Country Status (9)

Country Link
US (1) US7074784B2 (en)
EP (1) EP1265889B1 (en)
AT (1) ATE269321T1 (en)
AU (1) AU2001248331A1 (en)
DE (2) DE10012823A1 (en)
DK (1) DK1265889T3 (en)
ES (1) ES2222363T3 (en)
PT (1) PT1265889E (en)
WO (1) WO2001068640A1 (en)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
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WO2008154818A1 (en) * 2007-06-18 2008-12-24 Zhang, Zhongneng Fluorophenyl-substituted thiazolyl dihydropyrimidines
CN101328168B (en) * 2007-06-18 2011-09-07 张中能 Diethylcarbamyl-substituted thiazole dihydropyrimidine
PT2159224E (en) * 2007-06-18 2012-10-24 Sunshine Lake Pharma Co Ltd Bromo-phenyl substituted thiazolyl dihydropyrimidines
CN101328169B (en) * 2007-06-18 2011-05-25 张中能 A kind of ethoxycarbonyl-substituted thiazole dihydropyrimidine
WO2009018657A1 (en) * 2007-08-03 2009-02-12 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
JP2010535155A (en) * 2007-08-03 2010-11-18 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Viral polymerase inhibitor
CN103483251A (en) * 2007-12-19 2014-01-01 贝林格尔.英格海姆国际有限公司 Viral polymerase inhibitors
CN101744823B (en) * 2008-12-17 2013-06-19 广东东阳光药业有限公司 Solid dispersion of dihydropyrimidine compounds and preparation thereof for medical purpose
WO2010069147A1 (en) * 2008-12-17 2010-06-24 张中能 Dihydropyrimidine derivatives, compositions thereof and their use
CN101575318B (en) * 2009-06-25 2012-02-08 中国人民解放军军事医学科学院毒物药物研究所 Dihydropyrimidine compounds and their use in the preparation of medicines for treating and/or preventing viral diseases
CN104302626B (en) * 2012-01-06 2016-09-07 爱尔兰詹森科学公司 4,4-disubstituted-1,4-dihydropyrimidines and their use as medicaments for the treatment of hepatitis B
US20130267517A1 (en) * 2012-03-31 2013-10-10 Hoffmann-La Roche Inc. Novel 4-methyl-dihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
WO2013144129A1 (en) * 2012-03-31 2013-10-03 F. Hoffmann-La Roche Ag Novel 4-methyl-dihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
JP6263533B2 (en) * 2012-08-24 2018-01-17 サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． Dihydropyrimidine compounds and their application in medicine
CN103664897B (en) * 2012-09-01 2018-04-03 广东东阳光药业有限公司 Dihydropyrimidines and its application in medicine
CN103664925B (en) * 2012-09-07 2018-01-23 广东东阳光药业有限公司 The Dihydropyrimidines of heteroaryl substitution and its application in medicine
WO2014037480A1 (en) 2012-09-10 2014-03-13 F. Hoffmann-La Roche Ag 6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
CN103664899B (en) * 2012-09-11 2017-06-16 广东东阳光药业有限公司 The Dihydropyrimidines of heteroaryl substitution and its application in medicine
PE20151951A1 (en) * 2013-05-17 2015-12-26 Hoffmann La Roche HETEROARYLDIHYDROPYRIMIDINES LINKED BY 6 BRIDGES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
CN106255684B (en) * 2013-11-14 2019-08-23 诺维拉治疗公司 Azacycloheptane derivatives and methods of treating hepatitis B infection
CA2920415A1 (en) * 2013-11-19 2015-05-28 Sunshine Lake Pharma Co., Ltd. Dihydropyrimidine compounds and their application in pharmaceuticals
CA2927373C (en) 2013-11-27 2021-07-13 Sunshine Lake Pharma Co., Ltd. Processes for preparing dihydropyrimidine derivatives and intermediates thereof
SG11201605896WA (en) 2014-03-28 2016-08-30 Sunshine Lake Pharma Co Ltd Dihydropyrimidine compounds and their application in pharmaceuticals
WO2016016196A1 (en) * 2014-07-31 2016-02-04 F. Hoffmann-La Roche Ag Novel chiral resolution of 4-aryl-2-thiazol-2-yl-1,4-dihydropyrimidine-5-carboxylic acid esters
WO2016124126A1 (en) * 2015-02-07 2016-08-11 Sunshine Lake Pharma Co., Ltd. Complexes and salts of dihydropyrimidine derivatives and their application in pharmaceuticals
US10442788B2 (en) 2015-04-01 2019-10-15 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
WO2016183266A1 (en) 2015-05-13 2016-11-17 Enanta Pharmaceuticals, Inc. Ehpatitis b antiviral agents
WO2017011552A1 (en) * 2015-07-13 2017-01-19 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
US10301255B2 (en) 2015-07-22 2019-05-28 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
WO2017136403A1 (en) 2016-02-02 2017-08-10 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
AR107633A1 (en) 2016-02-19 2018-05-16 Hoffmann La Roche PROCEDURE FOR THE PREPARATION OF ACID 4-PHENYL-5-ALCOXICARBONIL-2-TIAZOL-2-IL-1,4-DIHYDROPIRIMIDIN-6-IL- [METHYL] -3-OXO-5,6,8,8A-TETRAHIDRO- 1H-IMIDAZO [1,5A] PIRAZIN-2-IL-CARBOXYL
EP3426245B1 (en) 2016-03-07 2022-12-14 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
EP3468561A4 (en) 2016-06-10 2019-12-04 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
AU2018291688B2 (en) 2017-06-27 2022-02-03 Janssen Pharmaceutica Nv Heteroaryldihydropyrimidine derivatives and methods of treating hepatitis B infections
CN107501257B (en) * 2017-08-17 2020-05-29 山东大学 Dihydropyrimidine-triazole derivative and preparation method and application thereof
UY37861A (en) 2017-08-28 2019-03-29 Enanta Pharm Inc ANTIVIRAL AGENTS AGAINST HEPATITIS B
BR112020008765A2 (en) 2017-11-02 2020-10-20 Aicuris Gmbh & Co. Kg indole-2-carboxamides pyrazolo-piperidine substituted highly active innovative active against the hepatitis b virus (hbv)
MA50524A (en) 2017-11-02 2020-09-09 Aicuris Gmbh & Co Kg NEW HIGHLY ACTIVE AMINO-THIAZOLE-SUBSTITUTED INDOLE-2-CARBOXAMIDES ACTING AGAINST THE HEPATITIS B VIRUS (HBV)
US11807623B2 (en) 2017-11-30 2023-11-07 Arrakis Therapeutics, Inc. Nucleic acid-binding photoprobes and uses thereof
TW201936192A (en) 2017-12-06 2019-09-16 美商因那塔製藥公司 Hepatitis B antiviral agents
US10428070B2 (en) 2017-12-06 2019-10-01 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
US11058678B2 (en) 2018-01-22 2021-07-13 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
WO2019191166A1 (en) 2018-03-29 2019-10-03 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
UY38383A (en) 2018-09-21 2020-04-30 Enanta Pharm Inc HETEROCYCLES FUNCTIONALIZED AS ANTIVIRAL AGENTS
KR102819704B1 (en) 2018-11-21 2025-06-11 이난타 파마슈티칼스, 인코포레이티드 Functionalized heterocycles as antiviral agents
WO2020193459A1 (en) 2019-03-25 2020-10-01 F. Hoffmann-La Roche Ag Solid forms of a compound of hbv core protein allosteric modifier
US11236111B2 (en) 2019-06-03 2022-02-01 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
US11760755B2 (en) 2019-06-04 2023-09-19 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
WO2020247575A1 (en) 2019-06-04 2020-12-10 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
US11738019B2 (en) 2019-07-11 2023-08-29 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
TW202122392A (en) * 2019-07-31 2021-06-16 愛爾蘭商健生科學愛爾蘭無限公司 Dihydropyrimidine derivatives and uses thereof in the treatment of hbv infection or of hbv-induced diseases
US11236108B2 (en) 2019-09-17 2022-02-01 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
US11802125B2 (en) 2020-03-16 2023-10-31 Enanta Pharmaceuticals, Inc. Functionalized heterocyclic compounds as antiviral agents
CN113512035B (en) * 2021-04-26 2023-11-24 山东大学 Dihydropyrimidine-pomalidomide conjugate, and preparation method and application thereof
WO2025093624A1 (en) * 2023-10-31 2025-05-08 Intervet International B.V. A process for preparing 3,5-difluoro-2-pyridinecarboxamide
CN120157666A (en) * 2025-05-19 2025-06-17 中国医学科学院医药生物技术研究所 A dihydropyrimidine compound and its preparation method and application, a dihydropyrimidine derivative and its application, a pharmaceutical composition and its application

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3234684A1 (en) 1982-09-18 1984-03-22 Bayer Ag, 5090 Leverkusen NEW DIHYDROPYRIMIDINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN MEDICINAL PRODUCTS
SE9702564D0 (en) * 1997-07-02 1997-07-02 Astra Ab New compounds
DE19817264A1 (en) 1998-04-18 1999-10-21 Bayer Ag New dihydropyrimidine derivatives and their corresponding mesomers useful as antiviral agents
DE19817265A1 (en) 1998-04-18 1999-10-21 Bayer Ag Treating hepatitis B using new or known dihydropyrimidine derivative antiviral agents
DE19817262A1 (en) 1998-04-18 1999-10-21 Bayer Ag New dihydropyrimidine derivatives and their corresponding mesomers useful in treatment of hepatitis

Also Published As

Publication number Publication date
DK1265889T3 (en) 2004-09-27
PT1265889E (en) 2004-09-30
ATE269321T1 (en) 2004-07-15
US20030232842A1 (en) 2003-12-18
ES2222363T3 (en) 2005-02-01
DE50102597D1 (en) 2004-07-22
EP1265889B1 (en) 2004-06-16
WO2001068640A1 (en) 2001-09-20
DE10012823A1 (en) 2001-09-20
EP1265889A1 (en) 2002-12-18
US7074784B2 (en) 2006-07-11

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