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AU2001247414A1 - Oligonucleotide analogues, methods of synthesis and methods of use - Google Patents

Oligonucleotide analogues, methods of synthesis and methods of use

Info

Publication number
AU2001247414A1
AU2001247414A1 AU2001247414A AU4741401A AU2001247414A1 AU 2001247414 A1 AU2001247414 A1 AU 2001247414A1 AU 2001247414 A AU2001247414 A AU 2001247414A AU 4741401 A AU4741401 A AU 4741401A AU 2001247414 A1 AU2001247414 A1 AU 2001247414A1
Authority
AU
Australia
Prior art keywords
methods
synthesis
oligonucleotide analogues
analogues
oligonucleotide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001247414A
Inventor
Dorothy Archdeacon
John Archdeacon
Alla Buryakova
Oksana Chakhmakhcheau
Mikhail Choob
Vladimir Efimov
Joseph Fernandez
Kyle Hondorp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Active Motif Inc
Original Assignee
Active Motif Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Active Motif Inc filed Critical Active Motif Inc
Publication of AU2001247414A1 publication Critical patent/AU2001247414A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003—Peptide-nucleic acids (PNAs)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
    • C12N2310/3181—Peptide nucleic acid, PNA

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2001247414A 2000-03-14 2001-03-13 Oligonucleotide analogues, methods of synthesis and methods of use Abandoned AU2001247414A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US18919000P 2000-03-14 2000-03-14
US60189190 2000-03-14
US25033400P 2000-11-30 2000-11-30
US60250334 2000-11-30
PCT/US2001/008111 WO2001068673A1 (en) 2000-03-14 2001-03-13 Oligonucleotide analogues, methods of synthesis and methods of use

Publications (1)

Publication Number Publication Date
AU2001247414A1 true AU2001247414A1 (en) 2001-09-24

Family

ID=26884873

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001247414A Abandoned AU2001247414A1 (en) 2000-03-14 2001-03-13 Oligonucleotide analogues, methods of synthesis and methods of use

Country Status (5)

Country Link
US (1) US7115738B2 (en)
EP (1) EP1263773A4 (en)
AU (1) AU2001247414A1 (en)
CA (1) CA2402319A1 (en)
WO (1) WO2001068673A1 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6962906B2 (en) * 2000-03-14 2005-11-08 Active Motif Oligonucleotide analogues, methods of synthesis and methods of use
AU2001247414A1 (en) 2000-03-14 2001-09-24 Active Motif Oligonucleotide analogues, methods of synthesis and methods of use
US20020081617A1 (en) * 2000-11-08 2002-06-27 Tione Buranda Fluorescence and FRET based assays for biomolecules on beads
US7527945B2 (en) * 2001-10-22 2009-05-05 Nucleonics, Inc. Transfection kinetics and structural promoters
US7897382B2 (en) * 2001-10-22 2011-03-01 Alnylam Pharmaceuticals, Inc. Transfection kinetics and structural promoters
CA2388049A1 (en) 2002-05-30 2003-11-30 Immunotech S.A. Immunostimulatory oligonucleotides and uses thereof
JPWO2005010181A1 (en) * 2003-07-25 2007-09-27 株式会社クレディアジャパン Nucleic acid detection method
EP1924591A4 (en) * 2005-09-16 2009-04-15 Primera Biosystems Inc Compositions and methods for purifying nucleic acids
US7960360B2 (en) 2006-11-13 2011-06-14 Jennifer Rubin Grandis Antisense guanidinium peptide nucleic acid (GPNA) oligonucleotides as antitumor agents
KR20090097960A (en) 2007-01-09 2009-09-16 비자 유에스에이 인코포레이티드 Mobile phone payment process including threshold indicator
JP2014531908A (en) 2011-10-14 2014-12-04 プレジデント アンド フェローズ オブ ハーバード カレッジ Sequencing by structural assembly
ES2991004T3 (en) 2011-12-22 2024-12-02 Harvard College Methods for the detection of analytes
EP4108782B1 (en) 2011-12-22 2023-06-07 President and Fellows of Harvard College Compositions and methods for analyte detection
US9914967B2 (en) * 2012-06-05 2018-03-13 President And Fellows Of Harvard College Spatial sequencing of nucleic acids using DNA origami probes
US10138509B2 (en) 2013-03-12 2018-11-27 President And Fellows Of Harvard College Method for generating a three-dimensional nucleic acid containing matrix
CA2904011A1 (en) * 2013-03-14 2014-10-02 Chimerochem Llc Synthetic polymers containing amino acid side chains
AU2014274939B2 (en) 2013-06-04 2020-03-19 President And Fellows Of Harvard College RNA-guideded transcriptional regulation
US10179932B2 (en) 2014-07-11 2019-01-15 President And Fellows Of Harvard College Methods for high-throughput labelling and detection of biological features in situ using microscopy
AU2016349288A1 (en) 2015-11-03 2018-05-31 President And Fellows Of Harvard College Method and apparatus for volumetric imaging of a three-dimensional nucleic acid containing matrix
CN109415761B (en) 2016-04-25 2022-09-20 哈佛学院董事及会员团体 Hybrid chain reaction method for in situ molecular detection
CN118389650A (en) 2016-08-31 2024-07-26 哈佛学院董事及会员团体 Methods for generating nucleic acid sequence libraries for detection by fluorescent in situ sequencing
CN118853848A (en) 2016-08-31 2024-10-29 哈佛学院董事及会员团体 Methods for combining detection of biomolecules into a single assay using fluorescent in situ sequencing
KR20190140906A (en) 2017-04-14 2019-12-20 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 Methods of Generating Cell-Derived Microfilament Networks
CA3098623A1 (en) 2018-05-07 2019-11-14 Alnylam Pharmaceuticals, Inc. Extrahepatic delivery
SG11202101934SA (en) 2018-07-30 2021-03-30 Readcoor Llc Methods and systems for sample processing or analysis
WO2020076976A1 (en) 2018-10-10 2020-04-16 Readcoor, Inc. Three-dimensional spatial molecular indexing
US20220049303A1 (en) 2020-08-17 2022-02-17 Readcoor, Llc Methods and systems for spatial mapping of genetic variants

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5508178A (en) 1989-01-19 1996-04-16 Rose; Samuel Nucleic acid amplification using single primer
US5783687A (en) 1990-03-14 1998-07-21 The Regents Of The University Of California Dyes designed for high sensitivity detection of double-stranded DNA
DE69126530T2 (en) 1990-07-27 1998-02-05 Isis Pharmaceutical, Inc., Carlsbad, Calif. NUCLEASE RESISTANT, PYRIMIDINE MODIFIED OLIGONUCLEOTIDES THAT DETECT AND MODULE GENE EXPRESSION
US5386023A (en) 1990-07-27 1995-01-31 Isis Pharmaceuticals Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling
US5432272A (en) 1990-10-09 1995-07-11 Benner; Steven A. Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases
US5641625A (en) 1992-05-22 1997-06-24 Isis Pharmaceuticals, Inc. Cleaving double-stranded DNA with peptide nucleic acids
DK51092D0 (en) 1991-05-24 1992-04-15 Ole Buchardt OLIGONUCLEOTIDE ANALOGUE DESCRIBED BY PEN, MONOMERIC SYNTHONES AND PROCEDURES FOR PREPARING THEREOF, AND APPLICATIONS THEREOF
US5766855A (en) 1991-05-24 1998-06-16 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity and sequence specificity
US5714331A (en) 1991-05-24 1998-02-03 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
US5719262A (en) 1993-11-22 1998-02-17 Buchardt, Deceased; Ole Peptide nucleic acids having amino acid side chains
US5539082A (en) 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
ATE226093T1 (en) 1991-11-26 2002-11-15 Isis Pharmaceuticals Inc INCREASED FORMATION OF TRIPLE AND DOUBLE HELICES FROM OLIGOMERS WITH MODIFIED PYRIMIDINES
US6020124A (en) 1992-04-27 2000-02-01 Trustees Of Dartmouth College Detection of soluble gene sequences in biological fluids
GB9211979D0 (en) 1992-06-05 1992-07-15 Buchard Ole Uses of nucleic acid analogues
ES2105698T3 (en) 1993-03-30 1997-10-16 Sanofi Sa OLIGONUCLEOTIDES MODIFIED WITH 7-DEAZAPURINE.
EP0695306A1 (en) 1993-04-19 1996-02-07 Gilead Sciences, Inc. Enhanced triple-helix and double-helix formation with oligomers containing modified purines
GB2284209A (en) 1993-11-25 1995-05-31 Ole Buchardt Nucleic acid analogue-induced transcription of RNA from a double-stranded DNA template
GB2285445A (en) 1993-12-06 1995-07-12 Pna Diagnostics As Protecting nucleic acids and methods of analysis
US5539083A (en) 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis
US5565554A (en) 1994-07-29 1996-10-15 The Regents Of The University Of California Dimeric fluorescent energy transfer dyes comprising asymmetric cyanine azole-indolenine chromophores
US6045995A (en) 1994-08-24 2000-04-04 Isis Pharmaceuticals, Inc. Capillary electrophoretic detection of nucleic acids
US5629178A (en) 1994-10-28 1997-05-13 Genetics & Ivf Institute Method for enhancing amplification in the polymerase chain reaction employing peptide nucleic acid (PNA)
US6150510A (en) 1995-11-06 2000-11-21 Aventis Pharma Deutschland Gmbh Modified oligonucleotides, their preparation and their use
PT739898E (en) 1995-03-13 2002-03-28 Aventis Pharma Gmbh PHOSPHONUCLETIC ACID MONO-ESTERS PROCESS FOR PREPARING AND USING
WO1997014793A1 (en) 1995-10-20 1997-04-24 Trustees Of Boston University Nucleic acid clamps
US5888733A (en) 1995-11-16 1999-03-30 Dako A/S In situ hybridization to detect specific nucleic acid sequences in eucaryotic samples
US6180767B1 (en) 1996-01-11 2001-01-30 Thomas Jefferson University Peptide nucleic acid conjugates
US6020126A (en) 1996-03-21 2000-02-01 Hsc, Reasearch And Development Limited Partnership Rapid genetic screening method
DE19637339A1 (en) 1996-09-13 1998-03-19 Hoechst Ag Methods for amplifying nucleic acids
DE19640974A1 (en) * 1996-10-04 1998-04-16 Bayer Ag Building blocks for DNA / PNA cooligomers
US6110676A (en) 1996-12-04 2000-08-29 Boston Probes, Inc. Methods for suppressing the binding of detectable probes to non-target sequences in hybridization assays
US6060242A (en) 1997-02-27 2000-05-09 Lorne Park Research, Inc. PNA diagnostic methods
US5932711A (en) 1997-03-05 1999-08-03 Mosaic Technologies, Inc. Nucleic acid-containing polymerizable complex
US6015887A (en) 1997-04-11 2000-01-18 Isis Pharmaceuticals, Inc. Chiral peptide nucleic acids and methods for preparing same
EP0975807B1 (en) 1997-05-02 2006-09-27 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
US6107470A (en) 1997-05-29 2000-08-22 Nielsen; Peter E. Histidine-containing peptide nucleic acids
EP0998577B1 (en) 1997-07-24 2004-10-27 Perseptive Biosystems, Inc. Conjugates of transporter peptides and nucleic acid analogs, and their use
WO1999014266A1 (en) 1997-09-17 1999-03-25 Japan Polychem Corporation Resin material for foam molding, foamed sheet obtained therefrom, and process for producing the same
CA2303908A1 (en) 1997-09-18 1999-03-25 Gene Therapy Systems, Inc. Chemical modification of dna using peptide nucleic acid conjugates
US6232066B1 (en) 1997-12-19 2001-05-15 Neogen, Inc. High throughput assay system
US6326479B1 (en) 1998-01-27 2001-12-04 Boston Probes, Inc. Synthetic polymers and methods, kits or compositions for modulating the solubility of same
DE19823454A1 (en) 1998-05-18 1999-11-25 Epigenomics Gmbh Photolithographic production of oligonucleotide array for manufacture of DNA chips
US6280946B2 (en) 1998-08-07 2001-08-28 Boston Probes, Inc. PNA probes, probe sets, methods and kits pertaining to the universal detection of bacteria and eucarya
WO2000034521A1 (en) 1998-12-08 2000-06-15 Boston Probes, Inc. Methods, kits and compositions for the identification of nucleic acids electrostatically bound to matrices
CN1361829A (en) 1999-03-18 2002-07-31 埃克西库恩公司 Detection of mutations in genes by specific LNA primers
IL145495A0 (en) 1999-03-18 2002-06-30 Exiqon As Xylo-lna analogues
WO2000056920A1 (en) 1999-03-18 2000-09-28 Exiqon A/S One step sample preparation and detection of nucleic acids in complex biological samples
AU3418800A (en) 1999-03-24 2000-10-09 Exiqon A/S Improved synthesis of (2.2.1)bicyclo nucleosides
EP1234182A2 (en) 1999-06-30 2002-08-28 Iris Bio Technologies Hybridization of target dna with immobilized nucleic acid analogs
US6312956B1 (en) 1999-10-01 2001-11-06 Vanderbilt University Nuclear targeted peptide nucleic acid oligomer
DE19957827C2 (en) 1999-11-25 2003-06-12 Epigenomics Ag Use of an oligomer array with PNA and / or DNA oligomers on a surface
AU2001247414A1 (en) 2000-03-14 2001-09-24 Active Motif Oligonucleotide analogues, methods of synthesis and methods of use

Also Published As

Publication number Publication date
EP1263773A4 (en) 2005-08-31
WO2001068673A1 (en) 2001-09-20
US20020155989A1 (en) 2002-10-24
CA2402319A1 (en) 2001-09-20
US7115738B2 (en) 2006-10-03
EP1263773A1 (en) 2002-12-11

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