AU2001244700A1 - Process for producing amine derivatives - Google Patents
Process for producing amine derivativesInfo
- Publication number
- AU2001244700A1 AU2001244700A1 AU2001244700A AU4470001A AU2001244700A1 AU 2001244700 A1 AU2001244700 A1 AU 2001244700A1 AU 2001244700 A AU2001244700 A AU 2001244700A AU 4470001 A AU4470001 A AU 4470001A AU 2001244700 A1 AU2001244700 A1 AU 2001244700A1
- Authority
- AU
- Australia
- Prior art keywords
- amine derivatives
- secretion
- inhibiting
- accumulation
- action
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 150000001412 amines Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 102000013455 Amyloid beta-Peptides Human genes 0.000 abstract 2
- 108010090849 Amyloid beta-Peptides Proteins 0.000 abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 238000009825 accumulation Methods 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 230000028327 secretion Effects 0.000 abstract 2
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
- 150000003512 tertiary amines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000-105398 | 2000-04-03 | ||
| JP2000105398 | 2000-04-03 | ||
| PCT/JP2001/002845 WO2001074756A1 (fr) | 2000-04-03 | 2001-04-02 | Procede de production de derives d'amine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2001244700A1 true AU2001244700A1 (en) | 2001-10-15 |
Family
ID=18618765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2001244700A Abandoned AU2001244700A1 (en) | 2000-04-03 | 2001-04-02 | Process for producing amine derivatives |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6784314B2 (fr) |
| EP (1) | EP1270545B1 (fr) |
| KR (1) | KR100769504B1 (fr) |
| CN (4) | CN1680280A (fr) |
| AT (1) | ATE413379T1 (fr) |
| AU (1) | AU2001244700A1 (fr) |
| CA (1) | CA2404736C (fr) |
| CY (1) | CY1108727T1 (fr) |
| DE (1) | DE60136446D1 (fr) |
| ES (1) | ES2312423T3 (fr) |
| WO (1) | WO2001074756A1 (fr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4354180B2 (ja) * | 2001-12-26 | 2009-10-28 | 武田薬品工業株式会社 | 軽度認知障害治療剤 |
| NZ550441A (en) * | 2004-05-05 | 2009-07-31 | Hoffmann La Roche | Arylsulfonyl benzodioxanes useful for modulating the 5-HT6 receptor, the 5-HT2A receptor or both |
| WO2006001463A1 (fr) | 2004-06-23 | 2006-01-05 | Ono Pharmaceutical Co., Ltd. | Composé ayant une activité de liaison aux récepteurs s1p et utilisation de celui-ci |
| AU2005318596B2 (en) * | 2004-12-21 | 2010-12-23 | F. Hoffmann-La Roche Ag | Chroman derivatives and their use as 5-HT receptor ligands |
| BRPI0515830A (pt) | 2004-12-21 | 2008-08-05 | F Hoffmann La Roche | derivados de cromano e usos dos mesmos no tratamento de distúrbios do sistema nervoso central |
| DK1831159T3 (da) * | 2004-12-21 | 2010-03-22 | Hoffmann La Roche | Tetralin og indanderivater samt anvendelser deraf |
| KR100889185B1 (ko) * | 2004-12-21 | 2009-03-16 | 에프. 호프만-라 로슈 아게 | 테트랄린 및 인단 유도체 및 5-ｈｔ 길항제로서의 이의용도 |
| BRPI0515835A (pt) * | 2004-12-21 | 2008-08-12 | Hoffmann La Roche | derivados de tetralina e de indano e seus usos |
| ATE499355T1 (de) * | 2005-11-03 | 2011-03-15 | Hoffmann La Roche | Arylsulfonylchromane als 5-ht6-inhibitoren |
| CA2653758A1 (fr) * | 2006-06-20 | 2007-12-27 | F. Hoffmann-La Roche Ag | Derives tetraline et indane et leurs utilisations |
| WO2007147763A1 (fr) * | 2006-06-20 | 2007-12-27 | F. Hoffmann-La Roche Ag | Dérivés arylsulfonylnaphtalène et leurs utilisations |
| KR101064001B1 (ko) * | 2006-06-20 | 2011-09-08 | 에프. 호프만-라 로슈 아게 | 아릴설폰아미딜 테트랄린 유도체 및 이의 용도 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3630903A1 (de) | 1986-09-11 | 1988-03-24 | Thomae Gmbh Dr K | Neue tetrahydronaphthalin- und indanderivate, verfahren zu deren herstellung sowie diese enthaltende arzneimittel |
| DE3807813A1 (de) | 1988-03-10 | 1989-09-21 | Thomae Gmbh Dr K | Neue benzocycloheptenderivate, diese verbindungen enthaltende arzneimittel und verfahren zu deren herstellung |
| DE3901814A1 (de) | 1988-07-28 | 1990-02-01 | Bayer Ag | Substituierte aminomethylzetraline sowie ihre heterocyclischen analoga |
| DK0589037T3 (da) | 1991-03-01 | 1996-09-16 | Zeria Pharm Co Ltd | Indanderivat og thromboxanantagonist indeholdende samme |
| EP0763034A1 (fr) | 1994-05-28 | 1997-03-19 | Smithkline Beecham Plc | Derives amide a activite antagoniste par rapport a 5ht1d |
| ES2098186B1 (es) | 1995-02-09 | 1998-02-01 | Consejo Superior Investigacion | Composiciones farmaceuticas a base de aminometilindoles para su aplicacion terapeutica como neuroprotectores en las enfermedades de parkinson y alzheimer. |
| US6225352B1 (en) | 1996-08-14 | 2001-05-01 | Warner-Lambert Company | Low molecular weight dendritic compounds as pharmaceutical agents |
| US6048877A (en) | 1997-02-21 | 2000-04-11 | Bristol-Myers Squibb Company | Tetralone derivatives as antiarrhythmic agents |
| DE69839305T2 (de) | 1997-02-27 | 2009-04-09 | Takeda Pharmaceutical Co. Ltd. | Aminderivate, ihre herstellung und verwendung als inhibitoren der produktion von amyloid-beta |
| JP3868096B2 (ja) * | 1997-02-27 | 2007-01-17 | 武田薬品工業株式会社 | アミン誘導体、その製造法および剤 |
| JP4367982B2 (ja) * | 1997-07-18 | 2009-11-18 | 武田薬品工業株式会社 | 光学異性体の製造法 |
-
2001
- 2001-04-02 WO PCT/JP2001/002845 patent/WO2001074756A1/fr not_active Ceased
- 2001-04-02 KR KR1020027013158A patent/KR100769504B1/ko not_active Expired - Fee Related
- 2001-04-02 ES ES01917774T patent/ES2312423T3/es not_active Expired - Lifetime
- 2001-04-02 EP EP01917774A patent/EP1270545B1/fr not_active Expired - Lifetime
- 2001-04-02 US US10/240,574 patent/US6784314B2/en not_active Expired - Fee Related
- 2001-04-02 AU AU2001244700A patent/AU2001244700A1/en not_active Abandoned
- 2001-04-02 DE DE60136446T patent/DE60136446D1/de not_active Expired - Lifetime
- 2001-04-02 CN CNA2005100591252A patent/CN1680280A/zh active Pending
- 2001-04-02 CN CNB018076440A patent/CN100486957C/zh not_active Expired - Fee Related
- 2001-04-02 CN CN2006100932675A patent/CN101058543B/zh not_active Expired - Fee Related
- 2001-04-02 CA CA2404736A patent/CA2404736C/fr not_active Expired - Fee Related
- 2001-04-02 CN CNB2005100591267A patent/CN100349872C/zh not_active Expired - Fee Related
- 2001-04-02 AT AT01917774T patent/ATE413379T1/de not_active IP Right Cessation
-
2009
- 2009-01-27 CY CY20091100099T patent/CY1108727T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2404736A1 (fr) | 2002-10-02 |
| CN101058543A (zh) | 2007-10-24 |
| CY1108727T1 (el) | 2014-04-09 |
| CN1680332A (zh) | 2005-10-12 |
| US6784314B2 (en) | 2004-08-31 |
| ATE413379T1 (de) | 2008-11-15 |
| EP1270545A4 (fr) | 2005-10-12 |
| CA2404736C (fr) | 2011-12-06 |
| CN100486957C (zh) | 2009-05-13 |
| CN1680280A (zh) | 2005-10-12 |
| EP1270545B1 (fr) | 2008-11-05 |
| CN1422244A (zh) | 2003-06-04 |
| CN100349872C (zh) | 2007-11-21 |
| US20030139602A1 (en) | 2003-07-24 |
| WO2001074756A1 (fr) | 2001-10-11 |
| KR100769504B1 (ko) | 2007-10-23 |
| DE60136446D1 (de) | 2008-12-18 |
| ES2312423T3 (es) | 2009-03-01 |
| KR20020089424A (ko) | 2002-11-29 |
| EP1270545A1 (fr) | 2003-01-02 |
| CN101058543B (zh) | 2010-05-26 |
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