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AU2001241420A1 - Screening assays using intramitochondrial calcium - Google Patents

Screening assays using intramitochondrial calcium

Info

Publication number
AU2001241420A1
AU2001241420A1 AU2001241420A AU4142001A AU2001241420A1 AU 2001241420 A1 AU2001241420 A1 AU 2001241420A1 AU 2001241420 A AU2001241420 A AU 2001241420A AU 4142001 A AU4142001 A AU 4142001A AU 2001241420 A1 AU2001241420 A1 AU 2001241420A1
Authority
AU
Australia
Prior art keywords
mitochondrial
agents
screening assays
calcium
detect
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001241420A
Inventor
Anne N. Murphy
Amy K. Stout
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Migenix Corp
Original Assignee
Mitokor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitokor Inc filed Critical Mitokor Inc
Publication of AU2001241420A1 publication Critical patent/AU2001241420A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5076—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving cell organelles, e.g. Golgi complex, endoplasmic reticulum
    • G01N33/5079—Mitochondria

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention provides methods for screening for agents that modulate mitochondrial function and in particular mitochondrial regulation of intracellular calcium. The methods may be used to detect agents that bind to a mitochondrial calcium uniporter and may also detect inhibitors or uncouplers of mitochondrial respiration. Agents identified using the screens provided herein have application in the prevention and treatment of a variety of diseases associated with abnormal mitochondrial function.
AU2001241420A 2000-01-14 2001-01-16 Screening assays using intramitochondrial calcium Abandoned AU2001241420A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17638400P 2000-01-14 2000-01-14
US60176384 2000-01-14
PCT/US2001/001500 WO2001051923A2 (en) 2000-01-14 2001-01-16 Screening assays using intramitochondrial calcium

Publications (1)

Publication Number Publication Date
AU2001241420A1 true AU2001241420A1 (en) 2001-07-24

Family

ID=22644141

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001241420A Abandoned AU2001241420A1 (en) 2000-01-14 2001-01-16 Screening assays using intramitochondrial calcium

Country Status (6)

Country Link
US (2) US6808873B2 (en)
EP (1) EP1247093B1 (en)
AT (1) ATE291737T1 (en)
AU (1) AU2001241420A1 (en)
DE (1) DE60109571D1 (en)
WO (1) WO2001051923A2 (en)

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US7879840B2 (en) 2005-08-25 2011-02-01 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US7718644B2 (en) 2004-01-22 2010-05-18 The Trustees Of Columbia University In The City Of New York Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
US8022058B2 (en) * 2000-05-10 2011-09-20 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
AU2001276846A1 (en) * 2000-06-29 2002-01-14 Mitokor Methods for identifying mitochondrial divalent cation transporters
EP1546183A4 (en) 2002-09-23 2008-06-18 Du Pont Isolation and use of ryanodine receptors
US7544678B2 (en) 2002-11-05 2009-06-09 The Trustees Of Columbia University In The City Of New York Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
EP1575575B1 (en) * 2002-11-08 2010-05-19 High Point Pharmaceuticals, LLC Safe chemical uncouplers for the treatment of obesity
GB0228139D0 (en) * 2002-12-03 2003-01-08 Kozlova Zwinderman Olga Fungal biosensor for contaminant detection
US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
US9238150B2 (en) 2005-07-22 2016-01-19 The Board Of Trustees Of The Leland Stanford Junior University Optical tissue interface method and apparatus for stimulating cells
US10052497B2 (en) 2005-07-22 2018-08-21 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
US9274099B2 (en) * 2005-07-22 2016-03-01 The Board Of Trustees Of The Leland Stanford Junior University Screening test drugs to identify their effects on cell membrane voltage-gated ion channel
US8906360B2 (en) 2005-07-22 2014-12-09 The Board Of Trustees Of The Leland Stanford Junior University Light-activated cation channel and uses thereof
US8926959B2 (en) 2005-07-22 2015-01-06 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
US20090093403A1 (en) 2007-03-01 2009-04-09 Feng Zhang Systems, methods and compositions for optical stimulation of target cells
US7704990B2 (en) 2005-08-25 2010-04-27 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
WO2007065080A2 (en) * 2005-11-29 2007-06-07 University Of Maryland, College Park Control of apoptosis by controlling the propensity of ceramide channel formation
US8398692B2 (en) 2007-01-10 2013-03-19 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
US8795609B2 (en) * 2007-02-08 2014-08-05 Biokit, S.A. Magnetic particle washing station
US8401609B2 (en) 2007-02-14 2013-03-19 The Board Of Trustees Of The Leland Stanford Junior University System, method and applications involving identification of biological circuits such as neurological characteristics
US10434327B2 (en) 2007-10-31 2019-10-08 The Board Of Trustees Of The Leland Stanford Junior University Implantable optical stimulators
US10035027B2 (en) 2007-10-31 2018-07-31 The Board Of Trustees Of The Leland Stanford Junior University Device and method for ultrasonic neuromodulation via stereotactic frame based technique
EP3165534B1 (en) 2008-04-23 2018-09-26 The Board of Trustees of The Leland Stanford Junior University Systems, methods and compositions for optical stimulation of target cells
ES2532235T3 (en) 2008-05-29 2015-03-25 The Board Of Trustees Of The Leland Stanford Junior University Cell line, system and procedure for the optical control of secondary messengers
JP5887136B2 (en) 2008-06-17 2016-03-16 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー Apparatus and method for controlling cell development
WO2009156422A1 (en) * 2008-06-25 2009-12-30 Novartis Forschungsstiftung Zweigniederlassung Friedrich Miescher Institute For Biomedical Research Novel mitochondrial dye
WO2010006049A1 (en) 2008-07-08 2010-01-14 The Board Of Trustees Of The Leland Stanford Junior University Materials and approaches for optical stimulation of the peripheral nervous system
NZ602416A (en) 2008-11-14 2014-08-29 Univ Leland Stanford Junior Optically-based stimulation of target cells and modifications thereto
WO2010111208A1 (en) * 2009-03-23 2010-09-30 University Of Miami Mitochondrial inhibitors and uses thereof
MY175954A (en) 2010-03-17 2020-07-16 The Board Of Trustees Of Leland Stanford Junior Univ Light-sensitive ion-passing molecules
CA2816971A1 (en) 2010-11-05 2012-05-10 The Board Of Trustees Of The Leland Stanford Junior University Light-activated chimeric opsins and methods of using the same
WO2012061744A2 (en) 2010-11-05 2012-05-10 The Board Of Trustees Of The Leland Stanford Junior University Stabilized step function opsin proteins and methods of using the same
CN110215614A (en) 2010-11-05 2019-09-10 斯坦福大学托管董事会 The upper conversion of light for light genetic method
CN106376525A (en) 2010-11-05 2017-02-08 斯坦福大学托管董事会 Control and characterization of memory function
JP6355335B2 (en) 2010-11-05 2018-07-11 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー Optogenetic control of reward-related behavior
CA3056186A1 (en) 2010-11-05 2012-05-10 Board Of Trustees Of The Leland Stanford Junior University Optically-controlled cns dysfunction
US8696722B2 (en) 2010-11-22 2014-04-15 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic magnetic resonance imaging
CN103687959B (en) * 2011-04-08 2016-10-12 贝斯泰医学中心公司 For measuring the method for mitochondrial function, compositions and test kit
CA3036859A1 (en) 2011-12-16 2013-06-20 The Board Of Trustees Of The Leland Stanford Junior University Opsin polypeptides and methods of use thereof
EP3205374B1 (en) 2012-02-21 2019-03-27 The Board of Trustees of The Leland Stanford Junior University Compositions for treating neurogenic disorders of the pelvic floor
US10974064B2 (en) 2013-03-15 2021-04-13 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic control of behavioral state
US9636380B2 (en) 2013-03-15 2017-05-02 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic control of inputs to the ventral tegmental area
CA2908864A1 (en) 2013-04-29 2014-11-06 The Board Of Trustees Of The Leland Stanford Junior University Devices, systems and methods for optogenetic modulation of action potentials in target cells
CN105829538A (en) 2013-08-14 2016-08-03 小利兰·斯坦福大学托管委员会 Silicone-modified polyester coating
US10568516B2 (en) 2015-06-22 2020-02-25 The Board Of Trustees Of The Leland Stanford Junior University Methods and devices for imaging and/or optogenetic control of light-responsive neurons
US11294165B2 (en) 2017-03-30 2022-04-05 The Board Of Trustees Of The Leland Stanford Junior University Modular, electro-optical device for increasing the imaging field of view using time-sequential capture
CA3063450A1 (en) 2017-05-19 2018-11-22 Lunella Biotech, Inc. Companion diagnostics for mitochondrial inhibitors
BR112022001207A2 (en) * 2019-07-24 2022-03-15 Luca Science Inc Method of obtaining mitochondria from cells and mitochondria obtained
CN113069530B (en) * 2021-03-31 2022-01-25 河南大学 Application of naphthalimide-polyamine derivative and cyclosporine A in preparation of antitumor drugs

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5015568A (en) * 1986-07-09 1991-05-14 The Wistar Institute Diagnostic methods for detecting lymphomas in humans
US5049673A (en) * 1987-10-30 1991-09-17 The Regents Of The University Of California Fluorescent indicator dyes for calcium working at long wavelengths
US5501980A (en) * 1994-05-20 1996-03-26 Molecular Probes, Inc. Benzazolylcoumarin-based ion indicators
US5888498A (en) * 1995-03-03 1999-03-30 Mitokor Cellular and animal models for diseases associated with mitochondrial defects
US6183948B1 (en) * 1998-04-15 2001-02-06 Johns Hopkins University Methods to identify compounds affecting mitochondria

Also Published As

Publication number Publication date
US20010046664A1 (en) 2001-11-29
EP1247093B1 (en) 2005-03-23
WO2001051923A2 (en) 2001-07-19
DE60109571D1 (en) 2005-04-28
US6808873B2 (en) 2004-10-26
ATE291737T1 (en) 2005-04-15
WO2001051923A3 (en) 2002-05-02
US20050170329A1 (en) 2005-08-04
EP1247093A2 (en) 2002-10-09

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