[go: up one dir, main page]

AU1246995A - Alpha-quaternary-alpha-amino acids for use as cns agents - Google Patents

Alpha-quaternary-alpha-amino acids for use as cns agents

Info

Publication number
AU1246995A
AU1246995A AU12469/95A AU1246995A AU1246995A AU 1246995 A AU1246995 A AU 1246995A AU 12469/95 A AU12469/95 A AU 12469/95A AU 1246995 A AU1246995 A AU 1246995A AU 1246995 A AU1246995 A AU 1246995A
Authority
AU
Australia
Prior art keywords
alpha
quaternary
amino acids
cns agents
cns
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU12469/95A
Inventor
David Edward Jane
Jeffrey Clifton Watkins
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Bristol
Tocris Cookson Ltd
Original Assignee
University of Bristol
Tocris Cookson Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Bristol, Tocris Cookson Ltd filed Critical University of Bristol
Publication of AU1246995A publication Critical patent/AU1246995A/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/30Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/301Acyclic saturated acids which can have further substituents on alkyl
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01Sulfonic acids
    • C07C309/28Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/57Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing carboxyl groups bound to the carbon skeleton
    • C07C309/61Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing carboxyl groups bound to the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/08Esters of oxyacids of phosphorus
    • C07F9/09Esters of phosphoric acids
    • C07F9/091Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808Acyclic saturated acids which can have further substituents on alkyl
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/02Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU12469/95A 1993-12-10 1994-12-09 Alpha-quaternary-alpha-amino acids for use as cns agents Abandoned AU1246995A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9325368 1993-12-10
GB939325368A GB9325368D0 (en) 1993-12-10 1993-12-10 Organic compounds
PCT/GB1994/002690 WO1995015940A1 (en) 1993-12-10 1994-12-09 Alpha-quaternary-alpha-amino acids for use as cns agents

Publications (1)

Publication Number Publication Date
AU1246995A true AU1246995A (en) 1995-06-27

Family

ID=10746453

Family Applications (1)

Application Number Title Priority Date Filing Date
AU12469/95A Abandoned AU1246995A (en) 1993-12-10 1994-12-09 Alpha-quaternary-alpha-amino acids for use as cns agents

Country Status (4)

Country Link
EP (1) EP0733036A1 (en)
AU (1) AU1246995A (en)
GB (1) GB9325368D0 (en)
WO (1) WO1995015940A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL182285B1 (en) * 1994-08-12 2001-12-31 Lilly Co Eli Synthetic amino acids and their esters and pharmaceutical preparations containing them. PL PL PL PL PL PL PL
US5661184A (en) * 1994-08-12 1997-08-26 Eli Lilly And Company Psychiatric agents
ES2162936T3 (en) * 1994-08-12 2002-01-16 Lilly Co Eli TREATMENT OF ANXIETY.
NZ291597A (en) * 1994-09-08 1998-12-23 Lilly Co Eli Carboxycyclopropan-1-yl derivatives, preparation, pharmaceutical compositions and intermediates thereof
US5717109A (en) * 1994-09-08 1998-02-10 Eli Lilly And Company Excitatory amino acid receptor antagonists
IL118727A (en) * 1995-06-29 2003-01-12 Lilly Co Eli (-)-2-spiro-5-hydantoinbicyclo [3.1.0] hexane-6-carboxylic acid, salts thereof and use thereof for the preparation of (+)-(2) aminobicyclo [3.1.0] hexane-2,6-dicarboxylic acid
US5688826A (en) * 1995-11-16 1997-11-18 Eli Lilly And Company Excitatory amino acid derivatives
US5912248A (en) * 1995-11-16 1999-06-15 Eli Lilly And Company Excitatory amino acid receptor antagonists
ZA969485B (en) * 1995-11-16 1998-05-12 Lilly Co Eli Excitatory amino acid receptor antagonists.
GB9617822D0 (en) * 1996-08-27 1996-10-09 Lilly Industries Ltd Pharmaceutical compounds
GB9621789D0 (en) * 1996-10-18 1996-12-11 Lilly Industries Ltd Pharmaceutical compounds
ES2131463B1 (en) * 1997-04-08 2000-03-01 Lilly Sa DERIVATIVES OF CYCLOPROPYLGLYCIN WITH PHARMACEUTICAL PROPERTIES.
US6825211B1 (en) 1997-07-18 2004-11-30 Georgetown University Bicyclic metabotropic glutamate receptor ligands
US6204292B1 (en) * 1997-07-18 2001-03-20 Georgetown University Bicyclic metabotropic glutamate receptor ligands
DE19801636A1 (en) 1998-01-17 1999-07-22 Bayer Ag New bi:cyclic lactone glutamate receptor modulators
DE19801647A1 (en) 1998-01-17 1999-07-22 Bayer Ag New beta, gamma-fused lactone glutamate receptor modulators for treating cerebral ischemia, cranial or brain trauma, pain or CNS-mediated spasms
DE19801646A1 (en) 1998-01-17 1999-07-22 Bayer Ag New bicyclic lactone glutamate receptor modulators for treating cerebral ischemia, cranial/brain trauma, pain or CNS-mediated spasms
CA2306170A1 (en) * 2000-04-18 2001-10-18 Kenneth Curry Novel amino, carboxy derivatives of barbituric acid
CN101166524B (en) 2005-04-28 2010-12-22 辉瑞有限公司 Amino acid derivatives
EP1937699A2 (en) * 2005-10-18 2008-07-02 Centre National De La Recherche Scientifique (Cnrs) Hypophosphorous acid derivatives and their therapeutical applications

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2658912A (en) * 1951-12-28 1953-11-10 Merck & Co Inc Alpha-methyl glutamic acid and salts and process for preparation
FR2392958A1 (en) * 1977-06-01 1978-12-29 Merck & Co Inc NEW FLUORINE AMINO ACIDS USEFUL AS A MEDICINAL PRODUCT
US4133964A (en) * 1977-07-01 1979-01-09 Merrell Toraude Et Compagnie α-Acetylenic derivatives of α-amino acids
US4260823A (en) * 1979-07-02 1981-04-07 Merrell Toruade Et Compagnie α-Acetylenic derivatives of α-amino acids
CA2025326C (en) * 1989-09-19 2001-04-24 Jeffrey P. Whitten Nmda antagonists

Also Published As

Publication number Publication date
WO1995015940A1 (en) 1995-06-15
GB9325368D0 (en) 1994-02-16
EP0733036A1 (en) 1996-09-25

Similar Documents

Publication Publication Date Title
AU6733994A (en) Chondroprotective agents
AU1272295A (en) Proinsulin-like compounds
AU7479594A (en) Chuck
AU7479694A (en) Chuck
AU6971794A (en) Novel compounds
AU1246995A (en) Alpha-quaternary-alpha-amino acids for use as cns agents
GB9325558D0 (en) Percaboxylic acids
AU6000794A (en) Cleansing composition
AU4041193A (en) Detergent composition
AU5261093A (en) Aminoalkylphenyl compounds
AU7836794A (en) New cytotoxic agents
AU7666394A (en) Detergent composition
AU7427494A (en) Collar for cartridge-needle unit
AU5195693A (en) Substituted benzoic acids
HU9503281D0 (en) Thioindole pyperidinyl derivatives used as antalgics
AU6544294A (en) Polystyrene-dissolving agent
AU3554995A (en) Antipicornaviral agents
AU6256994A (en) P-dinitroso benzole
PL319904A1 (en) Nitrobenzamides useful as antiarrythimic agents
AU6734094A (en) Chondroprotective agents
AU6973194A (en) Composition for ophthalmic use
AU4290993A (en) Michellamines useful as antiviral agents
AU7612394A (en) Cleansing composition
AU5394594A (en) New compounds
AU4570193A (en) Detergent composition