ATE95816T1 - 2-((4-piperidinyl)methyl>-1,2,3,4tetrahydroisochinolin-derivate, ihre herstellung und ihre therapeutische verwendung. - Google Patents

2-((4-piperidinyl)methyl>-1,2,3,4tetrahydroisochinolin-derivate, ihre herstellung und ihre therapeutische verwendung.

Info

Publication number: ATE95816T1
Authority: AT; Austria
Prior art keywords: methyl; group; piperidinyl; derivatives; preparation
Prior art date: 1988-07-12

Application number

AT89400306T

Other languages

English (en)

Inventor

Pascal George

Mireille Sevrin

Christian Maloizel

Arlette Tixidre

Jacques Froissant

Original Assignee

Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-07-12

Filing date

1989-02-03

Publication date

1993-10-15

1988-07-12 Priority claimed from FR8809447A external-priority patent/FR2634204B2/fr

1989-02-03 Application filed by Synthelabo filed Critical Synthelabo

1993-10-15 Application granted granted Critical

1993-10-15 Publication of ATE95816T1 publication Critical patent/ATE95816T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT89400306T 1988-07-12 1989-02-03 2-((4-piperidinyl)methyl>-1,2,3,4tetrahydroisochinolin-derivate, ihre herstellung und ihre therapeutische verwendung. ATE95816T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR8809447A FR2634204B2 (fr)	1987-08-07	1988-07-12	Derives de ((piperidinyl-4)methyl)-2 tetrahydro-1,2,3,4 isoquinoleines, leur preparation et leur application en therapeutique
EP89400306A EP0351255B1 (de)	1988-07-12	1989-02-03	2-[(4-Piperidinyl)methyl]-1,2,3,4-tetrahydroisochinolin-Derivate, ihre Herstellung und ihre therapeutische Verwendung

Publications (1)

Publication Number	Publication Date
ATE95816T1 true ATE95816T1 (de)	1993-10-15

Family

ID=9368349

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89400306T ATE95816T1 (de)	1988-07-12	1989-02-03	2-((4-piperidinyl)methyl>-1,2,3,4tetrahydroisochinolin-derivate, ihre herstellung und ihre therapeutische verwendung.

Country Status (15)

Country	Link
US (1)	US4925850A (de)
EP (1)	EP0351255B1 (de)
JP (1)	JPH0225481A (de)
KR (1)	KR900001676A (de)
AT (1)	ATE95816T1 (de)
AU (1)	AU606778B2 (de)
DE (1)	DE68909855D1 (de)
DK (1)	DK50089A (de)
FI (1)	FI890520L (de)
HU (1)	HU201543B (de)
IL (1)	IL89156A (de)
NO (1)	NO171786C (de)
NZ (1)	NZ227853A (de)
PT (1)	PT89643B (de)
ZA (1)	ZA89905B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3717561A1 (de) *	1987-05-25	1988-12-08	Thomae Gmbh Dr K	Indol-, isochinolin- und benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0306375A1 (de) *	1987-08-07	1989-03-08	Synthelabo	2-[(4-Piperidinyl)methyl]-1,2,3,4-tetrahydrochinolin-Derivate, ihre Herstellung und ihre therapeutische Verwendung
FR2661178B1 (fr) *	1990-04-24	1993-03-12	Synthelabo	Derives de [(tetrahydro-1,2,3,4 isoquinoleinyl-2)methyl]-4 piperidinecarboxylates-1 d'alkyle, leur preparation et leur application en therapeutique.
US5132311A (en) *	1990-06-27	1992-07-21	G. D. Searle & Co.	Cyanoquanidine type III antiarrhythmic agents and use
FR2747386B1 (fr) *	1996-04-12	1998-05-15	Synthelabo	Derives de 3-[(1,2,3,4-tetrahydroisoquinolein-2-yl)methyl] -8-azabicyclo [3.2.1] octane, leur preparation et leur application en therapeutique
DE69704060T2 (de) *	1996-08-14	2001-08-02	Smithkline Beecham P.L.C., Brentford	Tetrahydroisochinolinderivate und ihre pharmazeutische anwendung
GB9708805D0 (en)	1997-05-01	1997-06-25	Smithkline Beecham Plc	Compounds
GB9810876D0 (en)	1998-05-20	1998-07-22	Smithkline Beecham Plc	Compounds
BR9914370A (pt)	1998-10-08	2001-11-27	Smithkline Beecham Plc	Derivados de tetraidrobenzazepina úteis comomoduladores de receptores para a dopamina d3(agentes antipsicóticos)
DE10060176B4 (de)	2000-12-04	2008-06-19	Precitec Kg	Laserbearbeitungskopf
KR101042208B1 (ko) *	2008-09-26	2011-06-20	현대종합금속 주식회사	셀프 쉴디드(ｓｅｌｆ－ｓｈｉｅｌｄｅｄ) 아크 용접 플럭스 충전 와이어
PL2445899T3 (pl)	2009-06-26	2017-08-31	Sanofi	Nowe sole fumaranowe antagonisty receptora histaminy H3

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1670041A1 (de) *	1967-03-14	1972-03-02	American Home Prod	Isoindole und Isoindoline
FR7607M (de) *	1968-04-25	1970-01-19
GB1250719A (de) *	1969-03-19	1971-10-20
US3836536A (en) *	1972-06-08	1974-09-17	Warner Lambert Co	1,2,3,4-tetrahydro-3-aminomethyliso-quinolines
FR2426046A1 (fr) *	1978-05-18	1979-12-14	Synthelabo	Derive de tetrahydro-isoquinoleine, sa preparation et son application en therapeutique
US4220778A (en) *	1978-10-30	1980-09-02	G. D. Searle & Co.	8-Aryl-1,2,3,4-tetrahydroisoquinoline and derivatives thereof
US4766131A (en) *	1980-10-17	1988-08-23	Pennwalt Corporation	2-amino (or hydroxy) phenethyl-1,2,3,4-tetrahydroisoquinolines as analgesics
DE3717561A1 (de) *	1987-05-25	1988-12-08	Thomae Gmbh Dr K	Indol-, isochinolin- und benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0306375A1 (de) *	1987-08-07	1989-03-08	Synthelabo	2-[(4-Piperidinyl)methyl]-1,2,3,4-tetrahydrochinolin-Derivate, ihre Herstellung und ihre therapeutische Verwendung

1989
- 1989-02-02 IL IL89156A patent/IL89156A/xx not_active IP Right Cessation
- 1989-02-03 DE DE89400306T patent/DE68909855D1/de not_active Expired - Lifetime
- 1989-02-03 AU AU29617/89A patent/AU606778B2/en not_active Ceased
- 1989-02-03 AT AT89400306T patent/ATE95816T1/de not_active IP Right Cessation
- 1989-02-03 FI FI890520A patent/FI890520L/fi not_active Application Discontinuation
- 1989-02-03 DK DK050089A patent/DK50089A/da not_active Application Discontinuation
- 1989-02-03 NZ NZ227853A patent/NZ227853A/en unknown
- 1989-02-03 PT PT89643A patent/PT89643B/pt active IP Right Grant
- 1989-02-03 NO NO890440A patent/NO171786C/no unknown
- 1989-02-03 EP EP89400306A patent/EP0351255B1/de not_active Expired - Lifetime
- 1989-02-04 KR KR1019890001304A patent/KR900001676A/ko not_active Withdrawn
- 1989-02-06 US US07/306,497 patent/US4925850A/en not_active Expired - Fee Related
- 1989-02-06 ZA ZA89905A patent/ZA89905B/xx unknown
- 1989-02-06 HU HU89565A patent/HU201543B/hu not_active IP Right Cessation
- 1989-02-06 JP JP1027326A patent/JPH0225481A/ja active Pending

Also Published As

Publication number	Publication date
FI890520A0 (fi)	1989-02-03
JPH0225481A (ja)	1990-01-26
EP0351255A3 (en)	1990-05-02
AU2961789A (en)	1990-01-18
NO171786C (no)	1993-05-05
NO890440D0 (no)	1989-02-03
FI890520A7 (fi)	1990-01-13
ZA89905B (en)	1989-10-25
DK50089D0 (da)	1989-02-03
NZ227853A (en)	1990-06-26
DK50089A (da)	1990-01-13
DE68909855D1 (de)	1993-11-18
PT89643A (pt)	1989-10-04
HUT50327A (en)	1990-01-29
PT89643B (pt)	1994-02-28
KR900001676A (ko)	1990-02-27
EP0351255A2 (de)	1990-01-17
IL89156A (en)	1993-05-13
HU201543B (en)	1990-11-28
NO890440L (no)	1990-01-15
NO171786B (no)	1993-01-25
AU606778B2 (en)	1991-02-14
US4925850A (en)	1990-05-15
IL89156A0 (en)	1989-09-10
EP0351255B1 (de)	1993-10-13
FI890520L (fi)	1990-01-13

Publication	Publication Date	Title
DE3888756D1 (de)	1994-05-05	Carbamoylpyrrolidonderivate, ihre Verwendung und Herstellung.
ATE95816T1 (de)	1993-10-15	2-((4-piperidinyl)methyl>-1,2,3,4tetrahydroisochinolin-derivate, ihre herstellung und ihre therapeutische verwendung.
SE8603099L (sv)	1987-01-17	Distamycinderivat och forfarande for deras framstellning
ES551274A0 (es)	1988-04-01	Un procedimiento para la sintesis de derivados de imidazol.
DE69105572D1 (de)	1995-01-19	4-Phenylphthalazin-Derivate.
FI912888A0 (fi)	1991-06-14	2-(aminoalkyl)-5-(arylalkyl)-1,3 -dioxanderivat, deras framstaellning och terapeutiska tillaempning.
FI862909A0 (fi)	1986-07-10	Foerfarande foer framstaellning av nya indolkarboxamidderivat och deras salter.
SE8605458L (sv)	1987-06-21	4-hydroxikumaring-derivat
ES8201979A1 (es)	1982-01-16	Procedimiento para la obtencion de derivados de bifeni- lil-azoliletano
SE8005493L (sv)	1981-02-07	4-(haftalenyloxi)piperidin-derivat
DK0524512T3 (da)	2004-07-05	Antihypertensiv kombination
NO900646D0 (no)	1990-02-09	Fremgangsmaate for fremstilling av calsiumantagonister.
DE69301639D1 (de)	1996-04-04	Tetrahydronaphtalenderivate, ihre Herstellung und ihre therapeutische Verwendung
ES530878A0 (es)	1985-05-16	Un procedimiento para la preparacion de nuevos derivados de aminoeticpiridina o pirazina.
DK0538100T3 (da)	2002-04-29	Fremgangsmåde til fremstilling af derivater af fluorquinolin-3-carboxylsyre
DK0461012T3 (da)	1994-09-12	Derivater af ((1-arylpyrrolidin-2-yl)methyl)piperazin, fremstillingen heraf og deres terapeutiske anvendelse
FI953246A7 (fi)	1995-06-30	Välituotteet kinoliini-3-karboksyylihappojohdannaisten valmistamiseksi

Legal Events

Date	Code	Title	Description
1994-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties