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ATE753T1 - NEW SUBSTITUTED 2-PHEN YLAMINO-1,3-TETRAHYDROPYRIMIDINE-(2), THEIR ACID ADDITION SALTS, MEDICATIONS CONTAINING THEM AND PROCESSES FOR THE MANUFACTURE OF SAME. - Google Patents

NEW SUBSTITUTED 2-PHEN YLAMINO-1,3-TETRAHYDROPYRIMIDINE-(2), THEIR ACID ADDITION SALTS, MEDICATIONS CONTAINING THEM AND PROCESSES FOR THE MANUFACTURE OF SAME.

Info

Publication number
ATE753T1
ATE753T1 AT79102051T AT79102051T ATE753T1 AT E753 T1 ATE753 T1 AT E753T1 AT 79102051 T AT79102051 T AT 79102051T AT 79102051 T AT79102051 T AT 79102051T AT E753 T1 ATE753 T1 AT E753T1
Authority
AT
Austria
Prior art keywords
acid addition
addition salts
tetrahydropyrimidine
manufacture
processes
Prior art date
Application number
AT79102051T
Other languages
German (de)
Inventor
Helmut Dr. Staehle
Herbert Dr. Koeppe
Werner Dr. Kummer
Walter Prof. Dr. Kobinger
Christian Dr. Mag. Lillie
Ludwig Dr. Pichler
Original Assignee
C.H. Boehringer Sohn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by C.H. Boehringer Sohn filed Critical C.H. Boehringer Sohn
Application granted granted Critical
Publication of ATE753T1 publication Critical patent/ATE753T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/12—Nitrogen atoms not forming part of a nitro radical
    • C07D239/14—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to said nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

This invention relates to 2-phenylamino-1,3-tetrahydro-2-pyrimidines of general formula <IMAGE> (I) wherein R is a radical selected from the group consisting of <IMAGE> -CH2-CH=CH2, -CH2-CH=CH-CH3, and -CH2-C(CH3)=CH2, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds, including the salts, are useful as bradycardiacs.
AT79102051T 1978-07-19 1979-06-21 NEW SUBSTITUTED 2-PHEN YLAMINO-1,3-TETRAHYDROPYRIMIDINE-(2), THEIR ACID ADDITION SALTS, MEDICATIONS CONTAINING THEM AND PROCESSES FOR THE MANUFACTURE OF SAME. ATE753T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19782831600 DE2831600A1 (en) 1978-07-19 1978-07-19 NEW SUBSTITUTED 2-PHENYLAMINO-1, 3-TETRAHYDROPYRIMIDINE- (2), THE ACID ADDITION SALTS THEREOF, THE MEDICINAL PRODUCTS CONTAINING THE SAME AND METHOD FOR THE PRODUCTION THEREOF
EP79102051A EP0007024B1 (en) 1978-07-19 1979-06-21 Substituted 2-phenylamino-3,4,5,6-tetrahydropyrimidines, their acid addition salts, medicines containing them and process for their preparation

Publications (1)

Publication Number Publication Date
ATE753T1 true ATE753T1 (en) 1982-04-15

Family

ID=6044708

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79102051T ATE753T1 (en) 1978-07-19 1979-06-21 NEW SUBSTITUTED 2-PHEN YLAMINO-1,3-TETRAHYDROPYRIMIDINE-(2), THEIR ACID ADDITION SALTS, MEDICATIONS CONTAINING THEM AND PROCESSES FOR THE MANUFACTURE OF SAME.

Country Status (5)

Country Link
US (1) US4263300A (en)
EP (1) EP0007024B1 (en)
JP (1) JPS5519268A (en)
AT (1) ATE753T1 (en)
DE (2) DE2831600A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4788195A (en) * 1986-01-13 1988-11-29 American Cyanamid Company 4,5,6-substituted-N-(substituted-phenyl)-2-pyrimidinamines
US4876252A (en) * 1986-01-13 1989-10-24 American Cyanamid Company 4,5,6-substituted-N-(substituted-phenyl)-2-pyrimidinamines
EP0318926B1 (en) * 1987-11-30 1995-05-03 Kabushiki Kaisha Vitamin Kenkyusyo Intermediates for synthesizing 5,6,7,8-tetrahydro-L-erythro-biopterin and its derivatives
GB9016800D0 (en) * 1990-07-31 1990-09-12 Shell Int Research Tetrahydropyrimidine derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2691655A (en) * 1952-05-24 1954-10-12 Burroughs Wellcome Co 2-amino-4-substituted amino-6-aryl pyrimidines and process of preparing same
GB1453703A (en) * 1972-12-28 1976-10-27 Science Union & Cie Substituted cyclopropylmethylamines processes for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
JPS5519268A (en) 1980-02-09
EP0007024B1 (en) 1982-03-17
DE2962281D1 (en) 1982-04-15
US4263300A (en) 1981-04-21
DE2831600A1 (en) 1980-01-31
EP0007024A1 (en) 1980-01-23

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Legal Events

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REN Ceased due to non-payment of the annual fee