ATE67211T1 - C17-20-lyase-inhibitoren. - Google Patents
C17-20-lyase-inhibitoren.Info
- Publication number
- ATE67211T1 ATE67211T1 AT88106397T AT88106397T ATE67211T1 AT E67211 T1 ATE67211 T1 AT E67211T1 AT 88106397 T AT88106397 T AT 88106397T AT 88106397 T AT88106397 T AT 88106397T AT E67211 T1 ATE67211 T1 AT E67211T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- lyase inhibitors
- beta
- androst
- cyclopropylamino
- Prior art date
Links
- 239000002697 lyase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- LYFPAZBMEUSVNA-UHFFFAOYSA-N (10R)-3c-Hydroxy-10r.13c-dimethyl-(8cH.9tH.14tH)-Delta5-tetradecahydro-1H-cyclopenta[a]phenanthren Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCCC1(C)CC2 LYFPAZBMEUSVNA-UHFFFAOYSA-N 0.000 abstract 1
- LYFPAZBMEUSVNA-DYKIIFRCSA-N (3s,8s,9s,10r,13s,14s)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-ol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CCC[C@@]1(C)CC2 LYFPAZBMEUSVNA-DYKIIFRCSA-N 0.000 abstract 1
- 239000003098 androgen Substances 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 150000002081 enamines Chemical class 0.000 abstract 1
- 150000004678 hydrides Chemical class 0.000 abstract 1
- 150000002466 imines Chemical class 0.000 abstract 1
- 230000003637 steroidlike Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Detergent Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4117287A | 1987-04-22 | 1987-04-22 | |
| EP88106397A EP0288053B1 (de) | 1987-04-22 | 1988-04-21 | C17-20-Lyase-Inhibitoren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE67211T1 true ATE67211T1 (de) | 1991-09-15 |
Family
ID=21915133
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88106397T ATE67211T1 (de) | 1987-04-22 | 1988-04-21 | C17-20-lyase-inhibitoren. |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0288053B1 (de) |
| JP (1) | JP2711672B2 (de) |
| KR (1) | KR960015037B1 (de) |
| CN (1) | CN88102176A (de) |
| AT (1) | ATE67211T1 (de) |
| AU (1) | AU606677B2 (de) |
| CA (1) | CA1326234C (de) |
| DE (1) | DE3864725D1 (de) |
| DK (1) | DK217588A (de) |
| ES (1) | ES2038712T3 (de) |
| FI (1) | FI88397C (de) |
| GR (1) | GR3002713T3 (de) |
| HU (1) | HU198511B (de) |
| IL (1) | IL86139A (de) |
| NO (1) | NO169346C (de) |
| NZ (1) | NZ224288A (de) |
| PH (1) | PH24090A (de) |
| PT (1) | PT87294B (de) |
| ZA (1) | ZA882717B (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4891367A (en) * | 1987-04-22 | 1990-01-02 | Merrell Dow Pharmaceuticals Inc. | 17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors |
| US4954488A (en) * | 1989-06-14 | 1990-09-04 | Merrell Dow Pharmaceuticals Inc. | Method of treating hyperaldosteronism using 17β-cyclopropylaminoandrostene derivatives |
| US4966898A (en) * | 1989-08-15 | 1990-10-30 | Merrell Dow Pharmaceuticals Inc. | 4-substituted 17β-(cyclopropylamino)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors |
| US5209926A (en) * | 1990-06-12 | 1993-05-11 | Insite Vision Incorporated | Aminosteroids for ophthalmic use |
| US5124154A (en) * | 1990-06-12 | 1992-06-23 | Insite Vision Incorporated | Aminosteroids for ophthalmic use |
| US5256408A (en) * | 1990-06-12 | 1993-10-26 | Insite Vision Incorporated | Aminosteroids for ophthalmic use |
| US5252319A (en) * | 1990-06-12 | 1993-10-12 | Insite Vision Incorporated | Aminosteroids for ophthalmic use |
| US5604213A (en) * | 1992-03-31 | 1997-02-18 | British Technology Group Limited | 17-substituted steroids useful in cancer treatment |
| WO1993020097A1 (en) * | 1992-03-31 | 1993-10-14 | British Technology Group Ltd. | 17-substituted steroids useful in cancer treatment |
| US5486511A (en) * | 1993-05-25 | 1996-01-23 | Merrell Dow Pharmaceuticals Inc. | 4-amino-17β-(cyclopropyloxy)androst-4-en-3-one, 4-amino-17β-(cyclopropylamino)androst-4-en-3-one and related compounds as C17-20 lyase and 5α-reductase |
| KR100725442B1 (ko) | 2000-11-17 | 2007-06-07 | 다케다 야쿠힌 고교 가부시키가이샤 | 신규 이미다졸 유도체, 이의 제조 방법 및 이의 용도 |
| DE60144246D1 (de) | 2000-11-20 | 2011-04-28 | Takeda Pharmaceutical | Imidazolderivate, verfahren zu deren herstellung und deren verwendung |
| US7067537B2 (en) | 2000-12-08 | 2006-06-27 | Takeda Pharmaceutical Company Limited | Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparing the same and use thereof |
| AU2010264698C1 (en) | 2009-06-26 | 2013-05-16 | Novartis Ag | 1, 3-disubstituted imidazolidin-2-one derivatives as inhibitors of CYP 17 |
| KR101823275B1 (ko) | 2010-08-04 | 2018-03-08 | 펠피큐어 파마슈티걸즈 아이엔씨 | 전립선 암종의 치료를 위한 병용 요법 |
| EP2627648A1 (de) | 2010-09-16 | 2013-08-21 | Novartis AG | 17a-HYDROXYLASE-C17, 20-LYASE-INHIBITOREN |
| MX359399B (es) | 2011-04-28 | 2018-09-27 | Novartis Ag | Inhibidores de 17alfa-hidroxilasa/c17-20-liasa. |
| EP2968219B1 (de) | 2013-03-14 | 2019-04-24 | Pellficure Pharmaceuticals, Inc. | Neuartige therapie gegen prostatakarzinome |
| CA2960750A1 (en) | 2014-09-12 | 2016-03-17 | Pellficure Pharmaceuticals, Inc. | Compositions and methods for treatment of prostate carcinoma |
| EP3528799A1 (de) | 2016-10-24 | 2019-08-28 | Pellficure Pharmaceuticals, Inc. | Pharmazeutische zusammensetzungen aus 5-hydroxy-2-methylnaphthalen-1,4-dion |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL302932A (de) * | 1962-12-31 | |||
| US4891367A (en) * | 1987-04-22 | 1990-01-02 | Merrell Dow Pharmaceuticals Inc. | 17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors |
-
1988
- 1988-04-18 NZ NZ224288A patent/NZ224288A/xx unknown
- 1988-04-18 CA CA000564364A patent/CA1326234C/en not_active Expired - Fee Related
- 1988-04-18 AU AU14719/88A patent/AU606677B2/en not_active Ceased
- 1988-04-18 ZA ZA882717A patent/ZA882717B/xx unknown
- 1988-04-19 PH PH36817A patent/PH24090A/en unknown
- 1988-04-20 IL IL86139A patent/IL86139A/xx unknown
- 1988-04-21 ES ES198888106397T patent/ES2038712T3/es not_active Expired - Lifetime
- 1988-04-21 HU HU882029A patent/HU198511B/hu not_active IP Right Cessation
- 1988-04-21 KR KR1019880004512A patent/KR960015037B1/ko not_active Expired - Fee Related
- 1988-04-21 FI FI881877A patent/FI88397C/fi not_active IP Right Cessation
- 1988-04-21 NO NO881746A patent/NO169346C/no unknown
- 1988-04-21 EP EP88106397A patent/EP0288053B1/de not_active Expired - Lifetime
- 1988-04-21 JP JP63096969A patent/JP2711672B2/ja not_active Expired - Fee Related
- 1988-04-21 PT PT87294A patent/PT87294B/pt not_active IP Right Cessation
- 1988-04-21 CN CN198888102176A patent/CN88102176A/zh active Pending
- 1988-04-21 AT AT88106397T patent/ATE67211T1/de not_active IP Right Cessation
- 1988-04-21 DK DK217588A patent/DK217588A/da not_active Application Discontinuation
- 1988-04-21 DE DE8888106397T patent/DE3864725D1/de not_active Expired - Fee Related
-
1991
- 1991-09-12 GR GR91401315T patent/GR3002713T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0288053B1 (de) | 1991-09-11 |
| NZ224288A (en) | 1989-12-21 |
| PT87294B (pt) | 1992-08-31 |
| ES2038712T3 (es) | 1993-08-01 |
| IL86139A0 (en) | 1988-11-15 |
| HUT47307A (en) | 1989-02-28 |
| AU606677B2 (en) | 1991-02-14 |
| DK217588D0 (da) | 1988-04-21 |
| FI881877A7 (fi) | 1988-10-23 |
| JP2711672B2 (ja) | 1998-02-10 |
| AU1471988A (en) | 1988-10-27 |
| PT87294A (pt) | 1988-05-01 |
| NO881746D0 (no) | 1988-04-21 |
| GR3002713T3 (en) | 1993-01-25 |
| HU198511B (en) | 1989-10-30 |
| NO169346B (no) | 1992-03-02 |
| NO881746L (no) | 1988-10-24 |
| FI881877A0 (fi) | 1988-04-21 |
| DK217588A (da) | 1988-10-23 |
| DE3864725D1 (de) | 1991-10-17 |
| EP0288053A1 (de) | 1988-10-26 |
| PH24090A (en) | 1990-03-05 |
| CA1326234C (en) | 1994-01-18 |
| JPS63284195A (ja) | 1988-11-21 |
| NO169346C (no) | 1992-06-10 |
| FI88397B (fi) | 1993-01-29 |
| ZA882717B (en) | 1988-10-17 |
| KR960015037B1 (ko) | 1996-10-24 |
| IL86139A (en) | 1993-02-21 |
| FI88397C (fi) | 1993-05-10 |
| CN88102176A (zh) | 1988-11-23 |
| KR880012633A (ko) | 1988-11-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE67211T1 (de) | C17-20-lyase-inhibitoren. | |
| EP0413270A3 (en) | 4-substituted 17beta-(cyclopropylamino)androst-5-en-3beta-ol and related compounds useful as c17-20 lyase inhibitors | |
| NZ217773A (en) | Method of treatment for allergy using an n-substituted arylalkyl-heterocyclic amine | |
| IL95359A0 (en) | 4-substituted 17beta-(cyclopropylamino-androst-5-en-3beta-ol and related compounds useful as c17-20 lyase inhibitors | |
| YU48698A (sh) | Karboksamidni derivati pirolidina, piperidina i heksahidroazepina za lečenje oboljenja na bazi tromboze | |
| ZA882715B (en) | 17beta-(cyclopropyloxy)-androst-5-en-3beta-ol and related compounds useful as c17-20 lyase inhibitors | |
| ATE222491T1 (de) | Melatonin-derivate zur verwendung in der behandlung von schlafstörungen | |
| DE69432626D1 (de) | Melatonin-Derivate zur Verwendung in der Behandlung von Desynchronisierungs-Erkankungen | |
| ATE114468T1 (de) | Ethyl-(+)-apovincaminat zur behandlung der demyelinisierung klinischer erscheinungen autoimmunen ursprungs. | |
| ZA912236B (en) | Hydroxymethyl-indolizidines and quinolizidines |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |