ATE501268T1 - Vorrichtungen und verfahren zur bestimmung von proteaseaktivität - Google Patents
Vorrichtungen und verfahren zur bestimmung von proteaseaktivitätInfo
- Publication number
- ATE501268T1 ATE501268T1 AT05852712T AT05852712T ATE501268T1 AT E501268 T1 ATE501268 T1 AT E501268T1 AT 05852712 T AT05852712 T AT 05852712T AT 05852712 T AT05852712 T AT 05852712T AT E501268 T1 ATE501268 T1 AT E501268T1
- Authority
- AT
- Austria
- Prior art keywords
- protease activity
- methods
- devices
- determining protease
- determining
- Prior art date
Links
- 108091005804 Peptidases Proteins 0.000 title abstract 6
- 239000004365 Protease Substances 0.000 title abstract 6
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 2
- 238000003776 cleavage reaction Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 230000007017 scission Effects 0.000 abstract 2
- 102000035195 Peptidases Human genes 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43595—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63293104P | 2004-12-03 | 2004-12-03 | |
| US11/224,585 US7329506B2 (en) | 2004-12-03 | 2005-09-12 | Apparatuses and methods for determining protease activity |
| PCT/US2005/043572 WO2006060630A2 (en) | 2004-12-03 | 2005-12-01 | Apparatuses and methods for determining protease activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE501268T1 true ATE501268T1 (de) | 2011-03-15 |
Family
ID=36565750
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05852712T ATE501268T1 (de) | 2004-12-03 | 2005-12-01 | Vorrichtungen und verfahren zur bestimmung von proteaseaktivität |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7329506B2 (de) |
| EP (1) | EP1828404B1 (de) |
| JP (1) | JP2008521442A (de) |
| AT (1) | ATE501268T1 (de) |
| DE (1) | DE602005026855D1 (de) |
| WO (1) | WO2006060630A2 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7329506B2 (en) | 2004-12-03 | 2008-02-12 | Rutgers, The State University | Apparatuses and methods for determining protease activity |
| ES2890501T3 (es) | 2009-03-02 | 2022-01-20 | Massachusetts Inst Technology | Métodos y productos para la creación de perfiles enzimáticos in vivo |
| JP5645155B2 (ja) * | 2009-08-31 | 2014-12-24 | 国立大学法人 琉球大学 | 分子量マーカー及び分子量マーカーの作製方法 |
| JP6245990B2 (ja) | 2011-03-15 | 2017-12-13 | マサチューセッツ インスティテュート オブ テクノロジー | 同位体によりコード化されたレポーターによる多重検出 |
| JP6847660B2 (ja) | 2013-06-07 | 2021-03-24 | マサチューセッツ インスティテュート オブ テクノロジー | リガンドをコードする合成バイオマーカーのアフィニティベースの検出 |
| WO2017177115A1 (en) | 2016-04-08 | 2017-10-12 | Massachusetts Institute Of Technology | Methods to specifically profile protease activity at lymph nodes |
| CA3022928A1 (en) | 2016-05-05 | 2017-11-09 | Massachusetts Institute Of Technology | Methods and uses for remotely triggered protease activity measurements |
| AU2018248327B2 (en) | 2017-04-07 | 2024-10-10 | Massachusetts Institute Of Technology | Methods to spatially profile protease activity in tissue and sections |
| WO2019173332A1 (en) | 2018-03-05 | 2019-09-12 | Massachusetts Institute Of Technology | Inhalable nanosensors with volatile reporters and uses thereof |
| US11732009B2 (en) | 2018-06-08 | 2023-08-22 | Glympse Bio, Inc. | Activity sensor with tunable analyte |
| US11028425B2 (en) | 2018-06-08 | 2021-06-08 | Glympse Bio, Inc. | Diagnosis and monitoring of liver disease |
| US12173349B2 (en) | 2018-09-25 | 2024-12-24 | Massachusetts Institute Of Technology | Lung protease nanosensors and uses thereof |
| US11835522B2 (en) | 2019-01-17 | 2023-12-05 | Massachusetts Institute Of Technology | Sensors for detecting and imaging of cancer metastasis |
| CN113939597A (zh) | 2019-02-28 | 2022-01-14 | 佐治亚科技研究公司 | 用于生物活性逻辑门控分析的组合物和方法 |
| JP2023542867A (ja) | 2020-09-11 | 2023-10-12 | グリンプス バイオ， インコーポレイテッド | 疾患の検出／診断、病期分類、モニタリング及び処置のための生体外でのプロテアーゼ活性検出 |
| WO2022147138A1 (en) * | 2020-12-31 | 2022-07-07 | /1Glympse Bio, Inc. | Ex vivo detection of pathogens in body fluid samples |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010046668A1 (en) * | 1994-10-21 | 2001-11-29 | G.D. Searle & Co. | Fluorescence polarization method for determining protease activity |
| DE19843873A1 (de) * | 1998-09-25 | 2000-03-30 | Univ Halle Wittenberg | Verfahren zur Bestimmung von Proteaseaktivitäten auf Zelloberflächen |
| DE19941239A1 (de) * | 1999-08-26 | 2001-03-01 | Imb Inst Fuer Molekulare Biote | Proteasesubstrat und seine Verwendung |
| WO2001094332A1 (en) | 2000-06-02 | 2001-12-13 | Regents Of The University Of California | Profiling of protease specificity using combinatorial fluorogenic substrate libraries |
| DE10038382A1 (de) | 2000-08-07 | 2002-02-21 | Direvo Biotech Ag | Zweifarbiges fluorimetrisches Proteaseassay |
| GB0111459D0 (en) | 2001-05-10 | 2001-07-04 | Isis Innovation | Universal fluorescent sensors |
| AU2002315157A1 (en) * | 2001-06-14 | 2003-01-02 | Anadys Pharmaceuticals, Inc. | Methods of screening for ligands of target molecules |
| WO2004048935A2 (en) * | 2002-11-22 | 2004-06-10 | Marligen Biosciences, Inc. | Detection of protease enzymes |
| US20050214890A1 (en) * | 2003-11-26 | 2005-09-29 | Zhiqun Tan | Novel "Cleave-N-Read" system for protease activity assay and methods of use thereof |
| US7329506B2 (en) | 2004-12-03 | 2008-02-12 | Rutgers, The State University | Apparatuses and methods for determining protease activity |
-
2005
- 2005-09-12 US US11/224,585 patent/US7329506B2/en not_active Expired - Fee Related
- 2005-12-01 DE DE602005026855T patent/DE602005026855D1/de not_active Expired - Lifetime
- 2005-12-01 JP JP2007544525A patent/JP2008521442A/ja active Pending
- 2005-12-01 AT AT05852712T patent/ATE501268T1/de not_active IP Right Cessation
- 2005-12-01 WO PCT/US2005/043572 patent/WO2006060630A2/en not_active Ceased
- 2005-12-01 EP EP05852712A patent/EP1828404B1/de not_active Expired - Lifetime
-
2007
- 2007-11-09 US US11/937,608 patent/US7883863B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008521442A (ja) | 2008-06-26 |
| WO2006060630A3 (en) | 2009-05-14 |
| WO2006060630A2 (en) | 2006-06-08 |
| US20080241867A1 (en) | 2008-10-02 |
| US7329506B2 (en) | 2008-02-12 |
| DE602005026855D1 (de) | 2011-04-21 |
| EP1828404A4 (de) | 2010-03-03 |
| EP1828404B1 (de) | 2011-03-09 |
| US7883863B2 (en) | 2011-02-08 |
| EP1828404A2 (de) | 2007-09-05 |
| US20060121552A1 (en) | 2006-06-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |