ATE421593T1 - Polymerpfropfung mittels polysaccharide-synthase - Google Patents

Polymerpfropfung mittels polysaccharide-synthase

Info

Publication number: ATE421593T1
Authority: AT; Austria
Prior art keywords: present; relates; synthase; bioadhesive; biomaterial
Prior art date: 1998-11-11

Application number

AT99958858T

Other languages

English (en)

Inventor

Paul Deangelis

Original Assignee

Univ Oklahoma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-11-11

Filing date

1999-11-10

Publication date

2009-02-15

1999-11-10 Application filed by Univ Oklahoma filed Critical Univ Oklahoma

2009-02-15 Application granted granted Critical

2009-02-15 Publication of ATE421593T1 publication Critical patent/ATE421593T1/de

Links

229920000642 polymer Polymers 0.000 title abstract 5
150000004676 glycans Chemical class 0.000 title abstract 3
229920001282 polysaccharide Polymers 0.000 title abstract 3
239000005017 polysaccharide Substances 0.000 title abstract 3
239000012620 biological material Substances 0.000 abstract 4
241000606856 Pasteurella multocida Species 0.000 abstract 3
239000000227 bioadhesive Substances 0.000 abstract 3
238000000576 coating method Methods 0.000 abstract 3
229940051027 pasteurella multocida Drugs 0.000 abstract 3
KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract 2
102000003918 Hyaluronan Synthases Human genes 0.000 abstract 2
108090000320 Hyaluronan Synthases Proteins 0.000 abstract 2
239000003814 drug Substances 0.000 abstract 2
229920002674 hyaluronan Polymers 0.000 abstract 2
229960003160 hyaluronic acid Drugs 0.000 abstract 2
241000124008 Mammalia Species 0.000 abstract 1
150000001720 carbohydrates Chemical class 0.000 abstract 1
235000014633 carbohydrates Nutrition 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000012377 drug delivery Methods 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000002502 liposome Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000001681 protective effect Effects 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/08—Polysaccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/84—Manufacture, treatment, or detection of nanostructure
- Y10S977/895—Manufacture, treatment, or detection of nanostructure having step or means utilizing chemical property
- Y10S977/896—Chemical synthesis, e.g. chemical bonding or breaking
- Y10S977/898—Enzymatic

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Dermatology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Surgery (AREA)
Inorganic Chemistry (AREA)
Enzymes And Modification Thereof (AREA)
Materials For Medical Uses (AREA)
Medicinal Preparation (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Chemical Or Physical Treatment Of Fibers (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Graft Or Block Polymers (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

AT99958858T 1998-11-11 1999-11-10 Polymerpfropfung mittels polysaccharide-synthase ATE421593T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US10792998P	1998-11-11	1998-11-11
US28340299A	1999-04-01	1999-04-01

Publications (1)

Publication Number	Publication Date
ATE421593T1 true ATE421593T1 (de)	2009-02-15

Family

ID=26805343

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99958858T ATE421593T1 (de)	1998-11-11	1999-11-10	Polymerpfropfung mittels polysaccharide-synthase

Country Status (8)

Country	Link
US (3)	US6444447B1 (de)
EP (1)	EP1129209B1 (de)
JP (1)	JP2002529064A (de)
AT (1)	ATE421593T1 (de)
CA (1)	CA2351593C (de)
DE (1)	DE69940353D1 (de)
IL (1)	IL143080A0 (de)
WO (1)	WO2000027437A2 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7091008B1 (en)	1994-07-01	2006-08-15	The Board Of Regents Of The University Of Oklahoma	Hyaluronan synthase genes and expression thereof in Bacillus hosts
AU762036B2 (en) *	1997-10-31	2003-06-19	Board Of Regents Of The University Of Oklahoma, The	Hyaluronan synthase gene and uses thereof
US7223571B2 (en)	1998-04-02	2007-05-29	The Board Of Regents Of The Universtiy Of Oklahoma	Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US20060188966A1 (en)	1998-04-02	2006-08-24	Deangelis Paul L	Natural, chimeric and hybrid glycosaminoglycan polymers and methods of making and using same
AU770903B2 (en) *	1998-04-02	2004-03-04	Board Of Regents For Oklahoma State University, The	Nucleic acid encoding hyaluronan synthase and methods of use
US20030104601A1 (en)	1999-04-01	2003-06-05	Deangelis Paul L.	Chondroitin synthase gene and methods of making and using same
US6987023B2 (en) *	1998-04-02	2006-01-17	The Board Of Regents Of The University Of Oklahoma	DNA encoding hyaluronan synthase from Pasteurella multocida and methods of use
US20060105431A1 (en) *	1998-11-11	2006-05-18	Deangelis Paul L	Polymer grafting by polysaccharide synthases using artificial sugar acceptors
ATE421593T1 (de) *	1998-11-11	2009-02-15	Univ Oklahoma	Polymerpfropfung mittels polysaccharide-synthase
US7642071B2 (en)	1999-04-01	2010-01-05	The Board Of Regents Of The University Of Oklahoma	Methods of expressing gram-negative glycosaminoglycan synthase genes in gram-positive hosts
AU2001253805B2 (en) *	2000-04-25	2006-08-03	De Angelis, Paul L	Chondroitin synthase gene and methods of making and using same
US8580290B2 (en)	2001-05-08	2013-11-12	The Board Of Regents Of The University Of Oklahoma	Heparosan-based biomaterials and coatings and methods of production and use thereof
WO2003029261A2 (en) *	2001-07-13	2003-04-10	Deangelis Paul L	Glycosaminoglycan polymers and methods of making and using same
JP4702819B2 (ja)	2001-08-01	2011-06-15	生化学工業株式会社	コンドロイチン合成酵素
JP4101548B2 (ja) *	2001-08-10	2008-06-18	生化学工業株式会社	コンドロイチン合成酵素及びそれをコードするｄｎａ
RU2346049C2 (ru)	2001-12-21	2009-02-10	Новозимс Биополимер А/С	Способ получения гиалуронана в рекомбинантной клетке-хозяине
AU2003241686A1 (en) *	2002-05-31	2003-12-19	Amersham Biosciences K.K.	Chondroitin synthetase and nucleic acid coding for the enzyme
AU2003241687A1 (en) *	2002-05-31	2003-12-19	Amersham Biosciences K.K.	Chondroitin synthetase and dna coding for the enzyme
US7299805B2 (en) *	2002-06-07	2007-11-27	Marctec, Llc	Scaffold and method for implanting cells
WO2004032830A2 (en) *	2002-08-16	2004-04-22	University Of Oklahoma	Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US9150902B2 (en)	2005-06-28	2015-10-06	Seikagaku Corporation	Method for determination of N-deacetylase/N-sulfotransferase activity
WO2007023867A1 (ja)	2005-08-24	2007-03-01	Seikagaku Corporation	新規コンドロイチン画分製造方法
US8067204B2 (en)	2005-12-15	2011-11-29	Seikagaku Corporation	Long-chain chondroitin sugar chain and method for producing the same and method for promoting synthesis of chondroitin
CN101501075B (zh)	2006-08-04	2013-07-10	诺维信生物制药丹麦公司	支化透明质酸和制造方法
PL2173360T3 (pl) *	2007-03-30	2016-01-29	The Board Of Regents For The Univ Of Oklahoma	Biomateriały oparte na heparosanie i powłoki oraz sposoby ich wytwarzania i zastosowania
US7989615B2 (en) *	2007-07-13	2011-08-02	The Penn State Research Foundation	Separation of different isoforms of plasmid DNA using ultrafiltration
US9109051B2 (en)	2007-12-19	2015-08-18	Evonik Goldschmidt Gmbh	Crosslinked hyaluronic acid in emulsion
EP2262480B1 (de) *	2008-03-04	2018-02-14	Liquidia Technologies, Inc.	Immunomodulator-teilchen
US9925209B2 (en)	2008-03-19	2018-03-27	The Board Of Regents Of The University Of Oklahoma	Heparosan-polypeptide and heparosan-polynucleotide drug conjugates and methods of making and using same
US9687559B2 (en)	2008-03-19	2017-06-27	The Board Of Regents Of The University Of Oklahoma	Heparosan polymers and methods of making and using same for the enhancement of therapeutics
US20130209564A1 (en) *	2010-02-22	2013-08-15	Shyam M. Rele	Polysaccharide Particle Vaccines
JP5875531B2 (ja)	2010-03-01	2016-03-02	生化学工業株式会社	コンドロイチンの細菌生産のための組成物および方法
CA2863367A1 (en)	2011-01-31	2012-08-09	Paul Deangelis	Testosteronan, a novel heparosan analog, testosteronan synthase, and methods of production and use thereof
CA2835016A1 (en)	2011-05-30	2012-12-06	Novozymes Biopharma Dk A/S	Spray drying of high molecular weight hyaluronic acid
US8658593B2 (en)	2011-06-06	2014-02-25	The Cleveland Clinic Foundation	Treatment of extracellular matrix to reduce inflammation
CA2847328A1 (en)	2011-09-02	2013-03-07	Novozymes Biopharma Dk A/S	Oral formulations containing hyaluronic acid for sustained drug release
WO2013149161A1 (en)	2012-03-30	2013-10-03	Deangelis Paul L	High molecular weight heparosan polymers and methods of production and use thereof
WO2014100837A1 (en)	2012-12-17	2014-06-26	Bui The Duy	Computer aided implantation of body implants
RU2719140C1 (ru)	2019-07-26	2020-04-17	Общество с ограниченной ответственностью "ЦЕНТР ТРАНСФЕРА БИОТЕХНОЛОГИЙ ОКА-Биотех"	Бактерия рода bacillus, продуцирующая гиалуроновую кислоту, и способ получения гиалуроновой кислоты с использованием указанной бактерии
EP4487863A1 (de)	2023-07-07	2025-01-08	NuPep AS	Konsensuspeptide in hya zur verwendung bei der behandlung degenerierter gelenke
EP4487834A1 (de)	2023-07-07	2025-01-08	NuPep AS	Konsensuspeptide in hya
WO2025012149A1 (en)	2023-07-07	2025-01-16	Nupep As	Consensus peptides in hya

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2098506B (en) *	1981-05-14	1984-10-03	Biomed Res Inc	Drug coated materials
US4511478A (en)	1983-11-10	1985-04-16	Genetic Systems Corporation	Polymerizable compounds and methods for preparing synthetic polymers that integrally contain polypeptides
AU565354B2 (en)	1983-11-14	1987-09-10	Bio-Mimetics Inc.	Bioadhesive compositions and methods of treatment therewith
US4983392A (en)	1983-11-14	1991-01-08	Bio-Mimetics, Inc.	Bioadhesive compositions and methods of treatment therewith
US5336747A (en) *	1984-11-02	1994-08-09	Mitsui Petrochemical Industries, Ltd.	Random 1-butene/ethylene copolymer
US5171689A (en)	1984-11-08	1992-12-15	Matsushita Electric Industrial Co., Ltd.	Solid state bio-sensor
US4822867A (en)	1987-02-02	1989-04-18	Semih Erhan	Protein polymer grafts
US5015577A (en) *	1989-08-29	1991-05-14	Board Of Regents, The University Of Texas System	DNA encoding hyaluronate synthase
FR2652736A1 (fr)	1989-10-06	1991-04-12	Neftel Frederic	Dispositif implantable d'evaluation du taux de glucose.
IT1250421B (it)	1991-05-30	1995-04-07	Recordati Chem Pharm	Composizione farmaceutica a rilascio controllato con proprieta' bio-adesive.
US5837747A (en)	1991-10-29	1998-11-17	Vivorx, Inc.	Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release
US5217743A (en)	1992-02-07	1993-06-08	Paradigm Biotechnologies Partnership	Biomaterials of enhanced biocompatibility
US5826667A (en) *	1993-06-09	1998-10-27	Notaras; John Arthur	Lawn edger
EP0785988A1 (de) *	1993-07-15	1997-07-30	Neose Pharmaceuticals, Inc	Verfahren zur synthese von saccharidzusammensetzungen
CA2140298C (en)	1994-01-14	1998-12-08	Thomas L. Meade	Rumen by-pass feed supplement
JP3591837B2 (ja)	1994-02-17	2004-11-24	ニューヨーク・ブラッド・センター・インコーポレイテッド	フィブリン膠およびリポソームを含有する生物学的生体接着剤組成物、その製造方法および使用
IT1268954B1 (it)	1994-03-11	1997-03-18	Fidia Advanced Biopolymers Srl	Processo per la preparazione di acido ialuronico mediante sintesienzimatica e relative composizioni farmaceutiche
US5473034A (en)	1994-03-18	1995-12-05	Hyogo Prefectural Government	Method for producing protein-synthetic polymer conjugate and said conjugate produced thereby
US5928667A (en)	1994-06-24	1999-07-27	University Of Maryland	Drug delivery device and method for employing the same
US5851982A (en) *	1994-07-27	1998-12-22	Kao Corporation	Liquid softener compositions and quaternary ammonium salt
BE1008955A3 (fr)	1994-11-14	1996-10-01	Univ Catholique Louvain	Procede d'obtention de biomateriaux et produits obtenus.
AU5363596A (en)	1995-03-17	1996-10-08	Regents Of The University Of Minnesota	Biocompatible materials
WO1997020061A1 (en) *	1995-11-30	1997-06-05	The Scripps Research Institute	Synthesis of hyaluronic acid
US5610241A (en)	1996-05-07	1997-03-11	Cornell Research Foundation, Inc.	Reactive graft polymer with biodegradable polymer backbone and method for preparing reactive biodegradable polymers
US5885609A (en)	1997-05-23	1999-03-23	Northeastern University	Biocompatible articles and method for making same
US5945457A (en)	1997-10-01	1999-08-31	A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Science	Process for preparing biologically compatible polymers and their use in medical devices
AU770903B2 (en) *	1998-04-02	2004-03-04	Board Of Regents For Oklahoma State University, The	Nucleic acid encoding hyaluronan synthase and methods of use
ATE421593T1 (de) *	1998-11-11	2009-02-15	Univ Oklahoma	Polymerpfropfung mittels polysaccharide-synthase

1999
- 1999-11-10 AT AT99958858T patent/ATE421593T1/de not_active IP Right Cessation
- 1999-11-10 IL IL14308099A patent/IL143080A0/xx unknown
- 1999-11-10 US US09/437,277 patent/US6444447B1/en not_active Expired - Lifetime
- 1999-11-10 DE DE69940353T patent/DE69940353D1/de not_active Expired - Lifetime
- 1999-11-10 EP EP99958858A patent/EP1129209B1/de not_active Expired - Lifetime
- 1999-11-10 CA CA2351593A patent/CA2351593C/en not_active Expired - Fee Related
- 1999-11-10 WO PCT/US1999/026501 patent/WO2000027437A2/en not_active Ceased
- 1999-11-10 JP JP2000580666A patent/JP2002529064A/ja active Pending
2002
- 2002-06-27 US US10/184,485 patent/US20030077763A1/en not_active Abandoned
2005
- 2005-07-11 US US11/178,560 patent/US7575904B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1129209B1 (de)	2009-01-21
EP1129209A2 (de)	2001-09-05
US20060116348A1 (en)	2006-06-01
CA2351593A1 (en)	2000-05-18
US20030077763A1 (en)	2003-04-24
WO2000027437A9 (en)	2001-06-28
US6444447B1 (en)	2002-09-03
US7575904B2 (en)	2009-08-18
WO2000027437A2 (en)	2000-05-18
WO2000027437A3 (en)	2000-07-20
IL143080A0 (en)	2002-04-21
EP1129209A4 (de)	2004-04-07
DE69940353D1 (en)	2009-03-12
JP2002529064A (ja)	2002-09-10
CA2351593C (en)	2012-02-21

Publication	Publication Date	Title
ATE421593T1 (de)	2009-02-15	Polymerpfropfung mittels polysaccharide-synthase
Köwitsch et al.	2018	Medical application of glycosaminoglycans: a review
Hintze et al.	2022	Chemical modification of hyaluronan and their biomedical applications
Kirschning et al.	2018	Chemical functionalization of polysaccharides—Towards biocompatible hydrogels for biomedical applications
Miranda et al.	2016	A chitosan‐hyaluronic acid hydrogel scaffold for periodontal tissue engineering
Sahoo et al.	2008	Hydrolytically degradable hyaluronic acid hydrogels with controlled temporal structures
CA2887324C (en)	2020-12-15	Glucose responsive hydrogel comprising pba-grafted hyaluronic acid (ha)
Morelli et al.	2016	Design, preparation and characterization of ulvan based thermosensitive hydrogels
Palumbo et al.	2006	New graft copolymers of hyaluronic acid and polylactic acid: synthesis and characterization
Moura et al.	2007	Rheological study of genipin cross-linked chitosan hydrogels
Schnabelrauch et al.	2013	Sulfated glycosaminoglycans as promising artificial extracellular matrix components to improve the regeneration of tissues
Reitinger et al.	2012	Hyaluronan, a ready choice to fuel regeneration: a mini-review
Šedová et al.	2013	Preparation of hyaluronan polyaldehyde—a precursor of biopolymer conjugates
Mergy et al.	2012	Modification of polysaccharides via thiol‐ene chemistry: A versatile route to functional biomaterials
Rother et al.	2017	Hyaluronan/collagen hydrogels with sulfated hyaluronan for improved repair of vascularized tissue tune the binding of proteins and promote endothelial cell growth
JP2007500027A (ja)	2007-01-11	生物医学的な使用のための複合マトリックス
Knight et al.	2007	Structure, depolymerization, and cytocompatibility evaluation of glycol chitosan
Kristiansen et al.	2011	Periodate oxidized alginates: Depolymerization kinetics
EP1313772A1 (de)	2003-05-28	Neue vernetzte derivate der hyaluronsäure.
AU2002213870A1 (en)	2002-06-06	New cross-linked derivatives of hyaluronic acid
CA2521961A1 (en)	2004-10-28	Crosslinking of low-molecular weight and high-molecular weight polysaccharides; preparation of injectable monophase hydrogels; polysaccharides and hydrogels obtained
Serban et al.	2008	Synthesis, characterization and chondroprotective properties of a hyaluronan thioethyl ether derivative
Pravata et al.	2008	New amphiphilic lactic acid oligomer− hyaluronan conjugates: synthesis and physicochemical characterization
Zhao	2006	Synthesis and characterization of a novel hyaluronic acid hydrogel
Revuelta et al.	2021	Heparanized chitosans: towards the third generation of chitinous biomaterials

Legal Events

Date	Code	Title	Description
2009-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties