ATE410449T1 - Apoptose-induzierendes polypeptid - Google Patents
Apoptose-induzierendes polypeptidInfo
- Publication number
- ATE410449T1 ATE410449T1 AT01912268T AT01912268T ATE410449T1 AT E410449 T1 ATE410449 T1 AT E410449T1 AT 01912268 T AT01912268 T AT 01912268T AT 01912268 T AT01912268 T AT 01912268T AT E410449 T1 ATE410449 T1 AT E410449T1
- Authority
- AT
- Austria
- Prior art keywords
- apoptosis
- reconstructed
- polypeptides
- iap
- regions
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 102100032913 Leukocyte surface antigen CD47 Human genes 0.000 abstract 3
- 101710098610 Leukocyte surface antigen CD47 Proteins 0.000 abstract 3
- 230000006907 apoptotic process Effects 0.000 abstract 2
- 210000000601 blood cell Anatomy 0.000 abstract 2
- 208000019838 Blood disease Diseases 0.000 abstract 1
- 231100001015 blood dyscrasias Toxicity 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000035931 haemagglutination Effects 0.000 abstract 1
- 208000014951 hematologic disease Diseases 0.000 abstract 1
- 208000018706 hematopoietic system disease Diseases 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3061—Blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52309500A | 2000-03-10 | 2000-03-10 | |
| JP2000115246 | 2000-04-17 | ||
| JP2000321822 | 2000-10-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE410449T1 true ATE410449T1 (de) | 2008-10-15 |
Family
ID=27343106
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01912268T ATE410449T1 (de) | 2000-03-10 | 2001-03-12 | Apoptose-induzierendes polypeptid |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1262548B1 (de) |
| KR (1) | KR20020089390A (de) |
| CN (1) | CN1422333A (de) |
| AT (1) | ATE410449T1 (de) |
| AU (2) | AU4110001A (de) |
| CA (1) | CA2402896A1 (de) |
| DE (1) | DE60136054D1 (de) |
| ES (1) | ES2312418T3 (de) |
| IL (1) | IL151531A0 (de) |
| TW (2) | TWI242043B (de) |
| WO (1) | WO2001066737A1 (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7531643B2 (en) | 1997-09-11 | 2009-05-12 | Chugai Seiyaku Kabushiki Kaisha | Monoclonal antibody inducing apoptosis |
| US7696325B2 (en) | 1999-03-10 | 2010-04-13 | Chugai Seiyaku Kabushiki Kaisha | Polypeptide inducing apoptosis |
| CN1308448C (zh) | 2000-10-20 | 2007-04-04 | 中外制药株式会社 | 低分子化的tpo激动剂抗体 |
| WO2004033499A1 (ja) | 2002-10-11 | 2004-04-22 | Chugai Seiyaku Kabushiki Kaisha | 細胞死誘導剤 |
| JP2004279086A (ja) | 2003-03-13 | 2004-10-07 | Konica Minolta Holdings Inc | 放射線画像変換パネル及び放射線画像変換パネルの製造方法 |
| US20070281327A1 (en) * | 2003-12-12 | 2007-12-06 | Kiyotaka Nakano | Methods of Screening for Modified Antibodies With Agonistic Activities |
| TW200530269A (en) | 2003-12-12 | 2005-09-16 | Chugai Pharmaceutical Co Ltd | Anti-Mpl antibodies |
| WO2006106905A1 (ja) | 2005-03-31 | 2006-10-12 | Chugai Seiyaku Kabushiki Kaisha | 会合制御によるポリペプチド製造方法 |
| WO2006106903A1 (ja) | 2005-03-31 | 2006-10-12 | Chugai Seiyaku Kabushiki Kaisha | sc(Fv)2構造異性体 |
| CN101237890A (zh) | 2005-06-10 | 2008-08-06 | 中外制药株式会社 | 含有葡甲胺的蛋白质制剂的稳定剂及其利用 |
| US9241994B2 (en) | 2005-06-10 | 2016-01-26 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical compositions containing sc(Fv)2 |
| US9084777B2 (en) | 2005-12-28 | 2015-07-21 | Chugai Seiyaku Kabushiki Kaisha | Stabilized antibody-containing formulations |
| EP2009101B1 (de) | 2006-03-31 | 2017-10-25 | Chugai Seiyaku Kabushiki Kaisha | Antikörpermodifikationsverfahren für die aufreinigung eines bispezifischen antikörpers |
| WO2008023689A1 (fr) | 2006-08-21 | 2008-02-28 | National University Corporation Kobe University | Procédé de production d'une protéine de fusion |
| PE20091174A1 (es) | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | Formulacion liquida con contenido de alta concentracion de anticuerpo |
| EP4470556A3 (de) | 2008-01-15 | 2025-04-23 | The Board of Trustees of the Leland Stanford Junior University | Marker für stammzellen der akuten myeloischen leukämie |
| DK2242512T3 (en) | 2008-01-15 | 2016-06-06 | Univ Leland Stanford Junior | Method for manipulating phagocytosis mediated by CD47 |
| AR080428A1 (es) | 2010-01-20 | 2012-04-11 | Chugai Pharmaceutical Co Ltd | Formulaciones liquidas estabilizadas contentivas de anticuerpos |
| EP2735315B1 (de) | 2011-07-19 | 2019-10-02 | Chugai Seiyaku Kabushiki Kaisha | Proteinhaltige stabile zubereitung mit argininamid oder valinamid |
| MX359235B (es) | 2011-09-01 | 2018-09-20 | Chugai Pharmaceutical Co Ltd | Metodo para preparar una composicion que comprende anticuerpos altamente concentrados por ultrafiltracion. |
| JP2016507555A (ja) * | 2013-02-06 | 2016-03-10 | インヒブルクス エルピー | 血小板非減少性かつ赤血球非減少性ｃｄ４７抗体及びその使用方法 |
| KR102441231B1 (ko) | 2013-09-27 | 2022-09-06 | 추가이 세이야쿠 가부시키가이샤 | 폴리펩티드 이종 다량체의 제조방법 |
| MY181081A (en) | 2013-12-27 | 2020-12-17 | Chugai Pharmaceutical Co Ltd | Method for purifying antibody having low isoelectric point |
| JP6858559B2 (ja) | 2014-08-20 | 2021-04-14 | 中外製薬株式会社 | 蛋白質溶液の粘度測定方法 |
| BR112018009312A8 (pt) | 2015-12-28 | 2019-02-26 | Chugai Pharmaceutical Co Ltd | método para promover eficiência de purificação de polipeptídeo contendo região de fc |
| CN107383173B (zh) * | 2017-08-07 | 2020-08-21 | 沃昕生物科技(深圳)有限公司 | 诱导前列腺癌细胞凋亡的多肽及其应用 |
| TWI840360B (zh) | 2018-05-21 | 2024-05-01 | 日商中外製藥股份有限公司 | 密封於玻璃容器之凍結乾燥的製劑、套組、製造凍結乾燥製劑的方法、防止或減低凍結乾燥製劑的玻璃容器成霧的方法、及容器內面經過硫酸銨處理或ｖｉｓｔ處理之玻璃容器 |
| CN113711991A (zh) * | 2020-11-02 | 2021-11-30 | 江门赛尔康生物科技有限公司 | 一种以pap为靶点的药物筛选动物模型的构建方法和应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US6579692B1 (en) * | 1996-03-06 | 2003-06-17 | Chugai Seiyaku Kabushiki Kaisha | Method of screening apoptosis inducing substances |
| ATE395362T1 (de) * | 1997-09-11 | 2008-05-15 | Chugai Pharmaceutical Co Ltd | Monoklonale antikörper zur apoptosis-induzierung |
| CA2226962A1 (en) * | 1998-02-16 | 1999-08-16 | Marie Sarfati | Use of binding agents to cd47 and its ligands in the treatment or the prophylaxis of various inflammatory, autoimmune and allergic diseases and in the treatment of graft rejection |
| AU2940900A (en) * | 1999-03-10 | 2000-09-28 | Chugai Seiyaku Kabushiki Kaisha | Single-stranded fv inducing apoptosis |
-
2001
- 2001-03-09 TW TW093134302A patent/TWI242043B/zh not_active IP Right Cessation
- 2001-03-09 TW TW090105616A patent/TWI241345B/zh not_active IP Right Cessation
- 2001-03-12 ES ES01912268T patent/ES2312418T3/es not_active Expired - Lifetime
- 2001-03-12 WO PCT/JP2001/001912 patent/WO2001066737A1/ja active IP Right Grant
- 2001-03-12 AT AT01912268T patent/ATE410449T1/de not_active IP Right Cessation
- 2001-03-12 KR KR1020027011878A patent/KR20020089390A/ko not_active Ceased
- 2001-03-12 CA CA002402896A patent/CA2402896A1/en not_active Abandoned
- 2001-03-12 AU AU4110001A patent/AU4110001A/xx active Pending
- 2001-03-12 AU AU2001241100A patent/AU2001241100C1/en not_active Ceased
- 2001-03-12 CN CN01807591A patent/CN1422333A/zh active Pending
- 2001-03-12 EP EP01912268A patent/EP1262548B1/de not_active Expired - Lifetime
- 2001-03-12 DE DE60136054T patent/DE60136054D1/de not_active Expired - Lifetime
- 2001-03-12 IL IL15153101A patent/IL151531A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TWI242043B (en) | 2005-10-21 |
| ES2312418T3 (es) | 2009-03-01 |
| TW200510528A (en) | 2005-03-16 |
| CA2402896A1 (en) | 2001-09-13 |
| WO2001066737A1 (fr) | 2001-09-13 |
| DE60136054D1 (de) | 2008-11-20 |
| TWI241345B (en) | 2005-10-11 |
| AU2001241100C1 (en) | 2006-10-05 |
| EP1262548A4 (de) | 2004-05-26 |
| EP1262548A1 (de) | 2002-12-04 |
| EP1262548B1 (de) | 2008-10-08 |
| AU2001241100B2 (en) | 2005-08-18 |
| KR20020089390A (ko) | 2002-11-29 |
| CN1422333A (zh) | 2003-06-04 |
| AU4110001A (en) | 2001-09-17 |
| IL151531A0 (en) | 2003-04-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |