ATE470442T1 - Verwendung von gamma-tocotrienol als diuretika - Google Patents
Verwendung von gamma-tocotrienol als diuretikaInfo
- Publication number
- ATE470442T1 ATE470442T1 AT01915838T AT01915838T ATE470442T1 AT E470442 T1 ATE470442 T1 AT E470442T1 AT 01915838 T AT01915838 T AT 01915838T AT 01915838 T AT01915838 T AT 01915838T AT E470442 T1 ATE470442 T1 AT E470442T1
- Authority
- AT
- Austria
- Prior art keywords
- medicament
- preventing
- treating
- tocotrienol
- diuretic
- Prior art date
Links
- OTXNTMVVOOBZCV-UHFFFAOYSA-N 2R-gamma-tocotrienol Natural products OC1=C(C)C(C)=C2OC(CCC=C(C)CCC=C(C)CCC=C(C)C)(C)CCC2=C1 OTXNTMVVOOBZCV-UHFFFAOYSA-N 0.000 title abstract 2
- RZFHLOLGZPDCHJ-DLQZEEBKSA-N alpha-Tocotrienol Natural products Oc1c(C)c(C)c2O[C@@](CC/C=C(/CC/C=C(\CC/C=C(\C)/C)/C)\C)(C)CCc2c1C RZFHLOLGZPDCHJ-DLQZEEBKSA-N 0.000 title abstract 2
- 239000002934 diuretic Substances 0.000 title abstract 2
- 230000001882 diuretic effect Effects 0.000 title abstract 2
- OTXNTMVVOOBZCV-YMCDKREISA-N gamma-Tocotrienol Natural products Oc1c(C)c(C)c2O[C@@](CC/C=C(\CC/C=C(\CC/C=C(\C)/C)/C)/C)(C)CCc2c1 OTXNTMVVOOBZCV-YMCDKREISA-N 0.000 title abstract 2
- 239000011722 γ-tocotrienol Substances 0.000 title abstract 2
- OTXNTMVVOOBZCV-WAZJVIJMSA-N γ-tocotrienol Chemical compound OC1=C(C)C(C)=C2O[C@@](CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)(C)CCC2=C1 OTXNTMVVOOBZCV-WAZJVIJMSA-N 0.000 title abstract 2
- 235000019150 γ-tocotrienol Nutrition 0.000 title abstract 2
- 239000003814 drug Substances 0.000 abstract 4
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 208000019622 heart disease Diseases 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 208000017169 kidney disease Diseases 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000097442 | 2000-03-31 | ||
| PCT/JP2001/002479 WO2001074354A1 (en) | 2000-03-31 | 2001-03-27 | DIURETICS CONTAINING η-TOCOTRIENOL |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE470442T1 true ATE470442T1 (de) | 2010-06-15 |
Family
ID=18612062
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01915838T ATE470442T1 (de) | 2000-03-31 | 2001-03-27 | Verwendung von gamma-tocotrienol als diuretika |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6864280B2 (de) |
| EP (1) | EP1270004B1 (de) |
| KR (1) | KR100730338B1 (de) |
| AT (1) | ATE470442T1 (de) |
| AU (2) | AU2001242811B2 (de) |
| CA (1) | CA2403977C (de) |
| DE (1) | DE60142330D1 (de) |
| ES (1) | ES2346181T3 (de) |
| MY (1) | MY131758A (de) |
| WO (1) | WO2001074354A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003291012A1 (en) * | 2002-11-15 | 2004-06-15 | Galileo Pharmaceuticals, Inc. | Chroman derivatives for the reduction of inflammation symptoms |
| US7989006B2 (en) * | 2003-04-08 | 2011-08-02 | American River Nutrition, Inc. | Annatto extract compositions, including geranyl geraniols and methods of use |
| US20050037102A1 (en) * | 2003-07-18 | 2005-02-17 | Barrie Tan | Annatto extract compositions including tocotrienols and tocopherols and methods of use |
| WO2005023183A2 (en) * | 2003-08-28 | 2005-03-17 | Nitromed, Inc. | Nitrosated ad nitrosylated diuretic compouds, compositions and methods of use |
| WO2005115377A1 (en) * | 2004-05-26 | 2005-12-08 | Kgk Synergize Inc | Functional foods comprising flavonoids and tocotrienols and methods thereof |
| WO2006091716A2 (en) * | 2005-02-24 | 2006-08-31 | Nitromed, Inc. | Nitric oxide enhancing diuretic compounds, compositions and methods of use |
| CA2891164C (en) | 2012-11-13 | 2021-02-09 | Gordagen Pharmaceuticals Pty Ltd | Transmucosal delivery of tocotrienol |
| US9132117B2 (en) | 2013-06-17 | 2015-09-15 | Kgk Synergize, Inc | Compositions and methods for glycemic control of subjects with impaired fasting glucose |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR910007523A (ko) * | 1989-10-04 | 1991-05-30 | 브리스톨-마이어즈 스퀴브 컴페니 | 과콜레스테린혈증, 과지방혈증 및 혈전색전증 질병 치료용 토코트리엔올 |
| EP0669132A1 (de) * | 1994-02-23 | 1995-08-30 | van der Kraaij, Antonius Marinus Maria | Kombinationspräparat von Vitamine E und Acetylsalicylate zur Behandlung und Prophylaxis des Atherosclerosis |
| US6150402A (en) | 1994-08-15 | 2000-11-21 | Loma Linda University Medical Center | Natriuretic compounds |
| AU8768098A (en) * | 1997-08-04 | 1999-02-22 | Christopher J. Berry | Method of treating disease using a tocotrienol and alpha-lipoic acid r derivatives or an ester thereof |
| JP4271742B2 (ja) | 1997-08-07 | 2009-06-03 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 免疫機能改善剤 |
| AU746369B2 (en) * | 1997-11-17 | 2002-04-18 | Lipogenics, Inc. | Methods for preventing restenosis using tocotrienols |
| WO2000015201A2 (en) * | 1998-09-10 | 2000-03-23 | Forbes Medi-Tech Inc. | Compositions comprising one or more phytosterols, phytostanols or mixtures of both and one or more alpha, beta, delta, or gamma tocotrienols or derivatives thereof and use of the compositions in treating or preventing cardiovascular disease, its underlying conditions and other disorders |
-
2001
- 2001-03-27 AU AU2001242811A patent/AU2001242811B2/en not_active Ceased
- 2001-03-27 EP EP01915838A patent/EP1270004B1/de not_active Expired - Lifetime
- 2001-03-27 ES ES01915838T patent/ES2346181T3/es not_active Expired - Lifetime
- 2001-03-27 US US10/239,945 patent/US6864280B2/en not_active Expired - Fee Related
- 2001-03-27 WO PCT/JP2001/002479 patent/WO2001074354A1/ja not_active Ceased
- 2001-03-27 DE DE60142330T patent/DE60142330D1/de not_active Expired - Lifetime
- 2001-03-27 KR KR1020027012545A patent/KR100730338B1/ko not_active Expired - Fee Related
- 2001-03-27 AU AU4281101A patent/AU4281101A/xx active Pending
- 2001-03-27 CA CA002403977A patent/CA2403977C/en not_active Expired - Fee Related
- 2001-03-27 AT AT01915838T patent/ATE470442T1/de not_active IP Right Cessation
- 2001-03-30 MY MYPI20011518A patent/MY131758A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1270004A4 (de) | 2006-02-01 |
| CA2403977C (en) | 2009-09-01 |
| MY131758A (en) | 2007-08-30 |
| EP1270004B1 (de) | 2010-06-09 |
| CA2403977A1 (en) | 2002-09-25 |
| KR100730338B1 (ko) | 2007-06-19 |
| EP1270004A1 (de) | 2003-01-02 |
| KR20030019330A (ko) | 2003-03-06 |
| US20030139467A1 (en) | 2003-07-24 |
| US6864280B2 (en) | 2005-03-08 |
| AU4281101A (en) | 2001-10-15 |
| DE60142330D1 (de) | 2010-07-22 |
| ES2346181T3 (es) | 2010-10-13 |
| AU2001242811B2 (en) | 2005-07-14 |
| WO2001074354A1 (en) | 2001-10-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE356119T1 (de) | Pyrimidinone als melanin concentrating hormone receptor 1 | |
| NO20002217D0 (no) | Cyclopentan-heptansyre, 2-heteroarylalkenylderivater som terapeutiske midler | |
| BR9806752A (pt) | Ftalazinonas. | |
| DE59913784D1 (de) | Verwendung von Thiazolidinderivaten als antihyperglykämische Mittel | |
| DK1343782T3 (da) | Pyrimidinaminer som angiogenesemodulatorer | |
| DK1200418T3 (da) | Nematodicide trifluorbutener | |
| TR200000782T2 (tr) | Resorsinol türevleri. | |
| FI903331A0 (fi) | Substituerade kinazolinoner, vilka aer anvaendbara som angiotensin-ii-antagonister. | |
| DK5389D0 (da) | Substituerede pyrroler, pyrazoler og triazoler, fremgangsmaader til deres fremstilling samt deres anvendelse som angiotensin ii-antagonister | |
| ATE302775T1 (de) | Carbolinderivate | |
| ES2172864T3 (es) | 2-metoxibenzofenonas fungicidas. | |
| DK1083903T3 (da) | Brobundne indenopyrrolocarbazoler | |
| CO4940466A1 (es) | Sales metanosulfonato de 5-(2-(4-(1,2-benzoisotiazol-3-il)- 1-piperazinil)etil)-6-cloro-1,3-dihidro-2h-indol-2-ona dihidratadas | |
| BR0209149A (pt) | Ftalazinonas | |
| ATE346067T1 (de) | Carbolinderivate | |
| ATE300543T1 (de) | Kondensierte pyrazindionderivate als pde5 inhibitore | |
| BR0017157A (pt) | Derivados de 6-hidroxi-indazol para o tratamento de glaucoma | |
| TR200100885T2 (tr) | 2-Metil-tieno-benzodiazepin formülasyonu | |
| TR200001452T2 (tr) | Bifenilamidin türevleri. | |
| ATE470442T1 (de) | Verwendung von gamma-tocotrienol als diuretika | |
| DE60112960D1 (de) | Kondensierte pyridoindolderivate | |
| EA200400117A1 (ru) | Производные 6-[2-(фосфонометокси)алкокси]пиримидинов, обладающие антивирусной активностью, способ их получения (варианты) и способ лечения вирусной инфекции | |
| BR9902084A (pt) | Heterociclos. | |
| TR200202195T2 (tr) | 5-Yer değiştirmiş 1-(4-florofenil)-1,3- dihidroizobenzofuran'ın adım adım alkillenmesi | |
| MXPA03008736A (es) | Derivados de (p-aminohidroxifenil)acrilamida y colorantes que contienen dichos compuestos. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |