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ATE466574T1 - Verfahren und zusammensetzungen zur oralen fts- abgabe - Google Patents

Verfahren und zusammensetzungen zur oralen fts- abgabe

Info

Publication number
ATE466574T1
ATE466574T1 AT05787786T AT05787786T ATE466574T1 AT E466574 T1 ATE466574 T1 AT E466574T1 AT 05787786 T AT05787786 T AT 05787786T AT 05787786 T AT05787786 T AT 05787786T AT E466574 T1 ATE466574 T1 AT E466574T1
Authority
AT
Austria
Prior art keywords
fts
oral
delivery
compositions
methods
Prior art date
Application number
AT05787786T
Other languages
English (en)
Inventor
Victor Bauer
Original Assignee
Concordia Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Concordia Pharmaceuticals Inc filed Critical Concordia Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE466574T1 publication Critical patent/ATE466574T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C07C321/24—Thiols, sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
    • C07C321/28—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT05787786T 2004-08-18 2005-08-18 Verfahren und zusammensetzungen zur oralen fts- abgabe ATE466574T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60236104P 2004-08-18 2004-08-18
PCT/US2005/029389 WO2006023639A1 (en) 2004-08-18 2005-08-18 Methods and compositions for oral delivery of fts

Publications (1)

Publication Number Publication Date
ATE466574T1 true ATE466574T1 (de) 2010-05-15

Family

ID=35447506

Family Applications (2)

Application Number Title Priority Date Filing Date
AT05787786T ATE466574T1 (de) 2004-08-18 2005-08-18 Verfahren und zusammensetzungen zur oralen fts- abgabe
AT10004111T ATE535237T1 (de) 2004-08-18 2005-08-18 Verwendung von fts zur behandlung von malignen erkrankungen

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT10004111T ATE535237T1 (de) 2004-08-18 2005-08-18 Verwendung von fts zur behandlung von malignen erkrankungen

Country Status (9)

Country Link
US (4) US8088756B2 (de)
EP (3) EP2301528B1 (de)
AT (2) ATE466574T1 (de)
CA (1) CA2577310C (de)
DE (1) DE602005021115D1 (de)
ES (2) ES2343737T3 (de)
MX (1) MX2007001929A (de)
PL (1) PL1778209T3 (de)
WO (1) WO2006023639A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2301528B1 (de) * 2004-08-18 2013-04-03 Kadmon Corporation, LLC Verwendung von FTS zur Behandlung von malignen Erkrankungen
US8278349B2 (en) * 2005-11-28 2012-10-02 Ramot At Tel-Aviv University Ltd. Cancer treatment using FTS and 2-deoxyglucose
EP1986625B1 (de) * 2006-02-10 2012-08-01 Ramot at Tel-Aviv University Ltd. Behandlung von ovarialkrebs
WO2007144889A2 (en) * 2006-06-14 2007-12-21 Ramot At Tel Aviv University Ltd. Treatment of neurofibromatosis
US8232253B2 (en) 2006-12-19 2012-07-31 Ramot At Tel-Aviv University Ltd. Treatment of lung cancer
JP2013508458A (ja) * 2009-10-26 2013-03-07 ラモット・アット・テル−アヴィヴ・ユニヴァーシティ・リミテッド Ｆｔｓとｈｄａｃ阻害剤との組合せを用いたがん治療
CA2849421C (en) * 2011-10-07 2020-04-28 Pisces Therapeutics Llc Malignant and non-malignant disease treatment with ras antagonists
US9738614B2 (en) 2011-10-07 2017-08-22 Pisces Therapeutics, Llc Malignant and non-malignant disease treatment with Ras antagonists
CN117677398A (zh) * 2021-07-27 2024-03-08 东丽株式会社 用于癌的治疗和/或预防的药品

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5145684A (en) * 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
IL107587A (en) 1993-11-12 1998-08-16 Univ Ramot Farnesyl geranyl or geranyl-geranyl derivatives pharmaceutical compositions containing them and methods for their preparation
KR100312454B1 (ko) * 1998-03-27 2001-11-14 김용규 토토마이세틴을 생산하는 스트렙토마이세스 속 미생물 및 그로부터 생산된 토토마이세틴을 유효성분으로 함유하는 면역억제제
US20020115696A1 (en) * 1999-06-18 2002-08-22 Yoel Kloog Treatment of post-angioplasty restenosis and atherosclerosis with ras antagonists
US6462086B1 (en) 1999-06-18 2002-10-08 Ramot University Authority For Applied Research And Industrial Development Ltd. Non-malignant disease treatment with Ras antagonists
US20040072258A1 (en) * 2000-10-04 2004-04-15 Yoel Kloog Isoprenoid-dependent ras anchorage (idra) proteins
US20020169183A1 (en) * 2001-03-08 2002-11-14 Villar Hugo O. Acridines as stimulators for Fas-mediated apoptosis
EP1390472A4 (de) * 2001-05-29 2004-11-17 Sirna Therapeutics Inc Nukleinsäurebehandlung von krankheiten oder leiden im zusammenhang mit ras-, her2- und hiv-niveaus
US20060141472A1 (en) 2003-03-20 2006-06-29 Miikka Vikkula Medical use of ras antagonists for the treatment of capillary malformation
WO2004103352A1 (en) 2003-05-23 2004-12-02 Ramot At Tel Aviv University, Ltd. Ras antagonists for treating neurodegenerative disorders
CA2535944A1 (en) 2003-08-22 2005-03-03 University Of Virginia Patent Foundation Blockade of mtor to prevent a hormonal adaptive response
EP2301528B1 (de) 2004-08-18 2013-04-03 Kadmon Corporation, LLC Verwendung von FTS zur Behandlung von malignen Erkrankungen
US8278349B2 (en) 2005-11-28 2012-10-02 Ramot At Tel-Aviv University Ltd. Cancer treatment using FTS and 2-deoxyglucose

Also Published As

Publication number Publication date
US20160271089A1 (en) 2016-09-22
ATE535237T1 (de) 2011-12-15
US20090226512A1 (en) 2009-09-10
US20150191426A1 (en) 2015-07-09
EP1778209B8 (de) 2010-06-16
CA2577310A1 (en) 2006-03-02
ES2414861T3 (es) 2013-07-23
CA2577310C (en) 2011-01-11
EP1778209B1 (de) 2010-05-05
EP2301528A1 (de) 2011-03-30
US20120082722A1 (en) 2012-04-05
US8088756B2 (en) 2012-01-03
PL1778209T3 (pl) 2010-10-29
EP2301528B1 (de) 2013-04-03
ES2343737T3 (es) 2010-08-09
MX2007001929A (es) 2007-04-17
EP1778209A1 (de) 2007-05-02
WO2006023639A1 (en) 2006-03-02
EP2218451A1 (de) 2010-08-18
EP2218451B1 (de) 2011-11-30
DE602005021115D1 (de) 2010-06-17

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