ATE451360T1 - Halbsynthetisches verfahren zur herstellung von 10-desacetyl-n-desbenzoyl-paclitaxel - Google Patents

Halbsynthetisches verfahren zur herstellung von 10-desacetyl-n-desbenzoyl-paclitaxel

Info

Publication number: ATE451360T1
Authority: AT; Austria
Prior art keywords: paclitaxel; desbenzoyl; desacetyl; semi; producing
Prior art date: 2004-10-08

Application number

AT05798522T

Other languages

English (en)

Inventor

Bruno Gabetta

Andrea Gambini

Ezio Bombardelli

Gabriele Fontana

Original Assignee

Indena Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-10-08

Filing date

2005-10-07

Publication date

2009-12-15

2004-10-08 Priority claimed from EP04425752A external-priority patent/EP1647552A1/de

2005-04-11 Priority claimed from EP05007888A external-priority patent/EP1712552A1/de

2005-10-07 Application filed by Indena Spa filed Critical Indena Spa

2009-12-15 Application granted granted Critical

2009-12-15 Publication of ATE451360T1 publication Critical patent/ATE451360T1/de

Links

238000000034 method Methods 0.000 title abstract 3
229960001592 paclitaxel Drugs 0.000 title 1
ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 abstract 1
229940123237 Taxane Drugs 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229960003668 docetaxel Drugs 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Epoxy Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT05798522T 2004-10-08 2005-10-07 Halbsynthetisches verfahren zur herstellung von 10-desacetyl-n-desbenzoyl-paclitaxel ATE451360T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US61684004P	2004-10-08	2004-10-08
EP04425752A EP1647552A1 (de)	2004-10-08	2004-10-08	Teilsynthese für die Herstellung von 10-deacetyl-n-debenzoyl-paclitaxel
EP05007888A EP1712552A1 (de)	2005-04-11	2005-04-11	Teilsynthese für die Herstellung von 10-deacetyl-n-debenzoyl-paclitaxel
PCT/EP2005/010822 WO2006037653A1 (en)	2004-10-08	2005-10-07	Semisynthesis process for the preparation of 10-deacetyl-n-debenzoyl-paclitaxel

Publications (1)

Publication Number	Publication Date
ATE451360T1 true ATE451360T1 (de)	2009-12-15

Family

ID=35445727

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05798522T ATE451360T1 (de)	2004-10-08	2005-10-07	Halbsynthetisches verfahren zur herstellung von 10-desacetyl-n-desbenzoyl-paclitaxel

Country Status (20)

Country	Link
US (3)	US7446126B2 (de)
EP (2)	EP2161260B1 (de)
JP (2)	JP4971169B2 (de)
KR (2)	KR101146839B1 (de)
CN (2)	CN100584836C (de)
AT (1)	ATE451360T1 (de)
AU (2)	AU2005291357B2 (de)
CA (2)	CA2791783C (de)
DE (1)	DE602005018238D1 (de)
DK (2)	DK2161260T3 (de)
ES (2)	ES2531393T3 (de)
IL (2)	IL182396A (de)
MX (1)	MX2007004157A (de)
NO (2)	NO339631B1 (de)
NZ (2)	NZ585629A (de)
PL (2)	PL1797059T3 (de)
PT (2)	PT1797059E (de)
RU (2)	RU2510395C2 (de)
SI (2)	SI1797059T1 (de)
WO (1)	WO2006037653A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7446126B2 (en) *	2004-10-08	2008-11-04	Indena S.P.A.	Semisynthesis process for the preparation of 10-deacetyl-N-debenzoyl-paclitaxel
ITMI20050614A1 (it) *	2005-04-12	2006-10-13	Indena Spa	Processo per la purificazione della 10-deacetilbaccatina iii dalla 10-deacetil-2-debenzoil-2-pentenoilbaccatina iii
EP2001874A4 (de) *	2006-03-21	2010-04-07	Reddys Lab Ltd Dr	Docetaxel-polymorphe und entsprechende verfahren
PL210984B1 (pl) *	2006-10-31	2012-03-30	Inst Farmaceutyczny	Sposób wytwarzania docetakselu
PL388144A1 (pl)	2009-05-29	2010-12-06	Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością	Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
KR101149600B1 (ko) *	2009-12-31	2012-05-29	주식회사 삼양제넥스바이오	고순도 무수결정형 도세탁셀 제조방법
MX341082B (es)	2010-05-03	2016-08-08	Teikoku Pharma Usa Inc	Formulaciones de pro-emulsion de taxano no acuosas y metodos para hacer y usar las mismas.
JO3685B1 (ar)	2012-10-01	2020-08-27	Teikoku Pharma Usa Inc	صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها
WO2014200571A2 (en)	2013-02-19	2014-12-18	United Technologies Corporation	Composite attachment structure with 3d weave
CN108822062B (zh) *	2018-09-07	2020-08-28	无锡紫杉药业有限公司	一种多西他赛的精制方法
WO2020249507A1 (en)	2019-06-11	2020-12-17	Indena S.P.A.	Anhydrous crystalline form of cabazitaxel, a process for its preparation and pharmaceutical compositions containing it
KR102782629B1 (ko)	2021-11-12	2025-03-19	닥터아이앤비(주)	생산 시간을 단축하고 안정성이 개선된 의약품 제조방법

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX9102128A (es) *	1990-11-23	1992-07-08	Rhone Poulenc Rorer Sa	Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
FR2696458B1 (fr) *	1992-10-05	1994-11-10	Rhone Poulenc Rorer Sa	Procédé de préparation de dérivés du taxane.
US5475011A (en) *	1993-03-26	1995-12-12	The Research Foundation Of State University Of New York	Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
FR2718963B1 (fr) *	1994-04-25	1996-05-24	Rhone Poulenc Rorer Sa	Nouvelle composition pharmaceutique à base de taxoïdes.
CA2170661A1 (en) *	1995-03-22	1996-09-23	John K. Thottathil	Novel methods for the preparation of taxanes using oaxzolidine intermediates
IT1308636B1 (it) *	1999-03-02	2002-01-09	Indena Spa	Procedimento per la preparazione di tassani da 10-desacetilbaccatinaiii.
IT1318678B1 (it) *	2000-08-10	2003-08-27	Indena Spa	Procedimento per la preparazione di derivati della baccatina iii.
IT1320107B1 (it) *	2000-11-28	2003-11-18	Indena Spa	Procedimento per la preparazione di derivati tassanici.
US6881852B2 (en) *	2002-02-05	2005-04-19	Dabur India Limited	Process of purification of paclitaxel and docetaxel
ITMI20020782A1 (it) *	2002-04-12	2003-10-13	Indena Spa	Processo semisintetico per la preparazione di n-debenzoilpaclitaxel
PE20050206A1 (es) *	2003-05-26	2005-03-26	Schering Ag	Composicion farmaceutica que contiene un inhibidor de histona deacetilasa
US7446126B2 (en) *	2004-10-08	2008-11-04	Indena S.P.A.	Semisynthesis process for the preparation of 10-deacetyl-N-debenzoyl-paclitaxel

2005
- 2005-10-06 US US11/244,171 patent/US7446126B2/en active Active
- 2005-10-07 ES ES09175976T patent/ES2531393T3/es not_active Expired - Lifetime
- 2005-10-07 KR KR1020077007382A patent/KR101146839B1/ko not_active Expired - Lifetime
- 2005-10-07 DK DK09175976T patent/DK2161260T3/da active
- 2005-10-07 DK DK05798522.8T patent/DK1797059T3/da active
- 2005-10-07 PL PL05798522T patent/PL1797059T3/pl unknown
- 2005-10-07 AU AU2005291357A patent/AU2005291357B2/en not_active Expired
- 2005-10-07 PT PT05798522T patent/PT1797059E/pt unknown
- 2005-10-07 NZ NZ585629A patent/NZ585629A/en not_active IP Right Cessation
- 2005-10-07 WO PCT/EP2005/010822 patent/WO2006037653A1/en not_active Ceased
- 2005-10-07 DE DE602005018238T patent/DE602005018238D1/de not_active Expired - Lifetime
- 2005-10-07 EP EP09175976.1A patent/EP2161260B1/de not_active Expired - Lifetime
- 2005-10-07 EP EP05798522A patent/EP1797059B1/de not_active Expired - Lifetime
- 2005-10-07 RU RU2009143794/04A patent/RU2510395C2/ru active
- 2005-10-07 MX MX2007004157A patent/MX2007004157A/es active IP Right Grant
- 2005-10-07 SI SI200530893T patent/SI1797059T1/sl unknown
- 2005-10-07 SI SI200531961T patent/SI2161260T1/sl unknown
- 2005-10-07 US US11/664,782 patent/US20080167369A1/en not_active Abandoned
- 2005-10-07 KR KR1020097007134A patent/KR101216885B1/ko not_active Expired - Lifetime
- 2005-10-07 CA CA2791783A patent/CA2791783C/en not_active Expired - Lifetime
- 2005-10-07 CN CN200580033957A patent/CN100584836C/zh not_active Expired - Lifetime
- 2005-10-07 JP JP2007535103A patent/JP4971169B2/ja not_active Expired - Lifetime
- 2005-10-07 NZ NZ554344A patent/NZ554344A/en not_active IP Right Cessation
- 2005-10-07 CN CN200910220891.0A patent/CN101704804B/zh not_active Expired - Lifetime
- 2005-10-07 ES ES05798522T patent/ES2333738T3/es not_active Expired - Lifetime
- 2005-10-07 PT PT09175976T patent/PT2161260E/pt unknown
- 2005-10-07 PL PL09175976T patent/PL2161260T3/pl unknown
- 2005-10-07 AT AT05798522T patent/ATE451360T1/de active
- 2005-10-07 CA CA2582545A patent/CA2582545C/en not_active Expired - Lifetime
- 2005-10-07 RU RU2007112775/04A patent/RU2384578C2/ru active
2007
- 2007-04-10 NO NO20071835A patent/NO339631B1/no unknown
- 2007-04-10 IL IL182396A patent/IL182396A/en active IP Right Grant
2008
- 2008-04-17 US US12/104,715 patent/US8318957B2/en active Active
2010
- 2010-09-21 IL IL208290A patent/IL208290A/en active IP Right Grant
2011
- 2011-03-29 AU AU2011201419A patent/AU2011201419B2/en not_active Expired
2012
- 2012-03-01 JP JP2012045438A patent/JP5593342B2/ja not_active Expired - Lifetime
2016
- 2016-07-11 NO NO20161147A patent/NO340930B1/no unknown

Also Published As

Publication number	Publication date
EP2161260A1 (de)	2010-03-10
CN100584836C (zh)	2010-01-27
SI2161260T1 (sl)	2015-05-29
IL182396A (en)	2011-12-29
IL208290A0 (en)	2010-12-30
KR20070062533A (ko)	2007-06-15
US7446126B2 (en)	2008-11-04
RU2510395C2 (ru)	2014-03-27
KR20090038496A (ko)	2009-04-20
CA2791783C (en)	2014-12-09
RU2007112775A (ru)	2008-10-10
KR101146839B1 (ko)	2012-05-16
BRPI0516566A (pt)	2008-09-09
JP4971169B2 (ja)	2012-07-11
RU2009143794A (ru)	2011-06-10
DK2161260T3 (da)	2015-03-16
JP2008515840A (ja)	2008-05-15
PL2161260T3 (pl)	2015-06-30
NO339631B1 (no)	2017-01-16
CN101704804A (zh)	2010-05-12
US20060079571A1 (en)	2006-04-13
KR101216885B1 (ko)	2012-12-28
CA2582545A1 (en)	2006-04-13
PL1797059T3 (pl)	2010-05-31
JP2012136544A (ja)	2012-07-19
US20080167369A1 (en)	2008-07-10
MX2007004157A (es)	2007-06-20
JP5593342B2 (ja)	2014-09-24
IL208290A (en)	2012-03-29
EP1797059A1 (de)	2007-06-20
DE602005018238D1 (de)	2010-01-21
IL182396A0 (en)	2007-07-24
NO20161147A1 (no)	2007-05-07
WO2006037653A1 (en)	2006-04-13
ES2333738T3 (es)	2010-02-26
CN101704804B (zh)	2015-03-18
US8318957B2 (en)	2012-11-27
NO340930B1 (no)	2017-07-17
CN101048395A (zh)	2007-10-03
US20080200700A1 (en)	2008-08-21
CA2791783A1 (en)	2006-04-13
AU2005291357A1 (en)	2006-04-13
NZ554344A (en)	2010-09-30
AU2011201419B2 (en)	2012-01-19
SI1797059T1 (sl)	2010-02-26
CA2582545C (en)	2013-01-08
EP2161260B1 (de)	2015-01-21
EP1797059B1 (de)	2009-12-09
HK1140490A1 (en)	2010-10-15
PT1797059E (pt)	2009-12-21
NZ585629A (en)	2012-01-12
ES2531393T3 (es)	2015-03-13
NO20071835L (no)	2007-05-07
RU2384578C2 (ru)	2010-03-20
AU2005291357B2 (en)	2011-04-14
PT2161260E (pt)	2015-03-02
HK1108317A1 (en)	2008-05-02
DK1797059T3 (da)	2010-04-06
AU2011201419A1 (en)	2011-04-14

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