ATE394118T1 - Dipeptidyl peptidase iv inhibitoren zur senkung der chronische gewichtszunahme - Google Patents

Dipeptidyl peptidase iv inhibitoren zur senkung der chronische gewichtszunahme

Info

Publication number: ATE394118T1
Authority: AT; Austria
Prior art keywords: cells; pancreatic; inhibitors; weight gain; dipeptidyl peptidase
Prior art date: 2002-08-09

Application number

AT02767358T

Other languages

English (en)

Inventor

Hans-Ulrich Demuth

Konrad Glund

Andrew J Pospisilik

Kerstin Kuehn-Wache

Original Assignee

Prosidion Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-08-09

Filing date

2002-08-09

Publication date

2008-05-15

2002-08-09 Application filed by Prosidion Ltd filed Critical Prosidion Ltd

2008-05-15 Application granted granted Critical

2008-05-15 Publication of ATE394118T1 publication Critical patent/ATE394118T1/de

Links

230000001684 chronic effect Effects 0.000 title abstract 2
229940124213 Dipeptidyl peptidase 4 (DPP IV) inhibitor Drugs 0.000 title 1
239000003603 dipeptidyl peptidase IV inhibitor Substances 0.000 title 1
230000004584 weight gain Effects 0.000 title 1
235000019786 weight gain Nutrition 0.000 title 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 6
102000004877 Insulin Human genes 0.000 abstract 3
108090001061 Insulin Proteins 0.000 abstract 3
229940125396 insulin Drugs 0.000 abstract 3
230000004069 differentiation Effects 0.000 abstract 2
210000002237 B-cell of pancreatic islet Anatomy 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
210000000227 basophil cell of anterior lobe of hypophysis Anatomy 0.000 abstract 1
210000002919 epithelial cell Anatomy 0.000 abstract 1
239000000122 growth hormone Substances 0.000 abstract 1
229940088597 hormone Drugs 0.000 abstract 1
239000005556 hormone Substances 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
210000003205 muscle Anatomy 0.000 abstract 1
235000021095 non-nutrients Nutrition 0.000 abstract 1
210000004923 pancreatic tissue Anatomy 0.000 abstract 1
230000004962 physiological condition Effects 0.000 abstract 1
230000008929 regeneration Effects 0.000 abstract 1
238000011069 regeneration method Methods 0.000 abstract 1
230000035945 sensitivity Effects 0.000 abstract 1
238000004260 weight control Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Diabetes (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Obesity (AREA)
Hematology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pyrrole Compounds (AREA)
Peptides Or Proteins (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT02767358T 2002-08-09 2002-08-09 Dipeptidyl peptidase iv inhibitoren zur senkung der chronische gewichtszunahme ATE394118T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/EP2002/008931 WO2004017989A1 (en)	2002-08-09	2002-08-09	Methods for improving islet signaling in diabetes mellitus and for its prevention

Publications (1)

Publication Number	Publication Date
ATE394118T1 true ATE394118T1 (de)	2008-05-15

Family

ID=31896800

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02767358T ATE394118T1 (de)	2002-08-09	2002-08-09	Dipeptidyl peptidase iv inhibitoren zur senkung der chronische gewichtszunahme

Country Status (10)

Country	Link
EP (1)	EP1528931B1 (de)
AT (1)	ATE394118T1 (de)
AU (1)	AU2002331226A1 (de)
CY (1)	CY1108769T1 (de)
DE (1)	DE60226517D1 (de)
DK (1)	DK1528931T3 (de)
ES (1)	ES2306781T3 (de)
PT (1)	PT1528931E (de)
SI (1)	SI1528931T1 (de)
WO (1)	WO2004017989A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2296979T3 (es)	2001-06-27	2008-05-01	Smithkline Beecham Corporation	Fluoropirrolidinas como inhibidores de dipeptidil peptidasa.
KR20050122220A (ko)	2003-03-25	2005-12-28	다케다 샌디에고, 인코포레이티드	디펩티딜 펩티다제 억제제
EP1625122A1 (de)	2003-05-14	2006-02-15	Takeda San Diego, Inc.	Dipeptidylpeptidase-hemmer
US7169926B1 (en)	2003-08-13	2007-01-30	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
US7678909B1 (en)	2003-08-13	2010-03-16	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
KR20060041309A (ko)	2003-08-13	2006-05-11	다케다 야쿠힌 고교 가부시키가이샤	４-피리미돈 유도체 및 펩티딜 펩티다제 저해제로서의 그의용도
US7790734B2 (en)	2003-09-08	2010-09-07	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
US7732446B1 (en)	2004-03-11	2010-06-08	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
EA013427B1 (ru)	2004-03-15	2010-04-30	Такеда Фармасьютикал Компани Лимитед	Ингибиторы дипептидилпептидазы
JP2008501714A (ja)	2004-06-04	2008-01-24	武田薬品工業株式会社	ジペプチジルペプチダーゼインヒビター
WO2006019965A2 (en)	2004-07-16	2006-02-23	Takeda San Diego, Inc.	Dipeptidyl peptidase inhibitors
EP1828192B1 (de)	2004-12-21	2014-12-03	Takeda Pharmaceutical Company Limited	Dipeptidylpeptidasehemmer
PT1942898E (pt)	2005-09-14	2011-12-20	Takeda Pharmaceutical	Inibidores da dipeptidilpeptidase para o tratamento da diabetes
CN101360723A (zh)	2005-09-16	2009-02-04	武田药品工业株式会社	制备嘧啶二酮衍生物的方法
WO2007112347A1 (en)	2006-03-28	2007-10-04	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
US8324383B2 (en)	2006-09-13	2012-12-04	Takeda Pharmaceutical Company Limited	Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
TW200838536A (en)	2006-11-29	2008-10-01	Takeda Pharmaceutical	Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
US8093236B2 (en)	2007-03-13	2012-01-10	Takeda Pharmaceuticals Company Limited	Weekly administration of dipeptidyl peptidase inhibitors

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW492957B (en) *	1996-11-07	2002-07-01	Novartis Ag	N-substituted 2-cyanopyrrolidnes
DE04029691T1 (de) *	1998-02-02	2007-11-08	Trustees Of Tufts College, Medford	Verwendung von Dipetidylpeptidasehemmer zur Regulierung des Glukosemetabolismus
DE19823831A1 (de) *	1998-05-28	1999-12-02	Probiodrug Ges Fuer Arzneim	Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen
DE19828114A1 (de)	1998-06-24	2000-01-27	Probiodrug Ges Fuer Arzneim	Produgs instabiler Inhibitoren der Dipeptidyl Peptidase IV
DE19828113A1 (de)	1998-06-24	2000-01-05	Probiodrug Ges Fuer Arzneim	Prodrugs von Inhibitoren der Dipeptidyl Peptidase IV
DE19834591A1 (de) *	1998-07-31	2000-02-03	Probiodrug Ges Fuer Arzneim	Verfahren zur Steigerung des Blutglukosespiegels in Säugern
US6881564B1 (en)	1999-09-10	2005-04-19	The University Of Sydney	Dipeptidyl peptidases
CZ20023234A3 (cs) *	2000-03-31	2003-01-15	Probiodrug Ag	Léčivo proti diabetu
TW583185B (en) *	2000-06-13	2004-04-11	Novartis Ag	N-(substituted glycyl)-2-cyanopyrrolidines and pharmaceutical composition for inhibiting dipeptidyl peptidase-IV (DPP-IV) or for the prevention or treatment of diseases or conditions associated with elevated levels of DPP-IV comprising the same
WO2002004610A2 (en)	2000-07-10	2002-01-17	Bayer Aktiengesellschaft	Regulation of human dipeptidyl-peptidase iv-like enzyme
NZ525443A (en)	2000-10-12	2006-04-28	Ferring Bv	Dipeptidyl peptidase IV related genes
AUPR107800A0 (en)	2000-10-27	2000-11-23	University Of Sydney, The	Peptide and nucleic acid molecule ii

2002
- 2002-08-09 AU AU2002331226A patent/AU2002331226A1/en not_active Abandoned
- 2002-08-09 EP EP02767358A patent/EP1528931B1/de not_active Expired - Lifetime
- 2002-08-09 SI SI200230708T patent/SI1528931T1/sl unknown
- 2002-08-09 PT PT02767358T patent/PT1528931E/pt unknown
- 2002-08-09 WO PCT/EP2002/008931 patent/WO2004017989A1/en not_active Ceased
- 2002-08-09 ES ES02767358T patent/ES2306781T3/es not_active Expired - Lifetime
- 2002-08-09 DK DK02767358T patent/DK1528931T3/da active
- 2002-08-09 DE DE60226517T patent/DE60226517D1/de not_active Expired - Lifetime
- 2002-08-09 AT AT02767358T patent/ATE394118T1/de active
2008
- 2008-07-31 CY CY20081100811T patent/CY1108769T1/el unknown

Also Published As

Publication number	Publication date
AU2002331226A1 (en)	2004-03-11
EP1528931A1 (de)	2005-05-11
ES2306781T3 (es)	2008-11-16
SI1528931T1 (sl)	2008-10-31
DE60226517D1 (de)	2008-06-19
PT1528931E (pt)	2008-08-13
DK1528931T3 (da)	2008-09-08
EP1528931B1 (de)	2008-05-07
WO2004017989A1 (en)	2004-03-04
CY1108769T1 (el)	2014-04-09

Publication	Publication Date	Title
CY1108769T1 (el)	2014-04-09	Αναστολεις της διπεπτιδυλικης πεπτιδασης iv για μειωση του ρυθμου της χρονιας αυξησης βαρους
DK1283735T3 (da)	2009-04-06	Fremgangsmåde til fremstilling af hydrazon-derivater
Cheng et al.	2011	Inhibition of IL-17A in atherosclerosis
MX2010009623A (es)	2010-09-28	Derivados de 1-bencil-3-hidroximetilindazol novedosos y su uso en el tratamiento de enfermedades basadas en la expresion de mcp-1, cx3cr1 y p40.
MX2010009625A (es)	2010-09-28	Derivados de 1-bencil-3-hidroximetilindazol y uso de los mismos en el tratamiento de enfermedades basadas en la expresion de mcp-1, cx3cr1 y p40.
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DE60108489D1 (de)	2005-02-24	Kombinationstherapien mit gefässschädigender aktivität
MX2010009624A (es)	2010-09-28	Derivados de 1-bencil-3-hidroximetilindazol y uso de los mismos en el tratamiento de enfermedades basadas en la expresion de mcp-1 y cx3cr1.
ATE527378T1 (de)	2011-10-15	Antisense-modulation von p38-mitogen-aktivierter proteinkinase-expression
EP1543158A4 (de)	2007-06-06	Regulierte aptamer-therapeutika
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EA200500871A1 (ru)	2006-04-28	Пептиды, ингибирующие ангиогенез, миграцию клеток, инвазию клеток и пролиферацию клеток, композиции и их применение
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DE60335535D1 (de)	2011-02-10	Zusammensetzung und verfahren zur abtötung von tumoren
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