ATE391790T1 - Rekombinante expression von heterologen nukleinsäuren in protozoen - Google Patents
Rekombinante expression von heterologen nukleinsäuren in protozoenInfo
- Publication number
- ATE391790T1 ATE391790T1 AT00905982T AT00905982T ATE391790T1 AT E391790 T1 ATE391790 T1 AT E391790T1 AT 00905982 T AT00905982 T AT 00905982T AT 00905982 T AT00905982 T AT 00905982T AT E391790 T1 ATE391790 T1 AT E391790T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleic acids
- protozoa
- multifiliis
- transformants
- beta
- Prior art date
Links
- 102000039446 nucleic acids Human genes 0.000 title abstract 3
- 108020004707 nucleic acids Proteins 0.000 title abstract 3
- 150000007523 nucleic acids Chemical class 0.000 title abstract 3
- 238000003259 recombinant expression Methods 0.000 title 1
- 229930012538 Paclitaxel Natural products 0.000 abstract 2
- 241000223892 Tetrahymena Species 0.000 abstract 2
- 108090000704 Tubulin Proteins 0.000 abstract 2
- 229960001592 paclitaxel Drugs 0.000 abstract 2
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 2
- 230000009261 transgenic effect Effects 0.000 abstract 2
- 241000251468 Actinopterygii Species 0.000 abstract 1
- 108700028369 Alleles Proteins 0.000 abstract 1
- 241000248482 Ichthyophthirius multifiliis Species 0.000 abstract 1
- 241001494184 Myxozoa Species 0.000 abstract 1
- 241000248384 Tetrahymena thermophila Species 0.000 abstract 1
- 102000004243 Tubulin Human genes 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 208000036815 beta tubulin Diseases 0.000 abstract 1
- 210000000170 cell membrane Anatomy 0.000 abstract 1
- 239000013505 freshwater Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000010354 integration Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 238000002255 vaccination Methods 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/002—Protozoa antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11863499P | 1999-02-04 | 1999-02-04 | |
| US12237299P | 1999-03-02 | 1999-03-02 | |
| US12490599P | 1999-03-17 | 1999-03-17 | |
| US13112199P | 1999-04-27 | 1999-04-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE391790T1 true ATE391790T1 (de) | 2008-04-15 |
Family
ID=27494214
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00905982T ATE391790T1 (de) | 1999-02-04 | 2000-02-04 | Rekombinante expression von heterologen nukleinsäuren in protozoen |
Country Status (5)
| Country | Link |
|---|---|
| EP (2) | EP1151104A1 (de) |
| AT (1) | ATE391790T1 (de) |
| AU (2) | AU2756300A (de) |
| DE (1) | DE60038542D1 (de) |
| WO (2) | WO2000046373A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7326568B2 (en) | 1999-02-04 | 2008-02-05 | University Of Georgia Research Foundation, Inc. | Recombinant expression of heterologous nucleic acids in protozoa |
| EP1485489A2 (de) * | 2002-03-19 | 2004-12-15 | Cilian AG | Dna-sequenzen von sekretierten proteinen des ciliaten tetrahymena und deren verwendung |
| DE10214406A1 (de) * | 2002-03-30 | 2003-10-09 | Nutrinova Gmbh | Verfahren und Marker zur einfachen Transformation und Selektion von rekombinanten Protisten |
| DE10214413A1 (de) * | 2002-03-30 | 2003-10-09 | Nutrinova Gmbh | Expression von rekombinanten humanen Proteinen in Tetrahymena |
| US8361780B2 (en) | 2005-06-30 | 2013-01-29 | University Of Georgia Research Foundation, Inc. | Biological system and assay for identifying modulators of tubulin ligases |
| JP5355561B2 (ja) * | 2007-07-12 | 2013-11-27 | コンピュゲン エルティーディー． | 生物活性ペプチドおよびその使用方法 |
| GB2471093A (en) * | 2009-06-17 | 2010-12-22 | Cilian Ag | Viral protein expression in ciliates |
| GB201003701D0 (en) * | 2010-03-05 | 2010-04-21 | Cilian Ag | System for the expression of a protein |
| GB201501081D0 (en) | 2015-01-22 | 2015-03-11 | Cilian Ag | Use of enzymes with a wide pH activity range as medicaments for promoting digestion |
| WO2021260148A1 (en) | 2020-06-24 | 2021-12-30 | Cilian Ag | New lipase enzyme |
| CA3212187A1 (en) | 2021-04-09 | 2022-10-13 | Marcus Wolf William HARTMANN | Purification of proteins |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5780448A (en) * | 1995-11-07 | 1998-07-14 | Ottawa Civic Hospital Loeb Research | DNA-based vaccination of fish |
| US7026156B1 (en) * | 1999-02-04 | 2006-04-11 | The University Of Georgia Research Foundation, Inc. | Diagnostic and protective antigen gene sequences of ichthyophthirius |
-
2000
- 2000-02-04 AU AU27563/00A patent/AU2756300A/en not_active Abandoned
- 2000-02-04 WO PCT/US2000/002962 patent/WO2000046373A1/en not_active Ceased
- 2000-02-04 EP EP00905979A patent/EP1151104A1/de not_active Withdrawn
- 2000-02-04 DE DE60038542T patent/DE60038542D1/de not_active Expired - Lifetime
- 2000-02-04 AT AT00905982T patent/ATE391790T1/de not_active IP Right Cessation
- 2000-02-04 WO PCT/US2000/002966 patent/WO2000046381A1/en not_active Ceased
- 2000-02-04 AU AU27561/00A patent/AU2756100A/en not_active Abandoned
- 2000-02-04 EP EP00905982A patent/EP1151118B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1151118A1 (de) | 2001-11-07 |
| WO2000046381A1 (en) | 2000-08-10 |
| EP1151118B1 (de) | 2008-04-09 |
| AU2756300A (en) | 2000-08-25 |
| WO2000046373A1 (en) | 2000-08-10 |
| AU2756100A (en) | 2000-08-25 |
| DE60038542D1 (de) | 2008-05-21 |
| EP1151104A1 (de) | 2001-11-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |