ATE384067T1 - Verfahren zur herstellung von 3-cephemderivaten - Google Patents
Verfahren zur herstellung von 3-cephemderivatenInfo
- Publication number
- ATE384067T1 ATE384067T1 AT99926869T AT99926869T ATE384067T1 AT E384067 T1 ATE384067 T1 AT E384067T1 AT 99926869 T AT99926869 T AT 99926869T AT 99926869 T AT99926869 T AT 99926869T AT E384067 T1 ATE384067 T1 AT E384067T1
- Authority
- AT
- Austria
- Prior art keywords
- formula
- compound represented
- producing
- chem
- beta
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- FZEVMBJWXHDLDB-ZCFIWIBFSA-N (6r)-5-thia-1-azabicyclo[4.2.0]oct-2-en-8-one Chemical class S1CC=CN2C(=O)C[C@H]21 FZEVMBJWXHDLDB-ZCFIWIBFSA-N 0.000 title 1
- -1 3-cephem compound Chemical class 0.000 abstract 5
- 238000006243 chemical reaction Methods 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003262 carboxylic acid ester group Chemical class [H]C([H])([*:2])OC(=O)C([H])([H])[*:1] 0.000 abstract 1
- 238000000354 decomposition reaction Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 229910052698 phosphorus Inorganic materials 0.000 abstract 1
- 239000011574 phosphorus Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20277198A JP4383557B2 (ja) | 1998-07-01 | 1998-07-01 | ３−セフェム化合物の製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE384067T1 true ATE384067T1 (de) | 2008-02-15 |
Family
ID=16462913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99926869T ATE384067T1 (de) | 1998-07-01 | 1999-06-30 | Verfahren zur herstellung von 3-cephemderivaten |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6420554B1 (de) |
| EP (1) | EP1010701B1 (de) |
| JP (1) | JP4383557B2 (de) |
| KR (1) | KR100435063B1 (de) |
| CN (1) | CN1126754C (de) |
| AT (1) | ATE384067T1 (de) |
| DE (1) | DE69937988T2 (de) |
| ES (1) | ES2300147T3 (de) |
| WO (1) | WO2000001703A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100344635C (zh) * | 2003-07-22 | 2007-10-24 | 广州白云山制药股份有限公司 | 7－苯乙酰氨基－3－吡啶甲基－3－头孢菌素－4－羧酸对甲氧苄酯晶体及其制备方法 |
| CN100418972C (zh) * | 2004-01-19 | 2008-09-17 | 广州白云山制药股份有限公司 | 一种头孢烯类鎓盐化合物及其制备方法和用它制备头孢吡肟的应用 |
| WO2007013043A2 (en) * | 2005-07-29 | 2007-02-01 | Ranbaxy Laboratories Limited | Processes for the preparation of 7-amino-3-vinyl cephalosporanic acid |
| CN101805357B (zh) * | 2010-04-28 | 2012-01-11 | 陶灵刚 | 一种头孢克洛化合物及其制法 |
| CN102212072A (zh) * | 2011-04-21 | 2011-10-12 | 山东天信化工有限公司 | 7-氨基-3-乙烯基头孢烷酸的制备方法 |
| CN103275104B (zh) * | 2013-05-15 | 2015-05-20 | 苏州明锐医药科技有限公司 | 头孢托罗及头孢托罗酯的制备方法 |
| EP2873736A1 (de) | 2013-11-18 | 2015-05-20 | Sandoz AG | Chemoenzymatische Synthese des Cephalosporinzwischenprodukts 7-amino-3-alkenylcephem-4-Carbonsäure |
| CN105131015B (zh) * | 2015-09-14 | 2017-12-22 | 浙江华方药业股份有限公司 | 一种7‑氨基‑3‑乙烯基‑4‑头孢烷酸的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4252973A (en) * | 1979-07-06 | 1981-02-24 | E. R. Squibb & Sons, Inc. | Process for chemically removing the acyl sidechain from cephalosporins and penicillins |
| JPH064638B2 (ja) * | 1985-05-17 | 1994-01-19 | 大塚化学株式会社 | β−ラクタム誘導体の製造方法 |
| US5159071A (en) * | 1990-09-06 | 1992-10-27 | Ranbaxy Laboratories Limited | Process for the manufacture of 7-amino-3-exomethylene-3-cepham-4-carboxylic acid ester |
| JPH11124384A (ja) * | 1997-10-17 | 1999-05-11 | Otsuka Chem Co Ltd | ３−セフェム化合物の製造法 |
-
1998
- 1998-07-01 JP JP20277198A patent/JP4383557B2/ja not_active Expired - Lifetime
-
1999
- 1999-06-30 US US09/485,712 patent/US6420554B1/en not_active Expired - Lifetime
- 1999-06-30 KR KR10-2000-7001863A patent/KR100435063B1/ko not_active Expired - Lifetime
- 1999-06-30 DE DE69937988T patent/DE69937988T2/de not_active Expired - Lifetime
- 1999-06-30 EP EP99926869A patent/EP1010701B1/de not_active Expired - Lifetime
- 1999-06-30 CN CN99801062A patent/CN1126754C/zh not_active Expired - Lifetime
- 1999-06-30 AT AT99926869T patent/ATE384067T1/de active
- 1999-06-30 ES ES99926869T patent/ES2300147T3/es not_active Expired - Lifetime
- 1999-06-30 WO PCT/JP1999/003540 patent/WO2000001703A1/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP2000026470A (ja) | 2000-01-25 |
| DE69937988D1 (de) | 2008-03-06 |
| EP1010701A4 (de) | 2001-07-11 |
| CN1126754C (zh) | 2003-11-05 |
| JP4383557B2 (ja) | 2009-12-16 |
| WO2000001703A1 (en) | 2000-01-13 |
| US6420554B1 (en) | 2002-07-16 |
| DE69937988T2 (de) | 2008-12-24 |
| EP1010701A1 (de) | 2000-06-21 |
| EP1010701B1 (de) | 2008-01-16 |
| CN1273587A (zh) | 2000-11-15 |
| KR20010023233A (ko) | 2001-03-26 |
| KR100435063B1 (ko) | 2004-06-12 |
| ES2300147T3 (es) | 2008-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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