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ATE381340T1 - INCREASED SOLUBILITY OF FLAVANOLIGNAN PREPARATIONS - Google Patents

INCREASED SOLUBILITY OF FLAVANOLIGNAN PREPARATIONS

Info

Publication number
ATE381340T1
ATE381340T1 AT02757502T AT02757502T ATE381340T1 AT E381340 T1 ATE381340 T1 AT E381340T1 AT 02757502 T AT02757502 T AT 02757502T AT 02757502 T AT02757502 T AT 02757502T AT E381340 T1 ATE381340 T1 AT E381340T1
Authority
AT
Austria
Prior art keywords
flavanolignan
increased solubility
compositions
approaches
preparation
Prior art date
Application number
AT02757502T
Other languages
German (de)
Inventor
Kvetoslava Benesova
Ladislav Cvak
Milan Stuchlik
Original Assignee
Ivax Pharmaceuticals Sro
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ivax Pharmaceuticals Sro filed Critical Ivax Pharmaceuticals Sro
Application granted granted Critical
Publication of ATE381340T1 publication Critical patent/ATE381340T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • A61K31/79—Polymers of vinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

The inventors have devised novel approaches for the preparation of flavanolignan compositions of enhanced solubility and substantially free of toxic contaminants. Such novel approaches are based on spray drying or lyophilizing to dry a diluted preparation of flavanolignan. These approaches avoid the use of toxic excipients and or carriers commonly used to precipitate flavanolignan concentrates and thus address the drawbacks of existing methods and compositions.
AT02757502T 2001-08-30 2002-08-30 INCREASED SOLUBILITY OF FLAVANOLIGNAN PREPARATIONS ATE381340T1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CZ20013153A CZ292832B6 (en) 2001-08-30 2001-08-30 Process for preparing silymarin exhibiting increased solubility

Publications (1)

Publication Number Publication Date
ATE381340T1 true ATE381340T1 (en) 2008-01-15

Family

ID=5473538

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02757502T ATE381340T1 (en) 2001-08-30 2002-08-30 INCREASED SOLUBILITY OF FLAVANOLIGNAN PREPARATIONS

Country Status (15)

Country Link
US (1) US7384919B2 (en)
EP (1) EP1420802B1 (en)
JP (1) JP2005519863A (en)
KR (1) KR20040074052A (en)
CN (1) CN1582159A (en)
AT (1) ATE381340T1 (en)
AU (1) AU2002323517B2 (en)
CA (1) CA2458963A1 (en)
CZ (1) CZ292832B6 (en)
DE (1) DE60224202T2 (en)
MX (1) MXPA04001700A (en)
NO (1) NO20041300L (en)
NZ (1) NZ531429A (en)
TW (1) TWI238065B (en)
WO (1) WO2003020291A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005026755A1 (en) * 2005-06-09 2006-12-14 Basf Ag Production of solid solutions of sparingly soluble active ingredients by short-term overheating and rapid drying
WO2009052246A1 (en) 2007-10-17 2009-04-23 Ovokaitys, Todd, F. Process for the modification of the solid state of a compound and co-amorphous compositions produced with same
DE102008039271A1 (en) 2007-12-23 2009-06-25 Euromed Sa New milk thistle extract, method of preparation and use
CZ2008407A3 (en) 2008-06-26 2009-08-26 Agra Group, A. S. Water-soluble composition based on flavanonol lignanes and process for preparing thereof
JP5841048B2 (en) * 2009-05-14 2016-01-06 エウロメッド・エセ・ア Amorphous silibinin for the treatment of viral hepatitis
WO2010134519A1 (en) * 2009-05-19 2010-11-25 サントリーホールディングス株式会社 Glucosyltransferase specific to position-4 of furofuran-type lignan, and polynucleotide encoding same
CN102228430B (en) * 2011-06-14 2015-12-09 中国中医科学院中药研究所 Nano suspension of silybin-phospholipid complex and preparation method thereof
US8877259B2 (en) 2012-02-09 2014-11-04 Mary Kay Inc. Cosmetic formulation
ITMI20121317A1 (en) * 2012-07-27 2014-01-28 Indena Spa COMPOSITIONS FOR THE TREATMENT OF ONCOLOGICAL FATIGUE
JP2015113332A (en) * 2013-12-16 2015-06-22 花王株式会社 Herbal powder
US10202598B2 (en) 2014-05-30 2019-02-12 Todd Frank Ovokaitys Methods and systems for generation, use, and delivery of activated stem cells
WO2015187974A1 (en) 2014-06-06 2015-12-10 Ovokaitys Todd Frank Methods and compositions for increasing the bioactivity of nutrients
US10384985B2 (en) 2014-06-06 2019-08-20 B.K. Consultants, Inc. Methods and compositions for increasing the yield of, and beneficial chemical composition of, certain plants
JP6348024B2 (en) * 2014-09-03 2018-06-27 株式会社ファンケル Silymarin-containing composition with good water dispersibility
KR101598752B1 (en) 2015-01-28 2016-02-29 순천향대학교 산학협력단 Liposome formulations using surface area and porosity-modified sugar alcohol as a carrier and preparation methods thereof
ES2706008B8 (en) * 2017-09-22 2021-07-12 Euromed S A PROCEDURE FOR THE PREPARATION OF A COMPOSITION FROM MARIAN THISTLE AND COMPOSITION OBTAINED
JP2023552806A (en) 2020-12-08 2023-12-19 フランク オヴォカイツ トッド Methods and systems for increased production of stem cells

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1554662A (en) * 1976-05-05 1979-10-24 Inverni Della Beffa Spa Polyhydroxyphenylchromanones
IT1215291B (en) * 1985-07-17 1990-01-31 Inverni Della Beffa Spa FLAVANOLIGNANI COMPLEXES WITH PHOSPHOLIPIDS, THEIR PREPARATION AND RELATED PHARMACEUTICAL COMPOSITIONS.
US4767508A (en) * 1986-02-27 1988-08-30 Nippon Mining Co., Ltd. Strike plating solution useful in applying primer plating to electronic parts
IT1222012B (en) * 1987-07-10 1990-08-31 Indena Spa PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING COMPLEX FLAVONOLIGNANS WITH PHOSPHOLIPIDS
GB8716918D0 (en) * 1987-07-17 1987-08-26 Inverni Della Beffa Spa Soluble derivatives of silybin
US5019562A (en) * 1988-01-19 1991-05-28 The Trustees Of The University Of Pennsylvania/Childrens Hospital Corporation Growth inhibiting agent and the use thereof
IT1241673B (en) * 1989-10-09 1994-01-27 Istituto Biochimico Italiano INCLUSION COMPLEXES OF SILIBININ WITH CYCLODESTRINE, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
US5196448A (en) * 1991-01-22 1993-03-23 Stiefel Laboratories, Inc. Antiinflammatory compositions and method of use
DE19501266A1 (en) 1995-01-18 1996-07-25 Madaus Ag Process for the preparation of flavano-lignan preparations with improved release and resorbability, preparations available thereafter and their use for the production of medicaments
CZ287657B6 (en) 1996-06-12 2001-01-17 Mikrobiologický Ústav Av Čr Silybinin glycosides and process of their preparation
DE19744459A1 (en) 1997-10-08 1999-04-15 Schwabe Willmar Gmbh & Co Solubilised silymarin formulation

Also Published As

Publication number Publication date
CN1582159A (en) 2005-02-16
NZ531429A (en) 2005-11-25
EP1420802B1 (en) 2007-12-19
EP1420802A4 (en) 2005-02-09
US7384919B2 (en) 2008-06-10
NO20041300L (en) 2004-03-29
AU2002323517B2 (en) 2009-12-10
DE60224202D1 (en) 2008-01-31
WO2003020291A1 (en) 2003-03-13
US20050101546A1 (en) 2005-05-12
CA2458963A1 (en) 2003-03-13
TWI238065B (en) 2005-08-21
KR20040074052A (en) 2004-08-21
DE60224202T2 (en) 2008-12-04
CZ20013153A3 (en) 2003-04-16
CZ292832B6 (en) 2003-12-17
MXPA04001700A (en) 2005-04-11
JP2005519863A (en) 2005-07-07
EP1420802A1 (en) 2004-05-26

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties