ATE378423T1 - Polymorphismen des menschlichen hpxr gens und ihre anwendung in diagnose und therapie - Google Patents
Polymorphismen des menschlichen hpxr gens und ihre anwendung in diagnose und therapieInfo
- Publication number
- ATE378423T1 ATE378423T1 AT00958530T AT00958530T ATE378423T1 AT E378423 T1 ATE378423 T1 AT E378423T1 AT 00958530 T AT00958530 T AT 00958530T AT 00958530 T AT00958530 T AT 00958530T AT E378423 T1 ATE378423 T1 AT E378423T1
- Authority
- AT
- Austria
- Prior art keywords
- hpxr
- cyp3a7
- cyp3a4
- vectors
- proteins
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 9
- 238000002560 therapeutic procedure Methods 0.000 title abstract 2
- 238000003745 diagnosis Methods 0.000 title 1
- 102000054765 polymorphisms of proteins Human genes 0.000 title 1
- 108010081668 Cytochrome P-450 CYP3A Proteins 0.000 abstract 6
- 102100039205 Cytochrome P450 3A4 Human genes 0.000 abstract 6
- 102100039203 Cytochrome P450 3A7 Human genes 0.000 abstract 6
- 101000745715 Homo sapiens Cytochrome P450 3A7 Proteins 0.000 abstract 6
- 102000040430 polynucleotide Human genes 0.000 abstract 5
- 108091033319 polynucleotide Proteins 0.000 abstract 5
- 239000002157 polynucleotide Substances 0.000 abstract 5
- 238000000034 method Methods 0.000 abstract 4
- 102000004169 proteins and genes Human genes 0.000 abstract 4
- 239000013598 vector Substances 0.000 abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 239000003112 inhibitor Substances 0.000 abstract 3
- 208000035475 disorder Diseases 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000007257 malfunction Effects 0.000 abstract 1
- 238000001228 spectrum Methods 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0077—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Pathology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- High Energy & Nuclear Physics (AREA)
- Cell Biology (AREA)
- Public Health (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99118120A EP1088900A1 (de) | 1999-09-10 | 1999-09-10 | Polymorphismen des menschlichen CYP3A4, CYP3A7 und hPXR Gene, und ihre Anwendung in Diagnose und Therapie |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE378423T1 true ATE378423T1 (de) | 2007-11-15 |
Family
ID=8238983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00958530T ATE378423T1 (de) | 1999-09-10 | 2000-09-08 | Polymorphismen des menschlichen hpxr gens und ihre anwendung in diagnose und therapie |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7655771B1 (de) |
| EP (3) | EP1088900A1 (de) |
| JP (2) | JP2003509063A (de) |
| AT (1) | ATE378423T1 (de) |
| AU (2) | AU7513300A (de) |
| CA (2) | CA2379541A1 (de) |
| DE (1) | DE60037126T2 (de) |
| NO (2) | NO20021146L (de) |
| WO (2) | WO2001020025A2 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPP362898A0 (en) | 1998-05-21 | 1998-06-11 | University Of Sydney, The | Xenobiotic induction of gene expression |
| AUPR116100A0 (en) | 2000-11-01 | 2000-11-23 | University Of Sydney, The | P450 gene regulation |
| AU2002218602A1 (en) * | 2000-11-28 | 2002-06-11 | Csaba Finta | New cytochrome p450 proteins and the corresponding dna sequences |
| WO2002088305A2 (en) | 2001-04-12 | 2002-11-07 | Xenogen Corporation | Isolation and identification of mouse and human transcription control elements associated with cytochrome expression |
| JP2003304896A (ja) * | 2002-04-15 | 2003-10-28 | Yasushi Yamazoe | ヒトｃｙｐ３ａ誘導能の測定法 |
| JP2006503883A (ja) * | 2002-10-28 | 2006-02-02 | ファルマシア・イタリア・エス・ピー・エー | ネモルビシンの治療効果を最適化するための方法 |
| US7759541B2 (en) | 2004-12-13 | 2010-07-20 | Iti Life Sciences | Transgenic animals for assessing drug metabolism and toxicity |
| JP2007119359A (ja) * | 2005-10-25 | 2007-05-17 | Fujifilm Corp | 癌抑制剤 |
| CN102886326A (zh) * | 2006-10-23 | 2013-01-23 | 米歇尔技术公司 | 用于在涂覆过程中为基底充电的保持器 |
| US9441275B2 (en) | 2009-03-26 | 2016-09-13 | Ohio State Innovation Foundation | Polymorphism in CYP3A4 gene affecting drug metabolizing and uses thereof |
| US9938576B1 (en) | 2012-09-21 | 2018-04-10 | Ohio State Innovation Foundation | Materials and methods for determining metabolizer status in humans |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9001181D0 (en) * | 1990-01-18 | 1990-03-21 | Imp Cancer Res Tech | Genetic assay |
| JP3564579B2 (ja) * | 1994-05-06 | 2004-09-15 | 大塚製薬株式会社 | ヒトチトクロームｐ４５０２ｄ６遺伝子多型の検出方法 |
| FR2733251B1 (fr) * | 1995-04-18 | 1997-07-04 | Inst Nat Sante Rech Med | Depistage du glaucome juvenile |
| US6025131A (en) * | 1996-10-23 | 2000-02-15 | E. I. Du Pont De Namours And Company | Facile method for identifying regulated promoters |
| WO1998020165A2 (en) * | 1996-11-06 | 1998-05-14 | Whitehead Institute For Biomedical Research | Biallelic markers |
| EP1024193A4 (de) * | 1997-07-22 | 2004-12-15 | Chugai Pharmaceutical Co Ltd | Verfahren zum screenen von genen unter verwendung von zellkern-rezeptoren. |
| US6432639B1 (en) * | 1997-09-10 | 2002-08-13 | Dna Sciences Laboratories, Inc. | Isolated CYP3A4 nucleic acid molecules and detection methods |
| JP2002535241A (ja) * | 1998-03-27 | 2002-10-22 | グラクソ グループ リミテッド | オーファン核内受容体 |
| US6821724B1 (en) * | 1998-09-17 | 2004-11-23 | Affymetrix, Inc. | Methods of genetic analysis using nucleic acid arrays |
| US6183963B1 (en) * | 1998-10-23 | 2001-02-06 | Signalgene | Detection of CYP1A1, CYP3A4, CYP2D6 and NAT2 variants by PCR-allele-specific oligonucleotide (ASO) assay |
-
1999
- 1999-09-10 EP EP99118120A patent/EP1088900A1/de not_active Withdrawn
-
2000
- 2000-09-01 EP EP00964092A patent/EP1210463A2/de not_active Withdrawn
- 2000-09-01 US US10/070,587 patent/US7655771B1/en not_active Expired - Fee Related
- 2000-09-01 CA CA002379541A patent/CA2379541A1/en not_active Abandoned
- 2000-09-01 WO PCT/EP2000/008570 patent/WO2001020025A2/en not_active Ceased
- 2000-09-01 JP JP2001523796A patent/JP2003509063A/ja active Pending
- 2000-09-01 AU AU75133/00A patent/AU7513300A/en not_active Abandoned
- 2000-09-08 EP EP00958530A patent/EP1210462B1/de not_active Expired - Lifetime
- 2000-09-08 JP JP2001523797A patent/JP2003509064A/ja active Pending
- 2000-09-08 WO PCT/EP2000/008827 patent/WO2001020026A2/en not_active Ceased
- 2000-09-08 US US10/070,588 patent/US7122652B1/en not_active Expired - Fee Related
- 2000-09-08 DE DE60037126T patent/DE60037126T2/de not_active Expired - Lifetime
- 2000-09-08 AT AT00958530T patent/ATE378423T1/de not_active IP Right Cessation
- 2000-09-08 CA CA002381066A patent/CA2381066A1/en not_active Abandoned
- 2000-09-08 AU AU70018/00A patent/AU7001800A/en not_active Abandoned
-
2002
- 2002-03-07 NO NO20021146A patent/NO20021146L/no unknown
- 2002-03-07 NO NO20021147A patent/NO20021147L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO20021147L (no) | 2002-05-03 |
| WO2001020025A3 (en) | 2001-10-11 |
| JP2003509064A (ja) | 2003-03-11 |
| AU7001800A (en) | 2001-04-17 |
| CA2379541A1 (en) | 2001-03-22 |
| DE60037126D1 (de) | 2007-12-27 |
| WO2001020025A2 (en) | 2001-03-22 |
| EP1210462A2 (de) | 2002-06-05 |
| EP1210462B1 (de) | 2007-11-14 |
| WO2001020026A3 (en) | 2001-12-13 |
| JP2003509063A (ja) | 2003-03-11 |
| US7122652B1 (en) | 2006-10-17 |
| US7655771B1 (en) | 2010-02-02 |
| WO2001020026A2 (en) | 2001-03-22 |
| EP1210463A2 (de) | 2002-06-05 |
| EP1088900A1 (de) | 2001-04-04 |
| CA2381066A1 (en) | 2001-03-22 |
| DE60037126T2 (de) | 2008-09-18 |
| NO20021147D0 (no) | 2002-03-07 |
| AU7513300A (en) | 2001-04-17 |
| NO20021146D0 (no) | 2002-03-07 |
| NO20021146L (no) | 2002-04-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |