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ATE378364T1 - Polyamhydride mit therapeutisch verwendbaren abbauprodukten - Google Patents

Polyamhydride mit therapeutisch verwendbaren abbauprodukten

Info

Publication number
ATE378364T1
ATE378364T1 AT98946004T AT98946004T ATE378364T1 AT E378364 T1 ATE378364 T1 AT E378364T1 AT 98946004 T AT98946004 T AT 98946004T AT 98946004 T AT98946004 T AT 98946004T AT E378364 T1 ATE378364 T1 AT E378364T1
Authority
AT
Austria
Prior art keywords
ortho
aromatic
substituted
dicarboxylic acid
well
Prior art date
Application number
AT98946004T
Other languages
English (en)
Inventor
Kathryn Uhrich
Original Assignee
Univ Rutgers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rutgers filed Critical Univ Rutgers
Application granted granted Critical
Publication of ATE378364T1 publication Critical patent/ATE378364T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G67/00—Macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing oxygen or oxygen and carbon, not provided for in groups C08G2/00 - C08G65/00
    • C08G67/04—Polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Transplantation (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Polyethers (AREA)
AT98946004T 1997-09-10 1998-09-10 Polyamhydride mit therapeutisch verwendbaren abbauprodukten ATE378364T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5832897P 1997-09-10 1997-09-10

Publications (1)

Publication Number Publication Date
ATE378364T1 true ATE378364T1 (de) 2007-11-15

Family

ID=22016145

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98946004T ATE378364T1 (de) 1997-09-10 1998-09-10 Polyamhydride mit therapeutisch verwendbaren abbauprodukten

Country Status (13)

Country Link
EP (1) EP1032605B1 (de)
JP (2) JP4130305B2 (de)
KR (1) KR20010023852A (de)
CN (1) CN1158325C (de)
AT (1) ATE378364T1 (de)
AU (1) AU750424C (de)
CA (1) CA2302508C (de)
CY (1) CY1107857T1 (de)
DE (1) DE69838731T2 (de)
DK (1) DK1032605T3 (de)
ES (1) ES2296344T3 (de)
PT (1) PT1032605E (de)
WO (1) WO1999012990A1 (de)

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US6468519B1 (en) * 1997-09-10 2002-10-22 Rutgers, The State University Of New Jersey Polyanhydrides with biologically active degradation products
US6486214B1 (en) 1997-09-10 2002-11-26 Rutgers, The State University Of New Jersey Polyanhydride linkers for production of drug polymers and drug polymer compositions produced thereby
US20040038948A1 (en) 1999-12-07 2004-02-26 Uhrich Kathryn E. Therapeutic compositions and methods
US6685928B2 (en) * 1999-12-07 2004-02-03 Rutgers, The State University Of New Jersey Therapeutic compositions and methods
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US8109994B2 (en) 2003-01-10 2012-02-07 Abbott Cardiovascular Systems, Inc. Biodegradable drug delivery material for stent
US7875283B2 (en) 2000-04-13 2011-01-25 Advanced Cardiovascular Systems, Inc. Biodegradable polymers for use with implantable medical devices
WO2002009769A2 (en) 2000-07-27 2002-02-07 Rutgers, The State University Of New Jersey Therapeutic azo-compounds for drug delivery
MXPA03000821A (es) 2000-07-27 2004-03-18 Univ Rutgers Poliesteres y poliamidas terapeuticos.
IL140017A (en) * 2000-11-30 2009-09-22 Abraham J Domb Polyhedra
CA2466039A1 (en) 2001-11-23 2003-06-05 Rutgers, The State University Improved synthesis of polyanhydrides
EP1487513B1 (de) * 2002-03-20 2012-06-13 Abbott Cardiovascular Systems Inc. Bioabbaubares hydrophobes polymer für stents
CA2503841A1 (en) * 2002-10-28 2004-05-13 Polymerix Corporation Therapeutic compositions
CA2506319C (en) * 2002-11-18 2012-08-28 Polymerix Corporation Stents comprising biodegradable polymers associated with therapeutic agents
WO2005110485A1 (en) * 2004-05-14 2005-11-24 Interface Biologics Inc. Polymeric coupling agents and pharmaceutically-active polymers made therefrom
CA2467321A1 (en) 2004-05-14 2005-11-14 Paul J. Santerre Polymeric coupling agents and pharmaceutically-active polymers made therefrom
WO2006071813A2 (en) 2004-12-23 2006-07-06 Massachusetts Institute Of Technology Disposable medical supplies from hydrolytically biodegradable plastics
WO2006127667A1 (en) 2005-05-23 2006-11-30 Rutgers, The State University Of New Jersey Fast degrading polymers
US8318973B2 (en) 2005-10-21 2012-11-27 Bezwada Biomedical, Llc Functionalized sinapic acid and methyl sinapate
US8007526B2 (en) 2005-12-01 2011-08-30 Bezwada Biomedical, Llc Difunctionalized aromatic compounds and polymers therefrom
KR20090024242A (ko) * 2006-06-06 2009-03-06 루트거스, 더 스테이트 유니버시티 오브 뉴 저지 아이오딘화 중합체
WO2008034019A2 (en) 2006-09-13 2008-03-20 Polymerix Corporation Active agents and their oligomers and polymers
WO2008128193A1 (en) 2007-04-12 2008-10-23 Rutgers, The State University Of New Jersey Biodegradable polyanhydrides with natural bioactive molecules
US8217134B2 (en) 2007-08-30 2012-07-10 Bezwada Biomedical, Llc Controlled release of biologically active compounds
US8048980B2 (en) 2007-09-17 2011-11-01 Bezwada Biomedical, Llc Hydrolysable linkers and cross-linkers for absorbable polymers
CN101357244B (zh) * 2008-09-18 2011-06-01 复旦大学附属肿瘤医院 纳米粒子增强的光固化聚酸酐载药聚合物支架的制备方法
WO2011141341A1 (en) 2010-05-14 2011-11-17 Iberhospitex, S.A. Compounds for the synthesis of biostable polyurethane, polyurea or polyurea urethane polymers
US20140030341A1 (en) * 2011-04-06 2014-01-30 Rutgers, The State University Of New Jersey Polymers and methods for the treatment of pain
CN104363924B (zh) * 2012-03-16 2018-04-17 约翰霍普金斯大学 用于递送hif‑1抑制剂的控制释放调配物
JP6138904B2 (ja) * 2012-03-16 2017-05-31 ザ・ジョンズ・ホプキンス・ユニバーシティー 活性剤の送達のための非線状マルチブロックコポリマー薬物コンジュゲート
US9144579B2 (en) 2012-08-17 2015-09-29 Rutgers, The State University Of New Jersey Polyesters and methods of use thereof
US20140120057A1 (en) 2012-10-25 2014-05-01 Rutgers, The State University Of New Jersey Polymers and methods thereof for wound healing
CN103910875B (zh) * 2012-12-31 2017-06-13 张雅珍 蒽环类抗生素偶联非线性多嵌段共聚物及其制备方法和应用
US9387250B2 (en) 2013-03-15 2016-07-12 Rutgers, The State University Of New Jersey Therapeutic compositions for bone repair
US9862672B2 (en) 2013-05-29 2018-01-09 Rutgers, The State University Of New Jersey Antioxidant-based poly(anhydride-esters)
US10023521B2 (en) 2014-06-13 2018-07-17 Rutgers, The State University Of New Jersey Process and intermediates for preparing poly(anhydride-esters)
US10774176B2 (en) 2014-12-18 2020-09-15 Dexcel Pharma Technologies Ltd. Alternating and semi-alternating poly(ester-anhydride) copolymers
US10543162B2 (en) 2015-04-10 2020-01-28 Rutgers, The State University Of New Jersey Kojic acid polymers
EP3600438A4 (de) 2017-03-29 2020-10-28 Dexcel Pharma Technologies Ltd. Zusammensetzungen mit biologisch abbaubaren copolymeren
JP7502186B2 (ja) 2018-02-02 2024-06-18 リップル セラピューティクス コーポレーション ステロイド二量体を含むガラス製剤およびその使用
WO2020154815A1 (en) 2019-02-01 2020-08-06 Ripple Therapeutics Corporation Crystalline forms of dexamethasone dimers and uses thereof
US11376221B2 (en) * 2019-07-05 2022-07-05 The Regents Of The University Of Michigan Polymer particles for neutrophil injury
CN115956083A (zh) 2020-05-01 2023-04-11 波纹疗法公司 异二聚体组合物及用于治疗眼部病症的方法

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Also Published As

Publication number Publication date
JP4130305B2 (ja) 2008-08-06
PT1032605E (pt) 2007-12-12
JP2008150367A (ja) 2008-07-03
CN1269811A (zh) 2000-10-11
AU750424B2 (en) 2002-07-18
ES2296344T3 (es) 2008-04-16
CN1158325C (zh) 2004-07-21
CA2302508C (en) 2011-03-15
AU9311798A (en) 1999-03-29
WO1999012990A1 (en) 1999-03-18
EP1032605A1 (de) 2000-09-06
CA2302508A1 (en) 1999-03-18
DE69838731T2 (de) 2008-04-10
CY1107857T1 (el) 2013-06-19
JP2001515934A (ja) 2001-09-25
AU750424C (en) 2003-05-15
EP1032605B1 (de) 2007-11-14
DK1032605T3 (da) 2008-03-17
DE69838731D1 (de) 2007-12-27
KR20010023852A (ko) 2001-03-26
EP1032605A4 (de) 2002-03-13

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