ATE377008T1 - Imidazolderivate als glutamatrezeptorantagonisten - Google Patents

Imidazolderivate als glutamatrezeptorantagonisten

Info

Publication number: ATE377008T1
Authority: AT; Austria
Prior art keywords: glutama; receptor antagonists; imidazole derivatives; imidazole; derivatives
Prior art date: 2003-06-05

Application number

AT04739484T

Other languages

English (en)

Inventor

Bernd Buettelmann

Simona Ceccarelli

Georg Jaeschke

Richard Porter

Eric Vieira

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-06-05

Filing date

2004-06-01

Publication date

2007-11-15

2004-06-01 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2007-11-15 Application granted granted Critical

2007-11-15 Publication of ATE377008T1 publication Critical patent/ATE377008T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Addiction (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT04739484T 2003-06-05 2004-06-01 Imidazolderivate als glutamatrezeptorantagonisten ATE377008T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP03012200		2003-06-05

Publications (1)

Publication Number	Publication Date
ATE377008T1 true ATE377008T1 (de)	2007-11-15

Family

ID=33483899

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04739484T ATE377008T1 (de)	2003-06-05	2004-06-01	Imidazolderivate als glutamatrezeptorantagonisten

Country Status (38)

Country	Link
US (3)	US7332510B2 (de)
EP (1)	EP1636206B1 (de)
JP (1)	JP4401384B2 (de)
KR (1)	KR100778948B1 (de)
CN (1)	CN100408572C (de)
AR (1)	AR044478A1 (de)
AT (1)	ATE377008T1 (de)
AU (1)	AU2004245208B2 (de)
BR (1)	BRPI0411095B8 (de)
CA (1)	CA2527315C (de)
CL (1)	CL2004001347A1 (de)
CR (1)	CR8094A (de)
CY (1)	CY1107856T1 (de)
DE (1)	DE602004009796T2 (de)
DK (1)	DK1636206T3 (de)
EA (1)	EA010577B1 (de)
EC (1)	ECSP056202A (de)
ES (1)	ES2294504T3 (de)
GT (1)	GT200400117A (de)
HN (1)	HN2004000208A (de)
HR (1)	HRP20070529T3 (de)
IL (1)	IL171930A (de)
MA (1)	MA27881A1 (de)
MX (1)	MXPA05013149A (de)
MY (2)	MY137272A (de)
NO (1)	NO332143B1 (de)
NZ (1)	NZ543637A (de)
PA (1)	PA8604101A1 (de)
PE (1)	PE20050162A1 (de)
PL (1)	PL1636206T3 (de)
PT (1)	PT1636206E (de)
RS (1)	RS53183B (de)
SI (1)	SI1636206T1 (de)
TN (2)	TNSN05309A1 (de)
TW (1)	TWI338007B (de)
UA (1)	UA80888C2 (de)
WO (1)	WO2004108701A1 (de)
ZA (2)	ZA200509807B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7531529B2 (en)	2003-06-05	2009-05-12	Roche Palo Alto Llc	Imidazole derivatives
UA80888C2 (en) *	2003-06-05	2007-11-12	Hoffmann La Roche	Imidazole derivatives as glutmate receptor antagonists
US7452909B2 (en)	2003-09-04	2008-11-18	Hoffman-La Roche Inc.	Imidazole derivatives
EA011722B1 (ru) *	2004-06-01	2009-04-28	Ф.Хоффманн-Ля Рош Аг	Пиридин-4-илэтинилимидазолы и -пиразолы как антагонисты рецептора mglu5
GB0514296D0 (en) *	2005-07-12	2005-08-17	Novartis Ag	Organic compounds
DE102006011574A1 (de) *	2006-03-10	2007-10-31	Grünenthal GmbH	Substituierte Imidazo[2,1-b]thiazol-Verbindungen und ihre Verwendung zur Herstellung von Arzneimitteln
CA2673444C (en)	2006-12-21	2015-01-20	F. Hoffmann-La Roche Ag	Polymorphs of a mglur5 receptor antagonist
US8334287B2 (en) *	2009-07-17	2012-12-18	Hoffmann-La Roche Inc.	Imidazoles
US20120040008A1 (en) *	2010-08-11	2012-02-16	Ashish Chatterji	Pharmaceutical compositions of metabotropic glutamate 5 receptor (mglu5) antagonists
US20120039999A1 (en) *	2010-08-11	2012-02-16	Ashish Chatterji	Pharmaceutical compositions of metabotropic glutamate 5 receptor (mglu5) antagonists
KR20140018286A (ko)	2011-03-18	2014-02-12	노파르티스 아게	파킨슨병에서의 도파민 유발 이상운동증에서 사용하기 위한 알파 7 니코틴성 아세틸콜린 수용체 활성화제 및 mGluR5 길항제의 조합물
CN104718192B (zh) *	2012-10-18	2016-08-31	霍夫曼-拉罗奇有限公司	作为mglur5受体活性调节剂的乙炔基衍生物
NZ703537A (en) *	2012-10-18	2018-06-29	Hoffmann La Roche	Ethynyl derivatives
CA3018375A1 (en) *	2016-03-30	2017-10-05	Carin Sjolund	Negative allosteric modulators of mglur5 for use in the treatment of mature brain damages
EP4069685A1 (de) *	2019-12-02	2022-10-12	F. Hoffmann-La Roche AG	Alkynyl-(heteroaryl) -carboxamid-hcn-inhibitoren
KR20230027145A (ko)	2020-06-05	2023-02-27	노에마 파르마 아게	결절성 경화증 복합증의 치료 방법
AU2021316675A1 (en) *	2020-07-30	2023-01-19	Noema Pharma Ag	Methods of treatment of trigeminal neuralgia
WO2024163890A1 (en)	2023-02-02	2024-08-08	Noema Pharma Ag	Methods of treatment of dravet syndrome

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4508560A (en)	1981-11-11	1985-04-02	Ciba Geigy Corporation	Certain pyridylacetylene compounds, compositions containing same and herbicidal methods of use
TW544448B (en) *	1997-07-11	2003-08-01	Novartis Ag	Pyridine derivatives
JP4815083B2 (ja)	1999-08-31	2011-11-16	メルク・シャープ・エンド・ドーム・コーポレイション	複素環化合物およびそれの使用方法
WO2002008205A1 (en) *	2000-07-24	2002-01-31	Krenitsky Pharmaceuticals, Inc.	Substituted 5-alkynyl pyrimidines having neurotrophic activity
DK1349839T3 (da) *	2000-12-04	2005-06-06	Hoffmann La Roche	Phenylethenyl- eller phenylethinylderivater som glutamatraceptorantagonister
AU2002360621B2 (en) *	2001-12-19	2007-01-25	Merck & Co., Inc.	heteroaryl substituted imidazole modulators of metabotropic glutamate receptor-5
WO2004038374A2 (en) *	2002-10-24	2004-05-06	Merck & Co., Inc.	Alkyne derivatives as tracers for metabotropic glutamate receptor binding
TWI292318B (en) *	2003-03-10	2008-01-11	Hoffmann La Roche	Imidazol-4-yl-ethynyl-pyridine derivatives
UA80888C2 (en) *	2003-06-05	2007-11-12	Hoffmann La Roche	Imidazole derivatives as glutmate receptor antagonists
US7091222B2 (en) *	2003-07-03	2006-08-15	Hoffmann-La Roche Inc.	Imidazole derivatives

2004
- 2004-01-06 UA UAA200512695A patent/UA80888C2/uk unknown
- 2004-06-01 DK DK04739484T patent/DK1636206T3/da active
- 2004-06-01 AU AU2004245208A patent/AU2004245208B2/en not_active Expired
- 2004-06-01 RS YU20050892A patent/RS53183B/sr unknown
- 2004-06-01 WO PCT/EP2004/005881 patent/WO2004108701A1/en not_active Ceased
- 2004-06-01 BR BRPI0411095A patent/BRPI0411095B8/pt not_active IP Right Cessation
- 2004-06-01 NZ NZ543637A patent/NZ543637A/en not_active IP Right Cessation
- 2004-06-01 AT AT04739484T patent/ATE377008T1/de active
- 2004-06-01 MX MXPA05013149A patent/MXPA05013149A/es active IP Right Grant
- 2004-06-01 EP EP04739484A patent/EP1636206B1/de not_active Expired - Lifetime
- 2004-06-01 KR KR1020057023137A patent/KR100778948B1/ko not_active Expired - Lifetime
- 2004-06-01 PT PT04739484T patent/PT1636206E/pt unknown
- 2004-06-01 CA CA2527315A patent/CA2527315C/en not_active Expired - Lifetime
- 2004-06-01 PL PL04739484T patent/PL1636206T3/pl unknown
- 2004-06-01 EA EA200501887A patent/EA010577B1/ru not_active IP Right Cessation
- 2004-06-01 DE DE602004009796T patent/DE602004009796T2/de not_active Expired - Lifetime
- 2004-06-01 ES ES04739484T patent/ES2294504T3/es not_active Expired - Lifetime
- 2004-06-01 CN CNB2004800156669A patent/CN100408572C/zh not_active Expired - Lifetime
- 2004-06-01 SI SI200430525T patent/SI1636206T1/sl unknown
- 2004-06-01 JP JP2006508238A patent/JP4401384B2/ja not_active Expired - Lifetime
- 2004-06-01 HR HR20070529T patent/HRP20070529T3/xx unknown
- 2004-06-02 US US10/858,969 patent/US7332510B2/en not_active Expired - Lifetime
- 2004-06-02 PE PE2004000558A patent/PE20050162A1/es active IP Right Grant
- 2004-06-02 PA PA20048604101A patent/PA8604101A1/es unknown
- 2004-06-02 TW TW093115811A patent/TWI338007B/zh not_active IP Right Cessation
- 2004-06-02 CL CL200401347A patent/CL2004001347A1/es unknown
- 2004-06-03 GT GT200400117A patent/GT200400117A/es unknown
- 2004-06-03 MY MYPI20042150A patent/MY137272A/en unknown
- 2004-06-03 HN HN2004000208A patent/HN2004000208A/es unknown
- 2004-06-03 AR ARP040101908A patent/AR044478A1/es active IP Right Grant
2005
- 2005-05-27 MY MYPI20052424A patent/MY143353A/en unknown
- 2005-11-13 IL IL171930A patent/IL171930A/en active IP Right Grant
- 2005-11-14 CR CR8094A patent/CR8094A/es unknown
- 2005-11-18 NO NO20055465A patent/NO332143B1/no unknown
- 2005-12-01 TN TNP2005000309A patent/TNSN05309A1/fr unknown
- 2005-12-02 ZA ZA200509807A patent/ZA200509807B/en unknown
- 2005-12-02 EC EC2005006202A patent/ECSP056202A/es unknown
- 2005-12-09 MA MA28648A patent/MA27881A1/fr unknown
2006
- 2006-11-21 ZA ZA200609681A patent/ZA200609681B/xx unknown
- 2006-11-27 TN TNP2006000391A patent/TNSN06391A1/fr unknown
2007
- 2007-10-31 US US11/930,258 patent/US8481548B2/en active Active
- 2007-12-13 US US11/955,421 patent/US7973165B2/en active Active
2008
- 2008-01-11 CY CY20081100047T patent/CY1107856T1/el unknown

Also Published As

Publication number	Publication date
US20080103306A1 (en)	2008-05-01
MY137272A (en)	2009-01-30
NO332143B1 (no)	2012-07-02
TWI338007B (en)	2011-03-01
US8481548B2 (en)	2013-07-09
ZA200609681B (en)	2008-06-25
CY1107856T1 (el)	2013-06-19
PA8604101A1 (es)	2004-12-16
US7973165B2 (en)	2011-07-05
CA2527315C (en)	2010-08-10
UA80888C2 (en)	2007-11-12
ES2294504T3 (es)	2008-04-01
IL171930A (en)	2010-12-30
JP2006526588A (ja)	2006-11-24
BRPI0411095A (pt)	2006-07-18
EP1636206A1 (de)	2006-03-22
ECSP056202A (es)	2006-04-19
MY143353A (en)	2011-04-29
BRPI0411095B8 (pt)	2021-05-25
SI1636206T1 (sl)	2008-02-29
TNSN05309A1 (fr)	2007-07-10
MA27881A1 (fr)	2006-05-02
MXPA05013149A (es)	2006-03-17
US20080119489A1 (en)	2008-05-22
DK1636206T3 (da)	2008-02-11
EA200501887A1 (ru)	2006-10-27
TW200509920A (en)	2005-03-16
CN1802367A (zh)	2006-07-12
HN2004000208A (es)	2009-02-03
CN100408572C (zh)	2008-08-06
EP1636206B1 (de)	2007-10-31
RS20050892A (sr)	2007-12-31
AU2004245208B2 (en)	2007-04-26
CR8094A (es)	2006-05-30
PT1636206E (pt)	2008-01-28
AR044478A1 (es)	2005-09-14
DE602004009796D1 (de)	2007-12-13
NZ543637A (en)	2008-04-30
KR20060057537A (ko)	2006-05-26
IL171930A0 (en)	2006-04-10
NO20055465L (no)	2005-11-18
PE20050162A1 (es)	2005-03-22
HK1093070A1 (zh)	2007-02-23
US20040248888A1 (en)	2004-12-09
ZA200509807B (en)	2006-12-27
US7332510B2 (en)	2008-02-19
AU2004245208A1 (en)	2004-12-16
TNSN06391A1 (fr)	2008-02-22
GT200400117A (es)	2005-02-07
WO2004108701A1 (en)	2004-12-16
BRPI0411095B1 (pt)	2018-04-03
DE602004009796T2 (de)	2008-08-28
CL2004001347A1 (es)	2005-05-06
HRP20070529T3 (hr)	2008-05-31
JP4401384B2 (ja)	2010-01-20
CA2527315A1 (en)	2004-12-16
RS53183B (sr)	2014-06-30
KR100778948B1 (ko)	2007-11-28
EA010577B1 (ru)	2008-10-30
PL1636206T3 (pl)	2008-04-30

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