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ATE368050T1 - Androgene steroidderivate und ein verfahren zur herstellung und verwendung derselben - Google Patents

Androgene steroidderivate und ein verfahren zur herstellung und verwendung derselben

Info

Publication number
ATE368050T1
ATE368050T1 AT98960246T AT98960246T ATE368050T1 AT E368050 T1 ATE368050 T1 AT E368050T1 AT 98960246 T AT98960246 T AT 98960246T AT 98960246 T AT98960246 T AT 98960246T AT E368050 T1 ATE368050 T1 AT E368050T1
Authority
AT
Austria
Prior art keywords
production
same
steroid derivatives
androgenic steroid
androgenic
Prior art date
Application number
AT98960246T
Other languages
English (en)
Inventor
Edgar C Cook
John Kepler
Yue-Wei Lee
Mansukh Wani
Original Assignee
Res Triangle Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Res Triangle Inst filed Critical Res Triangle Inst
Application granted granted Critical
Publication of ATE368050T1 publication Critical patent/ATE368050T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/06—Anabolic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0077—Ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Neurology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT98960246T 1997-11-26 1998-11-23 Androgene steroidderivate und ein verfahren zur herstellung und verwendung derselben ATE368050T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/979,369 US5952319A (en) 1997-11-26 1997-11-26 Androgenic steroid compounds and a method of making and using the same

Publications (1)

Publication Number Publication Date
ATE368050T1 true ATE368050T1 (de) 2007-08-15

Family

ID=25526867

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98960246T ATE368050T1 (de) 1997-11-26 1998-11-23 Androgene steroidderivate und ein verfahren zur herstellung und verwendung derselben

Country Status (11)

Country Link
US (4) US5952319A (de)
EP (1) EP1042352B1 (de)
JP (1) JP2001524487A (de)
KR (1) KR100577129B1 (de)
CN (1) CN1257181C (de)
AT (1) ATE368050T1 (de)
AU (1) AU750663B2 (de)
CA (1) CA2311448A1 (de)
DE (1) DE69838146D1 (de)
NO (1) NO317879B1 (de)
WO (1) WO1999026962A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6828415B2 (en) * 1993-02-19 2004-12-07 Zentaris Gmbh Oligopeptide lyophilisate, their preparation and use
US5952319A (en) * 1997-11-26 1999-09-14 Research Triangle Institute Androgenic steroid compounds and a method of making and using the same
DE60021720T2 (de) * 1999-05-04 2006-06-01 Strakan International Ltd. Androgen glykoside und die androgenische aktivität davon
US6740645B1 (en) 1999-09-03 2004-05-25 Research Triangle Institute 17β-acyl-17α-propynyl-11β-(cyclic amino) aryl steroids and their derivatives having antagonist hormonal properties
US20030069215A1 (en) * 2001-03-30 2003-04-10 The Government Of The United States Of America, Methods of making and using 7a,11b-dimethyl-17b-hydroxy-4-estren-3-one 17b-trans-4-n-butylcyclohexane carboxylate and 7a,11b-dimethyl-17b-hydroxyestr-4-en-3-one 17-undecanoate
AU4966101A (en) * 2000-03-31 2001-10-15 Us Gov Health & Human Serv Methods of making and using 7alpha,11beta-dimethyl-17beta-hydroxy-4-estren-3-one17beta-trans-4-m-butylcyclohexane carboxylate and 7alpha,11beta-dimethyl-17beta -hydroxyestr-4-en-3-one 17-undecanoate
CA2409647C (en) * 2000-05-26 2012-07-03 Harry Fisch Methods of treating androgen deficiency in men using selective antiestrogens
GB0025221D0 (en) * 2000-10-14 2000-11-29 Astrazeneca Ab New process
IL156208A0 (en) * 2000-12-15 2003-12-23 Akzo Nobel Nv 14 (15)-unsaturated 15-and/or 16-substituted androgens with mixed androgen-progestational profile
DE10104327A1 (de) * 2001-01-24 2002-07-25 Schering Ag 11beta-Halogensteroide, deren Herstellung und Verwendung zur Herstellung von Arzneimitteln sowie 11beta-Halogensteroide enthaltende pharmazeutische Präparate
JP2005507886A (ja) * 2001-09-21 2005-03-24 メルク　エンド　カムパニー　インコーポレーテッド アンドロゲン受容体調節剤としてのアンドロスタン類
DE10234525A1 (de) * 2002-07-25 2004-02-05 Schering Ag Zusammensetzung, enthaltend ein androgenes 11ß-Halogensteroid und ein Gestagen sowie männliches Kontrazeptivum auf Basis dieser Zusammensetzung
US20040010138A1 (en) * 2002-03-21 2004-01-15 Schering Ag Process for the production of 7alpha-methyl steroids
WO2004011663A2 (de) 2002-07-24 2004-02-05 Schering Aktiengesellschaft Mikrobiologische verfahren zur herstellung von 7alpha-substituierten 11alpha-hydroxysteroiden
DE10233723A1 (de) * 2002-07-24 2004-02-12 Schering Ag Mikrobiologische Verfahren zur Herstellung von 7α-substituierten 11α-Hydroxysteroiden, daraus herstellbare 7α,17α-substituierte 11β-Halogensteroide, deren Herstellungsverfahren und Verwendung sowie pharmazeutische Präparate, die diese Verbindungen enthalten, sowie daraus herstellbare 7α-substituierte Estra-1,3,5(10)-triene
AU2003251636B2 (en) * 2002-07-25 2009-10-22 Bayer Schering Pharma Aktiengesellschaft Composition containing an androgenous 11beta-halogen steroid and a progestational hormone, and male contraceptive based on said composition
CA2496867A1 (en) 2002-08-28 2004-03-11 Hollis-Eden Pharmaceuticals, Inc. Therapeutic treatment methods
US8445469B2 (en) * 2004-12-30 2013-05-21 Bayer Intellectual Property Gmbh 18-methyl-19-nor-17-pregn-4-ene-21,17-carbolactones, as well as pharmaceutical preparations that contain the latter
AU2006211907B2 (en) * 2005-02-04 2011-09-08 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Nandrolone 17beta-carbonates
JP2014508784A (ja) * 2011-03-25 2014-04-10 ユニヴェルシテ ラヴァル １７β−ＨＳＤ１、１７β−ＨＳＤ３、および１７β−ＨＳＤ１０の阻害剤
EP4164743A2 (de) * 2020-06-11 2023-04-19 The United States of America, as represented by The Secretary, Department of Health and Human Services Darstellung monomerer und oligomerer verbindungen als kontrazeptiva und therapien sowie verfahren zur herstellung und verwendung davon

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB912036A (en) * 1960-06-23 1962-12-05 British Drug Houses Ltd 11-methylene-5ª--steroids
GB912037A (en) * 1960-06-27 1962-12-05 British Drug Houses Ltd 11-methylene steroids
GB912038A (en) * 1960-06-30 1962-12-05 British Drug Houses Ltd 11ª--methyl-5ª--steroids
US3846456A (en) * 1965-04-07 1974-11-05 Upjohn Co Organic compounds
US3325520A (en) * 1965-12-08 1967-06-13 Searle & Co (optionally 17-hydrocarbon-substituted) 11, 13beta-dialkylgon-4-en-3-ones and esters corresponding
US3652606A (en) * 1970-08-07 1972-03-28 Searle & Co 3-oxygenated 11beta-methylestr-4-en-17beta-ol and esters thereof
US3927046A (en) * 1972-12-09 1975-12-16 Akzona Inc Novel 11,11-alkylidene steroids
US4412993A (en) * 1980-01-25 1983-11-01 The Upjohn Company Method of treating pseudopregnancy, galactorrhea and mastitis in mammals
DE3909770A1 (de) * 1989-03-21 1990-09-27 Schering Ag Verfahren zur herstellung von 3-desoxy-4-en-steroiden
AU3257993A (en) * 1991-12-22 1993-07-28 Schering Aktiengesellschaft 3-methylsulphonylhydrazono and 3-oxyimino steroids, a method of preparing them, pharmaceutical preparations containing them and their use in the preparation of drugs
US5733565A (en) * 1996-02-23 1998-03-31 The Population Council, Center For Biomedical Research Male contraceptive implant
US5952319A (en) * 1997-11-26 1999-09-14 Research Triangle Institute Androgenic steroid compounds and a method of making and using the same
US20030069215A1 (en) 2001-03-30 2003-04-10 The Government Of The United States Of America, Methods of making and using 7a,11b-dimethyl-17b-hydroxy-4-estren-3-one 17b-trans-4-n-butylcyclohexane carboxylate and 7a,11b-dimethyl-17b-hydroxyestr-4-en-3-one 17-undecanoate
AU4966101A (en) 2000-03-31 2001-10-15 Us Gov Health & Human Serv Methods of making and using 7alpha,11beta-dimethyl-17beta-hydroxy-4-estren-3-one17beta-trans-4-m-butylcyclohexane carboxylate and 7alpha,11beta-dimethyl-17beta -hydroxyestr-4-en-3-one 17-undecanoate

Also Published As

Publication number Publication date
EP1042352A1 (de) 2000-10-11
NO20002676D0 (no) 2000-05-25
DE69838146D1 (de) 2007-09-06
CN1283200A (zh) 2001-02-07
EP1042352A4 (de) 2004-12-22
EP1042352B1 (de) 2007-07-25
US20020002156A1 (en) 2002-01-03
US6369047B2 (en) 2002-04-09
KR20010032449A (ko) 2001-04-25
US5952319A (en) 1999-09-14
US20020103177A1 (en) 2002-08-01
CN1257181C (zh) 2006-05-24
NO20002676L (no) 2000-05-25
AU1589199A (en) 1999-06-15
US6864248B2 (en) 2005-03-08
KR100577129B1 (ko) 2006-05-09
US20040097477A1 (en) 2004-05-20
CA2311448A1 (en) 1999-06-03
WO1999026962A1 (en) 1999-06-03
NO317879B1 (no) 2004-12-27
US6670352B2 (en) 2003-12-30
JP2001524487A (ja) 2001-12-04
AU750663B2 (en) 2002-07-25

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties