ATE366813T1 - Neue peptide - Google Patents
Neue peptideInfo
- Publication number
- ATE366813T1 ATE366813T1 AT00946453T AT00946453T ATE366813T1 AT E366813 T1 ATE366813 T1 AT E366813T1 AT 00946453 T AT00946453 T AT 00946453T AT 00946453 T AT00946453 T AT 00946453T AT E366813 T1 ATE366813 T1 AT E366813T1
- Authority
- AT
- Austria
- Prior art keywords
- amino acid
- new peptides
- compound
- activity
- replaced
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 abstract 1
- 102000018997 Growth Hormone Human genes 0.000 abstract 1
- 108010051696 Growth Hormone Proteins 0.000 abstract 1
- -1 amino acid compound Chemical class 0.000 abstract 1
- 229910001424 calcium ion Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000122 growth hormone Substances 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/461—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from fish
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/463—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from amphibians
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/465—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from birds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Nutrition Science (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21000299 | 1999-07-23 | ||
| JP33884199 | 1999-11-29 | ||
| JP2000126623 | 2000-04-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE366813T1 true ATE366813T1 (de) | 2007-08-15 |
Family
ID=27329078
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00946453T ATE366813T1 (de) | 1999-07-23 | 2000-07-24 | Neue peptide |
| AT07006224T ATE449174T1 (de) | 1999-07-23 | 2000-07-24 | Neue peptide |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07006224T ATE449174T1 (de) | 1999-07-23 | 2000-07-24 | Neue peptide |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US7385026B1 (de) |
| EP (3) | EP1795598B1 (de) |
| JP (2) | JP3471780B2 (de) |
| KR (1) | KR100827973B1 (de) |
| CN (2) | CN101693736B (de) |
| AT (2) | ATE366813T1 (de) |
| AU (2) | AU784035B2 (de) |
| BR (2) | BRPI0012688B8 (de) |
| CA (2) | CA2696819C (de) |
| CY (2) | CY1107724T1 (de) |
| DE (2) | DE60043361D1 (de) |
| DK (2) | DK1795598T3 (de) |
| ES (3) | ES2288151T3 (de) |
| IL (2) | IL147652A0 (de) |
| PT (2) | PT1795598E (de) |
| WO (1) | WO2001007475A1 (de) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1795598B1 (de) * | 1999-07-23 | 2009-11-18 | Kenji Kangawa | Neue Peptide |
| AU1925701A (en) * | 1999-11-22 | 2001-06-04 | Zymogenetics Inc. | Method of forming a peptide-receptor complex with zsig33 |
| US6897286B2 (en) | 2000-05-11 | 2005-05-24 | Zymogenetics, Inc. | Zsig33-like peptides |
| WO2001085804A1 (fr) | 2000-05-12 | 2001-11-15 | Kaneka Corporation | Procede de purification de polymere vinylique |
| WO2001092292A2 (en) * | 2000-05-30 | 2001-12-06 | Merck & Co., Inc. | Ghrelin analogs |
| WO2002008250A2 (en) * | 2000-07-24 | 2002-01-31 | Ardana Bioscience Limited | Ghrelin antagonists |
| EP1493747B1 (de) * | 2002-04-11 | 2012-12-19 | Daiichi Sankyo Company, Limited | Verfahren zur herstellung von modifiziertem peptid |
| BR0306685A (pt) | 2002-05-21 | 2005-04-26 | Daiichi Suntory Pharma Co Ltd | Composição farmacêutica contendo grelina |
| JP2006504653A (ja) * | 2002-07-19 | 2006-02-09 | サイトス バイオテクノロジー アーゲー | グレリン−担体複合体 |
| TWI325003B (en) * | 2002-07-23 | 2010-05-21 | Sod Conseils Rech Applic | Ghrelin analogs |
| TWI331922B (en) * | 2002-08-09 | 2010-10-21 | Ipsen Pharma Sas | Growth hormone releasing peptides |
| WO2004027064A2 (en) * | 2002-09-18 | 2004-04-01 | Centre Hospitalier De L'universite De Montreal (Chum) | Ghrh analogues |
| EP1407779A1 (de) | 2002-10-10 | 2004-04-14 | Gastrotech A/S | Verwendung von Ghrelin zur Behandlung von vermindertem Körpergewicht und Körperfett in Individuen mit Gastrektomie |
| ATE550029T1 (de) * | 2003-04-30 | 2012-04-15 | Kenji Kangawa | Mittel zur prävention oder heilung von hepatopathie |
| EP1633397A2 (de) * | 2003-06-04 | 2006-03-15 | Eli Lilly And Company | Anti-ghrelin fab antikörper |
| EP1670827A2 (de) * | 2003-09-05 | 2006-06-21 | Eli Lilly And Company | Anti-ghrelin-antikörper |
| CN1321131C (zh) * | 2003-12-26 | 2007-06-13 | 李宁 | 猪Ghrelin衍生物及其编码基因与应用 |
| AU2005205181A1 (en) * | 2004-01-20 | 2005-07-28 | Cytos Biotechnology Ag | Particle-induced ghrelin immune response |
| US7026175B2 (en) | 2004-03-29 | 2006-04-11 | Applied Materials, Inc. | High throughput measurement of via defects in interconnects |
| JP2007532495A (ja) * | 2004-04-07 | 2007-11-15 | ガストロテック・ファルマ・アクティーゼルスカブ | グレリン欠乏を治療するための分泌促進薬の使用 |
| WO2005097830A2 (en) * | 2004-04-07 | 2005-10-20 | Aditech Pharma Ab | Uses of isolated binding members capable of reducing the biological activity of secretagogue compounds |
| WO2005097831A2 (en) * | 2004-04-07 | 2005-10-20 | Gastrotech Pharma A/S | Uses of isolated binding members capable of binding specifically to secretagogues |
| WO2005110463A1 (en) * | 2004-05-11 | 2005-11-24 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, National Institutes Of Health | Methods of inhibiting proinflammatory cytokine expression using ghrelin |
| WO2005120484A1 (ja) * | 2004-06-09 | 2005-12-22 | Kurume University | グレリンの生理学的機能のレギュレーター |
| KR20070034583A (ko) * | 2004-07-14 | 2007-03-28 | 일라이 릴리 앤드 캄파니 | 항-그렐린 항체 |
| WO2006045319A2 (en) * | 2004-10-27 | 2006-05-04 | Gastrotech Pharma A/S | Uses of growth hormone secretagogues in the treatment of individuals suffering from renal and/or liver failure |
| EP1812045A2 (de) * | 2004-10-27 | 2007-08-01 | Gastrotech Pharma A/S | Verwendung von sekretagoga bei der behandlung von patienten nach einer organtransplantation |
| WO2006058539A2 (en) * | 2004-11-30 | 2006-06-08 | Gastrotech Pharma A/S | Growth hormone secretagogue receptor 1a ligands |
| US7803768B2 (en) | 2005-02-23 | 2010-09-28 | Kyoto University | Method for treatment of hyperglycemia in a subject in need thereof |
| EP1856154A1 (de) | 2005-02-23 | 2007-11-21 | Eli Lilly And Company | Humanisierte antighrelin-antikörper |
| RU2427587C2 (ru) * | 2005-09-28 | 2011-08-27 | Ипсен Фарма С.А.С. | Аналоги грелина |
| PL1937262T3 (pl) | 2005-09-29 | 2019-10-31 | Ipsen Pharma | Kompozycja do stosowania w leczeniu zaburzeń motoryki przewodu pokarmowego |
| JPWO2007058360A1 (ja) * | 2005-11-21 | 2009-05-07 | 国立大学法人 宮崎大学 | デスアシルグレリン及びその誘導体を有効成分とする皮膚修復促進治療剤 |
| AU2006316100B2 (en) * | 2005-11-21 | 2011-12-01 | Daiichi Sankyo Company, Limited | Therapeutic agent for skin or skin repair-promoting agent comprising ghrelin, derivative thereof or substance capable of acting on GHS-R1a as active ingredient |
| ES2424970T3 (es) | 2006-03-10 | 2013-10-10 | Ipsen Pharma | Uso de un agonista de la grelina para mejorar los efectos catabólicos del tratamiento con glucocorticoides |
| CA2645844C (en) | 2006-03-13 | 2016-04-26 | Liat Mintz | Use of ghrelin splice variant for treating cachexia and/or anorexia and/or anorexia-cachexia and/or malnutrition and/or lipodystrophy and/or muscle wasting and/or appetite-stimulation |
| AU2007281131B2 (en) * | 2006-08-01 | 2012-11-29 | The Scripps Research Institute | Vaccines and methods for controlling adiposity |
| EP2052738A1 (de) | 2006-08-11 | 2009-04-29 | University of Miyazaki | Therapeutisches mittel zur beschleunigung der spinalnervenreparatur mit ghrelin, einem derivat davon oder einer substanz mit wirkung auf ghs-r1a als wirkstoff |
| KR20090060290A (ko) * | 2006-08-11 | 2009-06-11 | 고쿠리츠 다이가쿠 호징 미야자키 다이가쿠 | 데스아실 그렐린 및 그 유도체를 유효성분으로 포함하는 척수 신경 수복 촉진 치료제 |
| CN101541341B (zh) * | 2006-09-27 | 2013-06-05 | 益普生制药两合公司 | N末端取代的生长素释放肽类似物 |
| HUE028539T2 (en) | 2008-05-23 | 2016-12-28 | Daiichi Sankyo Co Ltd | A peptide capable of extending the half-life of an important peptide in plasma |
| MX362028B (es) | 2009-02-03 | 2019-01-04 | Amunix Pharmaceuticals Inc | Polipeptidos recombinantes extendidos y composiciones que comprenden los mismos. |
| WO2010132580A2 (en) * | 2009-05-12 | 2010-11-18 | The Administrators Of The Tulane Educational Fund | Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof |
| US9724381B2 (en) | 2009-05-12 | 2017-08-08 | The Administrators Of The Tulane Educational Fund | Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof |
| JP6057314B2 (ja) | 2010-01-15 | 2017-01-11 | 国立大学法人 宮崎大学 | 加療中動物の回復促進治療剤 |
| CA2805406A1 (en) | 2010-06-16 | 2011-12-22 | Mcgill University | Growth hormone secretatogue receptor antagonists and uses thereof |
| BR112013021859A2 (pt) | 2011-03-03 | 2016-10-25 | Daiichi Sankyo Co Ltd | agente hipotérmico para um animal, agente hiportérmico, agente terapêutico para hipertermia em um animal, método para reduzir a temperatura corporal de um animal, método terapêutico para hipertermia em um animal, desacilada ou o seu derivado e uso de gralina desacilada ou o seu derivado |
| JP5560248B2 (ja) * | 2011-09-07 | 2014-07-23 | 花王株式会社 | ジペプチド誘導体及びその製造方法 |
| AU2013226090B2 (en) | 2012-02-27 | 2018-03-08 | Amunix Operating Inc. | XTEN conjugate compositions and methods of making same |
| CA3062003C (en) | 2012-05-17 | 2022-01-11 | Extend Biosciences, Inc. | Vitamin d as a targeting group for therapeutic peptides |
| WO2014054798A1 (ja) | 2012-10-04 | 2014-04-10 | 独立行政法人国立循環器病研究センター | 悪性腫瘍転移抑制用医薬 |
| CA2889499C (en) | 2012-10-24 | 2019-09-10 | Daiichi Sankyo Company, Limited | Growth hormone secretagogue receptor agonists for treating amyotrophic lateral sclerosis |
| JP6143270B2 (ja) * | 2013-01-31 | 2017-06-07 | 学校法人東京薬科大学 | マイオスタチン阻害ペプチド |
| TWI662967B (zh) * | 2013-03-25 | 2019-06-21 | 日商志瑞亞新藥工業股份有限公司 | 食後期之胃運動亢進劑 |
| WO2016065052A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Insulin vitamin d conjugates |
| EP3220961B1 (de) | 2014-10-22 | 2023-07-05 | Extend Biosciences, Inc. | Therapeutische vitamin-d-konjugate |
| US9789197B2 (en) | 2014-10-22 | 2017-10-17 | Extend Biosciences, Inc. | RNAi vitamin D conjugates |
| CN109879935B (zh) * | 2019-03-04 | 2020-11-20 | 南京工业大学 | 一种多肽的液相合成方法 |
| BR112022009217A2 (pt) | 2019-11-13 | 2022-08-02 | Amunix Pharmaceuticals Inc | Polipeptídeos xten com código de barras e composições destes, e métodos para produzir e usar os mesmos |
| JP2025534350A (ja) | 2022-09-30 | 2025-10-15 | エクステンド バイオサイエンシズ インコーポレーテッド | 長時間作用型副甲状腺ホルモン |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5194596A (en) * | 1989-07-27 | 1993-03-16 | California Biotechnology Inc. | Production of vascular endothelial cell growth factor |
| US5350836A (en) * | 1989-10-12 | 1994-09-27 | Ohio University | Growth hormone antagonists |
| IL98910A0 (en) * | 1990-07-24 | 1992-07-15 | Polygen Holding Corp | Polypeptide compounds having growth hormone releasing activity and pharmaceutical compositions containing them |
| US5663146A (en) * | 1991-08-22 | 1997-09-02 | Administrators Of The Tulane Educational Fund | Polypeptide analogues having growth hormone releasing activity |
| PT635025E (pt) * | 1992-04-07 | 2003-03-31 | Scripps Research Inst | Processo para preparar proteinas modificadas |
| MX9707433A (es) * | 1995-03-31 | 1997-12-31 | American Cyanamid Co | Peptidos con propiedades para la estimulacion del desarrollo. |
| IL118473A0 (en) | 1995-06-02 | 1996-09-12 | Suntory Ltd | Staphylococcus aureus V8 protease genes coding therefor and a method for the production thereof |
| JP3982866B2 (ja) | 1996-03-04 | 2007-09-26 | アスビオファーマ株式会社 | 分泌型Kex2誘導体の製造方法 |
| CA2198966C (en) | 1996-03-04 | 2011-06-21 | Yuji Suzuki | Method for cleaving chimeric protein using processing enzyme |
| JP4335318B2 (ja) * | 1997-03-24 | 2009-09-30 | ザイモジェネティクス,インコーポレイティド | モチリン相同体 |
| CA2328895A1 (en) | 1998-06-02 | 1999-12-09 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| CN1120846C (zh) * | 1999-02-13 | 2003-09-10 | 中国人民解放军军事医学科学院基础医学研究所 | 生长激素释放肽及其应用 |
| US6420521B1 (en) * | 1999-06-30 | 2002-07-16 | Zymogenetics, Inc. | Short gastrointestinal peptides |
| EP1795598B1 (de) * | 1999-07-23 | 2009-11-18 | Kenji Kangawa | Neue Peptide |
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2000
- 2000-07-24 EP EP07006224A patent/EP1795598B1/de not_active Expired - Lifetime
- 2000-07-24 CA CA2696819A patent/CA2696819C/en not_active Expired - Lifetime
- 2000-07-24 DE DE60043361T patent/DE60043361D1/de not_active Expired - Lifetime
- 2000-07-24 ES ES00946453T patent/ES2288151T3/es not_active Expired - Lifetime
- 2000-07-24 DE DE60035502T patent/DE60035502T2/de not_active Expired - Lifetime
- 2000-07-24 PT PT07006224T patent/PT1795598E/pt unknown
- 2000-07-24 DK DK07006224.5T patent/DK1795598T3/da active
- 2000-07-24 CN CN200910141231.3A patent/CN101693736B/zh not_active Expired - Lifetime
- 2000-07-24 DK DK00946453T patent/DK1197496T3/da active
- 2000-07-24 CN CNB008104409A patent/CN100506844C/zh not_active Expired - Lifetime
- 2000-07-24 BR BRPI0012688A patent/BRPI0012688B8/pt unknown
- 2000-07-24 IL IL14765200A patent/IL147652A0/xx unknown
- 2000-07-24 EP EP09166974A patent/EP2119785B1/de not_active Expired - Lifetime
- 2000-07-24 AU AU60231/00A patent/AU784035B2/en not_active Expired
- 2000-07-24 AT AT00946453T patent/ATE366813T1/de active
- 2000-07-24 JP JP2001512558A patent/JP3471780B2/ja not_active Expired - Lifetime
- 2000-07-24 ES ES07006224T patent/ES2335235T3/es not_active Expired - Lifetime
- 2000-07-24 BR BR0012688-8A patent/BR0012688A/pt not_active IP Right Cessation
- 2000-07-24 AT AT07006224T patent/ATE449174T1/de active
- 2000-07-24 CA CA2380058A patent/CA2380058C/en not_active Expired - Lifetime
- 2000-07-24 KR KR1020027000758A patent/KR100827973B1/ko not_active Expired - Lifetime
- 2000-07-24 ES ES09166974T patent/ES2401939T3/es not_active Expired - Lifetime
- 2000-07-24 EP EP00946453A patent/EP1197496B8/de not_active Expired - Lifetime
- 2000-07-24 PT PT00946453T patent/PT1197496E/pt unknown
- 2000-07-24 US US09/959,577 patent/US7385026B1/en not_active Expired - Lifetime
- 2000-07-24 WO PCT/JP2000/004907 patent/WO2001007475A1/ja not_active Ceased
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2002
- 2002-01-15 IL IL147652A patent/IL147652A/en active IP Right Grant
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2003
- 2003-07-07 JP JP2003271241A patent/JP4227857B2/ja not_active Expired - Lifetime
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2006
- 2006-04-13 AU AU2006201580A patent/AU2006201580B2/en not_active Expired
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2007
- 2007-08-28 CY CY20071101137T patent/CY1107724T1/el unknown
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2008
- 2008-01-30 US US12/010,838 patent/US8227570B2/en not_active Expired - Fee Related
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2010
- 2010-01-05 CY CY20101100012T patent/CY1109714T1/el unknown
- 2010-03-22 US US12/728,495 patent/US9573986B2/en not_active Expired - Fee Related
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2011
- 2011-03-31 US US13/076,844 patent/US8524871B2/en not_active Expired - Fee Related
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2012
- 2012-06-12 US US13/494,673 patent/US9938332B2/en not_active Expired - Fee Related
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