[go: up one dir, main page]

ATE363261T1 - Sequenzielles arzneimittelabgabesystem - Google Patents

Sequenzielles arzneimittelabgabesystem

Info

Publication number
ATE363261T1
ATE363261T1 AT02749899T AT02749899T ATE363261T1 AT E363261 T1 ATE363261 T1 AT E363261T1 AT 02749899 T AT02749899 T AT 02749899T AT 02749899 T AT02749899 T AT 02749899T AT E363261 T1 ATE363261 T1 AT E363261T1
Authority
AT
Austria
Prior art keywords
active ingredient
delivery system
drug delivery
absorption
dissolution
Prior art date
Application number
AT02749899T
Other languages
English (en)
Inventor
S Indiran Pather
John Hontz
John Siebert
Original Assignee
Cima Labs Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cima Labs Inc filed Critical Cima Labs Inc
Application granted granted Critical
Publication of ATE363261T1 publication Critical patent/ATE363261T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A61K9/025—Suppositories; Bougies; Bases therefor; Ovules characterised by shape or structure, e.g. hollow layered, coated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT02749899T 2001-07-10 2002-07-10 Sequenzielles arzneimittelabgabesystem ATE363261T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/901,983 US20030068356A1 (en) 2001-07-10 2001-07-10 Sequential drug delivery systems

Publications (1)

Publication Number Publication Date
ATE363261T1 true ATE363261T1 (de) 2007-06-15

Family

ID=25415151

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02749899T ATE363261T1 (de) 2001-07-10 2002-07-10 Sequenzielles arzneimittelabgabesystem

Country Status (10)

Country Link
US (3) US20030068356A1 (de)
EP (2) EP1818029B1 (de)
JP (1) JP4617081B2 (de)
AT (1) ATE363261T1 (de)
AU (2) AU2002320385B2 (de)
CA (1) CA2451106C (de)
DE (1) DE60220408T2 (de)
DK (1) DK1406568T3 (de)
ES (2) ES2604780T3 (de)
WO (1) WO2003005944A1 (de)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6974590B2 (en) * 1998-03-27 2005-12-13 Cima Labs Inc. Sublingual buccal effervescent
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
US20080213363A1 (en) * 2003-01-23 2008-09-04 Singh Nikhilesh N Methods and compositions for delivering 5-HT3 antagonists across the oral mucosa
EP1449525A1 (de) * 2003-02-20 2004-08-25 Cross Chem Llc Kaugummi in der Form von Mehrschichttabletten
UA81335C2 (uk) * 2003-07-11 2007-12-25 Ф.Хоффманн-Ля Рош Аг Оральна дозована форма саквінавіру мезилату
KR20070087194A (ko) * 2003-07-11 2007-08-27 에프. 호프만-라 로슈 아게 사퀴나비르 메실레이트 경구 투여 형태
SI1575565T1 (sl) 2003-08-08 2010-04-30 Biovail Lab Int Srl Tableta bupropion hidroklorida z modificiranim sprošŽŤanjem
WO2005065317A2 (en) 2003-12-31 2005-07-21 Cima Labs Inc. Effervescent oral fentanyl dosage form
US20050142197A1 (en) 2003-12-31 2005-06-30 Cima Labs Inc. Generally linear effervescent oral fentanyl dosage form and methods of administering
ATE500821T1 (de) * 2003-12-31 2011-03-15 Cima Labs Inc Brauseformen von opiaten zur oralen anwendung und verfahren zur verabreichung von oxycodon
US7658945B2 (en) 2004-02-17 2010-02-09 Transcept Pharmaceuticals, Inc. Compositions for delivering hypnotic agents across the oral mucosa and methods of use thereof
US7615028B2 (en) * 2004-12-03 2009-11-10 Chf Solutions Inc. Extracorporeal blood treatment and system having reversible blood pumps
GB0509317D0 (en) * 2005-05-06 2005-06-15 Clarke Anthony Pharmaceutical formulation of apomorphine
US20060276501A1 (en) * 2005-05-25 2006-12-07 Transoral Pharmaceuticals, Inc. Solid compositions for treating middle-of-the-night insomnia
US20070225322A1 (en) * 2005-05-25 2007-09-27 Transoral Pharmaceuticals, Inc. Compositions and methods for treating middle-of-the night insomnia
US20070287740A1 (en) * 2005-05-25 2007-12-13 Transcept Pharmaceuticals, Inc. Compositions and methods of treating middle-of-the night insomnia
US9289583B2 (en) 2006-01-06 2016-03-22 Acelrx Pharmaceuticals, Inc. Methods for administering small volume oral transmucosal dosage forms using a dispensing device
US8753308B2 (en) 2006-01-06 2014-06-17 Acelrx Pharmaceuticals, Inc. Methods for administering small volume oral transmucosal dosage forms using a dispensing device
US8252328B2 (en) 2006-01-06 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
US8202535B2 (en) 2006-01-06 2012-06-19 Acelrx Pharmaceuticals, Inc. Small-volume oral transmucosal dosage forms
US8357114B2 (en) 2006-01-06 2013-01-22 Acelrx Pharmaceuticals, Inc. Drug dispensing device with flexible push rod
US8865743B2 (en) 2006-01-06 2014-10-21 Acelrx Pharmaceuticals, Inc. Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US8252329B2 (en) 2007-01-05 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
US9066847B2 (en) 2007-01-05 2015-06-30 Aceirx Pharmaceuticals, Inc. Storage and dispensing devices for administration of oral transmucosal dosage forms
US8535714B2 (en) 2006-01-06 2013-09-17 Acelrx Pharmaceuticals, Inc. Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
EP1980240A1 (de) * 2007-04-11 2008-10-15 Cephalon France Lyophilisierte pharmazeutische Zusammensetzungen und Verfahren zu ihrer Herstellung und Verwendung
US20110009692A1 (en) * 2007-12-26 2011-01-13 Yossi Gross Nitric oxide generation to treat female sexual dysfunction
US20090198271A1 (en) * 2008-01-31 2009-08-06 Rainbow Medical Ltd. Electrode based filter
CA2736547C (en) 2008-09-09 2016-11-01 Pozen Inc. Method for delivering a pharmaceutical composition to patient in need thereof
US8945592B2 (en) 2008-11-21 2015-02-03 Acelrx Pharmaceuticals, Inc. Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same
WO2010118232A1 (en) * 2009-04-09 2010-10-14 Elan Pharma International Limited Controlled-release clozapine compositions
US9044475B2 (en) 2009-06-12 2015-06-02 Cynapsus Therapeutics, Inc. Sublingual apomorphine
JP2012531409A (ja) 2009-06-25 2012-12-10 アストラゼネカ・アクチエボラーグ Ｎｓａｉｄ関連潰瘍を発症するリスクがある患者の処置方法
WO2011025673A1 (en) * 2009-08-26 2011-03-03 Aptapharma, Inc. Multilayer minitablets
US20110202108A1 (en) * 2010-02-18 2011-08-18 Rainbow Medical Ltd. Electrical menorrhagia treatment
US8529914B2 (en) * 2010-06-28 2013-09-10 Richard C. Fuisz Bioactive dose having containing a material for modulating pH of a bodily fluid to help or hinder absorption of a bioactive
HRP20180425T1 (hr) 2010-12-16 2018-04-20 Novo Nordisk A/S Čvrste kompozicije koje sadrže agonist glp-1 i sol n-(8-(2-hidroksibenzoil)amino)kaprilne kiseline
ES2791715T3 (es) * 2010-12-16 2020-11-05 Sunovion Pharmaceuticals Inc Películas sublinguales
BR112013026195A2 (pt) 2011-04-12 2016-11-29 Novo Nordisk As derivados de glp-1 duplamente acilados
EP2915525B1 (de) 2011-09-19 2021-08-11 Orexo AB Mißbrauchssichere Sublingualtabletten enthaltend Buprenorphin und Naloxon
EP2797600A4 (de) 2011-12-28 2015-09-16 Pozen Inc Verbesserte zusammensetzungen und verfahren zur abgabe von omeprazol und acetylsalicylsäure
SMT201800491T1 (it) 2012-03-22 2018-11-09 Novo Nordisk As Composizioni di peptidi glp-1 e relativa preparazione
PT2827845T (pt) 2012-03-22 2019-03-29 Novo Nordisk As Composições compreendendo um agente de entrega e sua preparação
WO2013139695A1 (en) 2012-03-22 2013-09-26 Novo Nordisk A/S Compositions comprising a delivery agent and preparation thereof
CA2868362C (en) 2012-03-29 2018-07-31 Jerome Schentag Gastrointestinal site-specific oral vaccination formulations active on the ileum and appendix
SG11201407081PA (en) 2012-05-02 2014-11-27 Orexo Ab New alfentanil composition for the treatment of acute pain
JP6517690B2 (ja) 2012-06-20 2019-05-22 ノヴォ ノルディスク アー／エス ペプチド及び送達剤を含む錠剤製剤
BR112015023124A2 (pt) 2013-03-14 2017-07-18 Therabiome Llc liberação de organismos probióticos e/ou agentes terapêuticos almejada para o trato gastrintestinal
ES2688462T3 (es) 2013-05-02 2018-11-02 Novo Nordisk A/S Dosificación oral de compuestos de GLP-1
US11058856B2 (en) 2014-12-23 2021-07-13 Acelrx Pharmaceuticals, Inc. Systems, devices and methods for dispensing oral transmucosal dosage forms
WO2016172095A1 (en) 2015-04-21 2016-10-27 Cynapsus Therapeutics, Inc. Methods of treating parkinson's disease by administration of apomorphine to an oral mucosa
EP3746111B1 (de) 2018-02-02 2023-07-19 Novo Nordisk A/S Feste zusammensetzungen mit einem glp-1-agonisten, einem salz aus n-(8-(2-hydroxybenzoyl)amino)caprylsäure und einem schmierstoff

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3131123A (en) * 1959-03-13 1964-04-28 Lab Francais De Therapeutique Enteric tablets and manufacture thereof
US4443428A (en) * 1982-06-21 1984-04-17 Euroceltique, S.A. Extended action controlled release compositions
US4452808A (en) * 1982-12-07 1984-06-05 Smithkline Beckman Corporation 4-Aminoalkyl-2(3H)-indolones
US4756710A (en) * 1985-04-05 1988-07-12 Merck & Co., Inc. pH-Mediated drug delivery system
US4764375A (en) 1985-09-11 1988-08-16 Kv Pharmaceutical Company Sachet drug delivery system
GB8820327D0 (en) * 1988-08-26 1988-09-28 May & Baker Ltd New compositions of matter
DE3838431A1 (de) * 1988-11-12 1990-05-17 Bayer Ag Ibuprofen-brausezubereitungen
US5178878A (en) * 1989-10-02 1993-01-12 Cima Labs, Inc. Effervescent dosage form with microparticles
DK0494972T3 (da) * 1989-10-02 1997-05-12 Cima Labs Inc Brusedosisform samt fremgangsmåde til administration heraf
IT1246382B (it) * 1990-04-17 1994-11-18 Eurand Int Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon
US5102666A (en) * 1990-09-11 1992-04-07 Oramed, Inc. Calcium polycarbophil controlled release composition and method
TW212139B (de) * 1991-04-15 1993-09-01 Yamanouchi Pharma Co Ltd
US5503846A (en) * 1993-03-17 1996-04-02 Cima Labs, Inc. Base coated acid particles and effervescent formulation incorporating same
IT1270831B (it) 1993-09-17 1997-05-13 Romano Deghenghi Composizioni farmaceutiche orali effervescenti contenenti estrone
JP3021661B2 (ja) * 1994-03-07 2000-03-15 セラテック・インコーポレーテッド 薬剤含有接着複合体の経皮放出デバイス
AU696855B2 (en) * 1994-03-18 1998-09-17 Shire Laboratories, Inc. Emulsified drug delivery systems
JP3170139B2 (ja) 1994-04-08 2001-05-28 エスエス製薬株式会社 発泡性錠剤
WO1995028144A1 (en) * 1994-04-13 1995-10-26 Ciba-Geigy Ag Temporally controlled drug delivery systems
CA2192086C (en) 1994-06-15 2000-01-25 Tomas Norling Pellets
GB9417524D0 (en) * 1994-08-31 1994-10-19 Cortecs Ltd Pharmaceutical compositions
CA2160423A1 (en) * 1994-11-02 1996-05-03 Hemant N. Joshi Salts of nefazodone having improved dissolution rates
FR2732217B1 (fr) 1995-03-29 1997-06-06 Hesnard Xavier Forme d'administration solide a usage oral
GB9510830D0 (en) * 1995-05-27 1995-07-19 Zeneca Ltd Proteins
US5607697A (en) * 1995-06-07 1997-03-04 Cima Labs, Incorporated Taste masking microparticles for oral dosage forms
GB9517062D0 (en) * 1995-08-18 1995-10-25 Scherer Ltd R P Pharmaceutical compositions
WO1997017067A1 (en) * 1995-11-06 1997-05-15 Somerset Pharmaceuticals, Inc. Sublingual and buccal administration of selegiline
ATE246506T1 (de) 1998-03-11 2003-08-15 Grelan Pharmaceutical Co Darmlösliche sprudelnde zusammensetzungen
US6200604B1 (en) * 1998-03-27 2001-03-13 Cima Labs Inc. Sublingual buccal effervescent
US6974590B2 (en) * 1998-03-27 2005-12-13 Cima Labs Inc. Sublingual buccal effervescent
US20030118645A1 (en) * 1998-04-29 2003-06-26 Pather S. Indiran Pharmaceutical compositions for rectal and vaginal administration
US20030091629A1 (en) * 1998-03-27 2003-05-15 Cima Labs Inc. Sublingual buccal effervescent
US6350470B1 (en) * 1998-04-29 2002-02-26 Cima Labs Inc. Effervescent drug delivery system for oral administration
DE19814257A1 (de) * 1998-03-31 1999-10-07 Asta Medica Ag Brauseformulierungen
US6312728B1 (en) * 1998-07-07 2001-11-06 Cascade Development, Inc. Sustained release pharmaceutical preparation
AU5486899A (en) 1998-08-13 2000-03-06 Cima Labs, Inc. Microemulsions as solid dosage forms for oral administration
WO2000035418A2 (en) * 1998-12-18 2000-06-22 Bayer Corporation Chewable drug delivery system
US6210699B1 (en) 1999-04-01 2001-04-03 Watson Pharmaceuticals, Inc. Oral transmucosal delivery of drugs or any other ingredients via the inner buccal cavity
US6326384B1 (en) * 1999-08-26 2001-12-04 Robert R. Whittle Dry blend pharmaceutical unit dosage form
US6264981B1 (en) * 1999-10-27 2001-07-24 Anesta Corporation Oral transmucosal drug dosage using solid solution
US20050142197A1 (en) * 2003-12-31 2005-06-30 Cima Labs Inc. Generally linear effervescent oral fentanyl dosage form and methods of administering
US20070036853A1 (en) * 2003-12-31 2007-02-15 Cima Labs Inc. Generally linear effervescent oral fentanyl dosage form and methods of administering
ATE500821T1 (de) * 2003-12-31 2011-03-15 Cima Labs Inc Brauseformen von opiaten zur oralen anwendung und verfahren zur verabreichung von oxycodon
WO2005065317A2 (en) * 2003-12-31 2005-07-21 Cima Labs Inc. Effervescent oral fentanyl dosage form

Also Published As

Publication number Publication date
AU2008203464A1 (en) 2008-08-21
JP2004534839A (ja) 2004-11-18
CA2451106C (en) 2009-12-22
DK1406568T3 (da) 2007-10-01
AU2008203464B2 (en) 2010-07-01
HK1106126A1 (en) 2008-03-07
CA2451106A1 (en) 2003-01-23
EP1406568B1 (de) 2007-05-30
US7670617B2 (en) 2010-03-02
US20050031677A1 (en) 2005-02-10
ES2604780T3 (es) 2017-03-09
AU2002320385B2 (en) 2008-05-01
EP1406568A4 (de) 2004-12-15
EP1818029A2 (de) 2007-08-15
EP1818029B1 (de) 2016-09-07
WO2003005944A1 (en) 2003-01-23
JP4617081B2 (ja) 2011-01-19
US20030232080A1 (en) 2003-12-18
US20030068356A1 (en) 2003-04-10
EP1818029A3 (de) 2008-06-11
EP1406568A1 (de) 2004-04-14
DE60220408D1 (de) 2007-07-12
DE60220408T2 (de) 2008-01-31
ES2286263T3 (es) 2007-12-01

Similar Documents

Publication Publication Date Title
ATE363261T1 (de) Sequenzielles arzneimittelabgabesystem
ATE450252T1 (de) Arzneimittel-mikroteilchen
EP1585423A4 (de) Systeme und verfahren zur gesundheitsüberwachung und transdermalen medikamentenausgabe
DE60027921D1 (de) Vorrichtung zur gleichzeitigen verabreichung von gasen und medikamenten
DE69919713D1 (de) Pharmazeutische zubereitung mit verzögerter wirkstofffreisetzung von phenytoin natrium
SE0102276D0 (sv) Device and method for the administration of a medicament
NO20062504L (no) Sammensetninger og doseringsformer for forbedret absorpsjon
DE60115029D1 (de) Pharmazeutische zusammensetzungen enthaltend cannabidiol-derivate
CY1109861T1 (el) Διαδερμικο θεραπευτικο συστημα για την ασθενεια του παρκινσον που προκαλει υψηλα επιπεδα πλασματος της ροτιγοτινης
MXPA02004235A (es) Dosificacion de farmacos a traves de la mucosa oral usando una solucion solida.
BR0007974A (pt) Usos de um agente farmacologicamente ativo, deum constructo de gene e de um antìgeno, métodospara produzir uma composição farmacêutica em póe para administrar uma droga a um indivìduo emnecessidade dela, composição farmacêutica, formade dosagem unitária, e, artigo de manufatura parasuprimento transdérmico ou transmucoso de umagente farmacologicamente ativo a um indivìduo
IS6557A (is) Blandaðar sjúkdómsmeðferðir úr blóðþrýstingslækkandi efnum og efnum sem hamla æðamyndun
NO993520L (no) Doseringsformer og fremgangsmÕte for Õ bedre erektil dysfunksjon
EA200600817A1 (ru) Антагонисты в1 рецептора брадикинина (варианты), фармацевтическая композиция, лекарственное средство, способ лечения заболеваний (варианты)
ATE292453T1 (de) Antivirale arznei
WO2002055098A3 (en) Latency associated peptide for providing latency to pharmaceutically active proteins
CY1107819T1 (el) Φαρμακευτικη διαμορφωση της ολανζαπινης
NO20023464L (no) Sammensetning for intestinal avlevering
BRPI0406858A (pt) Liberação controlada de agentes altamente solúveis
EP1491210A4 (de) Therapeutisches arzneimittel unter verwendung von antikörper präsentierenden hohlen protein-nanoteilchen und hohle protein-nanoteilchen
ES2188513T3 (es) Utilizacion de desoxipeganina para el tratamiento de la drogodependencia.
BR0211323A (pt) Combinação de ingredientes ativos, uso de uma combinação de ingredientes ativos e método de terapia farmacológica de dependência de nicotina
BR0317292A (pt) Derivados de amida de ácido antranìlico e seu uso farmacêutico
ATE462411T1 (de) Darreichungssysteme von wirkstoffen und methoden zum schutz und zur verabreichung von wirkstoffen

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1406568

Country of ref document: EP