ATE361083T1 - Antiallergische verbindungen und diese enthaltende medikamente, nahrungsmittel, getränke oder kosmetika sowie verfahren zu deren herstellung - Google Patents
Antiallergische verbindungen und diese enthaltende medikamente, nahrungsmittel, getränke oder kosmetika sowie verfahren zu deren herstellungInfo
- Publication number
- ATE361083T1 ATE361083T1 AT01945660T AT01945660T ATE361083T1 AT E361083 T1 ATE361083 T1 AT E361083T1 AT 01945660 T AT01945660 T AT 01945660T AT 01945660 T AT01945660 T AT 01945660T AT E361083 T1 ATE361083 T1 AT E361083T1
- Authority
- AT
- Austria
- Prior art keywords
- beverages
- cosmetics
- foods
- processes
- production
- Prior art date
Links
- 239000002537 cosmetic Substances 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 235000013305 food Nutrition 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 230000003266 anti-allergic effect Effects 0.000 title 1
- 235000013361 beverage Nutrition 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 241000227653 Lycopersicon Species 0.000 abstract 3
- 235000007688 Lycopersicon esculentum Nutrition 0.000 abstract 3
- 239000000043 antiallergic agent Substances 0.000 abstract 3
- 229940119155 Histamine release inhibitor Drugs 0.000 abstract 2
- 239000003301 histamine release inhibitor Substances 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 150000002617 leukotrienes Chemical class 0.000 abstract 2
- YQHMWTPYORBCMF-ZZXKWVIFSA-N 2',4,4',6'-tetrahydroxychalcone Chemical compound C1=CC(O)=CC=C1\C=C\C(=O)C1=C(O)C=C(O)C=C1O YQHMWTPYORBCMF-ZZXKWVIFSA-N 0.000 abstract 1
- OAFXTKGAKYAFSI-ZDLWVMOESA-N 3,4,5-tris[[(e)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-1-hydroxycyclohexane-1-carboxylic acid Chemical compound C=1C=C(O)C(O)=CC=1/C=C/C(=O)OC1C(OC(=O)\C=C\C=2C=C(O)C(O)=CC=2)CC(C(=O)O)(O)CC1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 OAFXTKGAKYAFSI-ZDLWVMOESA-N 0.000 abstract 1
- YQHMWTPYORBCMF-UHFFFAOYSA-N Naringenin chalcone Natural products C1=CC(O)=CC=C1C=CC(=O)C1=C(O)C=C(O)C=C1O YQHMWTPYORBCMF-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- OAFXTKGAKYAFSI-UPHZGLEOSA-N tricaffeoylquinic acid Natural products OC(=O)[C@@]1(O)C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@H](OC(=O)C=Cc3ccc(O)c(O)c3)[C@@H](C1)OC(=O)C=Cc4ccc(O)c(O)c4 OAFXTKGAKYAFSI-UPHZGLEOSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/48—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
- A23L2/02—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof containing fruit or vegetable juices
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Medicinal Chemistry (AREA)
- Botany (AREA)
- Emergency Medicine (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000194825 | 2000-06-28 | ||
| JP2000198733 | 2000-06-30 | ||
| JP2000198734 | 2000-06-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE361083T1 true ATE361083T1 (de) | 2007-05-15 |
Family
ID=27343878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01945660T ATE361083T1 (de) | 2000-06-28 | 2001-06-28 | Antiallergische verbindungen und diese enthaltende medikamente, nahrungsmittel, getränke oder kosmetika sowie verfahren zu deren herstellung |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7511078B2 (de) |
| EP (1) | EP1312373B1 (de) |
| CN (2) | CN100420440C (de) |
| AT (1) | ATE361083T1 (de) |
| AU (1) | AU2001267856A1 (de) |
| DE (1) | DE60128238T2 (de) |
| ES (1) | ES2287137T3 (de) |
| WO (1) | WO2002000239A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060160702A1 (en) * | 1998-02-23 | 2006-07-20 | Etienne Soudant | Compositions comprising anti-proliferative agents and use thereof |
| CN1255095C (zh) * | 1999-10-08 | 2006-05-10 | 科蒂股份有限公司 | 含有协同增加自由基防护因数的活性物质的美容用制剂 |
| EP1763357A1 (de) * | 2004-05-31 | 2007-03-21 | Medasani Munisekhar | Verwendung von organischem und/oder anorganischem kalium und salzen davon zur behandlung von autoimmunerkrankungen und anderen erkrankungen und verfahren zu deren anwendung |
| ES2462925T3 (es) * | 2006-06-14 | 2014-05-26 | Symrise Ag | Compuestos con efecto antimicrobiano para el tratamiento de fetidez oral |
| FR2926955B1 (fr) | 2008-02-01 | 2012-07-20 | Agronomique Inst Nat Rech | Procede de preparation d'acides dicafeoylquiniques et leur utilisation dans la lutte contre les pucerons |
| KR101537293B1 (ko) * | 2008-11-19 | 2015-07-16 | (주)아모레퍼시픽 | 포제 처리된 감국 또는 진피 추출물을 함유하는 항산화용 화장료 조성물 |
| PL2512461T3 (pl) | 2009-12-18 | 2014-06-30 | Colgate Palmolive Co | Chalkony jako środek wzmacniający środki przeciwdrobnoustrojowe |
| JP5763676B2 (ja) | 2010-01-07 | 2015-08-12 | コルゲート・パーモリブ・カンパニーＣｏｌｇａｔｅ−Ｐａｌｍｏｌｉｖｅ Ｃｏｍｐａｎｙ | カルコン含有口腔ケア配合物の色の変化 |
| US8962686B2 (en) * | 2010-04-28 | 2015-02-24 | The Chinese University Of Hong Kong | Method and medication for prevention and treatment of ocular hypertension and glaucoma |
| US20130030009A1 (en) * | 2010-12-30 | 2013-01-31 | Ziv Harish | Method for the treatment and/or prevention of oral allergic symptions of the lips due to oral contact with a food allergen |
| CN102266318A (zh) * | 2011-05-23 | 2011-12-07 | 中国人民解放军第二军医大学 | 咖啡酰奎宁酸及其衍生物在制备抗补体药物中的应用 |
| CN105143171B (zh) * | 2013-04-08 | 2018-07-10 | 富士胶片株式会社 | 3,4,5-三咖啡酰奎尼酸的制造方法 |
| FR3065372B1 (fr) * | 2017-04-21 | 2019-12-20 | Jean Noel Thorel | Composition comprenant de la carboxy methyl naringenine chalcone pour le traitement du prurit et de la dermatite atopique |
| CN107986968B (zh) * | 2017-11-27 | 2019-12-06 | 山东农业大学 | 一种二咖啡酰基琥珀酰甲酯奎宁酸类化合物及制备方法和应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1283981A (en) * | 1969-03-05 | 1972-08-02 | Orsymonde | 2,4,6-trihydroxy chalcone derivatives |
| US4279930A (en) * | 1978-10-10 | 1981-07-21 | The Upjohn Company | Process for treating inflammation |
| JPS60192555A (ja) | 1984-03-13 | 1985-10-01 | Osaka Chem Lab | 抗アレルギ−食品 |
| JPS62207212A (ja) | 1986-03-08 | 1987-09-11 | Nippon Haipotsukusu:Kk | 抗アレルギ−剤 |
| JPH07116033B2 (ja) | 1987-03-06 | 1995-12-13 | 理化学研究所 | 抗アレルギ−薬剤 |
| KR0139296B1 (ko) | 1988-11-21 | 1998-05-15 | 가와무라 시게꾸니 | 칼콘 유도체 및 그 제조 방법 |
| CA2003856C (en) * | 1988-11-25 | 1996-01-30 | Toshio Satoh | Therapeutic agent for renal disorders |
| US5432068A (en) * | 1990-06-12 | 1995-07-11 | Pioneer Hi-Bred International, Inc. | Control of male fertility using externally inducible promoter sequences |
| JP3167713B2 (ja) | 1990-11-01 | 2001-05-21 | 株式会社資生堂 | 皮膚外用剤 |
| RU2058133C1 (ru) * | 1992-06-24 | 1996-04-20 | Парфюмерно-косметическая фабрика "Виорика" | Крем для лица |
| FR2693105B1 (fr) * | 1992-07-01 | 1994-09-02 | Oreal | Composition cosmétique et/ou dermatologique à action dépigmentante contenant un acide di- ou tri-caféoylquinique ou un mélange de ceux-ci. |
| US5874463A (en) * | 1994-10-24 | 1999-02-23 | Ancira; Margaret | Hydroxy-kojic acid skin peel |
| DE4444238A1 (de) * | 1994-12-13 | 1996-06-20 | Beiersdorf Ag | Kosmetische oder dermatologische Wirkstoffkombinationen aus Zimtsäurederivaten und Flavonglycosiden |
| US5744161A (en) * | 1995-02-24 | 1998-04-28 | Sabinsa Corporation | Use of piperine as a bioavailability enhancer |
| US5977184A (en) * | 1995-09-15 | 1999-11-02 | Thorne Research, Inc. | Quercetin chalcone and methods related thereto |
| US5665367A (en) * | 1996-09-27 | 1997-09-09 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Skin care compositions containing naringenin and/or quercetin and a retinoid |
| AU726930B2 (en) * | 1997-06-16 | 2000-11-23 | Unilever Plc | Food products and processes therefor |
| JPH1135444A (ja) * | 1997-07-18 | 1999-02-09 | Nikko Chem Kk | 新規化粧料 |
| WO2000004175A1 (en) | 1998-07-14 | 2000-01-27 | Unilever Plc | Methods and composition for modulating flavonoid content |
| US6534086B1 (en) * | 2000-03-06 | 2003-03-18 | Metagenics, Inc. | Composition and method for treatment of inflammation and pain in mammals |
-
2001
- 2001-06-28 CN CNB2005100657565A patent/CN100420440C/zh not_active Expired - Fee Related
- 2001-06-28 DE DE60128238T patent/DE60128238T2/de not_active Expired - Lifetime
- 2001-06-28 ES ES01945660T patent/ES2287137T3/es not_active Expired - Lifetime
- 2001-06-28 US US10/312,504 patent/US7511078B2/en not_active Expired - Fee Related
- 2001-06-28 WO PCT/JP2001/005553 patent/WO2002000239A1/ja not_active Ceased
- 2001-06-28 AU AU2001267856A patent/AU2001267856A1/en not_active Abandoned
- 2001-06-28 AT AT01945660T patent/ATE361083T1/de not_active IP Right Cessation
- 2001-06-28 CN CNB01812108XA patent/CN1253172C/zh not_active Expired - Fee Related
- 2001-06-28 EP EP01945660A patent/EP1312373B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN100420440C (zh) | 2008-09-24 |
| ES2287137T3 (es) | 2007-12-16 |
| AU2001267856A1 (en) | 2002-01-08 |
| EP1312373B1 (de) | 2007-05-02 |
| EP1312373A1 (de) | 2003-05-21 |
| CN1679527A (zh) | 2005-10-12 |
| EP1312373A8 (de) | 2003-09-10 |
| US7511078B2 (en) | 2009-03-31 |
| DE60128238T2 (de) | 2008-01-03 |
| DE60128238D1 (de) | 2007-06-14 |
| CN1253172C (zh) | 2006-04-26 |
| US20030138511A1 (en) | 2003-07-24 |
| EP1312373A4 (de) | 2004-10-13 |
| CN1440293A (zh) | 2003-09-03 |
| WO2002000239A1 (en) | 2002-01-03 |
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