ATE353887T1 - METHOD FOR PRODUCING OPTICALLY PURE OR OPTICALLY ENRICHED SULFOXIDE COMPOUNDS INCLUDING AMORPHENE ESOMEPRAZOLE AND SALTS THEREOF - Google Patents
METHOD FOR PRODUCING OPTICALLY PURE OR OPTICALLY ENRICHED SULFOXIDE COMPOUNDS INCLUDING AMORPHENE ESOMEPRAZOLE AND SALTS THEREOFInfo
- Publication number
- ATE353887T1 ATE353887T1 AT03762106T AT03762106T ATE353887T1 AT E353887 T1 ATE353887 T1 AT E353887T1 AT 03762106 T AT03762106 T AT 03762106T AT 03762106 T AT03762106 T AT 03762106T AT E353887 T1 ATE353887 T1 AT E353887T1
- Authority
- AT
- Austria
- Prior art keywords
- esomeprazole
- amorphene
- salts
- optically
- compounds including
- Prior art date
Links
- SUBDBMMJDZJVOS-DEOSSOPVSA-N esomeprazole Chemical compound C([S@](=O)C1=NC2=CC=C(C=C2N1)OC)C1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-DEOSSOPVSA-N 0.000 title abstract 2
- 229960004770 esomeprazole Drugs 0.000 title abstract 2
- QMAYBMKBYCGXDH-KFWWJZLASA-N (1r,4as,8ar)-4,7-dimethyl-1-propan-2-yl-1,2,4a,5,6,8a-hexahydronaphthalene Chemical compound C1CC(C)=C[C@H]2[C@@H](C(C)C)CC=C(C)[C@H]21 QMAYBMKBYCGXDH-KFWWJZLASA-N 0.000 title 1
- -1 SULFOXIDE COMPOUNDS Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical class N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 abstract 1
- 208000012895 Gastric disease Diseases 0.000 abstract 1
- 229960000381 omeprazole Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003462 sulfoxides Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A process of preparation of optically pure or optically enriched isomers of omeprazole and structurally related sulfoxides is provided. Also provided ar e an amorphous form of esomeprazole, as well a pharmaceutical composition containing it and a method of using it for treatment of gastric disorders.</ SDOAB>
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN489MA2002 | 2002-06-27 | ||
| IN493MA2002 | 2002-06-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE353887T1 true ATE353887T1 (en) | 2007-03-15 |
Family
ID=34276871
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03762106T ATE353887T1 (en) | 2002-06-27 | 2003-06-27 | METHOD FOR PRODUCING OPTICALLY PURE OR OPTICALLY ENRICHED SULFOXIDE COMPOUNDS INCLUDING AMORPHENE ESOMEPRAZOLE AND SALTS THEREOF |
Country Status (5)
| Country | Link |
|---|---|
| CN (1) | CN100378093C (en) |
| AT (1) | ATE353887T1 (en) |
| AU (1) | AU2003247729B2 (en) |
| CA (1) | CA2491118A1 (en) |
| DE (1) | DE60311809T2 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2143722A1 (en) * | 2008-07-09 | 2010-01-13 | Lek Pharmaceuticals D.D. | Process for preparation of esomeprazole sodium of high chemical purity and new forms of esomeprazole sodium |
| CN103145694B (en) * | 2011-12-06 | 2016-01-20 | 重庆煜澍丰医药有限公司 | Crystal R of Esomeprazole sodium salt and its production and use |
| CN102993184A (en) * | 2013-01-08 | 2013-03-27 | 湖南方盛制药股份有限公司 | Esomeprazole and preparation method of magnesium trihydrate of esomeprazole |
| CN103664887B (en) * | 2013-12-18 | 2015-09-16 | 成都医路康医学技术服务有限公司 | The preparation method of Esomeprazole sodium |
| CN104530003A (en) * | 2014-06-10 | 2015-04-22 | 广东东阳光药业有限公司 | Preparation method of salt of pyridylmethylsulfinyl-1H-benzimidazole compound |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE510666C2 (en) * | 1996-12-20 | 1999-06-14 | Astra Ab | New Crystal Modifications |
| SE510650C2 (en) * | 1997-05-30 | 1999-06-14 | Astra Ab | New association |
| US6369087B1 (en) * | 1999-08-26 | 2002-04-09 | Robert R. Whittle | Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
-
2003
- 2003-06-27 CN CNB038151529A patent/CN100378093C/en not_active Expired - Fee Related
- 2003-06-27 AT AT03762106T patent/ATE353887T1/en not_active IP Right Cessation
- 2003-06-27 CA CA002491118A patent/CA2491118A1/en not_active Abandoned
- 2003-06-27 DE DE60311809T patent/DE60311809T2/en not_active Expired - Lifetime
- 2003-06-27 AU AU2003247729A patent/AU2003247729B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DE60311809D1 (en) | 2007-03-29 |
| AU2003247729B2 (en) | 2009-10-08 |
| AU2003247729A1 (en) | 2004-01-19 |
| CN100378093C (en) | 2008-04-02 |
| CN1665805A (en) | 2005-09-07 |
| CA2491118A1 (en) | 2004-01-08 |
| DE60311809T2 (en) | 2007-11-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |