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ATE341624T1 - Oligonukleotide und deren verwendung um die expression der tyrosinase, die in der synthese von melanischen pigmenten beteiligt ist, zu modulieren - Google Patents

Oligonukleotide und deren verwendung um die expression der tyrosinase, die in der synthese von melanischen pigmenten beteiligt ist, zu modulieren

Info

Publication number
ATE341624T1
ATE341624T1 AT01907764T AT01907764T ATE341624T1 AT E341624 T1 ATE341624 T1 AT E341624T1 AT 01907764 T AT01907764 T AT 01907764T AT 01907764 T AT01907764 T AT 01907764T AT E341624 T1 ATE341624 T1 AT E341624T1
Authority
AT
Austria
Prior art keywords
oligonucleotides
modulate
synthesis
expression
tyrosinase involved
Prior art date
Application number
AT01907764T
Other languages
English (en)
Inventor
Robin Kurfurst
Regine Joly
Original Assignee
Lvmh Rech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lvmh Rech filed Critical Lvmh Rech
Application granted granted Critical
Publication of ATE341624T1 publication Critical patent/ATE341624T1/de

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/606—Nucleosides; Nucleotides; Nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/12—Face or body powders for grooming, adorning or absorbing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/08—Preparations for bleaching the hair
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y110/00—Oxidoreductases acting on diphenols and related substances as donors (1.10)
    • C12Y110/03—Oxidoreductases acting on diphenols and related substances as donors (1.10) with an oxygen as acceptor (1.10.3)
    • C12Y110/03001—Catechol oxidase (1.10.3.1), i.e. tyrosinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/312—Phosphonates
    • C12N2310/3125—Methylphosphonates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/345—Spatial arrangement of the modifications having at least two different backbone modifications
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
AT01907764T 2000-02-11 2001-02-09 Oligonukleotide und deren verwendung um die expression der tyrosinase, die in der synthese von melanischen pigmenten beteiligt ist, zu modulieren ATE341624T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0001730A FR2804960B1 (fr) 2000-02-11 2000-02-11 Nouveaux oligonucleotides et utilisation d'oligonucleotides modulant l'expression de la tyrosinase et de la tyrosinase- related-protein 1 comme agents depigmentants

Publications (1)

Publication Number Publication Date
ATE341624T1 true ATE341624T1 (de) 2006-10-15

Family

ID=8846916

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01907764T ATE341624T1 (de) 2000-02-11 2001-02-09 Oligonukleotide und deren verwendung um die expression der tyrosinase, die in der synthese von melanischen pigmenten beteiligt ist, zu modulieren

Country Status (10)

Country Link
US (1) US7087743B2 (de)
EP (1) EP1255827B8 (de)
JP (3) JP4056743B2 (de)
KR (1) KR100671533B1 (de)
CN (2) CN101067135B (de)
AT (1) ATE341624T1 (de)
AU (1) AU2001235651A1 (de)
DE (1) DE60123580T2 (de)
FR (1) FR2804960B1 (de)
WO (1) WO2001058918A2 (de)

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KR100837517B1 (ko) 2002-03-26 2008-06-12 (주)아모레퍼시픽 멜라닌 생성 억제 펩티드, 그 제조방법, 및 이를함유하는 피부 외용제 조성물
DE60332112D1 (de) * 2002-06-03 2010-05-27 Oreal Topische anwendung mindestens eines doppelsträngigen rna-oligonucleotids (ds rna) gegen tyrosinase
FR2840217B1 (fr) * 2002-06-03 2005-06-24 Oreal Compositions cosmetiques comprenant au moins un oligonucleotide d'arn double brin (dsrna)et leurs utilisations
AU2004285134B2 (en) * 2003-10-21 2012-01-19 Dyad Pharmaceutical Corporation Methods and compositions for treating 5alpha-reductase type 1 and type 2 dependent conditions
DE10351149A1 (de) * 2003-11-03 2005-06-30 Beiersdorf Ag Oligoribonukleotide zur Behandlung von unerwünschter Pigmentierung der Haut und der Haare durch RNA-Interferenz
FR2864539B1 (fr) * 2003-12-30 2012-10-26 Lvmh Rech Oligonucleotide et son utilisation pour moduler l'expression de la proteine-kinase c isoforme beta-1 comme agent de depigmentation cutanee
DE102004007032A1 (de) * 2004-02-12 2005-08-25 Beiersdorf Ag Antisense-Oligonukleotide zur Behandlung von unerwünschter Pigmentierung der Haut und der Haare
KR100843168B1 (ko) 2004-12-10 2008-07-02 주식회사 엘지생활건강 올리고뉴클레오타이드를 포함하는 미백제
US20090209623A1 (en) * 2005-07-25 2009-08-20 Jon Tomono Anti-sense nucleic acid derived from organism
FR2890074B1 (fr) * 2005-09-01 2007-11-23 Lvmh Rech Nouveaux oligonucleotides anti-genes specifiques de la tyrosinase comme agents depigmentants
FR2890859B1 (fr) 2005-09-21 2012-12-21 Oreal Oligonucleotide d'arn double brin inhibant l'expression de la tyrosinase
FR2894582B1 (fr) 2005-12-12 2008-02-22 Fabre Pierre Dermo Cosmetique Sirna anti myosine va et depigmentation de la peau
JP5025253B2 (ja) * 2006-03-31 2012-09-12 日生バイオ株式会社 基礎化粧品用配合剤及び基礎化粧品
FR2902324B1 (fr) * 2006-06-20 2009-04-03 Oreal Utilisation d'acide ellagique pour le traitement de la canitie
JP4981381B2 (ja) * 2006-08-04 2012-07-18 株式会社ナリス化粧品 美白用皮膚外用剤
JP5030533B2 (ja) * 2006-11-01 2012-09-19 株式会社ナリス化粧品 美白用皮膚組成物
FR2909383B1 (fr) * 2006-12-05 2009-04-17 L V M H Rech Groupement D Inte Nouveaux oligonucleotides et utilisation d'oligonucleotides interagissant avec le gene codant pour la tyrosinase related protein-1 (trp-1) pour en moduler son expression comme agents depigmentants.
FR2930151A1 (fr) * 2008-04-22 2009-10-23 Centre Nat Rech Scient Nouvelles compositions inhibant la melanogenese et leurs utilisations
FR2930152A1 (fr) * 2008-04-22 2009-10-23 Centre Nat Rech Scient Nouvelles compositions inhibant la melanogenese et leurs utilisations
CA2720664A1 (fr) 2008-04-22 2009-11-26 Centre National De La Recherche Scientifique Nouvelles compositions inhibant la melanogenese et leurs utilisations
FR2958845B1 (fr) * 2010-04-16 2012-06-01 Clc Technologie Nouvelles compositions depigmentantes
CN102077925B (zh) * 2010-12-09 2012-09-05 广东省微生物研究所 一种促进鱼类表皮黑色素合成和树突状分散的制剂
EA201400911A1 (ru) 2012-02-13 2014-11-28 Юнилевер Н.В. Осветляющая кожу композиция
JP2013256452A (ja) * 2012-06-11 2013-12-26 Kawaken Fine Chem Co Ltd メラニン産生抑制剤とその組成物
EP2719762A1 (de) * 2012-10-11 2014-04-16 Secutech International Pte. Ltd. Tyrosinaseinhibitoren zur Depigmentierung oder Haarentfernung
FR3000105B1 (fr) * 2012-12-24 2015-05-15 Lvmh Rech Aptameres inhibiteurs de l'activite enzymatique de la tyrosinase
EP2990027A1 (de) 2014-09-01 2016-03-02 Institut Curie Peptidische Hautbleichungsagenzien
US10900039B2 (en) 2014-09-05 2021-01-26 Phio Pharmaceuticals Corp. Methods for treating aging and skin disorders using nucleic acids targeting Tyr or MMP1
MX367563B (es) 2015-03-20 2019-08-27 Unilever Nv Composición antitranspirante.
CN106265116A (zh) * 2015-05-26 2017-01-04 徐加英 一种新型防晒护肤品的制备方法
ES2839503T3 (es) * 2016-05-29 2021-07-05 Scientis Sa Uso de derivados de tiofosfato como agentes despigmentantes de la piel
CN107445972A (zh) * 2017-07-27 2017-12-08 陕西科技大学 一种可生物降解pbs基脂肪族聚酯成核剂及其制备方法
US10272026B2 (en) 2017-07-31 2019-04-30 L'oreal Water-in-oil emulsion compositions suitable for altering the color of hair
CN114525278B (zh) * 2021-12-21 2023-12-08 上海澄穆生物科技有限公司 一种裂蹄木层孔菌的miRNA及其应用
WO2023131829A1 (en) 2022-01-05 2023-07-13 Ramakrishna Reddy Isanaka A formulation for treatment of pigmentary disorders
CN115491410B (zh) * 2022-10-18 2024-05-17 浙江大学 二氧化钛/锌铝水滑石类氧化物纳米材料在寡核苷酸测序中的应用
WO2024104663A1 (en) 2022-11-16 2024-05-23 Unilever Ip Holdings B.V. Method of reducing malodour
WO2024228406A1 (ko) * 2023-05-02 2024-11-07 제이원글로벌(주) 저색소 질환의 예방, 개선 또는 치료용 조성물
CN117904149A (zh) * 2023-10-25 2024-04-19 中国医学科学院北京协和医院 一种表达酪氨酸酶的mRNA及用途

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Also Published As

Publication number Publication date
JP2003521929A (ja) 2003-07-22
AU2001235651A1 (en) 2001-08-20
DE60123580T2 (de) 2007-06-21
CN1325643C (zh) 2007-07-11
EP1255827A2 (de) 2002-11-13
DE60123580D1 (de) 2006-11-16
JP2008043334A (ja) 2008-02-28
WO2001058918A2 (fr) 2001-08-16
US7087743B2 (en) 2006-08-08
FR2804960B1 (fr) 2005-06-24
FR2804960A1 (fr) 2001-08-17
JP4056743B2 (ja) 2008-03-05
HK1051557A1 (en) 2003-08-08
EP1255827B8 (de) 2006-12-06
EP1255827B1 (de) 2006-10-04
CN101067135A (zh) 2007-11-07
CN1411508A (zh) 2003-04-16
KR20030004349A (ko) 2003-01-14
CN101067135B (zh) 2012-10-03
KR100671533B1 (ko) 2007-01-18
JP5237247B2 (ja) 2013-07-17
JP2010090145A (ja) 2010-04-22
WO2001058918A3 (fr) 2002-03-14
US20040014700A1 (en) 2004-01-22

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