ATE201990T1 - Kristallinische cyclodextrin-einschlusskomplexe von ranitidinhxdrochlorid und verfahren - Google Patents
Kristallinische cyclodextrin-einschlusskomplexe von ranitidinhxdrochlorid und verfahrenInfo
- Publication number
- ATE201990T1 ATE201990T1 AT94909927T AT94909927T ATE201990T1 AT E201990 T1 ATE201990 T1 AT E201990T1 AT 94909927 T AT94909927 T AT 94909927T AT 94909927 T AT94909927 T AT 94909927T AT E201990 T1 ATE201990 T1 AT E201990T1
- Authority
- AT
- Austria
- Prior art keywords
- inclusion complexes
- pct
- date
- ranitidine
- hxdrochloride
- Prior art date
Links
- 229920000858 Cyclodextrin Polymers 0.000 title abstract 5
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 title abstract 3
- VMXUWOKSQNHOCA-LCYFTJDESA-N ranitidine Chemical compound [O-][N+](=O)/C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-LCYFTJDESA-N 0.000 title 1
- 229960000620 ranitidine Drugs 0.000 title 1
- 229960001520 ranitidine hydrochloride Drugs 0.000 abstract 2
- GGWBHVILAJZWKJ-KJEVSKRMSA-N ranitidine hydrochloride Chemical compound [H+].[Cl-].[O-][N+](=O)\C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 GGWBHVILAJZWKJ-KJEVSKRMSA-N 0.000 abstract 2
- 229920001450 Alpha-Cyclodextrin Polymers 0.000 abstract 1
- 239000008139 complexing agent Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nanotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Furan Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9306024 | 1993-03-05 | ||
| PCT/EP1994/000645 WO1994020091A1 (en) | 1993-03-05 | 1994-03-04 | Crystalline cyclodextrin inclusion complexes of ranitidine hydrochloride and process for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE201990T1 true ATE201990T1 (de) | 2001-06-15 |
Family
ID=10984320
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94909927T ATE201990T1 (de) | 1993-03-05 | 1994-03-04 | Kristallinische cyclodextrin-einschlusskomplexe von ranitidinhxdrochlorid und verfahren |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5665767A (de) |
| EP (1) | EP0687174B1 (de) |
| JP (1) | JPH09502698A (de) |
| AT (1) | ATE201990T1 (de) |
| CA (1) | CA2157190A1 (de) |
| CZ (1) | CZ224995A3 (de) |
| DE (1) | DE69427467T2 (de) |
| RU (1) | RU2143896C1 (de) |
| WO (1) | WO1994020091A1 (de) |
| ZA (1) | ZA941544B (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0768897A1 (de) * | 1994-07-06 | 1997-04-23 | Farmarc Nederland B.V. | Inklusion-komplexe von ranatidine |
| PL193229B1 (pl) * | 1996-11-18 | 2007-01-31 | F Biotechnologische Forschung | Epotylon C, epotylon D, epotylon E i epotylon F, sposób biotransformacji epotylonu A, sposób biotransformacji epotylonu B oraz środek leczniczy |
| AU1513699A (en) * | 1998-08-18 | 2000-03-14 | Nikolai Borisovich Leonidov | Physically stable and x-ray amorphous form of hydrochloride ranitidine having anincreased antitumoral activity and method for producing the same |
| GB9915231D0 (en) | 1999-06-29 | 1999-09-01 | Pfizer Ltd | Pharmaceutical complex |
| ITMI20012749A1 (it) * | 2001-12-21 | 2003-06-21 | Chiesi Farma Spa | Procedimento per la preparazione mediante trattamento con microonde di composti di inclusione tra farmaco e ciclodestrine e prodotti ottenut |
| US20040202694A1 (en) * | 2003-04-11 | 2004-10-14 | Vascular Control Systems, Inc. | Embolic occlusion of uterine arteries |
| FR2854079B1 (fr) * | 2003-04-25 | 2007-11-30 | Pf Medicament | Procede de preparation de complexes moleculaires |
| CN101123989B (zh) * | 2004-08-02 | 2010-12-15 | 奇斯药制品公司 | 制备吡罗昔康:β-环糊精包合物的方法 |
| CN101056538A (zh) * | 2004-09-27 | 2007-10-17 | 嘉吉公司 | 环糊精包合复合物和其制备方法 |
| US8722684B2 (en) | 2006-06-16 | 2014-05-13 | H. Lundbeck A/S | 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl] piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1A activity for the treatment of cognitive impairment |
| US8889243B2 (en) | 2012-08-16 | 2014-11-18 | 3M Innovative Properties Company | Mechanical fastening nets and methods of making the same |
| WO2021079183A1 (en) * | 2019-10-21 | 2021-04-29 | Sms Pharmaceuticals Limited | Isopropyl alcohol solvent free crystalline ranitidine hydrochloride form-2 which is free of nitrosamine (ndma) impurity |
| CA3167273A1 (en) * | 2020-03-19 | 2021-09-23 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Stabilization of compounds as cyclodextrin complexes |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3346123A1 (de) * | 1983-12-21 | 1985-06-27 | Janssen Pharmaceutica, N.V., Beerse | Pharmazeutische praeparate von in wasser schwerloeslichen oder instabilen arzneistoffen und verfahren zu ihrer herstellung |
| GB8506792D0 (en) * | 1985-03-15 | 1985-04-17 | Janssen Pharmaceutica Nv | Derivatives of y-cyclodextrin |
| IL90245A (en) * | 1988-05-11 | 1994-04-12 | Glaxo Group Ltd | Resin adsorbate comprising ranitidine together with a synthetic cation exchange resin, its preparation and pharmaceutical compositions containing it |
| EP0518930A4 (en) * | 1990-03-02 | 1993-09-15 | Australian Commercial Research & Development Limited | Cyclodextrin compositions and methods for pharmaceutical and industrial applications |
| IT1241417B (it) * | 1990-03-06 | 1994-01-14 | Vectorpharma Int | Composizioni terapeutiche a rilascio controllato di farmaci supportatisu polimeri reticolati e rivestiti con film polimerici,e loro processodi preparazione |
-
1994
- 1994-03-04 ZA ZA941544A patent/ZA941544B/xx unknown
- 1994-03-04 WO PCT/EP1994/000645 patent/WO1994020091A1/en not_active Ceased
- 1994-03-04 CA CA002157190A patent/CA2157190A1/en not_active Abandoned
- 1994-03-04 EP EP94909927A patent/EP0687174B1/de not_active Expired - Lifetime
- 1994-03-04 AT AT94909927T patent/ATE201990T1/de not_active IP Right Cessation
- 1994-03-04 DE DE69427467T patent/DE69427467T2/de not_active Expired - Lifetime
- 1994-03-04 CZ CZ952249A patent/CZ224995A3/cs unknown
- 1994-03-04 JP JP6519579A patent/JPH09502698A/ja active Pending
- 1994-03-04 US US08/513,779 patent/US5665767A/en not_active Expired - Fee Related
- 1994-03-04 RU RU95121629A patent/RU2143896C1/ru active
Also Published As
| Publication number | Publication date |
|---|---|
| EP0687174A1 (de) | 1995-12-20 |
| WO1994020091A1 (en) | 1994-09-15 |
| JPH09502698A (ja) | 1997-03-18 |
| EP0687174B1 (de) | 2001-06-13 |
| ZA941544B (en) | 1994-10-31 |
| RU2143896C1 (ru) | 2000-01-10 |
| DE69427467T2 (de) | 2002-06-06 |
| CZ224995A3 (en) | 1995-12-13 |
| US5665767A (en) | 1997-09-09 |
| DE69427467D1 (de) | 2001-07-19 |
| CA2157190A1 (en) | 1994-09-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |