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ATE277187T1 - Verfahren zur effizienten herstellung von 7-adca via 2-(carboxyethylthio)acetyl-7-adca und 3- (carboxymethylthio)propionyl-7-adca - Google Patents

Verfahren zur effizienten herstellung von 7-adca via 2-(carboxyethylthio)acetyl-7-adca und 3- (carboxymethylthio)propionyl-7-adca

Info

Publication number
ATE277187T1
ATE277187T1 AT94924828T AT94924828T ATE277187T1 AT E277187 T1 ATE277187 T1 AT E277187T1 AT 94924828 T AT94924828 T AT 94924828T AT 94924828 T AT94924828 T AT 94924828T AT E277187 T1 ATE277187 T1 AT E277187T1
Authority
AT
Austria
Prior art keywords
adca
pct
carboxyethylthio
carboxymethylthio
propionyl
Prior art date
Application number
AT94924828T
Other languages
English (en)
Inventor
Roelof Ary Lans Bovenberg
Bertus Pieter Koekman
Andreas Hoekema
Der Laan Jan Metske Van
Jan Verweij
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Application granted granted Critical
Publication of ATE277187T1 publication Critical patent/ATE277187T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/02—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by desacylation of the substituent in the 7 position

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
AT94924828T 1993-07-30 1994-07-29 Verfahren zur effizienten herstellung von 7-adca via 2-(carboxyethylthio)acetyl-7-adca und 3- (carboxymethylthio)propionyl-7-adca ATE277187T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP93202259 1993-07-30
EP93203696 1993-12-24
PCT/EP1994/002543 WO1995004148A1 (en) 1993-07-30 1994-07-29 Process for the efficient production of 7-adca via 2-(carboxyethylthio)acetyl-7-adca and 3-(carboxymethylthio)propionyl-7-adca

Publications (1)

Publication Number Publication Date
ATE277187T1 true ATE277187T1 (de) 2004-10-15

Family

ID=26133940

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94924828T ATE277187T1 (de) 1993-07-30 1994-07-29 Verfahren zur effizienten herstellung von 7-adca via 2-(carboxyethylthio)acetyl-7-adca und 3- (carboxymethylthio)propionyl-7-adca

Country Status (12)

Country Link
US (1) US5726032A (de)
KR (1) KR100336174B1 (de)
CN (1) CN1103814C (de)
AT (1) ATE277187T1 (de)
BR (1) BR9407108A (de)
CA (1) CA2168431A1 (de)
CZ (1) CZ285604B6 (de)
DE (1) DE69434023D1 (de)
HU (1) HU219259B (de)
PL (1) PL180799B1 (de)
SK (1) SK282624B6 (de)
WO (1) WO1995004148A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6709859B1 (en) * 1986-01-31 2004-03-23 Beecham Group P.L.C. Chromosomal DNA Fragments Encoding Enzymes for Encoding B-Lactam Biosynthesis Enzymes, and Vector and Transformants for Their Expression
EP0233715B1 (de) * 1986-01-31 1994-05-25 BEECHAM GROUP plc Isolierung und Expression von bei der Biosynthese von Beta-Laktamen beteiligten Genen
EP0783581B1 (de) * 1994-09-28 2006-07-26 Novozymes A/S Verfahren zur herstellung von sekundären metaboliten
HUP9801906A3 (en) * 1995-06-02 2001-01-29 Gist Brocades Bv Process for the production of 7-adca via expandase activity on penicillin g
US5731165A (en) * 1995-06-02 1998-03-24 Gist-Brocades, B.V. Process for the production of 7-ADCA via expandase activity on penicillin G
AU1097297A (en) * 1995-11-27 1997-06-19 Gist-Brocades B.V. Improved process for the production of semi-synthetic cephalosporins via expandase activity on penicillin
WO1997038107A1 (en) * 1996-04-04 1997-10-16 Gist-Brocades B.V. An enzyme with high adipoyl-coenzyme a synthetase activity and uses thereof
CN1127571C (zh) * 1997-02-20 2003-11-12 Dsm公司 用化学上确定的培养基以工业规模发酵生产有价值的化合物
JP5303084B2 (ja) 1997-04-11 2013-10-02 コニンクリーケ デーエスエム ナムローゼ フェンノートシャップ 工業的組み換え生物を溝築するための手段としての遺伝子変換
RU2208644C2 (ru) * 1997-04-22 2003-07-20 Дсм Гист Б.В. Способ получения n-деацилированного цефалоспорина
ZA983396B (en) * 1997-04-22 1998-10-27 Gist Brocades Bv A method for controlling the solubility of a beta-lactam nucleus
RO120653B1 (ro) * 1997-04-22 2006-05-30 Gist-Brocades B.V. Procedeu îmbunătăţit pentru preparare de cefalosporine
KR20000022109A (ko) * 1997-04-22 2000-04-25 한스 발터 라벤 탈아실화된 세팔로스포린의 발효제조방법
BR9909108A (pt) 1998-03-27 2000-12-12 Dsm Nv Novo processo para a produção fermentativa da cefalosporina
US6383773B2 (en) 1998-04-23 2002-05-07 Massachusetts Institute Of Technology Penicillin conversion
KR100648480B1 (ko) 1998-05-19 2006-11-24 디에스엠 아이피 어셋츠 비.브이. 세팔로스포린의 개선된 생체내 생산
JP2002533092A (ja) * 1998-12-22 2002-10-08 デーエスエム・ナムローゼ・フェンノートシャップ セファロスポリンの改良されたｉｎｖｉｖｏ産生
ES2165276B1 (es) * 1999-06-18 2003-03-01 Antibioticos Sau Procedimiento biotecnologico para la produccion de acido 7-aminocefal osporanico (7-adca) y compuestos de sintesis intermedios particularmente penicilina n y desacetoxicefalosporina c (daoc)
PT1284978E (pt) 2000-05-13 2004-12-31 Smithkline Beecham Plc Processo para a purificacao de um sal de acido clavulanico
EP1799817B1 (de) * 2004-10-13 2012-11-21 DSM Sinochem Pharmaceuticals Netherlands B.V. Modifizierte expandasen
WO2007073947A2 (en) 2005-12-28 2007-07-05 Dsm Ip Assets B.V. Mutant type ii beta- lactam acylases
EP2123772A1 (de) 2008-04-29 2009-11-25 DSM IP Assets B.V. Beta-Lactamantibiotikum produzierende Stämme
CN102131917A (zh) * 2008-08-05 2011-07-20 帝斯曼知识产权资产管理有限公司 生产己二酰基-7-adca的菌株
EP2392649A3 (de) 2008-08-05 2012-01-11 DSM IP Assets B.V. Adipoyl-7-ADCA-produzierende Stämme
WO2010115838A1 (en) 2009-04-03 2010-10-14 Dsm Ip Assets B.V. Fermentation process
HRP20171985T1 (hr) 2010-06-22 2018-02-23 Dsm Sinochem Pharmaceuticals Netherlands B.V. Postupci fermentacije s mjehurićima zraka
WO2012032040A1 (en) 2010-09-07 2012-03-15 Dsm Sinochem Pharmaceuticals Netherlands B.V. Process for the production of cephalosporins
BR112013022521B1 (pt) 2011-03-03 2019-05-07 Dsm Sinochem Pharmaceuticals Netherlands B.V. PROCESSO PARA A DEGRADAÇÃO DE UM COMPOSTO ß-LACTÂMICO E USO DE SULFITO NA DEGRADAÇÃO DE UM COMPOSTO ß-LACTÂMICO
HK1201877A1 (en) 2012-01-31 2015-09-11 灿盛制药有限公司荷兰公司 Mbth-like proteins in the production of semi synthetic antibiotics
WO2015091455A1 (en) 2013-12-17 2015-06-25 Dpx Holdings B.V. Bioreactor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5082772A (en) * 1988-10-24 1992-01-21 Eli Lilly And Company Process for preparing deacetylcephalosporin c
US5318896A (en) * 1991-09-11 1994-06-07 Merck & Co., Inc. Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA)
KR100227711B1 (ko) * 1991-10-15 1999-12-01 한스 발터 라벤 7-아미노세팔로스포란산 및 7-아미노데아세틸세팔로스포란산 제조를 위한 신규한 생물학적 공정

Also Published As

Publication number Publication date
WO1995004148A1 (en) 1995-02-09
DE69434023D1 (de) 2004-10-28
SK282624B6 (sk) 2002-10-08
HU9600194D0 (en) 1996-03-28
HUT75377A (en) 1997-05-28
KR100336174B1 (ko) 2002-11-01
SK9796A3 (en) 1996-09-04
CZ15896A3 (en) 1996-06-12
CA2168431A1 (en) 1995-02-09
CN1103814C (zh) 2003-03-26
PL180799B1 (pl) 2001-04-30
US5726032A (en) 1998-03-10
BR9407108A (pt) 1996-08-27
PL312746A1 (en) 1996-05-13
CN1128045A (zh) 1996-07-31
HU219259B (en) 2001-03-28
CZ285604B6 (cs) 1999-09-15

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