ATE271383T1 - Pulverformulierung zur inhalation - Google Patents
Pulverformulierung zur inhalationInfo
- Publication number
- ATE271383T1 ATE271383T1 AT01908465T AT01908465T ATE271383T1 AT E271383 T1 ATE271383 T1 AT E271383T1 AT 01908465 T AT01908465 T AT 01908465T AT 01908465 T AT01908465 T AT 01908465T AT E271383 T1 ATE271383 T1 AT E271383T1
- Authority
- AT
- Austria
- Prior art keywords
- inhalation
- powder formulation
- excipient
- particle size
- size distribution
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 238000009472 formulation Methods 0.000 title abstract 2
- 239000000843 powder Substances 0.000 title abstract 2
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 3
- 239000013543 active substance Substances 0.000 abstract 2
- 239000002245 particle Substances 0.000 abstract 2
- 239000006069 physical mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0031—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up by bursting or breaking the package, i.e. without cutting or piercing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2206/00—Characteristics of a physical parameter; associated device therefor
- A61M2206/10—Flow characteristics
- A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Otolaryngology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00200550A EP1129705A1 (de) | 2000-02-17 | 2000-02-17 | Pulverformulierung zur Inhalation |
| PCT/NL2001/000133 WO2001060341A1 (en) | 2000-02-17 | 2001-02-19 | Powder formulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE271383T1 true ATE271383T1 (de) | 2004-08-15 |
Family
ID=8171037
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01908465T ATE271383T1 (de) | 2000-02-17 | 2001-02-19 | Pulverformulierung zur inhalation |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7344734B2 (de) |
| EP (2) | EP1129705A1 (de) |
| AT (1) | ATE271383T1 (de) |
| AU (1) | AU2001236207A1 (de) |
| DE (1) | DE60104399T2 (de) |
| PT (1) | PT1257260E (de) |
| WO (1) | WO2001060341A1 (de) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2241611T3 (es) | 1999-06-05 | 2005-11-01 | Innovata Biomed Limited | Sisstema de suministro de medicamentos. |
| US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| GB9920839D0 (en) | 1999-09-04 | 1999-11-10 | Innovata Biomed Ltd | Inhaler |
| PE20020066A1 (es) | 2000-06-23 | 2002-02-23 | Norton Healthcare Ltd | Deposito de dosis medidas previamente para inhalador de polvo seco accionado por la respiracion |
| DE10129703A1 (de) * | 2001-06-22 | 2003-01-02 | Sofotec Gmbh & Co Kg | Zerstäubungssystem für eine Pulvermischung und Verfahren für Trockenpulverinhalatoren |
| US6681768B2 (en) | 2001-06-22 | 2004-01-27 | Sofotec Gmbh & Co. Kg | Powder formulation disintegrating system and method for dry powder inhalers |
| GB0128148D0 (en) | 2001-11-23 | 2002-01-16 | Innovata Biomed Ltd | Assembly |
| SI1494732T1 (sl) | 2002-03-20 | 2008-08-31 | Mannking Corp | Inhalacijski aparat |
| ATE453422T1 (de) | 2002-04-19 | 2010-01-15 | 3M Innovative Properties Co | Abstandstück für die frühzeitige entfernung des nicht-einatembaren anteils eines medizinischen aerosols |
| JP2006503865A (ja) * | 2002-09-30 | 2006-02-02 | アキュスフィア， インコーポレイテッド | 吸入のための徐放性の多孔性微粒子 |
| US6962006B2 (en) * | 2002-12-19 | 2005-11-08 | Acusphere, Inc. | Methods and apparatus for making particles using spray dryer and in-line jet mill |
| US20040121003A1 (en) * | 2002-12-19 | 2004-06-24 | Acusphere, Inc. | Methods for making pharmaceutical formulations comprising deagglomerated microparticles |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| EP1488819A1 (de) | 2003-06-16 | 2004-12-22 | Rijksuniversiteit te Groningen | Trockenpulverinhalator und Verfahren zur pulmonalen Inhalation von Trockenpulver |
| GB0327723D0 (en) * | 2003-09-15 | 2003-12-31 | Vectura Ltd | Pharmaceutical compositions |
| CA2533887A1 (en) * | 2003-09-30 | 2005-04-14 | Acusphere, Inc. | Injectable, oral, or topical sustained release pharmaceutical formulations |
| GB0326632D0 (en) | 2003-11-14 | 2003-12-17 | Jagotec Ag | Dry powder formulations |
| JP2007533387A (ja) | 2004-04-21 | 2007-11-22 | イノベータ バイオメド リミテッド | 吸入器 |
| GB0409197D0 (en) | 2004-04-24 | 2004-05-26 | Innovata Biomed Ltd | Device |
| SE530006C2 (sv) * | 2004-06-18 | 2008-02-05 | Mederio Ag | Inhalator som använder balja |
| KR101273120B1 (ko) | 2004-08-20 | 2013-06-13 | 맨카인드 코포레이션 | 다이케토피페라진 합성의 촉매 작용 |
| BR122019022692B1 (pt) | 2004-08-23 | 2023-01-10 | Mannkind Corporation | Composição terapêutica em pó seco contendo dicetopiperazina, pelo menos um tipo de cátion e um agente biologicamente ativo |
| US9365905B2 (en) | 2005-02-10 | 2016-06-14 | Dmv-Fonterra Excipients Technology Gmbh | Processes for making lactose utilizing pre-classification techniques and pharmaceutical formulations formed therefrom |
| WO2007009164A1 (en) | 2005-07-15 | 2007-01-25 | Eiffel Technologies Limited | Method of particle formation |
| KR101486829B1 (ko) | 2005-09-14 | 2015-01-29 | 맨카인드 코포레이션 | 결정질 미립자 표면에 대한 활성제의 친화력의 증가를 기반으로 하는 약물 제제의 방법 |
| GB0525254D0 (en) | 2005-12-12 | 2006-01-18 | Jagotec Ag | Powder compositions for inhalation |
| EP1978933A2 (de) * | 2005-12-15 | 2008-10-15 | Acusphere, Inc. | Verfahren zur herstellung von pharmazeutischen formulierungen auf teilchenbasis zur oralen verabreichung |
| EP1986679B1 (de) | 2006-02-22 | 2017-10-25 | MannKind Corporation | Verfahren zur verbesserung der pharmazeutischen eigenschaften von mikropartikeln mit diketopiperazin und einem wirkstoff |
| GB0622818D0 (en) * | 2006-11-15 | 2006-12-27 | Jagotec Ag | Improvements in or relating to organic compounds |
| ES2382982T3 (es) | 2007-07-21 | 2012-06-15 | Albany Molecular Research, Inc. | Indazoles sustituidos con 5-piridinona y composiciones farmacéuticas de los mismos |
| EP2020249A1 (de) | 2007-08-01 | 2009-02-04 | Boehringer Ingelheim Pharma GmbH & Co. KG | Inhalator |
| EP2222639A1 (de) | 2007-11-21 | 2010-09-01 | Decode Genetics EHF | Biaryle als pde4-inhibitoren zur behandlung von lungen- und herz-kreislauf-erkrankungen |
| KR101614723B1 (ko) | 2008-01-11 | 2016-04-22 | 알바니 몰레큘라 리써치, 인크. | Ｍｃｈ 길항물질로서 (1-아지논)-치환된 피리도인돌 |
| EP2082769B1 (de) * | 2008-01-24 | 2015-06-03 | Vectura Delivery Devices Limited | Inhalator |
| US8485180B2 (en) * | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
| TWI677355B (zh) | 2008-06-13 | 2019-11-21 | 美商曼凱公司 | 用於藥物傳輸之乾粉吸入器及系統 |
| ES2421385T3 (es) * | 2008-06-20 | 2013-09-02 | Mannkind Corp | Aparato interactivo y procedimiento para establecer el perfil, en tiempo real, de esfuerzos de inhalación |
| TWI614024B (zh) | 2008-08-11 | 2018-02-11 | 曼凱公司 | 超快起作用胰島素之用途 |
| GB0818476D0 (en) * | 2008-10-09 | 2008-11-12 | Vectura Delivery Device Ltd | Inhaler |
| GB201020130D0 (en) * | 2010-11-26 | 2011-01-12 | Vectura Delivery Devices Ltd | Inhaler |
| WO2010059836A1 (en) | 2008-11-20 | 2010-05-27 | Decode Genetics Ehf | Substituted aza-bridged bicyclics for cardiovascular and cns disease |
| WO2010060876A1 (de) * | 2008-11-28 | 2010-06-03 | Boehringer Ingelheim International Gmbh | Dispergierverfahren zur bestimmung der partikelhaftkraft |
| US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
| CA2750777C (en) | 2009-01-26 | 2018-04-03 | Israel Institute For Biological Research | Bicyclic heterocyclic spiro compounds |
| EP2676695A3 (de) | 2009-03-11 | 2017-03-01 | MannKind Corporation | Vorrichtung, System und Verfahren zur Messung des Widerstandes eines Inhalators |
| MY186975A (en) | 2009-06-12 | 2021-08-26 | Mannkind Corp | Diketopiperazine microparticles with defined specific surface areas |
| DE102009037840B4 (de) * | 2009-08-18 | 2012-08-16 | Gamptec Gmbh | Inhalationsvorrichtung und Verfahren zur Inhalation eines Wirkstoffs aus einer Kapsel |
| US9016147B2 (en) | 2009-11-03 | 2015-04-28 | Mannkind Corporation | Apparatus and method for simulating inhalation efforts |
| GB0919465D0 (en) * | 2009-11-06 | 2009-12-23 | Norton Healthcare Ltd | Airflow adaptor for a breath-actuated dry powder inhaler |
| MX359281B (es) | 2010-06-21 | 2018-09-21 | Mannkind Corp | Sistema y metodos para suministrar un farmaco en polvo seco. |
| US8925726B2 (en) | 2011-04-01 | 2015-01-06 | Mannkind Corporation | Blister package for pharmaceutical cartridges |
| WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
| CA2852536A1 (en) | 2011-10-24 | 2013-05-02 | Mannkind Corporation | Methods and compositions for treating pain |
| CA2878457C (en) | 2012-07-12 | 2021-01-19 | Mannkind Corporation | Dry powder drug delivery systems and methods |
| EP2911690A1 (de) | 2012-10-26 | 2015-09-02 | MannKind Corporation | Inhalierbare influenza-impfstoffzusammensetzungen und verfahren |
| EP2970149B1 (de) | 2013-03-15 | 2019-08-21 | MannKind Corporation | Mikrokristalline diketopiperazinzusammensetzungen und verfahren |
| RU2016103313A (ru) | 2013-07-03 | 2017-08-08 | Биопраксис Рисерч Аиэ | Липидная наночастица с полимиксином |
| EP3021834A1 (de) | 2013-07-18 | 2016-05-25 | MannKind Corporation | Hitzestabile pharmazeutische trockenpulverzusammensetzungen und verfahren |
| CN105517607A (zh) | 2013-08-05 | 2016-04-20 | 曼金德公司 | 吹入设备和方法 |
| US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
| US10953070B2 (en) | 2014-07-25 | 2021-03-23 | Agency For Science, Technology And Research | Antibiotic compositions for treating bacterial infections |
| US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
| CA2965759C (en) | 2014-10-31 | 2023-12-12 | Glaxosmithkline Intellectual Property Development Limited | Powdered polypeptides with decreased disulfide impurities comprising divalent cationic materials |
| AU2019240065A1 (en) | 2018-03-20 | 2020-09-24 | Icahn School Of Medicine At Mount Sinai | Kinase inhibitor compounds and compositions and methods of use |
| JP2021536467A (ja) | 2018-09-06 | 2021-12-27 | インノファーマスクリーン インコーポレイテッド | 喘息またはパーキンソン病の処置のための方法および組成物 |
| WO2020142485A1 (en) | 2018-12-31 | 2020-07-09 | Icahn School Of Medicine At Mount Sinai | Kinase inhibitor compounds and compositions and methods of use |
| US12029709B2 (en) | 2022-08-11 | 2024-07-09 | De Motu Cordis Pty Ltd | Inhalable epinephrine formulation |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1242211A (en) * | 1967-08-08 | 1971-08-11 | Fisons Pharmaceuticals Ltd | Pharmaceutical composition |
| US5048227A (en) * | 1988-05-05 | 1991-09-17 | Junya Okubo | Method of cultivating agaricus blazei mushroom |
| DE4140689B4 (de) | 1991-12-10 | 2007-11-22 | Boehringer Ingelheim Kg | Inhalationspulver und Verfahren zu ihrer Herstellung |
| DE4211475A1 (de) * | 1991-12-14 | 1993-06-17 | Asta Medica Ag | Pulverinhalator |
| GB9322014D0 (en) | 1993-10-26 | 1993-12-15 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
| GB9501841D0 (en) | 1995-01-31 | 1995-03-22 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
| GB9515182D0 (en) * | 1995-07-24 | 1995-09-20 | Co Ordinated Drug Dev | Improvements in and relating to powders for use in dry powder inhalers |
| ATE202481T1 (de) * | 1996-11-15 | 2001-07-15 | Pathogenesis Corp | Reines, biologisch aktives colistin, seine bestandteile und eine colistin-zubereitung zur behandlung von entzündungen der atemwege |
| GB9626263D0 (en) * | 1996-12-18 | 1997-02-05 | Innovata Biomed Ltd | Powder inhaler |
| JP3051073B2 (ja) * | 1996-12-20 | 2000-06-12 | 住友林業株式会社 | 抗腫瘍活性物質 |
| SE9700133D0 (sv) | 1997-01-20 | 1997-01-20 | Astra Ab | New formulation |
| JP3781434B2 (ja) * | 1997-02-12 | 2006-05-31 | アイ・エム・ビー株式会社 | アガリクス葺の子実体の人工菌床栽培方法 |
| US6465218B1 (en) * | 1997-04-08 | 2002-10-15 | Japan Applied Microbiology Research Institute Co., Ltd. | Biologically active substance and process of preparing the same |
| EP0876814A1 (de) | 1997-05-07 | 1998-11-11 | "PHARLYSE", Société Anonyme | Trägerstoff für Trockenpulverinhalator, Verfahren zu dessen Herstellung und diesen enthaltende Arzneimittel |
| US5980918A (en) * | 1997-10-24 | 1999-11-09 | Brennen Medical, Inc. | β-D-glucan topical composition |
| GB9820746D0 (en) * | 1998-09-23 | 1998-11-18 | Pharmax Limited | Micronised pharmaceutical compositions |
| US6120772A (en) * | 1998-10-08 | 2000-09-19 | Hitoshi Ito | Oral drugs for treating AIDS patients |
-
2000
- 2000-02-17 EP EP00200550A patent/EP1129705A1/de not_active Withdrawn
-
2001
- 2001-02-19 PT PT01908465T patent/PT1257260E/pt unknown
- 2001-02-19 EP EP01908465A patent/EP1257260B1/de not_active Revoked
- 2001-02-19 AU AU2001236207A patent/AU2001236207A1/en not_active Abandoned
- 2001-02-19 WO PCT/NL2001/000133 patent/WO2001060341A1/en not_active Ceased
- 2001-02-19 AT AT01908465T patent/ATE271383T1/de not_active IP Right Cessation
- 2001-02-19 DE DE60104399T patent/DE60104399T2/de not_active Expired - Lifetime
-
2002
- 2002-08-19 US US10/223,707 patent/US7344734B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| PT1257260E (pt) | 2004-12-31 |
| DE60104399T2 (de) | 2005-09-08 |
| US20030053960A1 (en) | 2003-03-20 |
| AU2001236207A1 (en) | 2001-08-27 |
| EP1129705A1 (de) | 2001-09-05 |
| DE60104399D1 (de) | 2004-08-26 |
| EP1257260A1 (de) | 2002-11-20 |
| US7344734B2 (en) | 2008-03-18 |
| EP1257260B1 (de) | 2004-07-21 |
| WO2001060341A1 (en) | 2001-08-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |