ATE115143T1 - N-(PYRIDINYL)-1H-INDOL-1-AMINES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS MEDICINES. - Google Patents
N-(PYRIDINYL)-1H-INDOL-1-AMINES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS MEDICINES.Info
- Publication number
- ATE115143T1 ATE115143T1 AT88106121T AT88106121T ATE115143T1 AT E115143 T1 ATE115143 T1 AT E115143T1 AT 88106121 T AT88106121 T AT 88106121T AT 88106121 T AT88106121 T AT 88106121T AT E115143 T1 ATE115143 T1 AT E115143T1
- Authority
- AT
- Austria
- Prior art keywords
- loweralkyl
- arylloweralkyl
- sec
- aryl
- halogen
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- -1 hydroxy, nitro, amino Chemical group 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 150000002431 hydrogen Chemical group 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 125000003435 aroyl group Chemical group 0.000 abstract 1
- 125000005239 aroylamino group Chemical group 0.000 abstract 1
- 125000005100 aryl amino carbonyl group Chemical group 0.000 abstract 1
- 125000005129 aryl carbonyl group Chemical group 0.000 abstract 1
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004802 cyanophenyl group Chemical group 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 125000006501 nitrophenyl group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
There are disclosed compounds of the formula <CHEM> where m is 1 or 2; n is 1 or 2; P is 0 or 1; each R is independently hydrogen, halogen, loweralkyl, loweralkoxy, hydroxy, nitro, amino, loweralkylamino, loweralkylcarbonylamino, cyano, formyl, loweralkoxycarbonyl, loweralkylthio or loweralkoxycarbonylloweralkylthio; each R1 is independently hydrogen, loweralkyl, loweralkenyl, formyl, loweralkylcarbonyl, arylloweralkylcarbonyl, arylcarbonyl, halogen, arylloweralkenyl, arylloweralkyl, heteroarylloweralkenyl, heteroarylloweralkyl, cyanoloweralkenyl, cyanoloweralkyl, methoxyloweralkenyl, methoxyloweralkyl, loweralkoxycarbonylloweralkenyl, loweralkoxycarbonylloweralkyl, cycloalkylloweralkenyl or cycloalkylloweralkyl, the term heteroaryl signifying a group of the formula <CHEM> where W is O, S, NH or CH=N, cyano, -CH(OH)R4, -C(OH)R4R5 or -CH2OR5, R4 being hydrogen, loweralkyl, arylloweralkyl or aryl and R5 being loweralkyl, arylloweralkyl or aryl; each R2 is independently hydrogen, loweralkyl, loweralkenyl, loweralkynyl, loweralkoxycarbonylloweralkyl, loweralkylaminocarbonylloweralkyl, aminocarbonylloweralkyl, arylloweralkyl, phenyl, nitrophenyl, cyanophenyl, trifluoromethylphenyl, aminophenyl, loweralkanoylaminophenyl, loweralkoxycarbonyl, arylloweralkoxycarbonyl, aryloxycarbonyl, loweralkylaminocarbonyl, arylloweralkylaminocarbonyl, arylaminocarbonyl, alkanoyl, arylloweralkanoyl, aroyl, alkenoyl, alkynoyl or -R6-NR min R sec where R6 is loweralkylene, loweralkenylene or loweralkynylene and R min and R sec are each independently loweralkyl or alternatively the group -NR min R sec as a whole is 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl, 4-loweralkyl-1-piperazinyl or 4-aryl-1-piperazinyl; and R3 is hydrogen, nitro, amino, halogen, loweralkanoylamino, arylloweralkanoylamino, aroylamino, alkylamino, arylloweralkylamino or loweralkyl and a process for their preparation. The compounds are useful for enhancing memory and also as analgesic and antidepressant agents.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4207987A | 1987-04-24 | 1987-04-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE115143T1 true ATE115143T1 (en) | 1994-12-15 |
Family
ID=21919923
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88106121T ATE115143T1 (en) | 1987-04-24 | 1988-04-18 | N-(PYRIDINYL)-1H-INDOL-1-AMINES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS MEDICINES. |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0287982B1 (en) |
| JP (1) | JP2683360B2 (en) |
| KR (1) | KR960015003B1 (en) |
| AT (1) | ATE115143T1 (en) |
| AU (1) | AU594876B2 (en) |
| CA (1) | CA1330661C (en) |
| DE (1) | DE3852335T2 (en) |
| DK (1) | DK172153B1 (en) |
| ES (1) | ES2065324T3 (en) |
| FI (1) | FI90978C (en) |
| IE (1) | IE65349B1 (en) |
| IL (1) | IL86154A (en) |
| NO (1) | NO168104C (en) |
| NZ (1) | NZ224338A (en) |
| PH (1) | PH26127A (en) |
| PT (1) | PT87308B (en) |
| ZA (1) | ZA882810B (en) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4868190A (en) * | 1988-12-27 | 1989-09-19 | Hoechst-Roussel Pharmaceuticals, Inc. | N-pyridinyl-9H-carbazol-9-amines |
| US4983615A (en) * | 1989-06-28 | 1991-01-08 | Hoechst-Roussel Pharmaceuticals Inc. | Heteroarylamino- and heteroaryloxypyridinamine compounds which are useful in treating skin disorders |
| US5179119A (en) * | 1989-08-02 | 1993-01-12 | Hoechst-Roussel Pharmaceuticals Incorporated | 1,3-dihydro-1-(pyridinylamino)-2H-indol-1-ones and intermediates for the preparation thereof |
| EP0415103B1 (en) * | 1989-08-02 | 1995-02-01 | Hoechst-Roussel Pharmaceuticals Incorporated | 2,3-Dihydro-1-(pyridinylamino)-indoles, a process for their preparation and their use as medicaments |
| US5179099A (en) * | 1989-08-02 | 1993-01-12 | Hoechst-Roussel Pharmaceuticals Incorporated | 2,3-dihydro-1-(pyridinylamino)-indoles |
| US5006537A (en) * | 1989-08-02 | 1991-04-09 | Hoechst-Roussel Pharmaceuticals, Inc. | 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones |
| US4983608A (en) | 1989-09-05 | 1991-01-08 | Hoechst-Roussell Pharmaceuticals, Inc. | N-substituted-4-pyrimidinamines and pyrimidinediamines |
| US5102891A (en) * | 1990-07-23 | 1992-04-07 | Hoechst-Roussel Pharmaceuticals Inc. | 1-(substituted pyridinylamino)-1H-indol-5-yl substituted carbamates |
| US5214038A (en) * | 1991-04-15 | 1993-05-25 | Hoechst-Roussel Pharmaceuticals Inc. | 1-(pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles and intermediates for the preparation thereof |
| US5328920A (en) * | 1991-04-17 | 1994-07-12 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted (pyridinylamino)-indoles |
| US5185350A (en) * | 1991-09-23 | 1993-02-09 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted pyridinylamino-1h-indoles,1h-indazoles,2h-indazoles, benzo (b)thiophenes and 1,2-benzisothiazoles |
| US5356910A (en) * | 1993-07-19 | 1994-10-18 | Hoechst-Roussel Pharmaceuticals Inc. | Use of N-(pyridinyl)-1H-indol-1-amines for the treatment of obsessive-compulsive disorder |
| US5459274A (en) * | 1994-05-13 | 1995-10-17 | Hoechst-Roussel Pharmaceuticals Inc. | Preparation of N-alkyl-N-pyridinyl-1H-indol-1-amines |
| ATE218343T1 (en) * | 1995-07-27 | 2002-06-15 | Aventis Pharma Inc | USE OF SUBSTITUTED AND UNSUBSTITUTED N-(PYRROL-1-YL)PYRIDINAMINES AS ANTICONVULSIVES |
| HUP9802413A3 (en) * | 1995-07-27 | 2002-02-28 | Aventis Pharmaceuticals Inc Br | Use of n-(pyrrol-1-yl)pyridinamines as anticonvulsant agents and for the preparation of a pharmaceutical composition for the treatment of convulsions |
| HUP0000783A2 (en) * | 1996-12-27 | 2001-04-28 | Hoechst Marion Roussel, Inc. | N-(pyridinylamino)isoindolines and their derivatives, process for their production, pharmaceutical preparations containing these compounds and their use |
| JP4683166B2 (en) * | 1999-03-10 | 2011-05-11 | 東ソー株式会社 | Method for producing nitrogen-containing heterocyclic compound |
| DE60016068T2 (en) | 1999-03-10 | 2005-11-03 | Tosoh Corp., Shinnanyo | Process for the preparation of nitrogen heterocyclic compounds |
| JP4779185B2 (en) * | 1999-03-10 | 2011-09-28 | 東ソー株式会社 | Nitrogen-containing heterocyclic compound and method for producing the same |
| GB0119435D0 (en) * | 2001-02-15 | 2001-10-03 | Aventis Pharm Prod Inc | Method of treating of demyelinating diseases or conditions |
| US7538227B2 (en) | 2004-01-13 | 2009-05-26 | Sanofi-Aventis Deutschland Gmbh | Process for stabilizing 4-halopyridines |
| GT200500063A (en) * | 2004-04-01 | 2005-10-14 | METHOD FOR TREATMENT OF SCHIZOPHRENIA AND / OR GLUCOREGULATORY ABNORMALITIES | |
| FR2888238B1 (en) * | 2005-07-07 | 2007-09-07 | Servier Lab | NOVEL 1H-INDOLE-PYRIDINECARBOXAMIDE AND 1H-INDOLE-PIPERIDINECARBOXAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARCEUMATIC COMPOSITIONS CONTAINING THEM |
| FR2911780A1 (en) * | 2007-01-26 | 2008-08-01 | Urogene | TREATMENT OF FECAL INCONTINENCE. |
| KR20100015546A (en) * | 2007-04-13 | 2010-02-12 | 사노피-아벤티스 | A transition metal catalyzed synthesis of n-aminoindoles |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3242185A (en) * | 1963-10-07 | 1966-03-22 | Merck & Co Inc | Lower aliphatic acids, salts and derivatives thereof |
| DE1670184A1 (en) * | 1967-01-20 | 1971-01-21 | Boehringer Sohn Ingelheim | Process for the preparation of heterocyclically substituted hydrazino-imidazoline- (2) |
| CH603581A5 (en) * | 1974-03-29 | 1978-08-31 | Siegfried Ag | |
| US4260767A (en) * | 1979-12-26 | 1981-04-07 | American Cyanamid Company | 2-Pyridylhydrazides |
| US4792562A (en) * | 1985-12-04 | 1988-12-20 | Hoechst-Roussel Pharmaceuticals, Inc. | N-(pyrrol-1-yl)pyridinamines having memory enhancing activity |
-
1988
- 1988-04-18 AT AT88106121T patent/ATE115143T1/en not_active IP Right Cessation
- 1988-04-18 EP EP88106121A patent/EP0287982B1/en not_active Expired - Lifetime
- 1988-04-18 ES ES88106121T patent/ES2065324T3/en not_active Expired - Lifetime
- 1988-04-18 DE DE3852335T patent/DE3852335T2/en not_active Expired - Lifetime
- 1988-04-21 ZA ZA882810A patent/ZA882810B/en unknown
- 1988-04-21 FI FI881874A patent/FI90978C/en not_active IP Right Cessation
- 1988-04-22 JP JP63098467A patent/JP2683360B2/en not_active Expired - Lifetime
- 1988-04-22 DK DK223488A patent/DK172153B1/en not_active IP Right Cessation
- 1988-04-22 PH PH36833A patent/PH26127A/en unknown
- 1988-04-22 AU AU15100/88A patent/AU594876B2/en not_active Expired
- 1988-04-22 NZ NZ224338A patent/NZ224338A/en unknown
- 1988-04-22 IL IL86154A patent/IL86154A/en not_active IP Right Cessation
- 1988-04-22 IE IE121388A patent/IE65349B1/en not_active IP Right Cessation
- 1988-04-22 PT PT87308A patent/PT87308B/en not_active IP Right Cessation
- 1988-04-22 NO NO881776A patent/NO168104C/en not_active IP Right Cessation
- 1988-04-22 CA CA000564923A patent/CA1330661C/en not_active Expired - Lifetime
- 1988-04-23 KR KR1019880004605A patent/KR960015003B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA1330661C (en) | 1994-07-12 |
| PH26127A (en) | 1992-02-24 |
| KR880012591A (en) | 1988-11-28 |
| JPS63280079A (en) | 1988-11-17 |
| EP0287982B1 (en) | 1994-12-07 |
| JP2683360B2 (en) | 1997-11-26 |
| PT87308A (en) | 1988-05-01 |
| NO168104B (en) | 1991-10-07 |
| AU594876B2 (en) | 1990-03-15 |
| NO881776L (en) | 1988-10-25 |
| DK172153B1 (en) | 1997-12-01 |
| FI90978B (en) | 1994-01-14 |
| EP0287982A3 (en) | 1991-03-27 |
| FI90978C (en) | 1994-04-25 |
| ZA882810B (en) | 1988-10-20 |
| DE3852335T2 (en) | 1995-05-11 |
| IL86154A (en) | 1992-03-29 |
| ES2065324T3 (en) | 1995-02-16 |
| PT87308B (en) | 1992-08-31 |
| AU1510088A (en) | 1988-10-27 |
| DK223488D0 (en) | 1988-04-22 |
| FI881874A7 (en) | 1988-10-25 |
| NZ224338A (en) | 1991-07-26 |
| FI881874A0 (en) | 1988-04-21 |
| IE65349B1 (en) | 1995-10-18 |
| IE881213L (en) | 1988-10-24 |
| DE3852335D1 (en) | 1995-01-19 |
| DK223488A (en) | 1988-10-25 |
| NO168104C (en) | 1992-01-15 |
| EP0287982A2 (en) | 1988-10-26 |
| NO881776D0 (en) | 1988-04-22 |
| IL86154A0 (en) | 1988-11-15 |
| KR960015003B1 (en) | 1996-10-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EELA | Cancelled due to lapse of time |