ATE113988T1 - PROCESS FOR PREPARING A PURIFIED AQUEOUS INDOLE SOLUTION. - Google Patents
PROCESS FOR PREPARING A PURIFIED AQUEOUS INDOLE SOLUTION.Info
- Publication number
- ATE113988T1 ATE113988T1 AT88908359T AT88908359T ATE113988T1 AT E113988 T1 ATE113988 T1 AT E113988T1 AT 88908359 T AT88908359 T AT 88908359T AT 88908359 T AT88908359 T AT 88908359T AT E113988 T1 ATE113988 T1 AT E113988T1
- Authority
- AT
- Austria
- Prior art keywords
- indole
- preparing
- water
- solution
- purified aqueous
- Prior art date
Links
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title abstract 10
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 title abstract 5
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 title abstract 5
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000012535 impurity Substances 0.000 abstract 2
- 238000005192 partition Methods 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 239000008346 aqueous phase Substances 0.000 abstract 1
- 239000012431 aqueous reaction media Substances 0.000 abstract 1
- 239000007791 liquid phase Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
- C12P13/227—Tryptophan
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Indole Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
A process for preparing a substantially purified aqueous indole solution, which comprises dissolving crude indole containing organic impurities in a water-immiscible organic solvent wherein said impurities have a larger partition coefficient than said indole has between said solvent and water, and bringing the solution into contact with water or an aqueous reaction medium to form two liquid phases and transfer the indole to the aqueous phase by partition.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP23900187 | 1987-09-25 | ||
| CA000594656A CA1335970C (en) | 1987-09-25 | 1989-03-23 | Process for preparing purified aqueous indole solution |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE113988T1 true ATE113988T1 (en) | 1994-11-15 |
Family
ID=25672551
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88908359T ATE113988T1 (en) | 1987-09-25 | 1988-09-22 | PROCESS FOR PREPARING A PURIFIED AQUEOUS INDOLE SOLUTION. |
Country Status (5)
| Country | Link |
|---|---|
| AT (1) | ATE113988T1 (en) |
| AU (1) | AU615232B2 (en) |
| CA (1) | CA1335970C (en) |
| DE (1) | DE3852098T2 (en) |
| WO (1) | WO1989002923A1 (en) |
-
1988
- 1988-09-22 WO PCT/JP1988/000968 patent/WO1989002923A1/en not_active Ceased
- 1988-09-22 DE DE3852098T patent/DE3852098T2/en not_active Expired - Fee Related
- 1988-09-22 AT AT88908359T patent/ATE113988T1/en active
- 1988-09-22 AU AU25206/88A patent/AU615232B2/en not_active Ceased
-
1989
- 1989-03-23 CA CA000594656A patent/CA1335970C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO1989002923A1 (en) | 1989-04-06 |
| AU615232B2 (en) | 1991-09-26 |
| DE3852098T2 (en) | 1995-03-23 |
| AU2520688A (en) | 1989-04-18 |
| CA1335970C (en) | 1995-06-20 |
| DE3852098D1 (en) | 1994-12-15 |
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