ATE168674T1 - NEW PERHYDROISOINDOLE DERIVATIVES AND THEIR PRODUCTION - Google Patents
NEW PERHYDROISOINDOLE DERIVATIVES AND THEIR PRODUCTIONInfo
- Publication number
- ATE168674T1 ATE168674T1 AT93909004T AT93909004T ATE168674T1 AT E168674 T1 ATE168674 T1 AT E168674T1 AT 93909004 T AT93909004 T AT 93909004T AT 93909004 T AT93909004 T AT 93909004T AT E168674 T1 ATE168674 T1 AT E168674T1
- Authority
- AT
- Austria
- Prior art keywords
- radical
- pct
- date oct
- derivatives
- sec
- Prior art date
Links
- ODSNARDHJFFSRH-UHFFFAOYSA-N 2,3,3a,4,5,6,7,7a-octahydro-1h-isoindole Chemical class C1CCCC2CNCC21 ODSNARDHJFFSRH-UHFFFAOYSA-N 0.000 title abstract 2
- -1 phenyl radicals Chemical class 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical compound [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- ADNPLDHMAVUMIW-CUZNLEPHSA-N substance P Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N)C1=CC=CC=C1 ADNPLDHMAVUMIW-CUZNLEPHSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PCT No. PCT/FR93/00351 Sec. 371 Date Oct. 11, 1994 Sec. 102(e) Date Oct. 11, 1994 PCT Filed Apr. 8, 1993 PCT Pub. No. WO93/21154 PCT Pub. Date Oct. 28, 1993.This ivention relates to novel perhydroisoindole derivatives having formula (I), <IMAGE> (I) wherein the symbols R, which are the same or different, are phenyl radicals optionally 2- or 3-substituted by a halogen atom or a methyl radical, R' is a phenyl radical optionally 2-substituted by a C1-2 alkylk or alkyloxy radical, R'' is a fluorine atom or a hydroxy radical, and R''' is a hydrogen atom, or else R' and R''' are hydroxy radicals, or R'' and R''' together form a bond, and Ro is a hydrogen atom or a protective radical; salts thereof whereever applicable; and preparation thereof. These products are synthetic intermediates for the preparation of derivatives having P substance antagonist activity.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR929204391A FR2689889B1 (en) | 1992-04-10 | 1992-04-10 | NOVEL PERHYDROISOINDOLE DERIVATIVES AND THEIR PREPARATION. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE168674T1 true ATE168674T1 (en) | 1998-08-15 |
Family
ID=9428708
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93909004T ATE168674T1 (en) | 1992-04-10 | 1993-04-08 | NEW PERHYDROISOINDOLE DERIVATIVES AND THEIR PRODUCTION |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5463077A (en) |
| EP (1) | EP0635002B1 (en) |
| JP (1) | JPH07505409A (en) |
| KR (1) | KR950700879A (en) |
| AT (1) | ATE168674T1 (en) |
| AU (1) | AU667365B2 (en) |
| CA (1) | CA2133841A1 (en) |
| CZ (1) | CZ284596B6 (en) |
| DE (1) | DE69319902T2 (en) |
| DK (1) | DK0635002T3 (en) |
| ES (1) | ES2118954T3 (en) |
| FI (1) | FI105022B (en) |
| FR (1) | FR2689889B1 (en) |
| HU (1) | HUT71330A (en) |
| IL (2) | IL105256A0 (en) |
| MX (1) | MX9301985A (en) |
| NO (1) | NO300418B1 (en) |
| PL (1) | PL172753B1 (en) |
| RU (1) | RU2120438C1 (en) |
| SK (1) | SK122194A3 (en) |
| TW (1) | TW224969B (en) |
| WO (1) | WO1993021154A1 (en) |
| ZA (1) | ZA932528B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2689888B1 (en) * | 1992-04-10 | 1994-06-10 | Rhone Poulenc Rorer Sa | NOVEL PERHYDROISOINDOLE DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
| FR2703679B1 (en) * | 1993-04-05 | 1995-06-23 | Rhone Poulenc Rorer Sa | NOVEL PERHYDROISOINDOLE DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
| FR2709752B1 (en) * | 1993-07-30 | 1995-10-06 | Rhone Poulenc Rorer Sa | New perhydroisoindole derivatives, their preparation and the pharmaceutical compositions containing them. |
| TW365603B (en) * | 1993-07-30 | 1999-08-01 | Rhone Poulenc Rorer Sa | Novel perhydroisoindole derivatives, their preparation and pharmaceutical compositions which contain them |
| FR2710913B1 (en) * | 1993-10-07 | 1995-11-24 | Rhone Poulenc Rorer Sa | New perhydroisoindole derivatives, their preparation and the pharmaceutical compositions containing them. |
| CN100391945C (en) * | 2005-05-31 | 2008-06-04 | 浙江大学 | A kind of synthetic method of S-(-)-indoline-2-carboxylic acid |
| WO2013004766A1 (en) | 2011-07-04 | 2013-01-10 | Ferrari Giulio | Nk-1 receptor antagonists for treating corneal neovascularisation |
| CA3091944A1 (en) | 2018-02-26 | 2019-08-29 | Ospedale San Raffaele S.R.L. | Nk-1 antagonists for use in the treatment of ocular pain |
| WO2021180885A1 (en) | 2020-03-11 | 2021-09-16 | Ospedale San Raffaele S.R.L. | Treatment of stem cell deficiency |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4042707A (en) * | 1976-02-19 | 1977-08-16 | E. I. Du Pont De Nemours And Company | 3α-Arylhydroisoindoles |
| DE3617183A1 (en) * | 1985-11-16 | 1987-05-27 | Bayer Ag | SUBSTITUTED BENZYL ETHERS |
| FR2654726B1 (en) * | 1989-11-23 | 1992-02-14 | Rhone Poulenc Sante | NEW ISOINDOLONE DERIVATIVES AND THEIR PREPARATION. |
| FR2654725B1 (en) * | 1989-11-23 | 1992-02-14 | Rhone Poulenc Sante | NEW ISOINDOLONE DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
| FR2676443B1 (en) * | 1991-05-17 | 1993-08-06 | Rhone Poulenc Rorer Sa | NOVEL PERHYDROISOINDOLE DERIVATIVES AND THEIR PREPARATION. |
-
1992
- 1992-04-10 FR FR929204391A patent/FR2689889B1/en not_active Expired - Fee Related
-
1993
- 1993-04-01 IL IL105256A patent/IL105256A0/en unknown
- 1993-04-01 IL IL10525697A patent/IL105256A/en not_active IP Right Cessation
- 1993-04-06 MX MX9301985A patent/MX9301985A/en not_active IP Right Cessation
- 1993-04-08 AT AT93909004T patent/ATE168674T1/en active
- 1993-04-08 DE DE69319902T patent/DE69319902T2/en not_active Expired - Fee Related
- 1993-04-08 WO PCT/FR1993/000351 patent/WO1993021154A1/en not_active Ceased
- 1993-04-08 US US08/313,120 patent/US5463077A/en not_active Expired - Fee Related
- 1993-04-08 ZA ZA932528A patent/ZA932528B/en unknown
- 1993-04-08 CZ CZ942483A patent/CZ284596B6/en unknown
- 1993-04-08 ES ES93909004T patent/ES2118954T3/en not_active Expired - Lifetime
- 1993-04-08 EP EP93909004A patent/EP0635002B1/en not_active Expired - Lifetime
- 1993-04-08 AU AU39564/93A patent/AU667365B2/en not_active Ceased
- 1993-04-08 CA CA002133841A patent/CA2133841A1/en not_active Abandoned
- 1993-04-08 DK DK93909004T patent/DK0635002T3/en active
- 1993-04-08 PL PL93305359A patent/PL172753B1/en unknown
- 1993-04-08 JP JP5518040A patent/JPH07505409A/en active Pending
- 1993-04-08 RU RU94045867A patent/RU2120438C1/en active
- 1993-04-08 HU HU9402912A patent/HUT71330A/en unknown
- 1993-04-08 SK SK1221-94A patent/SK122194A3/en unknown
- 1993-04-09 TW TW082102663A patent/TW224969B/zh active
-
1994
- 1994-10-05 NO NO943738A patent/NO300418B1/en unknown
- 1994-10-06 KR KR1019940703537A patent/KR950700879A/en not_active Withdrawn
- 1994-10-07 FI FI944728A patent/FI105022B/en active
Also Published As
| Publication number | Publication date |
|---|---|
| HU9402912D0 (en) | 1995-01-30 |
| WO1993021154A1 (en) | 1993-10-28 |
| PL172753B1 (en) | 1997-11-28 |
| IL105256A0 (en) | 1993-08-18 |
| NO943738L (en) | 1994-10-05 |
| ZA932528B (en) | 1993-10-28 |
| FR2689889A1 (en) | 1993-10-15 |
| JPH07505409A (en) | 1995-06-15 |
| RU2120438C1 (en) | 1998-10-20 |
| NO300418B1 (en) | 1997-05-26 |
| IL105256A (en) | 1997-08-14 |
| KR950700879A (en) | 1995-02-20 |
| FI944728A0 (en) | 1994-10-07 |
| EP0635002A1 (en) | 1995-01-25 |
| HUT71330A (en) | 1995-11-28 |
| FI944728L (en) | 1994-10-07 |
| EP0635002B1 (en) | 1998-07-22 |
| AU667365B2 (en) | 1996-03-21 |
| DE69319902D1 (en) | 1998-08-27 |
| US5463077A (en) | 1995-10-31 |
| SK122194A3 (en) | 1995-05-10 |
| CZ284596B6 (en) | 1999-01-13 |
| AU3956493A (en) | 1993-11-18 |
| RU94045867A (en) | 1996-09-10 |
| TW224969B (en) | 1994-06-11 |
| DK0635002T3 (en) | 1999-02-22 |
| FR2689889B1 (en) | 1994-06-10 |
| ES2118954T3 (en) | 1998-10-01 |
| MX9301985A (en) | 1994-05-31 |
| CA2133841A1 (en) | 1993-10-28 |
| FI105022B (en) | 2000-05-31 |
| NO943738D0 (en) | 1994-10-05 |
| CZ248394A3 (en) | 1995-11-15 |
| DE69319902T2 (en) | 1999-03-18 |
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