AT527700A1 - Analyzer with cooling device - Google Patents

Abstract

The invention relates to an analyzer (1) for analyzing samples, for example by clinical-chemical analysis and/or heterogeneous immunoassays, comprising an interior space (2) for analyzing the samples, a reagent storage space (3a) accessible via the interior space (2), a cooling device (4) with which the reagent storage space (3a) can be cooled, a coolant being movable in a cooling circuit of the cooling device (4) in a cooling circuit direction (R), and a ventilation device (5) with which air can be introduced into the interior space (2). According to the invention, for effective interior cooling, the cooling device (4) comprises at least one heat exchanger (6) arranged in the cooling circuit, through which the coolant can be guided, and the ventilation device (5) is configured to supply air to the heat exchanger (6) during introduction into the interior space (2). The invention further relates to a method for analyzing samples, in particular using such an analyzer (1).

Description

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Analyzer with cooling device

The invention relates to an analyzer for analyzing samples by, for example, clinical-chemical analysis and/or heterogeneous immunoassays, comprising an interior space for analyzing the samples, a reagent storage accessible via the interior space, and a cooling device with which the reagent storage can be cooled, wherein a coolant in a cooling circuit of the cooling device is movable in a cooling circuit direction, and a ventilation device with which air is circulated into the

interior can be brought.

Furthermore, the invention relates to a method for analyzing samples by, for example, clinical-chemical analysis and/or heterogeneous immunoassays, wherein the samples are prepared for analysis in an interior of an analyzer, in particular in the interior of an analyzer of the type mentioned above, and are mixed with reagents from a reagent storage, wherein the reagent storage is cooled by a cooling device with which coolant is guided in a cooling circuit

and air is moved in the interior.

Automatic analyzers are known from the prior art, with which chemical, biochemical and/or immunochemical analyses can be carried out. Such analyzers have a sample area in which samples are prepared for analysis. Furthermore, such analyzers comprise a reagent storage in which various reagents are prepared. In an interior of the analyzer, the samples can be analyzed, for example, using spectroscopic methods. For this purpose, a measuring station equipped with cuvettes is provided in the interior. Using automated pipetting devices, so-called pipettors, samples are fed into the measuring cuvettes, where they are mixed with one or more reagents, after which, for example, light absorption or light emission can be measured in order to determine sample properties. Analyzers of this type are disclosed, for example, in WO 2019/0110514 A1 or WO 2019/204841 A1.

In analyzers of this type, the cuvettes should be kept at a temperature of about 37 °C

which is approximately the same as the body temperature of a human.

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The analyzer, in particular the measuring station, includes a thermostatted cuvette block, with which the liquids can be brought to the target temperature. The reagent storage is cooled with a cooling device so that the reagents, which are charged less frequently than the samples, can be stored for a longer period.

period can be used.

The thermostatting of the cuvette block is achieved using suitable heating and cooling elements, usually using the Peltier effect. However, problems can arise during temperature adjustment if the temperature in the analyzer's environment becomes too high and approaches the target temperature of 37°C for the cuvette block. In this case, precise control of the cuvette block temperature is difficult or even impossible because the temperature difference between the temperature inside the analyzer and the cuvette block is too small to allow for quick and accurate control. Inaccurate temperature adjustment can result in measurement errors, assuming operation is possible at all. This problem is particularly relevant in areas where the ambient temperature can regularly exceed 30°C, for example

in South America, Africa, Asia or Australia.

In connection with this, the invention sets itself the task of developing an analyzer of the type mentioned at the outset in such a way that this problem is avoided or at least

is reduced.

A further aim of the invention is to develop a method of the type mentioned in the introduction in such a way that even at high ambient temperatures a good controllability of the temperature of an analyzer component such as a cuvette block in the

interior of the analyzer is possible.

The object of the invention is achieved if, in an analyzer of the type mentioned at the outset, the cooling device comprises at least one heat exchanger arranged in the cooling circuit, through which the coolant can be guided, and the ventilation device is designed to circulate air during introduction into the interior

to the heat exchanger.

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One advantage achieved by the invention is, in particular, that the interior can be cooled using very simple means, so that measurement can be carried out with the analyzer even at high ambient temperatures of, for example, 30 °C or more. The invention also takes advantage of the fact that reagent storage in corresponding analyzers is generally cooled to a temperature of approximately 4 °C to 8 °C, for example, approximately 5 °C. This usually results in excess cooling capacity, which can then be used additionally. Since the heat exchanger provided according to the invention is arranged in the cooling circuit through which the coolant can be guided, part or possibly all of the excess cooling capacity can be used. For this purpose, a ventilation device is arranged and configured to supply air to the heat exchanger during introduction into the interior. The air moved from the ventilation device to the heat exchanger and subsequently from the heat exchanger is thereby cooled and can then be supplied cooled, for example via a line, to the interior. This allows the interior to be cooled in a targeted manner and, if necessary, to a

maintain a certain temperature of, for example, a maximum of 30 °C.

The reagent storage is designed to provide reagents used for sample analysis. For this purpose, the reagent storage can be located inside the chamber. Optionally, the reagent storage can be pulled out of the chamber like a drawer for quick access and easy refilling.

To enable exchange of reagents.

Furthermore, the analyzer may have a sample storage device configured to provide samples to be analyzed. For this purpose, the sample storage device may be

be arranged in the interior.

The interior may further comprise a working area, for example delimited by a work surface, in which a pipettor is arranged to be movable in order to transfer liquids, in particular samples and/or reagents, between the sample storage, the reagent storage and a likewise at least partially in the working area

arranged, in particular adjacent, cuvette block.

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The work surface can separate a measuring and supply area of the interior, which in particular at least partially or predominantly comprises the reagent storage and/or sample storage, from the work area. Access devices comprising one or more access openings can be arranged in the work surface in order to provide the pipettor with access to the reagent storage and/or the

to enable sample storage.

By means of the ventilation system, the air is preferably circulated in the measuring and

supply area of the interior so that at least this area is cooled.

The cooling device and/or components of the cooling device, such as the heat exchanger, coolant lines and the like, are preferably protected from the environment of the cooling device, in particular from the cooling device

surrounding interior of the analyzer, thermally insulated.

In one variant, the at least one heat exchanger can be arranged upstream of the reagent storage in the cooling circuit direction. The cooling circuit direction is the direction in which the coolant for cooling the reagent storage is guided from an expansion tank to a compression refrigeration system and then to the reagent storage and subsequently further in the circuit back to the expansion tank. Alternatively, it is also possible for the at least one heat exchanger to be arranged downstream of the reagent storage in the cooling circuit direction. It is also possible for several heat exchangers to be provided. For example, one heat exchanger can be arranged upstream of the reagent storage and one downstream of the reagent storage. The performance of the heat exchanger(s) can be tailored to the required cooling capacity for the reagent storage on the one hand and the desired

Interior cooling on the other hand.

The cooling device may comprise a compression refrigeration system arranged in the cooling circuit, wherein the at least one heat exchanger is preferably arranged in the cooling circuit direction between the compression refrigeration system and the reagent storage

is arranged.

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In order to move the coolant in the cooling circuit direction, it is advisable that the

Cooling device comprises a pump arranged in the cooling circuit.

In general, it can be provided that the cooling device comprises a compression refrigeration system and a pump, wherein the pump is arranged upstream of the compression refrigeration system in the cooling circuit direction. In this context, it can be provided, in particular, that the at least one heat exchanger is arranged between the reagent storage and the pump of the cooling device, in particular between the reagent storage and a compensation tank of the cooling device. In this embodiment, the coolant is initially used to cool the reagent storage. The outflow of the coolant from the reagent storage is still cold enough to enable sufficient cooling of forced-air by the heat exchanger arranged between the reagent storage and, in particular, the compensation tank. The air cooled in this way can then be fed into the interior, in particular into the previously described measuring and

supply area.

Advantageously, the ventilation device is configured to supply air from the interior space, in particular the measuring and supply area of the interior space, to the at least one heat exchanger and to return it to the interior space, in particular the measuring and supply area of the interior space. This enables air to circulate through the interior space. The ventilation device is advantageously arranged outside the interior space or inside the interior space at a boundary plane between the interior space and the environment of the analyzer. For supplying and discharging the air, the interior space has suitable openings to which supply and discharge air can be connected.

Connect leads.

The ventilation device can also be configured to supply air from the environment of the analyzer to the at least one heat exchanger and to guide it into the interior. It is possible for the air from the environment of the analyzer to be guided in a continuous flow through the interior and then removed from it again without circulation. In this variant, the interior is perfused with air extracted from the environment and cooled.

Ventilation system must also be equipped with suitable valves and pipes so that

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It is also possible to operate the ventilation of the interior either in circulation mode or alternatively in flow-through mode. Furthermore, it is also possible to circulate on the one hand, but also to continuously or quasi-continuously supply fresh air from the analyzer's surroundings on the other.

In this case, it can be provided that the ventilation device has a filter unit through which the air is passed in order to filter the air obtained from the environment.

This can in particular be a particle and/or dust filter.

The cooling device together with the at least one heat exchanger and/or the ventilation device is preferably arranged within the interior, preferably outside the working area, in particular in the measuring and supply area.

This results in a particularly compact design.

Alternatively, it can also be provided that the cooling device together with the at least one heat exchanger and/or the ventilation device is arranged at least partially outside the interior, with the cooling circuit leading from outside the interior into the interior and out again. Thus, the analyzer itself can be designed to be particularly small. The cooling device and/or the ventilation device can be attached to the analyzer as a separate component, in particular in a modular manner.

which results in a particularly flexible structure.

For practical reasons, components not relevant for the measurement as such are located outside the interior, so that the interior is completely available for the measurement and the corresponding instruments. This also applies to the ventilation system, which for the same reasons is also located outside the interior.

interior can be arranged.

The measurement and supply area is preferably cooled in the interior, especially since this is where those components are located that require cooling when the ambient temperature is too high. The working area in which

For example, the pipettor works, can also be cooled.

The analyzer may include a drain device for removing condensate from the

Interior, especially for draining condensate from the cooling system,

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This not only allows the interior to be kept within a certain temperature range, but also makes it possible to keep humidity low, which is also important for a reliable measurement result. The discharge device can be designed as an additional pump, which is used to extract

Condensation from the interior is set up.

The analyzer may further comprise an openable housing which seals the interior when closed, so that air circulation in the interior

a controllable zone, particularly one that can be controlled in terms of temperature and humidity.

The cooling circuit is advantageously designed to run through the reagent storage. For this purpose, an extruded profile made of a material with a high thermal conductivity coefficient, such as copper, a copper alloy, or an aluminum alloy, can be provided. This profile has an inlet and an outlet for the coolant. Between the inlet and the outlet, the profile is divided into several, for example four, chambers, which ensure heat exchange with the reagent storage and maintain it at a predetermined temperature, for example 5 °C. The chambers run through the reagent storage and

ensure effective heat dissipation from the reagent storage.

An analyzer according to the invention can, apart from the cooling device, be designed in particular like an analyzer disclosed in WO 2019/010514 A1 or WO 2019/2048411 A1. The content of these two documents is hereby incorporated in its entirety. In particular, the analyzer can, in addition to the

Cooling device and the heat exchanger must be designed as:

— Automatic analyzer for carrying out chemical, biochemical and/or immunochemical analyses of liquid samples present in a sample storage unit of the analyzer, using liquid

Reagents present in at least one reagent storage of the analyzer,

with cuvettes for holding the liquid samples and reagents, the

preferably one side entry window and at least one side

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Exit windows, with a plurality of cuvettes optionally available as

at least one stationary, linear cuvette array is arranged in the analyzer,

with movable and stationary machine components, at least comprising: a pipettor designed to be movable in the x-direction along a line of movement defined by the linear cuvette array, which is equipped with at least one pipetting module movable in the y-direction — essentially normal to the x-direction — whose at least one hollow needle can be lowered in the z-direction into the cuvettes and into individual vessels of the sample and/or reagent storage

is executed,

optionally a mixer unit for mixing the samples and reagents in the

cuvettes,

an optical measuring unit, with a stationary light supply unit, which has at least one light distribution device, which directs the light of several light sources emitting spectrally differently in the UV/VIS/NIR wavelength range, such as LED light sources, into the entrance windows of the individual cuvettes

of the cuvette array, as well as

with a stationary, assigned to the exit windows of the cuvettes

Detection unit, which preferably has several photodiodes,

a cuvette washing unit that can be moved in the x-direction for cleaning the

cuvettes,

a needle washing unit for cleaning the at least one hollow needle,

a stationary thermostat unit for setting a preset

Measuring temperature in the cuvettes, as well as

an evaluation and control unit, wherein optionally the light distribution device has a cavity whose

inner surfaces at least partially mirrored and/or diffusely reflecting

are executed, and

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Optionally, each cuvette of the stationary cuvette array is assigned at least one photodiode. In addition to the cooling device and the heat exchanger, the analyzer can, for example,

also be trained as:

— Automatic analyzer for carrying out chemical, biochemical and/or immunochemical analyses of liquid samples present in a sample storage unit of the analyzer, using liquid

Reagents present in at least one reagent storage of the analyzer,

with cuvettes for holding the liquid samples and reagents, wherein a plurality of cuvettes are arranged as at least one stationary, linear cuvette array in the

Analyzer is arranged,

with movable and stationary machine components, at least comprising:

a pipettor designed to be movable in the x-direction along a line of movement defined by the linear cuvette array, which is equipped with at least one pipetting needle designed to be lowered into the cuvettes in the z-direction and in a y-direction substantially perpendicular to the x-direction between the cuvettes and the sample storage and/or the

Reagent storage is designed to be movable,

a mixer unit for mixing the samples and reagents in the cuvettes,

an optical measuring unit, which in particular — for obtaining a measuring signal — through a measuring window arranged on the side of the cuvette

receives outgoing measuring radiation,

Optionally a cuvette washing unit that can be moved in the x-direction for

Cleaning the cuvettes,

a needle washing unit for cleaning at least one pipetting needle, and

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a stationary thermostat unit for setting a preset

measuring temperature in the cuvettes,

wherein at least two machine components are designed to be movable independently of one another along or parallel to the movement line defined by the linear cuvette array in the x-direction and each have access to different

Cuvettes or groups of cuvettes in a freely selectable order.

The further aim of the invention is achieved if, in a method of the type mentioned at the beginning, the air moved in the interior and/or into the interior is

Heat exchange with the cooling circuit is cooled.

The advantage of a method according to the invention is that the temperature in the interior of the analyzer can be adjusted using simple means. This usually involves using existing cooling circuits that are used for heat exchange. This can be achieved in a simple manner, especially when a cooling device of the type described above is used. In addition to the desired temperature control of the interior, a high process efficiency is also achieved because

excess cooling capacity can be utilized.

The method can provide for air to be supplied to and removed from the interior space, wherein the air is cooled during the supply to the interior space by heat exchange with the cooling circuit. The air can be circulated through the interior space and thus supplied to and removed from it, or taken from an environment and guided through the interior space without any circulation of the air. In the latter case, the interior space is cooled by air from the environment, which is previously cooled by heat exchange, in a certain

Temperature window maintained.

The cooling device may comprise at least one heat exchanger, through which the air is guided during supply into the interior. This allows for efficient heat exchange with the cooling circuit. In principle, a single heat exchanger

sufficient to bring the interior into the desired temperature range.

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However, several heat exchangers can also be provided, provided that a higher

Cooling capacity is required for the interior.

The air can be circulated in a circuit. In this case, the air can be moved through the interior by a ventilation device located outside the interior. In this variant, the interior is continuously

Heat exchange of cooled air.

It is advantageous if the temperature of the air in the interior is measured and, based on the measured values, the air is cooled by heat exchange with the cooling circuit. This allows the interior to be kept stable in a

maintain a predetermined temperature window.

In a further aspect, the invention relates to a use of an analyzer according to the invention at an ambient temperature of more than 25 °C,

especially more than 30 °C.

Further features, advantages and effects of the invention will become apparent from the following exemplary embodiments. In the drawings, to which reference is made

Reference is made to:

Fig. 1 is a first perspective view of an analyzer;

Fig. 2 is a second perspective view of the analyzer;

Fig. 3 is a first cross-sectional view of the analyzer;

Fig. 4 is a second cross-sectional view of the analyzer;

Fig. 5 shows an analyzer according to the prior art;

Fig. 6 shows a first variant of an analyzer according to the invention;

Fig. 7 shows a second variant of an analyzer according to the invention.

In Fig. 1 and Fig. 2, an analyzer 1 for analyzing samples is shown in perspective view. Furthermore, the analyzer 1 is shown in schematic cross-sectional representation in Fig. 3 along the line | shown in Fig. 1 and in Fig. 4 along the

shown in Fig. 1 line II.

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The analyzer 1 comprises an interior space 2 and a reagent storage 3a for providing reagents and substances used for conducting clinical-chemical analyses and/or heterogeneous immunoassays, and preferably a sample storage 3b for providing samples to be analyzed. The reagent storage 3a and, if appropriate, the sample storage 3b can be arranged, in particular, in a measuring and supply space 14 of the interior space 2. Particularly preferably, the reagent storage 3a is designed like a drawer, so that it is accessible from outside the interior space 2.

for example to refill reagents.

In the interior 2, measurements are carried out on samples by mixing them with reagents and, for example, measuring them photometrically. For this purpose, the samples are mixed with the reagents in cuvettes, which are held in a thermostatted cuvette block 12. The reagent storage 3a is arranged in such a way that it is accessible via a work area 11 of the interior 2, so that, for example, reagents can be removed by a pipettor and filled into cuvettes.

can be introduced.

Preferably, the analyzer comprises, as shown in Fig. 1 and Fig. 2, a housing 10, in particular one that can be opened, which delimits the interior space 2. The working area 11 and the measuring and supply area 14 together form the interior space 2. The housing 10 is shown in Fig. 1 in a closed position and in Fig. 2 in an open position.

Configuration shown.

As can be seen from a synopsis of Fig. 2 to Fig. 4, the interior 2 preferably comprises the working area 11, which is bounded downwards, for example, by a working surface AF. For example, the pipettor (not shown) can be arranged so as to be movable in the working area 11. The cuvette block 12, the reagent storage 3a and/or the sample storage 3b are preferably arranged below the working surface AF, in particular outside the working area 11, and in a

Working area 11 adjacent measuring and supply area 14.

In Fig. 2 the working area 11 of the analyzer 1 is visible, where only

schematically the cuvette block 12, an access device 13a to the

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Reagent storage 3a and an access device 13b to the sample storage 3b are shown. The cuvette block 12 and the access devices 13a, 13b can, for example, have one or more access openings, in particular arranged in the work surface AF, through which the pipettor can dispense reagents or samples into the cuvettes or remove them from the respective storage 3a, 3b.

For the sake of clarity, the pipettor is not shown in Fig. 1 and Fig. 2.

In addition, the analyzer 1 comprises a cooling device 4, which is explained in more detail below in connection with Fig. 5 to Fig. 7 and is designed to

To cool reagent storage 3a.

Furthermore, the analyzer 1 has a ventilation device 5, by means of which air is introduced into the

can be introduced into and/or circulated within the interior.

Fig. 5 shows a highly simplified schematic representation of an analyzer 1 according to the prior art. This shows a cooling circuit of the cooling device 4. The cooling device 4 comprises a compression refrigeration system 7 and, upstream thereof, a pump 8 and an expansion tank 9. The cooling circuit has a cooling circuit direction R, which begins with the expansion tank 9 and extends over the

Pump 8 to the compression refrigeration system 7 and then to the reagent storage 3a and then again to the expansion tank 9. The cooling circuit direction R is also the direction in which the coolant is moved to the reagent storage 3a in order to achieve its cooling. With the cooling device 4, the reagent storage 3a can be kept at a relatively low temperature of 4 °C to 8 °C. Furthermore, a ventilation device 5 is provided, with which fresh air from the

environment of the analyzer 1.

An analyzer 1 according to the invention can be seen in Fig. 6. The analyzer 1 shown in Fig. 6 is basically constructed in the same way as the analyzer 1 according to Figs. 1 to 5 with regard to the interior space 2 and the reagent storage 3a. Again, the reagent storage 3a is accessible via the working area 11, in particular for a pipettor that can be moved in different spatial directions, in particular a pipettor that can be moved linearly in each case.

Pipettor movable in x-direction, y-direction and z-direction.

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Not shown in Fig. 6 is a cuvette block 12, which is preferably equipped with a temperature control and is arranged in the interior 2, in particular in the working area 11, and which accommodates cuvettes. Reagents and samples from a sample storage 3b (not shown in Fig. 6), which is also accessible via the working area 11, can be introduced into the cuvettes located in the cuvette block 12 via the pipettor. A measurement can then be performed, for example an absorption or emission measurement, for example a

Chemiluminescence measurement.

The samples in sample storage 3b and the reagents in reagent storage 3a can be inserted into corresponding receptacles in the respective area (sample storage 3b or reagent storage 3a). This allows for a quick change of samples and refilling of reagents by simply removing the

present container and replacing it.

In contrast to an analyzer 1 according to Fig. 5, the cooling device 4 additionally has a heat exchanger 6. This heat exchanger 6 is integrated into the cooling circuit and is part of the cooling device 4. The heat exchanger 6 is arranged in the cooling circuit direction R, starting with the compensation tank 9 after the reagent storage 3a and is located between the reagent storage 3a and

Expansion tank 9.

The analyzer 1 further comprises a ventilation device 5, which is designed to move air along a flow path. The ventilation device 5 is designed such that the air conveyed thereby comes into contact with the heat exchanger 6, whereby the air is cooled. The air can originate from the interior 2 and be returned thereto, thus ensuring air circulation (circulation mode). However, the air can also originate from the environment of the analyzer 1 and is then first cooled via the heat exchanger 6 before the thus cooled air is fed to the interior 2 and later discharged therefrom (flow-through mode). If suitable valves are provided, it is possible to switch between these two modes (circulation mode and flow-through mode). By forcing the air through the ventilation device 5 via the

Heat exchanger 6 cools the air that enters the interior 2

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This makes it possible, particularly at high ambient temperatures, to keep the interior 2 comparatively cool and thus to obtain reliable measurement results even at high ambient temperatures, especially when the ambient temperature of the analyzer 1 is more than 25 °C.

especially more than 30 °C.

Fig. 7 shows another embodiment of the analyzer 1 according to the invention. In this case, with the design otherwise identical to that shown in Fig. 4, the heat exchanger 6 is arranged in the cooling circuit direction R, beginning with the expansion tank 9, upstream of the reagent storage 3a, specifically between the compression refrigeration system 7 and the reagent storage 3a. Such an arrangement may be expedient,

if higher cooling capacity is required for interior 2.

In Fig. 5 to Fig. 7, the measuring and supply area 14 is shown in a highly simplified and schematic manner as a rectangle, with the cooling device 4 and the reagent storage 3 being shown outside this rectangle for reasons of clarity. Of course, the cooling device 4, the reagent storage 3 and/or the sample storage 3b can each be arranged entirely or at least partially within the measuring and supply area 14, as is shown by way of example in Fig. 1 to

Fig. 4 is shown.

The above embodiments are not intended to be limiting in any way. Within the scope of the invention, it is also possible to have multiple heat exchangers 6 integrated into the cooling circuit, wherein the heat exchangers 6 each interact with the ventilation device 5 or, if appropriate, multiple ventilation devices 5 to cool supplied or circulated air. It is also possible to implement the cooling circuit and the cooling device 4 with other components, as long as a heat exchanger 6 is provided which is dimensioned such that the supplied air can be cooled to a temperature of below 30 °C, in particular below 25 °C.

before it is fed into the interior 2.

Claims (20)

15 20 25 30 16 patent claims 1. Analyzer (1) for analyzing samples by, for example, clinical-chemical analysis and/or heterogeneous immunoassays, comprising an interior space (2) for analyzing the samples, a reagent storage (3a) accessible via the interior space (2), and a cooling device (4) with which the reagent storage (3a) can be cooled, wherein a coolant in a cooling circuit of the cooling device (4) is movable in a cooling circuit direction (R), and a ventilation device (5) with which air can be brought into the interior space (2), characterized in that the cooling device (4) comprises at least one heat exchanger (6) arranged in the cooling circuit, through which the coolant can be guided, and the ventilation device (5) is designed to Introduction into the interior (2) to the heat exchanger (6). 2. Analyzer (1) according to claim 1, characterized in that the at least one heat exchanger (6) is arranged in the cooling circuit direction (R) in front of the reagent storage (3a) is arranged. 3. Analyzer (1) according to claim 1, characterized in that the at least one heat exchanger (6) is arranged in the cooling circuit direction (R) after the reagent storage (3a) is arranged. 4. Analyzer (1) according to claim 1 or 2, characterized in that the cooling device (4) comprises a compression refrigeration system (7) arranged in the cooling circuit, wherein the at least one heat exchanger (6) is preferably arranged in the cooling circuit direction (R) between the compression refrigeration system (7) and the reagent storage (3a) is arranged. 5. Analyzer (1) according to one of claims 1 to 4, characterized in that the cooling device (4) comprises a pump (8) arranged in the cooling circuit. 6. Analyzer (1) according to claim 1, characterized in that the cooling device (4) comprises a compression refrigeration system (7) and a pump (8), wherein the pump (8) is arranged in the cooling circuit direction (R) upstream of the compression refrigeration system (7) is arranged. 15 20 25 30 17 7. Analyzer (1) according to claim 6, characterized in that the at least one heat exchanger (6) is arranged in the cooling circuit direction (R) between the reagent storage (3a) and the pump (8) of the cooling device (4), in particular between the reagent storage (3a) and an expansion tank (9) of the cooling device (4). 8. Analyzer (1) according to one of claims 1 to 7, characterized in that the ventilation device (5) is designed to supply air from the interior (2) to the to supply at least one heat exchanger (6) and return it to the interior (2). 9. Analyzer (1) according to one of claims 1 to 8, characterized in that the ventilation device (5) is designed to supply air from an environment of the analyzer (1) to the at least one heat exchanger (6) and to interior (2). 10. Analyzer (1) according to one of claims 1 to 9, characterized in that the cooling device (4) together with the at least one heat exchanger (6) is arranged outside the interior (2). 11. Analyzer (1) according to one of claims 1 to 10, characterized in that the ventilation device (5) is arranged outside the interior space (2). 12. Analyzer (1) according to one of claims 1 to 11, characterized in that the analyzer (1) has a discharge device for discharging condensate water from the interior (2), in particular for discharging condensate water from the cooling device (4). 13. Analyzer (1) according to claim 12, characterized in that the discharge device comprises a further pump which is used to suck out condensate from the interior (2). 14. Analyzer (1) according to one of claims 1 to 13, characterized in that the analyzer (1) comprises an openable housing (10) which seals the interior (2) in the closed state, so that in the interior (2) with air circulation a adjustable, particularly temperature and humidity adjustable, zone. 15 20 25 18 15. A method for analyzing samples, for example by clinical-chemical analysis and/or heterogeneous immunoassays, wherein the samples are prepared for analysis in an interior space (2) of an analyzer (1), in particular in the interior space (2) of an analyzer (1) according to one of claims 1 to 14, and are mixed with reagents from a reagent storage (3a), wherein the reagent storage (3a) is cooled by a cooling device (4) with which coolant is guided in a cooling circuit, and wherein air is moved in the interior space (2), characterized in that the air moved in the interior space (2) and/or into the interior space (2) is cooled by heat exchange with cooled by the cooling circuit. 16. Method according to claim 15, characterized in that air is supplied into the interior space (2) and discharged therefrom, the air being cooled during the supply into the interior space (2) by heat exchange with the cooling circuit becomes. 17. Method according to claim 15 or 16, characterized in that the cooling device (4) comprises at least one heat exchanger (6) via which the air during feeding into the interior (2). 18. Method according to one of claims 15 to 17, characterized in that the Air is circulated in a circuit. 19. Method according to one of claims 15 to 18, characterized in that a temperature of the air in the interior (2) is measured and, based on the measured values obtained, a cooling of the air by heat exchange with the Cooling circuit is regulated. 20. Use of an analyzer (1) according to one of claims 1 to 14 in a Ambient temperature of more than 25 °C, especially more than 30 °C.