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AR247879A1 - Procedimiento para preparar nuevos derivados de 4-acilaminopirrolidina y sus sales farmaceuticamente aceptables - Google Patents

Procedimiento para preparar nuevos derivados de 4-acilaminopirrolidina y sus sales farmaceuticamente aceptables

Info

Publication number
AR247879A1
AR247879A1 AR88310720A AR31072088A AR247879A1 AR 247879 A1 AR247879 A1 AR 247879A1 AR 88310720 A AR88310720 A AR 88310720A AR 31072088 A AR31072088 A AR 31072088A AR 247879 A1 AR247879 A1 AR 247879A1
Authority
AR
Argentina
Prior art keywords
hydrogen
alkyl
acil
alcoxy
halo
Prior art date
Application number
AR88310720A
Other languages
English (en)
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878710352A external-priority patent/GB8710352D0/en
Priority claimed from GB878716438A external-priority patent/GB8716438D0/en
Priority claimed from GB878730027A external-priority patent/GB8730027D0/en
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Application granted granted Critical
Publication of AR247879A1 publication Critical patent/AR247879A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

PREPARACION DE DERIVADOS DE 4-ACILAMINOPIRROLIDINA DE FORMULA I, EN DONDE R1 ES HIDROGENO O ACILO, COMO SER U1: FENILSULFONILO SUSTITUIDO O NO POR CF3, HALO, NITRO, ALQUILO O ALCOXI, U2 ALQUIL OXICARBONILO BENZOILO, ALQUIL SULFONILO, FENILCARBAMOILO O TIENILSULFONILO; R2 ES UN FENILSULFONILO O SUSTITUIDO O NO POR CF3, HALO, ALQUILO O ALCOXI; A ES SEGUN FORMULA DONDE R8 ES HIDROGENO O ALQUILO, R3 ES CARBOXIALQUILO, ALQUIL OXICARBONILFENILO O SUSTITUIDO O NO POR UNO O DOS ATOMOS DE CARBONO, R7 ES HIDROGENO O ALQUILO, QUE COMPRENDE HACER REACCIONAR FOSFORONAS DE FORMULA B O SUS SALES, DONDE R4 ES FENILO CON COMPUESTOS DE PIRROLIDINA DE FORMULA II O SUS SALES DONDE RA1 ES UN ACILO ELEGIDO ENTRE LOS GRUPOS ACILO (U1) Y (US), Y SI ES NECESARIO: I) TRATAR (I) DONDE R1 ES (U1) O (U2) CON ACIDO TRIFLUORACETICO O HCE CONCENTRADO PARA DAR (I) DONDE R1 ES HIDROGENO; II) ACILAR (I) DONDE R1 ES HIDROGENO CON X-RB1 DONDE X ES HALO Y RB1 ES ACILO ELEGIDO ENTRE (U1) Y (U2) PARADAR (I) DONDE R1 ESÑ UN ACILO SEGUN (U1) Y (U2) Y III) HIDROLIZAR (I) DONDE R3 ALCOXI CARBONILALQUILO O ALCOXI CARBONILFENILO CON ACIDO CLORHIDRICO ACUOSO PARA DAR (I) DONDE R1 ES CARBOXIALQUILO O CARBOXIFENILO.
AR88310720A 1987-05-01 1988-04-29 Procedimiento para preparar nuevos derivados de 4-acilaminopirrolidina y sus sales farmaceuticamente aceptables AR247879A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB878710352A GB8710352D0 (en) 1987-05-01 1987-05-01 Pyrrolidine derivatives
GB878716438A GB8716438D0 (en) 1987-07-13 1987-07-13 Pyrrolidine derivatives
GB878730027A GB8730027D0 (en) 1987-12-23 1987-12-23 Pyrrolidine derivatives

Publications (1)

Publication Number Publication Date
AR247879A1 true AR247879A1 (es) 1995-04-28

Family

ID=27263412

Family Applications (1)

Application Number Title Priority Date Filing Date
AR88310720A AR247879A1 (es) 1987-05-01 1988-04-29 Procedimiento para preparar nuevos derivados de 4-acilaminopirrolidina y sus sales farmaceuticamente aceptables

Country Status (18)

Country Link
US (1) US4916152A (es)
EP (1) EP0289911B1 (es)
JP (1) JPS63295553A (es)
KR (1) KR970005190B1 (es)
CN (1) CN1020899C (es)
AR (1) AR247879A1 (es)
AU (1) AU613360B2 (es)
CA (1) CA1329391C (es)
DE (1) DE3881755T2 (es)
DK (1) DK233888A (es)
ES (1) ES2054729T3 (es)
FI (1) FI88716C (es)
HU (1) HU208671B (es)
IE (1) IE62862B1 (es)
IL (1) IL86173A (es)
NO (1) NO173330C (es)
PH (1) PH24950A (es)
PT (1) PT87359B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5264453A (en) * 1988-10-31 1993-11-23 Fujisawa Pharmaceutical Co., Ltd. Pyrrolidine derivatives
US5130323A (en) * 1988-10-31 1992-07-14 Fujisawa Pharmaceutical Co., Ltd. Pyrrolidine derivatives
FR2685325B1 (fr) * 1991-12-20 1994-02-04 Adir Cie Nouveaux derives de pyrrolidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2687146B1 (fr) * 1992-02-12 1994-04-01 Adir Cie Nouveaux derives de pyrrolidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5543525A (en) * 1992-07-02 1996-08-06 Fujisawa Pharmaceutical Co., Ltd. Process for producing pyrrolidine derivative and salt thereof
KR100671658B1 (ko) 2005-01-05 2007-01-19 삼성에스디아이 주식회사 마스크 프레임 및 이를 사용한 마스크 고정방법
WO2009082607A2 (en) * 2007-12-04 2009-07-02 Alnylam Pharmaceuticals, Inc. Targeting lipids
CN109912487B (zh) * 2019-03-25 2023-01-10 山东理工大学 一种合成1-对甲苯磺酰基-2-乙烯基-1氢-吡咯的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3577440A (en) * 1968-12-23 1971-05-04 Robins Co Inc A H 1-substituted-3-amido-pyrrolidines
US4282243A (en) * 1972-04-03 1981-08-04 A. H. Robins Company, Inc. Optical isomers of 4-amino-N-(1-cyclohexyl-3-pyrrolidinyl)-N-methylbenzamide
US4210660A (en) * 1978-12-20 1980-07-01 Yamanouchi Pharmaceutical Co., Ltd. Benzamide derivatives
EP0042639B1 (en) * 1980-06-23 1984-08-22 E.R. Squibb & Sons, Inc. Azido, imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids having hypotensive activity
GB8509703D0 (en) * 1985-04-16 1985-05-22 Fujisawa Pharmaceutical Co Pyrrolidine derivatives
US4785119A (en) * 1985-10-11 1988-11-15 Tokyo Kasei Kogyo Co., Ltd. 3-aminopyrrolidine compound and process for preparation thereof
JPH07108898B2 (ja) * 1986-08-20 1995-11-22 大日本製薬株式会社 ３−アミノピロリジン誘導体およびその塩の製造法
US5130323A (en) * 1988-10-31 1992-07-14 Fujisawa Pharmaceutical Co., Ltd. Pyrrolidine derivatives

Also Published As

Publication number Publication date
HU208671B (en) 1993-12-28
FI88716B (fi) 1993-03-15
AU613360B2 (en) 1991-08-01
CN88102511A (zh) 1988-11-23
DK233888D0 (da) 1988-04-28
PH24950A (en) 1990-12-26
FI882015L (fi) 1988-11-02
PT87359B (pt) 1992-08-31
NO173330B (no) 1993-08-23
ES2054729T3 (es) 1994-08-16
DE3881755T2 (de) 1993-10-21
NO881884L (no) 1988-11-02
AU1534888A (en) 1988-11-03
IL86173A (en) 1992-02-16
FI882015A0 (fi) 1988-04-29
NO881884D0 (no) 1988-04-29
KR970005190B1 (ko) 1997-04-14
KR880013889A (ko) 1988-12-22
NO173330C (no) 1993-12-01
IL86173A0 (en) 1988-11-15
JPS63295553A (ja) 1988-12-01
IE881260L (en) 1988-11-01
PT87359A (pt) 1989-05-31
EP0289911A2 (en) 1988-11-09
US4916152A (en) 1990-04-10
CA1329391C (en) 1994-05-10
FI88716C (fi) 1993-06-28
CN1020899C (zh) 1993-05-26
HUT48579A (en) 1989-06-28
JPH0546335B2 (es) 1993-07-13
IE62862B1 (en) 1995-03-08
DE3881755D1 (de) 1993-07-22
EP0289911A3 (en) 1989-08-16
DK233888A (da) 1988-11-02
EP0289911B1 (en) 1993-06-16

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