AR245725A1 - Un procedimiento para la preparacion de derivados de tieno-triazolodiazepina. - Google Patents
Un procedimiento para la preparacion de derivados de tieno-triazolodiazepina.Info
- Publication number
- AR245725A1 AR245725A1 AR90316812A AR31681290A AR245725A1 AR 245725 A1 AR245725 A1 AR 245725A1 AR 90316812 A AR90316812 A AR 90316812A AR 31681290 A AR31681290 A AR 31681290A AR 245725 A1 AR245725 A1 AR 245725A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- procedure
- preparation
- triazolo
- derivatives
- Prior art date
Links
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229910052698 phosphorus Inorganic materials 0.000 abstract 2
- 239000011574 phosphorus Substances 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 239000011593 sulfur Substances 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- CFHGBZLNZZVTAY-UHFFFAOYSA-N lawesson's reagent Chemical compound C1=CC(OC)=CC=C1P1(=S)SP(=S)(C=2C=CC(OC)=CC=2)S1 CFHGBZLNZZVTAY-UHFFFAOYSA-N 0.000 abstract 1
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Natural products C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 abstract 1
- OCYSGIYOVXAGKQ-FVGYRXGTSA-N phenylephrine hydrochloride Chemical compound [H+].[Cl-].CNC[C@H](O)C1=CC=CC(O)=C1 OCYSGIYOVXAGKQ-FVGYRXGTSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
UN PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE TIENO-TRIAZOLO- DIAZEPINA DE FORMULA (A), DONDE Y ES OXIGENO O AZUFRE Y R ES ALQUILO, FENILO, SUSTITUIDO O NO POR ALQUILO, ALCOXI, TRIFLUOROMETILO O FENOXI SUSTITUIDO O NO; O UN ANILLO FURANO O TIOFENO, QUE CONSISTE EN TRATAR EL COMPUESTO DE TIENO-TRIAZOLO-DIAZEPINA DE FORMULA (B) CON UN COMPUESTO DE FORMULA RSCH2COOH, BAJO CIRCULACIONDE NITROGENO, EN PRESENCIA DE UN LEVE EXCESO ESTEQUIOMETRICO DE HIDROXIBENZOTRIAZOL Y DICICLOHEXILCARBODIIMIDA, Y TRATAR OPTATIVAMENTE EL DERIVADO DE TIENO-TRIAZOLO-DIAZEPINA DE FORMULA GENERAL (A) DONDE Y OXIGENO, CON REACTIVO DE LAWESSON O CON PENTASULFURO DE FOSFORO (P2S5) EN UN SOLVENTE APROTICO, PARA OBTENER EL DERIVADO DE TIENO- TRIAZOLO-DIAZEPINA DE FORMULA A, DONDE Y ES AZUFRE.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898911030A GB8911030D0 (en) | 1989-05-13 | 1989-05-13 | Hetrazepine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR245725A1 true AR245725A1 (es) | 1994-02-28 |
Family
ID=10656702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR90316812A AR245725A1 (es) | 1989-05-13 | 1990-05-09 | Un procedimiento para la preparacion de derivados de tieno-triazolodiazepina. |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US5049559A (es) |
| JP (1) | JPH06104668B2 (es) |
| KR (1) | KR900018113A (es) |
| AR (1) | AR245725A1 (es) |
| AT (1) | AT399153B (es) |
| AU (1) | AU628171B2 (es) |
| BE (1) | BE1004122A3 (es) |
| CA (1) | CA2016551C (es) |
| CH (1) | CH681009A5 (es) |
| DE (1) | DE4015137C2 (es) |
| DK (1) | DK102990A (es) |
| DZ (1) | DZ1414A1 (es) |
| ES (1) | ES2019840A6 (es) |
| FI (1) | FI93119C (es) |
| FR (2) | FR2646851B1 (es) |
| GB (2) | GB8911030D0 (es) |
| GR (1) | GR1000295B (es) |
| HK (1) | HK94992A (es) |
| IE (1) | IE65246B1 (es) |
| IN (1) | IN174000B (es) |
| IT (1) | IT1240935B (es) |
| LU (1) | LU87733A1 (es) |
| MA (1) | MA21842A1 (es) |
| NL (1) | NL9001089A (es) |
| NO (1) | NO173607C (es) |
| NZ (1) | NZ233574A (es) |
| OA (1) | OA09209A (es) |
| PT (1) | PT94008B (es) |
| SE (1) | SE505407C2 (es) |
| SG (1) | SG91992G (es) |
| TN (1) | TNSN90061A1 (es) |
| ZA (1) | ZA903305B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5221671A (en) * | 1988-10-31 | 1993-06-22 | Eisai Co., Ltd. | Triazolo-1,4-diazepine derivatives and their use in pharmaceuticals |
| US5468740A (en) * | 1988-10-31 | 1995-11-21 | Eisai Co., Ltd. | 1,4-diazepine derivative and its pharmaceutical use |
| US5382579A (en) * | 1988-10-31 | 1995-01-17 | Eisai Co., Ltd. | Triazolo-1,4-diazepine derivatives and their use in pharmaceuticals |
| FI95708C (fi) * | 1988-10-31 | 1996-03-11 | Eisai Co Ltd | Analogiamenetelmä 1,4-diatsepiinijohdannaisen ja sen farmaseuttisesti sopivan suolan valmistamiseksi |
| US5304553A (en) * | 1988-10-31 | 1994-04-19 | Eisai Co., Ltd. | 1,4-diazepine derivative and its pharmaceutical use |
| AT394563B (de) * | 1990-05-09 | 1992-05-11 | Scras | Verfahren zur herstellung von thieno-triazolodiazepinderivaten |
| GB9207645D0 (en) * | 1992-04-08 | 1992-05-27 | Smithkline Beecham Corp | Methods |
| ES2061406B1 (es) * | 1993-05-07 | 1995-06-01 | Uriach & Cia Sa J | Nuevos derivados de la 2-(quinolina) con actividad farmacologica. |
| US6262044B1 (en) * | 1998-03-12 | 2001-07-17 | Novo Nordisk A/S | Modulators of protein tyrosine phosphatases (PTPASES) |
| FR2779652B1 (fr) * | 1998-06-15 | 2001-06-08 | Sod Conseils Rech Applic | Utilisation de diazepines pour la preparation de medicaments destines a traiter les etats pathologiques ou les maladies dans lesquels un des recepteurs de la somatostatine est implique |
| WO2001083440A2 (en) * | 2000-04-28 | 2001-11-08 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Synthesis and use of thienotriazolodiazepines |
| JP4901474B2 (ja) | 2003-05-30 | 2012-03-21 | ランバクシー ラボラトリーズ リミテッド | 置換ピロール誘導体 |
| KR101329112B1 (ko) | 2005-11-08 | 2013-11-14 | 랜박시 래보러터리스 리미티드 | (3ｒ,5ｒ)-7-〔2-(4-플루오로페닐)-5-이소프로필-3-페닐-4-〔(4-히드록시 메틸 페닐 아미노)카르보닐〕-피롤-1-일〕-3,5-디히드록시 헵탄산 헤미 칼슘염의 제조 방법 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3435973A1 (de) * | 1984-10-01 | 1986-04-10 | Boehringer Ingelheim KG, 6507 Ingelheim | Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung |
| DE3724031A1 (de) * | 1986-07-22 | 1988-01-28 | Boehringer Ingelheim Kg | Neue hetrazepine und verfahren zu ihrer herstellung |
| PH30676A (en) * | 1986-07-22 | 1997-09-16 | Boehringer Ingelhein Kg | Hetrazepine compounds which have useful pharmaceutical utility |
| WO1988009792A1 (fr) * | 1987-06-08 | 1988-12-15 | Yoshitomi Pharmaceutical Industries, Ltd. | Composes de thienotriazolodiazepine a substitution ether et leur utilisation en medecine |
-
1989
- 1989-05-13 GB GB898911030A patent/GB8911030D0/en active Pending
-
1990
- 1990-04-24 NO NO901813A patent/NO173607C/no not_active IP Right Cessation
- 1990-04-25 AT AT0095690A patent/AT399153B/de not_active IP Right Cessation
- 1990-04-26 DK DK102990A patent/DK102990A/da not_active Application Discontinuation
- 1990-04-27 GR GR900100319A patent/GR1000295B/el not_active IP Right Cessation
- 1990-04-30 ZA ZA903305A patent/ZA903305B/xx unknown
- 1990-05-01 IE IE158390A patent/IE65246B1/en not_active IP Right Cessation
- 1990-05-03 IN IN419DE1990 patent/IN174000B/en unknown
- 1990-05-04 CH CH1522/90A patent/CH681009A5/fr not_active IP Right Cessation
- 1990-05-07 NZ NZ233574A patent/NZ233574A/en unknown
- 1990-05-07 BE BE9000479A patent/BE1004122A3/fr not_active IP Right Cessation
- 1990-05-07 NL NL9001089A patent/NL9001089A/nl active Search and Examination
- 1990-05-09 SE SE9001670A patent/SE505407C2/sv not_active IP Right Cessation
- 1990-05-09 AR AR90316812A patent/AR245725A1/es active
- 1990-05-09 GB GB9010403A patent/GB2231330B/en not_active Expired - Lifetime
- 1990-05-10 LU LU87733A patent/LU87733A1/fr unknown
- 1990-05-11 FR FR909005881A patent/FR2646851B1/fr not_active Expired - Lifetime
- 1990-05-11 IT IT20276A patent/IT1240935B/it active IP Right Grant
- 1990-05-11 TN TNTNSN90061A patent/TNSN90061A1/fr unknown
- 1990-05-11 PT PT94008A patent/PT94008B/pt not_active IP Right Cessation
- 1990-05-11 US US07/522,235 patent/US5049559A/en not_active Expired - Lifetime
- 1990-05-11 ES ES9001320A patent/ES2019840A6/es not_active Expired - Lifetime
- 1990-05-11 DE DE4015137A patent/DE4015137C2/de not_active Expired - Fee Related
- 1990-05-11 CA CA002016551A patent/CA2016551C/en not_active Expired - Fee Related
- 1990-05-11 JP JP2120188A patent/JPH06104668B2/ja not_active Expired - Lifetime
- 1990-05-11 OA OA59788A patent/OA09209A/xx unknown
- 1990-05-11 FI FI902355A patent/FI93119C/fi not_active IP Right Cessation
- 1990-05-11 MA MA22108A patent/MA21842A1/fr unknown
- 1990-05-11 FR FR909005880A patent/FR2646774B1/fr not_active Expired - Lifetime
- 1990-05-11 AU AU54931/90A patent/AU628171B2/en not_active Ceased
- 1990-05-12 KR KR1019900006793A patent/KR900018113A/ko not_active Withdrawn
- 1990-05-12 DZ DZ900081A patent/DZ1414A1/fr active
-
1992
- 1992-09-11 SG SG919/92A patent/SG91992G/en unknown
- 1992-11-26 HK HK949/92A patent/HK94992A/xx not_active IP Right Cessation
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