[go: up one dir, main page]

AR131658A1 - Hidrazidas bloqueadoras de nav 1.7 y/o nav 1.8, sus procesos de obtención, composiciones, usos, métodos de tratamiento de los mismos y sus kits - Google Patents

Hidrazidas bloqueadoras de nav 1.7 y/o nav 1.8, sus procesos de obtención, composiciones, usos, métodos de tratamiento de los mismos y sus kits

Info

Publication number
AR131658A1
AR131658A1 ARP240100138A ARP240100138A AR131658A1 AR 131658 A1 AR131658 A1 AR 131658A1 AR P240100138 A ARP240100138 A AR P240100138A AR P240100138 A ARP240100138 A AR P240100138A AR 131658 A1 AR131658 A1 AR 131658A1
Authority
AR
Argentina
Prior art keywords
nav
hydrazides
kits
compositions
blocking
Prior art date
Application number
ARP240100138A
Other languages
English (en)
Inventor
Gabriela Barreiro
De Santana Danilo Pereira
Monteiro Jlia Lammoglia
Gamba Luis Eduardo Reina
Fraga Carlos Alberto Manssour
Lacerda Barreiro Eliezer Jesus De
Lima Ldia Moreira
Original Assignee
Eurofarma Laboratorios S A
Univ Federal Do Rio De Janeiro Ufrj
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eurofarma Laboratorios S A, Univ Federal Do Rio De Janeiro Ufrj filed Critical Eurofarma Laboratorios S A
Publication of AR131658A1 publication Critical patent/AR131658A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C15/00—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/10—Hydrazines
    • C07C243/12—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms
    • C07C243/14—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/38—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a hidrazidas bloqueadoras de Nav 1.7 y/o Nav 1.8. Más específicamente, la presente invención relata hidrazidas que comprenden la fórmula (1), en que los sustituyentes R¹ a R⁸ son seleccionados independientemente de los grupos definidos en la memoria descriptiva, así como sus procesos de obtención, sus composiciones que comprenden al menos uno de los mismos compuestos, sus usos, sus métodos de tratamiento para tratar o prevenir patologías relacionadas al dolor y kits. La presente invención pertenece a los campos de la química medicinal, síntesis orgánica, al igual que al tratamiento de enfermedades relacionadas al dolor.
ARP240100138A 2023-01-30 2024-01-22 Hidrazidas bloqueadoras de nav 1.7 y/o nav 1.8, sus procesos de obtención, composiciones, usos, métodos de tratamiento de los mismos y sus kits AR131658A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US202363482235P 2023-01-30 2023-01-30

Publications (1)

Publication Number Publication Date
AR131658A1 true AR131658A1 (es) 2025-04-16

Family

ID=92145561

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP240100138A AR131658A1 (es) 2023-01-30 2024-01-22 Hidrazidas bloqueadoras de nav 1.7 y/o nav 1.8, sus procesos de obtención, composiciones, usos, métodos de tratamiento de los mismos y sus kits

Country Status (6)

Country Link
EP (1) EP4660181A1 (es)
AR (1) AR131658A1 (es)
CO (1) CO2025011775A2 (es)
MX (1) MX2025008868A (es)
UY (1) UY40623A (es)
WO (1) WO2024159284A1 (es)

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0104330D0 (sv) * 2001-12-19 2001-12-19 Astrazeneca Ab Therapeutic agents
US20060122243A1 (en) * 2002-06-06 2006-06-08 Susumu Muto Antiallergic
CA2508171C (en) * 2002-12-13 2012-08-28 Cytopia Pty Ltd Nicotinamide-based kinase inhibitors
GB0302673D0 (en) * 2003-02-06 2003-03-12 Astrazeneca Ab Pharmaceutical formulations
GB0314057D0 (en) * 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
WO2006006569A1 (ja) * 2004-07-12 2006-01-19 Nihon Nohyaku Co., Ltd. フェニルピリジン類又はその塩類、これらを有効成分とする除草剤及びその使用方法
US7928107B2 (en) 2004-09-02 2011-04-19 Vertex Pharmaceuticals Incorporated Quinazolines useful as modulators of ion channels
EP1814856A1 (en) * 2004-11-12 2007-08-08 Galapagos N.V. Nitrogen heteroaromatic compounds which bind to the active site of protein kinase enzymes
PE20080906A1 (es) * 2006-08-17 2008-07-05 Kemia Inc Derivados heteroarilo como inhibidores de citocina
US7786139B2 (en) * 2006-11-21 2010-08-31 Omeros Corporation PDE10 inhibitors and related compositions and methods
BRPI0809498A2 (pt) * 2007-04-02 2014-09-23 Inst Oneworld Health Compostos inibidores de cftr e seus usos
WO2011026240A1 (en) 2009-09-04 2011-03-10 Zalicus Pharmaceuticals Ltd. Oxopiperazine derivatives for the treatment of pain and epilepsy
US8518968B2 (en) * 2009-12-04 2013-08-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hydrazone and diacyl hydrazine compounds and methods of use
WO2012007836A1 (en) 2010-07-16 2012-01-19 Purdue Pharma .Lp. Pyridine compounds as sodium channel blockers
EP2951168B1 (en) 2013-01-31 2017-01-04 Vertex Pharmaceuticals Incorporated Quinoline and quinoxaline amides as modulators of sodium channels
KR102295748B1 (ko) 2013-01-31 2021-09-01 버텍스 파마슈티칼스 인코포레이티드 나트륨 채널의 조절제로서의 피리돈 아미드
US9120786B2 (en) 2013-03-04 2015-09-01 Purdue Pharma, L.P. Triazine carboxamides as sodium channel blockers
RU2741810C2 (ru) 2013-07-10 2021-01-28 Вертекс Фармасьютикалз Инкорпорейтед Амиды конденсированного пиперидина в качестве модуляторов ионных каналов
TWI703154B (zh) 2013-12-13 2020-09-01 美商維泰克斯製藥公司 作為鈉通道調節劑之吡啶酮醯胺之前藥
CN105218426A (zh) * 2014-06-17 2016-01-06 中国科学院兰州化学物理研究所 一种高效合成吲哚和异喹啉衍生物的方法
JP2017001991A (ja) 2015-06-11 2017-01-05 大日本住友製薬株式会社 新規ベンズオキサゾロン化合物
EP3445746A1 (en) 2016-04-20 2019-02-27 Bristol-Myers Squibb Company ACYL SULFONAMIDE NaV1.7 INHIBITORS
US10633371B2 (en) * 2016-04-22 2020-04-28 Dana-Farber Cancer Institute, Inc. EZH2 inhibitors and uses thereof
UA124857C2 (uk) 2017-05-16 2021-12-01 Вертекс Фармасьютикалз Інкорпорейтед Дейтеровані піридонаміди і їх проліки як модулятори натрієвих каналів
CN110612285B (zh) 2017-06-20 2023-04-04 拉夸里亚创药株式会社 作为Nav1.7及Nav1.8阻断剂的酰胺衍生物
UY37806A (es) 2017-07-11 2020-01-31 Vertex Pharma Carboxamidas como moduladores de los canales de sodio
KR102812202B1 (ko) 2018-11-02 2025-05-23 머크 샤프 앤드 돔 엘엘씨 Nav1.8 억제제로서의 2-아미노-n-헤테로아릴-니코틴아미드
EP3902544A1 (en) * 2018-12-26 2021-11-03 RaQualia Pharma Inc. Heterocyclic derivatives as nav1.7 and nav1.8 blockers
WO2020210428A1 (en) * 2019-04-09 2020-10-15 Baylor College Of Medicine Novel inhibitors of flavivirus protease for prevention and treatment of zika, dengue and other flavivirus infections
CA3142902A1 (en) 2019-06-27 2020-12-30 Glaxosmithkline Intellectual Property Development Limited 2,3-dihydroquinazolin compounds as nav1.8 inhibitors
AU2021347364A1 (en) * 2020-09-25 2023-03-23 Neuropore Therapies, Inc. Compounds and compositions as modulators of TLR signaling

Also Published As

Publication number Publication date
EP4660181A1 (en) 2025-12-10
WO2024159284A1 (pt) 2024-08-08
CO2025011775A2 (es) 2025-09-08
UY40623A (es) 2024-07-31
MX2025008868A (es) 2025-10-01

Similar Documents

Publication Publication Date Title
CL2020002511A1 (es) Compuestos heterocíclicos como inmunomoduladores.
CO2024002075A2 (es) Compuestos n-acilhidrazónicos inhibidores de nav 1.7 y/o nav 1.8, sus procesos de obtención, composiciones, usos, métodos de tratamiento de estos y kits
UY28157A1 (es) Miméticos de glucocorticoides métodos para su elaboración composiciones farmacéuticas y sus usos
UY28333A1 (es) Inhibidores de caspasa y sus usos.
AR123424A1 (es) Nuevos compuestos heterocíclicos
UY28695A1 (es) Derivados de difenilazetidona
AR132340A1 (es) Compuestos tricíclicos para el tratamiento de cáncer
CO2022013856A2 (es) Derivados de benzodiazepinas como pam de gaba a gamma1
AR132703A1 (es) Compuestos tricíclicos y usos de los mismos
CL2022002255A1 (es) Compuestos heterocíclicos de heteroarilo y usos de los mismos
ATE432930T1 (de) Benzosulfonamide derivate, deren verfahren zum herstellung, und deren verwendung zur behandlung von schmerzen
CL2024000558A1 (es) Malonamidas herbicidas
AR131658A1 (es) Hidrazidas bloqueadoras de nav 1.7 y/o nav 1.8, sus procesos de obtención, composiciones, usos, métodos de tratamiento de los mismos y sus kits
CL2023000772A1 (es) Compuestos heterocíclicos de heteroarilo y usos de los mismos
AR131715A1 (es) AMIDAS BLOQUEADORAS DE Nav 1.7 Y/O Nav 1.8, SUS PROCESOS DE OBTENCIÓN, COMPOSICIONES, USOS, MÉTODOS DE TRATAMIENTO DE LOS MISMOS Y KITS
AR124717A1 (es) Compuestos de derivados sustituidos en 4,6 de ip4
UY39882A (es) COMPUESTOS NACILHIDRAZÓNICOS INHIBIDORES DE Nav 1.7 Y/O Nav 1.8, SUS PROCESOS DE OBTENCIÓN, COMPOSICIONES, USOS, MÉTODOS DE TRATAMIENTO DE ESTOS Y KITS
CO2025011772A2 (es) Hidroxamatos bloqueadores de nav 1.7 y/o nav 1.8, sus procesos de obtención, composiciones, usos, métodos de tratamiento de los mismos y kits
UY40627A (es) Compuestos arilpiridinas bloqueadores de nav 1.7 y/o nav 1.8, sus procesos de obtención...
UY40625A (es) COMPUESTOS FENÓLICOS BLOQUEADORES DE Nav 1.7 Y/O Nav 1.8, SUS PROCESOS DE OBTENCIÓN...
CL2024000559A1 (es) Malonamidas herbicidas
CO2023008049A2 (es) Compuestos químicos útiles para inhibir los canales de sodio activados por voltaje de nav1.8 y tratar las enfermedades mediadas por nav1.8
AR130168A1 (es) Derivados bicíclicos de tetrahidrotiazepina