AR130115A2 - STABLE PROTEIN SOLUTION FORMULATION CONTAINING A HIGH CONCENTRATION OF AN ANTI-VEGF ANTIBODY - Google Patents
STABLE PROTEIN SOLUTION FORMULATION CONTAINING A HIGH CONCENTRATION OF AN ANTI-VEGF ANTIBODYInfo
- Publication number
- AR130115A2 AR130115A2 ARP230102051A ARP230102051A AR130115A2 AR 130115 A2 AR130115 A2 AR 130115A2 AR P230102051 A ARP230102051 A AR P230102051A AR P230102051 A ARP230102051 A AR P230102051A AR 130115 A2 AR130115 A2 AR 130115A2
- Authority
- AR
- Argentina
- Prior art keywords
- high concentration
- antibody
- protein solution
- formulation containing
- vegf antibody
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- 238000009472 formulation Methods 0.000 title 1
- 239000012460 protein solution Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 3
- 238000002347 injection Methods 0.000 abstract 2
- 239000007924 injection Substances 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000002776 aggregation Effects 0.000 abstract 1
- 238000004220 aggregation Methods 0.000 abstract 1
- 239000006172 buffering agent Substances 0.000 abstract 1
- 239000013618 particulate matter Substances 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención proporciona anticuerpos anti-VEGF formulados como composiciones farmacéuticas acuosas, de alta concentración, adecuados para una inyección, preferentemente una inyección intravítrea. Las composiciones farmacéuticas acuosas son útiles para la administración de una alta concentración del ingrediente activo del anticuerpo a un paciente sin altos niveles de agregación de anticuerpo y sin un alto nivel de materia particulada subvisible. Una composición acuosa de la invención comprende un anticuerpo que tiene una concentración de al menos 50 mg/ml. Una composición farmacéutica acuosa de la invención incluye azúcar, un agente de amortiguación y un tensioactivo.The present invention provides anti-VEGF antibodies formulated as high concentration, aqueous pharmaceutical compositions suitable for injection, preferably intravitreal injection. The aqueous pharmaceutical compositions are useful for administration of a high concentration of the antibody active ingredient to a patient without high levels of antibody aggregation and without a high level of subvisible particulate matter. An aqueous composition of the invention comprises an antibody having a concentration of at least 50 mg/ml. An aqueous pharmaceutical composition of the invention includes sugar, a buffering agent and a surfactant.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462076770P | 2014-11-07 | 2014-11-07 | |
| US202062088061P | 2020-12-05 | 2020-12-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR130115A2 true AR130115A2 (en) | 2024-11-06 |
Family
ID=93840427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP230102051A AR130115A2 (en) | 2014-11-07 | 2023-08-03 | STABLE PROTEIN SOLUTION FORMULATION CONTAINING A HIGH CONCENTRATION OF AN ANTI-VEGF ANTIBODY |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR130115A2 (en) |
-
2023
- 2023-08-03 AR ARP230102051A patent/AR130115A2/en unknown
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