[go: up one dir, main page]

AR122385A1 - VACCINE BASED ON RECOMBINANT POXVIRUS AGAINST SARS-CoV-2 VIRUS - Google Patents

VACCINE BASED ON RECOMBINANT POXVIRUS AGAINST SARS-CoV-2 VIRUS

Info

Publication number
AR122385A1
AR122385A1 ARP210100512A ARP210100512A AR122385A1 AR 122385 A1 AR122385 A1 AR 122385A1 AR P210100512 A ARP210100512 A AR P210100512A AR P210100512 A ARP210100512 A AR P210100512A AR 122385 A1 AR122385 A1 AR 122385A1
Authority
AR
Argentina
Prior art keywords
virus
cov
sars
poxvirus
protein
Prior art date
Application number
ARP210100512A
Other languages
Spanish (es)
Inventor
Seth Lederman
Scott J Goebel
David Evans
Ryan Noyce
Original Assignee
TONIX Pharmaceuticals Holding Corp
Scott J Goebel
Univ Alberta
David Evans
Ryan Noyce
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TONIX Pharmaceuticals Holding Corp, Scott J Goebel, Univ Alberta, David Evans, Ryan Noyce filed Critical TONIX Pharmaceuticals Holding Corp
Publication of AR122385A1 publication Critical patent/AR122385A1/en

Links

Landscapes

  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Distintos aspectos de un poxvirus recombinante que comprende un ácido nucleico que codifica para una proteína del virus SARS-CoV-2, métodos para producir dichos virus y uso de dichos virus. Los poxvirus recombinantes son bien adecuados, entre otras cosas, como vacunas basadas en virus protectoras contra el virus SARS-CoV-2. Reivindicación 1: Un poxvirus recombinante caracterizado porque comprende un ácido nucleico que codifica para una proteína del virus SARS-CoV-2, en donde la proteína del SARS-CoV-2 se selecciona del grupo que consiste en la proteína espícula (S), la proteína de membrana (M) y la proteína de la nucleocápside (N), o combinaciones de dos o más de dichas proteínas. Reivindicación 25: Una composición farmacéutica caracterizada porque comprende un poxvirus recombinante de acuerdo con una cualquiera de las reivindicaciones 1 a 24 y un vehículo farmacéuticamente aceptable. Reivindicación 30: Una célula caracterizada porque está infectada con un poxvirus recombinante de acuerdo con una cualquiera de las reivindicaciones 1 a 29. Reivindicación 33: Un método para seleccionar una célula que expresa una proteína del virus SARS-CoV-2, caracterizado porque comprende infectar dicha célula con un poxvirus recombinante de acuerdo con una cualquiera de las reivindicaciones 1 a 24 y seleccionar la célula infectada que expresa dicha proteína del virus SARS-CoV-2. Reivindicación 60: Un método para generar un poxvirus recombinante de acuerdo con una cualquiera de las reivindicaciones 1 a 59, caracterizado porque el método comprende: (a) Infectar una célula huésped con un poxvirus; (b) Transfectar la célula infectada del paso (a) con un ácido nucleico que codifica para una proteína del virus SARS-CoV-2 para generar un poxvirus recombinante; y (c) Seleccionar un poxvirus recombinante, en donde el ácido nucleico que codifica para una proteína del virus SARS-CoV-2 se localiza, ante su transfección, en una región del poxvirus que no es esencial para la replicación del poxvirus. Reivindicación 80: Una vacuna contra un virus SARS-CoV-2 caracterizada porque comprende un virus recombinante de acuerdo con las reivindicaciones 1 a 23 o una composición farmacéutica de acuerdo con las reivindicaciones 25 a 29. Reivindicación 81: Una vacuna bivalente contra un virus SARS-CoV-2 y un poxvirus caracterizada porque comprende un virus recombinante de acuerdo con las reivindicaciones 1 a 24 o una composición farmacéutica de acuerdo con las reivindicaciones 25 a 29. Reivindicación 82: Una vacuna bivalente contra un virus SARS-CoV-2 y un poxvirus, caracterizada porque el poxvirus es un virus vacuna, virus variola, virus de la viruela equina o virus de la viruela de los monos.Different aspects of a recombinant poxvirus comprising a nucleic acid encoding a SARS-CoV-2 virus protein, methods for producing said viruses and use of said viruses. Recombinant poxviruses are well suited, inter alia, as protective virus-based vaccines against the SARS-CoV-2 virus. Claim 1: A recombinant poxvirus characterized in that it comprises a nucleic acid encoding a SARS-CoV-2 virus protein, wherein the SARS-CoV-2 protein is selected from the group consisting of the spike protein (S), the membrane protein (M) and nucleocapsid protein (N), or combinations of two or more of said proteins. Claim 25: A pharmaceutical composition characterized in that it comprises a recombinant poxvirus according to any one of claims 1 to 24 and a pharmaceutically acceptable carrier. Claim 30: A cell characterized in that it is infected with a recombinant poxvirus according to any one of claims 1 to 29. Claim 33: A method for selecting a cell that expresses a SARS-CoV-2 virus protein, characterized in that it comprises infecting said cell with a recombinant poxvirus according to any one of claims 1 to 24 and selecting the infected cell that expresses said SARS-CoV-2 virus protein. Claim 60: A method for generating a recombinant poxvirus according to any one of claims 1 to 59, characterized in that the method comprises: (a) Infecting a host cell with a poxvirus; (b) Transfecting the infected cell of step (a) with a nucleic acid encoding a SARS-CoV-2 virus protein to generate a recombinant poxvirus; and (c) Selecting a recombinant poxvirus, in which the nucleic acid encoding a SARS-CoV-2 virus protein is localized, upon transfection, to a region of the poxvirus that is not essential for poxvirus replication. Claim 80: A vaccine against a SARS-CoV-2 virus characterized in that it comprises a recombinant virus according to claims 1 to 23 or a pharmaceutical composition according to claims 25 to 29. Claim 81: A bivalent vaccine against a SARS virus -CoV-2 and a poxvirus characterized in that it comprises a recombinant virus according to claims 1 to 24 or a pharmaceutical composition according to claims 25 to 29. Claim 82: A bivalent vaccine against a SARS-CoV-2 virus and a poxvirus, characterized in that the poxvirus is a vaccinia virus, variola virus, horsepox virus or monkeypox virus.

ARP210100512A 2020-02-26 2021-02-26 VACCINE BASED ON RECOMBINANT POXVIRUS AGAINST SARS-CoV-2 VIRUS AR122385A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US202062981997P 2020-02-26 2020-02-26

Publications (1)

Publication Number Publication Date
AR122385A1 true AR122385A1 (en) 2022-09-07

Family

ID=83444528

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP210100512A AR122385A1 (en) 2020-02-26 2021-02-26 VACCINE BASED ON RECOMBINANT POXVIRUS AGAINST SARS-CoV-2 VIRUS

Country Status (1)

Country Link
AR (1) AR122385A1 (en)

Similar Documents

Publication Publication Date Title
BR112022016992A2 (en) VACCINE BASED ON RECOMBINANT POXVIRUS AGAINST SARS-COV-2 VIRUS
Sánchez-Sampedro et al. The evolution of poxvirus vaccines
EA200801756A1 (en) ANTIGRIPOPOSIC VACCINES CONTAINING HEMAGGLUTININ AND PROTEINS OF MATRIX
WO2021150874A1 (en) Recombinant influenza viruses with stabilized na
EA201891415A8 (en) HUMAN IMMUNODEFICIENCY VIRUS ANTIGENS, VECTORS, COMPOSITIONS AND WAYS OF THEIR APPLICATION
AR108781A1 (en) INCREASE IN THE IMMUNOGENICITY OF THE HUMAN PAPILOMA VIRUS L2 PEPTIDE (HPV)
MX340880B (en) IMPROVED VACCINES AND METHODS FOR THE SAME USE.
Stubbs et al. Vesicular stomatitis virus chimeras expressing the Oropouche virus glycoproteins elicit protective immune responses in mice
RU2009101382A (en) THE PROCESS OF OBTAINING POXVIRUSES AND COMPOSITIONS OF POXVIRUSES
CL2019000704A1 (en) Canine adenovirus vectors.
BR112015002131A8 (en) RECOMBINANT VACCINIA ANKARA VIRUS (MVA), PHARMACEUTICAL COMPOSITION AND USE OF SUCH RECOMBINANT MVA
CL2012000447A1 (en) Composition or vaccine comprising a recombinant avian paramyxovirus 8 (apmv-8) viral vector; method of producing said vector; and use to prepare medicament useful for inducing an immune response.
EP4396333A1 (en) Utilization of micro-rna for downregulation of cytotoxic transgene expression by modified vaccinia virus ankara (mva)
Di Pilato et al. Modification of promoter spacer length in vaccinia virus as a strategy to control the antigen expression
CO6140071A2 (en) MAPACHE POXVIRUS EXPRESSING RABY GLICOPROTEINS
Weyer et al. Generation and evaluation of a recombinant modified vaccinia virus Ankara vaccine for rabies
BR112017024283A2 (en) dengue vaccines
CO2023006544A2 (en) Oncolytic immunotherapy by remodeling the tumor microenvironment
AR108014A1 (en) UNIVERSAL VACCINE FOR VIRAL DISEASES AND VACCINATION METHOD
CL2019000405A1 (en) Viral vaccines
Croft et al. Surprisingly effective priming of CD8+ T cells by heat-inactivated vaccinia virus virions
AR122385A1 (en) VACCINE BASED ON RECOMBINANT POXVIRUS AGAINST SARS-CoV-2 VIRUS
AR066823A1 (en) INCREASE IN PLANTS PERFORMANCE BY MODULATION OF GARP TRANSMISSION ZMRR10-P FACTOR
BR112018000037A2 (en) recombinant virus-like particles using bovine immunodeficiency virus gag protein (bgag vlp), vaccine, transfer plasmid vector to produce bgag vlp, method for making bgag vlp, method for preparing the vaccine
CN1723285A (en) Recombinant MVA and methods of producing the same