AR120158A2 - SUBSTITUTED INDOL MONO OR DI DERIVATIVES AS INHIBITORS OF DENGUE VIRAL REPLICATION - Google Patents
SUBSTITUTED INDOL MONO OR DI DERIVATIVES AS INHIBITORS OF DENGUE VIRAL REPLICATIONInfo
- Publication number
- AR120158A2 AR120158A2 ARP200102756A ARP200102756A AR120158A2 AR 120158 A2 AR120158 A2 AR 120158A2 AR P200102756 A ARP200102756 A AR P200102756A AR P200102756 A ARP200102756 A AR P200102756A AR 120158 A2 AR120158 A2 AR 120158A2
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- mono
- dengue viral
- relates
- ocf3
- Prior art date
Links
- 208000001490 Dengue Diseases 0.000 title abstract 4
- 206010012310 Dengue fever Diseases 0.000 title abstract 4
- 208000025729 dengue disease Diseases 0.000 title abstract 4
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000029812 viral genome replication Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- 208000036142 Viral infection Diseases 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 3
- 238000002360 preparation method Methods 0.000 abstract 3
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 3
- 230000009385 viral infection Effects 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- -1 di-substituted indole group Chemical group 0.000 abstract 1
- 150000002475 indoles Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente se refiere a compuestos de indol mono o disustituidos, a métodos para prevenir o tratar infecciones virales por dengue usando dichos compuestos y también se refiere a dichos compuestos para su uso como un medicamento, más preferiblemente para su uso como una medicina para tratar o prevenir infecciones virales por dengue. La presente se refiere adicionalmente a composiciones farmacéuticas o preparaciones de combinación de los compuestos, a las composiciones o preparaciones para su uso como un medicamento, más preferiblemente para la prevención o tratamiento de infecciones virales por dengue. La presente también se refiere a procesos para la preparación de los compuestos. Reivindicación 1: Un compuesto de fórmula (1) una forma estereoisomérica, una sal, solvato o polimorfo farmacéuticamente aceptables del mismo que comprende un grupo indol mono o disustituido; dicho compuesto se selecciona del grupo en el que: R¹ es H, R² es F y R³ es H o CH₃, R¹ es H, CH₃ o F, R² es OCH₃ y R³ es H, y R¹ es H, R² es OCH₃ y R³ es CH₃, R¹ es CH₃, R² es F y R³ es H, R¹ es CF₃ o OCF₃, R² es H y R³ es H, R¹ es OCF₃, R² es OCH₃ y R³ es H y R¹ es OCF₃, R² es H y R³ es CH₃.The present relates to mono- or disubstituted indole compounds, to methods of preventing or treating dengue viral infections using said compounds, and also relates to said compounds for use as a medicament, more preferably for use as a medicine to treat or prevent dengue viral infections. The present further relates to pharmaceutical compositions or combination preparations of the compounds, to compositions or preparations for use as a medicament, more preferably for the prevention or treatment of dengue viral infections. This also relates to processes for the preparation of the compounds. Claim 1: A compound of formula (1) a stereoisomeric form, a pharmaceutically acceptable salt, solvate or polymorph thereof comprising a mono- or di-substituted indole group; said compound is selected from the group in which: R¹ is H, R² is F and R³ is H or CH₃, R¹ is H, CH₃ or F, R² is OCH₃ and R³ is H, and R¹ is H, R² is OCH₃ and R³ is CH₃, R¹ is CH₃, R² is F and R³ is H, R¹ is CF₃ or OCF₃, R² is H and R³ is H, R¹ is OCF₃, R² is OCH₃ and R³ is H and R¹ is OCF₃, R² is H and R³ is CH₃.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15166900 | 2015-05-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR120158A2 true AR120158A2 (en) | 2022-02-02 |
Family
ID=53059008
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP160101248A AR104504A1 (en) | 2015-05-08 | 2016-05-03 | DERIVATIVES OF INDOL MONO OR DISABLED AS INHIBITORS OF THE VIRAL REPLICATION OF DENGUE |
| ARP200102756A AR120158A2 (en) | 2015-05-08 | 2020-10-05 | SUBSTITUTED INDOL MONO OR DI DERIVATIVES AS INHIBITORS OF DENGUE VIRAL REPLICATION |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP160101248A AR104504A1 (en) | 2015-05-08 | 2016-05-03 | DERIVATIVES OF INDOL MONO OR DISABLED AS INHIBITORS OF THE VIRAL REPLICATION OF DENGUE |
Country Status (3)
| Country | Link |
|---|---|
| AR (2) | AR104504A1 (en) |
| MA (1) | MA43507B1 (en) |
| MY (1) | MY185672A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114989131B (en) * | 2022-05-30 | 2023-10-24 | 云南大学 | N' - (2- (benzo [1,3] dioxolan-5-yl) acyl) aryl hydrazide compound as well as synthesis and application thereof |
-
2016
- 2016-05-03 AR ARP160101248A patent/AR104504A1/en not_active Application Discontinuation
- 2016-05-04 MY MYPI2017001601A patent/MY185672A/en unknown
- 2016-05-04 MA MA43507A patent/MA43507B1/en unknown
-
2020
- 2020-10-05 AR ARP200102756A patent/AR120158A2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR104504A1 (en) | 2017-07-26 |
| MY185672A (en) | 2021-05-29 |
| MA43507B1 (en) | 2021-08-31 |
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