AR120117A2 - PD-1 BINDING MOLECULES AND METHODS OF USE THEREOF - Google Patents
PD-1 BINDING MOLECULES AND METHODS OF USE THEREOFInfo
- Publication number
- AR120117A2 AR120117A2 ARP200102705A ARP200102705A AR120117A2 AR 120117 A2 AR120117 A2 AR 120117A2 AR P200102705 A ARP200102705 A AR P200102705A AR P200102705 A ARP200102705 A AR P200102705A AR 120117 A2 AR120117 A2 AR 120117A2
- Authority
- AR
- Argentina
- Prior art keywords
- mab
- binding
- antibodies
- methods
- present
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 102100040678 Programmed cell death protein 1 Human genes 0.000 abstract 21
- 101710089372 Programmed cell death protein 1 Proteins 0.000 abstract 21
- 239000012634 fragment Substances 0.000 abstract 2
- 101100022187 Caenorhabditis elegans mab-10 gene Proteins 0.000 abstract 1
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 abstract 1
- 102000037982 Immune checkpoint proteins Human genes 0.000 abstract 1
- 108091008036 Immune checkpoint proteins Proteins 0.000 abstract 1
- 241000282567 Macaca fascicularis Species 0.000 abstract 1
- 102000048362 human PDCD1 Human genes 0.000 abstract 1
- 210000002865 immune cell Anatomy 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 229940127121 immunoconjugate Drugs 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente se dirige a anticuerpos antiPD-1 seleccionados capaces de unirse tanto a PD-1 de mono cynomolgus y a PD-1 de humano: mAb 1 de PD-1, mAb 2 de PD-1, mAb 3 de PD-1, mAb 4 de PD-1, mAb 5 de PD-1, mAb 6 de PD-1, mAb 7 de PD-1, mAb 8 de PD-1, mAb 9 de PD-1, mAb 10 de PD-1, mAb 11 de PD-1, mAb 12 de PD-1, mAb 13 de PD-1, mAb 14 de PD-1 o mAb 15 de PD-1, y a versiones humanizadas o quiméricas de tales anticuerpos. La presente pertenece de manera adicional a moléculas de unión a PD-1 que comprenden fragmentos de unión a PD-1 de tales anticuerpos anti-PD-1, inmunoconjugados, y a moléculas biespecíficas, que incluyen diacuerpos, BiTE, anticuerpos biespecíficos, etc., que comprenden (i) tales fragmentos de unión a PD-1, y (ii) un dominio capaz de unir un epítopo de una molécula involucrada en regular un punto de control inmune presente en la superficie de células inmunes. La presente también pertenece a métodos para utilizar moléculas que se unen a PD-1 para estimular respuestas inmunes, así como a métodos para detectar PD-1.This is directed to selected anti-PD-1 antibodies capable of binding to both cynomolgus monkey PD-1 and human PD-1: PD-1 mAb 1, PD-1 mAb 2, PD-1 mAb 3, mAb PD-1 mAb 4, PD-1 mAb 5, PD-1 mAb 6, PD-1 mAb 7, PD-1 mAb 8, PD-1 mAb 9, PD-1 mAb 10, mAb 11 PD-1 mAb, PD-1 mAb 12, PD-1 mAb 13, PD-1 mAb 14 or PD-1 mAb 15, and humanized or chimeric versions of such antibodies. The present invention further pertains to PD-1 binding molecules comprising PD-1 binding fragments of such anti-PD-1 antibodies, immunoconjugates, and to bispecific molecules, including diabodies, BiTE, bispecific antibodies, etc., comprising (i) such PD-1 binding fragments, and (ii) a domain capable of binding an epitope of a molecule involved in regulating an immune checkpoint present on the surface of immune cells. The present invention also pertains to methods of using PD-1 binding molecules to stimulate immune responses, as well as methods of detecting PD-1.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562198867P | 2015-07-30 | 2015-07-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR120117A2 true AR120117A2 (en) | 2022-02-02 |
Family
ID=60244687
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP160102301A AR105520A1 (en) | 2015-07-30 | 2016-07-28 | PD-1 BINDING MOLECULES AND SAME USE METHODS |
| ARP200102705A AR120117A2 (en) | 2015-07-30 | 2020-09-29 | PD-1 BINDING MOLECULES AND METHODS OF USE THEREOF |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP160102301A AR105520A1 (en) | 2015-07-30 | 2016-07-28 | PD-1 BINDING MOLECULES AND SAME USE METHODS |
Country Status (2)
| Country | Link |
|---|---|
| AR (2) | AR105520A1 (en) |
| MA (1) | MA47137B1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3104778A1 (en) * | 2018-07-11 | 2020-01-16 | Kahr Medical Ltd. | Pd1-4-1bbl variant fusion protein and methods of use thereof |
| CN116854820B (en) * | 2023-06-26 | 2024-02-06 | 华中科技大学同济医学院附属协和医院 | PD-1 non-blocking scavenging antibodies and their uses |
-
2016
- 2016-07-28 AR ARP160102301A patent/AR105520A1/en unknown
- 2016-07-28 MA MA47137A patent/MA47137B1/en unknown
-
2020
- 2020-09-29 AR ARP200102705A patent/AR120117A2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR105520A1 (en) | 2017-10-11 |
| MA47137A (en) | 2019-10-30 |
| MA47137B1 (en) | 2021-08-31 |
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