AR113275A1 - Compuestos de cefem con grupos reactivos latentes - Google Patents
Compuestos de cefem con grupos reactivos latentesInfo
- Publication number
- AR113275A1 AR113275A1 ARP180102869A ARP180102869A AR113275A1 AR 113275 A1 AR113275 A1 AR 113275A1 AR P180102869 A ARP180102869 A AR P180102869A AR P180102869 A ARP180102869 A AR P180102869A AR 113275 A1 AR113275 A1 AR 113275A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- penems
- leaving group
- cephemes
- activity against
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 239000003153 chemical reaction reagent Substances 0.000 title 1
- 150000002961 penems Chemical class 0.000 abstract 5
- 230000003115 biocidal effect Effects 0.000 abstract 3
- 125000001550 cephem group Chemical group 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 2
- 229930186147 Cephalosporin Natural products 0.000 abstract 2
- 229940041011 carbapenems Drugs 0.000 abstract 2
- 229940124587 cephalosporin Drugs 0.000 abstract 2
- 150000001780 cephalosporins Chemical class 0.000 abstract 2
- 150000001782 cephems Chemical class 0.000 abstract 2
- 150000005206 1,2-dihydroxybenzenes Chemical class 0.000 abstract 1
- 108010056874 AmpC beta-lactamases Proteins 0.000 abstract 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 108020004256 Beta-lactamase Proteins 0.000 abstract 1
- 241000192125 Firmicutes Species 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 102000006635 beta-lactamase Human genes 0.000 abstract 1
- 108010068385 carbapenemase Proteins 0.000 abstract 1
- 150000002009 diols Chemical class 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000036457 multidrug resistance Effects 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- YCIMNLLNPGFGHC-UHFFFAOYSA-N o-dihydroxy-benzene Natural products OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 abstract 1
- 125000002217 penem group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000001228 spectrum Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/57—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with a further substituent in position 7, e.g. cephamycines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Compuestos de cefem y penem que tienen un resto estirilmetileno en la posición 3 en el anillo de cefem o penem al que está unido un grupo saliente cargado positivamente y donde el grupo saliente contiene un diol vecino o está unido a un catecol no sustituido o sustituido. El grupo saliente puede ser un grupo saliente de nitrógeno con carga positiva. Las cefemas incluyen cefalosporinas, cefamicinas, carbacefemas y oxacefemas. Los penems incluyen penems, carbapenems y oxapenems. Las cefemas preferidas son cefalosporinas. Los penems preferidos son carbapenems. Los compuestos exhiben actividad antibiótica contra bacterias gramnegativas y/o bacterias grampositivas. Los compuestos exhiben actividad antibiótica contra bacterias que exhiben resistencia a múltiples fármacos. Los compuestos de la presente exhiben actividad antibiótica contra cepas bacterianas que producen b-lactamasas de espectro extendido (ESBL), que producen AmpC b-lactamasas o que producen una carbapenemasa. Composiciones farmacéuticas que comprenden una o más cefemas o penems o métodos de tratamiento de infecciones bacterianas con dichos compuestos y composiciones.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762568104P | 2017-10-04 | 2017-10-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR113275A1 true AR113275A1 (es) | 2020-03-11 |
Family
ID=65895920
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP180102869A AR113275A1 (es) | 2017-10-04 | 2018-10-04 | Compuestos de cefem con grupos reactivos latentes |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20190100534A1 (es) |
| AR (1) | AR113275A1 (es) |
| TW (1) | TW201922755A (es) |
| WO (1) | WO2019070973A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020206381A1 (en) * | 2019-04-03 | 2020-10-08 | Sutton Larry D | Cephem compounds with latent reactive groups and methods of using and making same |
| CN110950893B (zh) * | 2019-12-03 | 2022-01-07 | 华南理工大学 | 一种多功能荧光探针及其制备方法和应用 |
| CN118598802B (zh) * | 2024-08-07 | 2024-12-06 | 蒲城驭腾新材料科技有限公司 | 一种吡啶季铵盐型全氟烃基醚化合物及其制备方法和应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2526046B2 (ja) * | 1986-12-26 | 1996-08-21 | サントリー株式会社 | ペネム誘導体、その製造法およびその用途 |
| DE3839987A1 (de) * | 1988-11-26 | 1990-05-31 | Hoechst Ag | Penemderivate und verfahren zu ihrer herstellung |
| CA2089366C (en) * | 1990-08-20 | 2001-10-16 | Hiromitsu Iwata | Penem compounds |
| US6271222B1 (en) * | 1998-05-28 | 2001-08-07 | Merck & Co., Inc. | Penem antibacterial compounds, compositions and methods of treatment |
| US8883772B2 (en) * | 2007-10-09 | 2014-11-11 | Sopharmia, Inc. | Broad spectrum beta-lactamase inhibitors |
| US20100261700A1 (en) * | 2009-04-09 | 2010-10-14 | Larry Sutton | Beta-lactamase inhibitors |
| ES2700575T3 (es) * | 2013-03-12 | 2019-02-18 | Gladius Pharmaceuticals Corp | 3-Estiril-cefalosporinas derivadas |
-
2018
- 2018-10-04 AR ARP180102869A patent/AR113275A1/es unknown
- 2018-10-04 US US16/151,479 patent/US20190100534A1/en not_active Abandoned
- 2018-10-04 TW TW107135063A patent/TW201922755A/zh unknown
- 2018-10-04 WO PCT/US2018/054364 patent/WO2019070973A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019070973A1 (en) | 2019-04-11 |
| TW201922755A (zh) | 2019-06-16 |
| US20190100534A1 (en) | 2019-04-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Elshamy et al. | A review on bacterial resistance to carbapenems: epidemiology, detection and treatment options | |
| Girija et al. | Prevalence of carbapenem-hydrolyzing OXA-type β-lactamases among Acinetobacter baumannii in patients with severe urinary tract infection | |
| Pop-Vicas et al. | The clinical impact of multidrug-resistant gram-negative bacilli in the management of septic shock | |
| Tissera et al. | Isolation of extended spectrum β-lactamase (ESBL) producing bacteria from urban surface waters in Malaysia | |
| CO6331438A2 (es) | Inhibidores de beta-lactamasa | |
| AR113275A1 (es) | Compuestos de cefem con grupos reactivos latentes | |
| Bedenić et al. | Molecular characterization of class b carbapenemases in advanced stage of dissemination and emergence of class d carbapenemases in Enterobacteriaceae from Croatia | |
| EA201890150A1 (ru) | 3-тетразолил-бензол-1,2-дисульфонамидные производные в качестве ингибиторов металло-бета-лактамазы | |
| RU2014109447A (ru) | Азотсодержащие соединения и их применение | |
| MX2019013260A (es) | Derivados de 3-(((((2s-5r)-2-carbamoil-7-oxo-1,6-diazabiciclo [3.2.1]octan-6-il)oxi)sulfonil)oxi)-2,2-dimetilprop noato y compuestos relacionados como profarmacos oralmente administrados de inhibidores de beta-lactamasa para el tratamiento de infecciones bacterianas. | |
| Bhaskar et al. | Molecular characterization of extended spectrum β-lactamase and carbapenemase producing Klebsiella pneumoniae from a tertiary care hospital | |
| Cicora et al. | Infections with blaKPC-2-producing Klebsiella pneumoniae in renal transplant patients: a retrospective study | |
| Bae et al. | Molecular epidemiology of Pseudomonas aeruginosa clinical isolates from Korea producing β-lactamases with extended-spectrum activity | |
| Pobiega et al. | Molecular characterization of carbapenem-resistant Pseudomonas aeruginosa strains isolated from patients with urinary tract infections in Southern Poland | |
| Kamruzzaman et al. | Genetic diversity and antibiotic resistance in Escherichia coli from environmental surface water in Dhaka City, Bangladesh | |
| Tavajjohi et al. | Detection and characterization of multidrug resistance and extended-spectrum-beta-lactamase-producing (ESBLS) Pseudomonas aeruginosa isolates in teaching hospital | |
| NZ706734A (en) | Pharmaceutical compositions useful for the treatment or control of bacterial infections | |
| Abate et al. | Cedecea davisae bacteremia in a neutropenic patient with acute myeloid leukemia | |
| Bielen et al. | Activity of fosfomycin against nosocomial multiresistant bacterial pathogens from Croatia: a multicentric study | |
| Mitsuwan et al. | Occurrence of multidrug resistance associated with extended-spectrum β‑lactamase and the biofilm forming ability of Escherichia coli in environmental swine husbandry | |
| Rout et al. | Surveillance of extended-spectrum β-lactamase producing bacteria in an Indian teaching hospital | |
| TW200716104A (en) | Tricyclic 6-alkylidene-penems as class-D β -lactamases inhibitors | |
| Okwu et al. | Prevalence and antimicrobial susceptibility profiles of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) isolates among healthy individuals in Okada, South-South, Nigeria | |
| Shahid et al. | Molecular epidemiology of carbapenem-resistant Enterobacteriaceae from a North Indian Tertiary Hospital | |
| Taheri et al. | Antibiotic resistance pattern and phylogenetic groups of the Uropathogenic Escherichia coli isolates recovered from the urinary catheters of the hospitalized patients |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |