AR110675A1 - MODIFIED OLIGONUCLEOTIDES AND METHODS OF USE - Google Patents
MODIFIED OLIGONUCLEOTIDES AND METHODS OF USEInfo
- Publication number
- AR110675A1 AR110675A1 ARP170102544A ARP170102544A AR110675A1 AR 110675 A1 AR110675 A1 AR 110675A1 AR P170102544 A ARP170102544 A AR P170102544A AR P170102544 A ARP170102544 A AR P170102544A AR 110675 A1 AR110675 A1 AR 110675A1
- Authority
- AR
- Argentina
- Prior art keywords
- oligonucleotide
- methods
- modified oligonucleotides
- cell
- nucleobase
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Chemical class Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title abstract 2
- 108091034117 Oligonucleotide Proteins 0.000 abstract 4
- 241000700605 Viruses Species 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se describen oligonucleótidos modificados que comprenden modificaciones en las posiciones 2’ y/o 3’ en conjunto con métodos para laborarlas y usos, por ejemplo, contra HBV. Reivindicación 1: Un oligonucleótido que comprende uno o más nucleótidos de la fórmula (1), en donde R es H o un contraión con carga positiva; B es una nucleobase; R¹ es -(CR’₂)₂OCR’₃; y R’ es independientemente en cada caso H o F. Reivindicación 104: Un método para inhibir la replicación de un virus en una célula; el método comprende poner en contacto la célula con un oligonucleótido o con una composición que comprende el oligonucleótido de cualquiera de las reivindicaciones 1 a 97, en donde el oligonucleótido contiene una secuencia de nucleobases que es complementaria o se híbrida con una porción de un ARN objetivo viral.Modified oligonucleotides are described which comprise modifications in the 2 ’and / or 3’ positions in conjunction with methods for working them and uses, for example, against HBV. Claim 1: An oligonucleotide comprising one or more nucleotides of the formula (1), wherein R is H or a positively charged counterion; B is a nucleobase; R¹ is - (CR’₂) ₂OCR’₃; and R ’is independently in each case H or F. Claim 104: A method of inhibiting the replication of a virus in a cell; The method comprises contacting the cell with an oligonucleotide or with a composition comprising the oligonucleotide of any one of claims 1 to 97, wherein the oligonucleotide contains a nucleobase sequence that is complementary or hybridizes with a portion of a target RNA. viral.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662394738P | 2016-09-14 | 2016-09-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR110675A1 true AR110675A1 (en) | 2019-04-24 |
Family
ID=66326296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP170102544A AR110675A1 (en) | 2016-09-14 | 2017-09-14 | MODIFIED OLIGONUCLEOTIDES AND METHODS OF USE |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR110675A1 (en) |
-
2017
- 2017-09-14 AR ARP170102544A patent/AR110675A1/en not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |