AR118925A1 - CONCENTRATED LIQUID SOLUTION OF NON-STEROID ANTIANDROGENS AND PROCEDURE FOR PREPARING THE SOLUTION - Google Patents
CONCENTRATED LIQUID SOLUTION OF NON-STEROID ANTIANDROGENS AND PROCEDURE FOR PREPARING THE SOLUTIONInfo
- Publication number
- AR118925A1 AR118925A1 ARP200101366A ARP200101366A AR118925A1 AR 118925 A1 AR118925 A1 AR 118925A1 AR P200101366 A ARP200101366 A AR P200101366A AR P200101366 A ARP200101366 A AR P200101366A AR 118925 A1 AR118925 A1 AR 118925A1
- Authority
- AR
- Argentina
- Prior art keywords
- solution
- concentrated liquid
- preparing
- procedure
- antiandrogens
- Prior art date
Links
- 239000006193 liquid solution Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000000051 antiandrogen Substances 0.000 title 1
- 229940030495 antiandrogen sex hormone and modulator of the genital system Drugs 0.000 title 1
- 229920001531 copovidone Polymers 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000003956 nonsteroidal anti androgen Substances 0.000 abstract 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 2
- HJBWBFZLDZWPHF-UHFFFAOYSA-N apalutamide Chemical compound C1=C(F)C(C(=O)NC)=CC=C1N1C2(CCC2)C(=O)N(C=2C=C(C(C#N)=NC=2)C(F)(F)F)C1=S HJBWBFZLDZWPHF-UHFFFAOYSA-N 0.000 abstract 1
- 229950007511 apalutamide Drugs 0.000 abstract 1
- WXCXUHSOUPDCQV-UHFFFAOYSA-N enzalutamide Chemical compound C1=C(F)C(C(=O)NC)=CC=C1N1C(C)(C)C(=O)N(C=2C=C(C(C#N)=CC=2)C(F)(F)F)C1=S WXCXUHSOUPDCQV-UHFFFAOYSA-N 0.000 abstract 1
- 229960004671 enzalutamide Drugs 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Solución líquida concentrada de antiandrógenos no esteroideos, conteniendo entre 80 mg y 140 mg de enzalutamida o apalutamida por cada gramo de solución, que comprende copovidona y polioxilgliceridos de caprilocaproilo como excipientes. Se provee además un procedimiento de obtención, en donde se prepara una mezcla de copovidona y polioxilgliceridos de caprilocaproilo y luego se adiciona a la mezcla un antriandrógeno no esteroideo, manteniendo la agitación a una temperatura de 100ºC o más hasta formar una solución.Concentrated liquid solution of nonsteroidal antiandrogens, containing between 80 mg and 140 mg of enzalutamide or apalutamide per gram of solution, comprising copovidone and caprylocaproyl polyoxylglycerides as excipients. A process for obtaining it is also provided, in which a mixture of copovidone and caprylocaproyl polyoxylglycerides is prepared and then a non-steroidal antiandrogen is added to the mixture, maintaining stirring at a temperature of 100ºC or more until a solution is formed.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ARP200101366A AR118925A1 (en) | 2020-05-13 | 2020-05-13 | CONCENTRATED LIQUID SOLUTION OF NON-STEROID ANTIANDROGENS AND PROCEDURE FOR PREPARING THE SOLUTION |
| PCT/IB2020/055416 WO2021229278A1 (en) | 2020-05-13 | 2020-06-09 | Concentrated liquid non-steroidal antiandrogen solution and method for preparing the solution |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ARP200101366A AR118925A1 (en) | 2020-05-13 | 2020-05-13 | CONCENTRATED LIQUID SOLUTION OF NON-STEROID ANTIANDROGENS AND PROCEDURE FOR PREPARING THE SOLUTION |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR118925A1 true AR118925A1 (en) | 2021-11-10 |
Family
ID=78525123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP200101366A AR118925A1 (en) | 2020-05-13 | 2020-05-13 | CONCENTRATED LIQUID SOLUTION OF NON-STEROID ANTIANDROGENS AND PROCEDURE FOR PREPARING THE SOLUTION |
Country Status (2)
| Country | Link |
|---|---|
| AR (1) | AR118925A1 (en) |
| WO (1) | WO2021229278A1 (en) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2892029T3 (en) * | 2012-09-11 | 2022-02-01 | Medivation Prostate Therapeutics Llc | Enzalutamide formulations |
| US20190209469A1 (en) * | 2016-08-20 | 2019-07-11 | Ftf Pharma Private Limited | Pharmaceutical composition comprising an androgen receptor inhibitor |
| RU2020105102A (en) * | 2017-07-04 | 2021-08-04 | Бдр Фармасьютикалз Интернэшнл Прайвит Лимитед | NEW COMPOSITION OF ENZALUTAMIDE ORAL DOSAGE FORM AND METHOD FOR ITS PREPARATION |
| WO2019155416A2 (en) * | 2018-02-09 | 2019-08-15 | Kashiv Pharma Llc | A stable pharmaceutical composition of poorly soluble nonsteroidal antiandrogens |
-
2020
- 2020-05-13 AR ARP200101366A patent/AR118925A1/en unknown
- 2020-06-09 WO PCT/IB2020/055416 patent/WO2021229278A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021229278A1 (en) | 2021-11-18 |
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