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AR101558A1 - Difluoropirrolidinas como moduladores del receptor de orexina - Google Patents

Difluoropirrolidinas como moduladores del receptor de orexina

Info

Publication number
AR101558A1
AR101558A1 ARP150102622A ARP150102622A AR101558A1 AR 101558 A1 AR101558 A1 AR 101558A1 AR P150102622 A ARP150102622 A AR P150102622A AR P150102622 A ARP150102622 A AR P150102622A AR 101558 A1 AR101558 A1 AR 101558A1
Authority
AR
Argentina
Prior art keywords
alkyl
substituted
group
co2h
haloalkyl
Prior art date
Application number
ARP150102622A
Other languages
English (en)
Inventor
He Yuanjun
Kamenecka Theodore
Original Assignee
Eolas Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eolas Therapeutics Inc filed Critical Eolas Therapeutics Inc
Publication of AR101558A1 publication Critical patent/AR101558A1/es

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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Neurology (AREA)
  • Biomedical Technology (AREA)
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  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Nutrition Science (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Reivindicación 1: Un compuesto caracterizado porque es de fórmula (1), donde X es NR⁴ ó O; R¹ es un grupo heteroarilo monocíclico o bicíclico, donde R¹ no está sustituido o está sustituido con uno o más sustituyentes seleccionados en forma independiente entre el grupo que consiste en alquilo, haloalquilo, halo, -OH, -O-alquilo, -CN, -NRᵃRᵇ, -N(Rᵃ)C(O)alquilo, -N(Rᵃ)CO₂-alquilo, -N(Rᵃ)SO₂-alquilo, -C(O)alquilo, -CO₂H, -CO₂-alquilo, -CONRᵃRᵇ, -SO₂-alquilo, y -SO₂NRᵃRᵇ; donde Rᵃ y Rᵇ son en forma independiente entre sí H o alquilo; R² es fenilo o un heteroarilo monocíclico, donde R² no está sustituido o está sustituido con uno o más sustituyentes seleccionados en forma independiente entre el grupo que consiste en alquilo, haloalquilo, cicloalquilo, halo, -OH, -O-alquilo, -CN, -NRᶜRᵈ, -N(Rᵃ)C(O)alquilo, -N(Rᶜ)CO₂-alquilo, -N(Rᶜ)SO₂-alquilo, -C(O)alquilo, -CO₂H, -CO₂-alquilo, -CONRᶜRᵈ, -SO₂-alquilo, y -SO₂NRᶜRᵈ; donde Rᶜ y Rᵈ son en forma independiente entre sí H o alquilo; R³ es fenilo o un heteroarilo monocíclico, donde R³ no está sustituido o está sustituido con uno o más sustituyentes seleccionados en forma independiente entre el grupo que consiste en alquilo, haloalquilo, halo, -OH, -O-alquilo, -CN, -NRᵉRᶠ, -N(Rᵉ)C(O)alquilo, -N(Rᵉ)CO₂-alquilo, -N(Rᵉ)SO₂-alquilo, -C(O)alquilo, -CO₂H, -CO₂-alquilo, -CONRᵉRᶠ, -SO₂-alquilo, y -SO₂NRᵉRᶠ; donde Rᵉ y Rᶠ son en forma independiente entre sí H o alquilo; y R⁴ es H o alquilo; o una sal farmacéuticamente aceptable del mismo.
ARP150102622A 2014-08-13 2015-08-13 Difluoropirrolidinas como moduladores del receptor de orexina AR101558A1 (es)

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US201462037024P 2014-08-13 2014-08-13

Publications (1)

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AR101558A1 true AR101558A1 (es) 2016-12-28

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US (1) US10221170B2 (es)
EP (1) EP3180332B1 (es)
JP (1) JP6663909B2 (es)
AR (1) AR101558A1 (es)
ES (1) ES2901418T3 (es)
TW (1) TW201613902A (es)
UY (1) UY36272A (es)
WO (1) WO2016025669A1 (es)

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