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AR106100A1 - Compuestos bicíclicos como inhibidores duales atx / ca - Google Patents

Compuestos bicíclicos como inhibidores duales atx / ca

Info

Publication number
AR106100A1
AR106100A1 ARP160102880A ARP160102880A AR106100A1 AR 106100 A1 AR106100 A1 AR 106100A1 AR P160102880 A ARP160102880 A AR P160102880A AR P160102880 A ARP160102880 A AR P160102880A AR 106100 A1 AR106100 A1 AR 106100A1
Authority
AR
Argentina
Prior art keywords
alkyl
substituted
alkoxy
cycloalkyl
thiophenyl
Prior art date
Application number
ARP160102880A
Other languages
English (en)
Inventor
Ullmer Christoph
Schmitz Petra
Rudolph Markus
Mattei Patrizio
Hunziker Daniel
Hert Jrme
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR106100A1 publication Critical patent/AR106100A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Composiciones que contienen dichos compuestos y uso de tales compuestos, en el tratamiento de trastornos oculares. Reivindicación 1: Compuestos de la fórmula (1), en la que: R¹ es fenilo sustituido, (fenilo sustituido)-alquilo C₁₋₆, (fenoxi sustituido)-alquilo C₁₋₆, (fenilo sustituido)-alquenilo C₂₋₆, (fenilo sustituido)-alquinilo C₂₋₆, piridinilo sustituido, (piridinilo sustituido)-alquilo C₁₋₆, (piridinilo sustituido)-alquenilo C₂₋₆, (piridinilo sustituido)-alquinilo C₂₋₆, tiofenilo sustituido, (tiofenilo sustituido)-alquilo C₁₋₆, (tiofenilo sustituido)-alquenilo C₂₋₆ o (tiofenilo sustituido)-alquinilo C₂₋₆, dichos fenilo sustituido, (fenilo sustituido)-alquilo C₁₋₆, (fenoxi sustituido)-alquilo C₁₋₆, (fenilo sustituido)-alquenilo C₂₋₆, (fenilo sustituido)-alquinilo C₂₋₆, piridinilo sustituido, (piridinilo sustituido)-alquilo C₁₋₆, (piridinilo sustituido)-alquenilo C₂₋₆, (piridinilo sustituido)-alquinilo C₂₋₆, tiofenilo sustituido, (tiofenilo sustituido)-alquilo C₁₋₆, (tiofenilo sustituido)-alquenilo C₂₋₆ y (tiofenilo sustituido)-alquinilo C₂₋₆ están sustituidos por R³, R⁴ y R⁵; Y es -OC(O)- o -C(O)-; W es -C(O)-, -S(O)₂- o -CR⁶R⁷-; R² es fenilo sustituido, piridinilo sustituido o tiofenilo sustituido, dichos fenilo sustituido, piridinilo sustituido y tiofenilo sustituido están sustituidos por R⁶, R⁷ y R⁸; R³ es halógeno, hidroxi, ciano, alquilo C₁₋₆, alcoxi C₁₋₆, (alcoxi C₁₋₆)-alquilo C₁₋₆, haloalcoxi C₁₋₆, haloalquilo C₁₋₆, hidroxi-alquilo C₁₋₆, cicloalquilo C₃₋₈, (cicloalquilo C₃₋₈)-alquilo C₁₋₆, (cicloalquilo C₃₋₈)-alcoxi C₁₋₆, cicloalcoxi C₃₋₈, (cicloalcoxi C₃₋₈)-alquilo C₁₋₆, alquilamino C₁₋₆, (alquil C₁₋₆)-carbonilamino, (cicloalquil C₃₋₈)-carbonilamino, (alquil C₁₋₆)-tetrazolilo, (alquil C₁₋₆)-tetrazolil-alquilo C₁₋₆ o heterocicloalquil-alcoxi C₁₋₆; R⁴ y R⁵ con independencia entre sí se eligen entre H, halógeno, hidroxi, ciano, alquilo C₁₋₆, alcoxi C₁₋₆, (alcoxi C₁₋₆)-alquilo C₁₋₆, haloalcoxi C₁₋₆, haloalquilo C₁₋₆, hidroxi-alquilo C₁₋₆, cicloalquilo C₃₋₈, (cicloalquilo C₃₋₈)-alquilo C₁₋₆, (cicloalquilo C₃₋₈)-alcoxi C₁₋₆, cicloalcoxi C₃₋₈, (cicloalcoxi C₃₋₈)-alquilo C₁₋₆, (alquil C₁₋₆)-carbonilamino, (cicloalquil C₃₋₈)-carbonilamino, (alquil C₁₋₆)-tetrazolilo, (alquil C₁₋₆)-tetrazolil-alquilo C₁₋₆ y heterocicloalquil-alcoxi C₁₋₆; R⁶ es aminosulfonilo; R⁷ y R⁸ se eligen con independencia entre H, halógeno, hidroxi, ciano, alquilo C₁₋₆, alcoxi C₁₋₆, (alcoxi C₁₋₆)-alquilo C₁₋₆, haloalcoxi C₁₋₆, haloalquilo C₁₋₆, hidroxi-alquilo C₁₋₆, cicloalquilo C₃₋₈, (cicloalquil C₃₋₈)-alquilo C₁₋₆, (cicloalquil C₃₋₈)-alcoxi C₁₋₆, cicloalcoxi C₃₋₈ y (cicloalcoxi C₃₋₈)-alquilo C₁₋₆; R⁹ es alquilo C₁₋₆, alcoxi C₁₋₆ o halógeno; m, n, p y q con independencia entre sí se eligen entre los números 1 y 2; o las sales farmacéuticamente aceptables.
ARP160102880A 2015-09-24 2016-09-22 Compuestos bicíclicos como inhibidores duales atx / ca AR106100A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15186642 2015-09-24

Publications (1)

Publication Number Publication Date
AR106100A1 true AR106100A1 (es) 2017-12-13

Family

ID=54199040

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP160102880A AR106100A1 (es) 2015-09-24 2016-09-22 Compuestos bicíclicos como inhibidores duales atx / ca

Country Status (19)

Country Link
US (2) US10738053B2 (es)
EP (1) EP3353181B1 (es)
JP (1) JP6845230B2 (es)
KR (1) KR20180053408A (es)
CN (1) CN107614505B (es)
AR (1) AR106100A1 (es)
AU (1) AU2016328365B2 (es)
BR (1) BR112017026682A2 (es)
CA (1) CA2984585A1 (es)
CL (1) CL2018000649A1 (es)
CO (1) CO2017011152A2 (es)
CR (1) CR20180143A (es)
IL (1) IL255511B (es)
MX (1) MX2017015034A (es)
PE (1) PE20180233A1 (es)
PH (1) PH12018500409A1 (es)
RU (1) RU2725138C2 (es)
TW (1) TW201725206A (es)
WO (1) WO2017050747A1 (es)

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