AR092630A1 - Metodos y composiciones para prevenir la incorporacion erronea de norleucina en proteinas - Google Patents
Metodos y composiciones para prevenir la incorporacion erronea de norleucina en proteinasInfo
- Publication number
- AR092630A1 AR092630A1 ARP130103369A ARP130103369A AR092630A1 AR 092630 A1 AR092630 A1 AR 092630A1 AR P130103369 A ARP130103369 A AR P130103369A AR P130103369 A ARP130103369 A AR P130103369A AR 092630 A1 AR092630 A1 AR 092630A1
- Authority
- AR
- Argentina
- Prior art keywords
- norleucine
- methods
- prevent
- compositions
- protein
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y203/00—Acyltransferases (2.3)
- C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C12Y203/01046—Homoserine O-succinyltransferase (2.3.1.46)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
- C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
- C12Y205/01006—Methionine adenosyltransferase (2.5.1.6), i.e. adenosylmethionine synthetase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
La presente se refiere a métodos y composiciones para prevenir la incorporación de norleucina en proteínas durante la producción de proteína recombinada en bacterias. Además se provee células huéspedes de microorganismos y moléculas de ácido nucleico para el uso con los métodos y las composiciones que se proveen en la presente solicitud. Reivindicación 1: Un método para la prevención o reducción de la incorporación errónea de norleucina en una proteína o en un polipéptido, donde el método comprende la expresión de la proteína o el polipéptido en un microorganismo, donde el microorganismo es un microorganismo mutante que produce metionina a un grado o alcance suficiente para prevenir o reducir la incorporación errónea de norleucina en la proteína o el polipéptido.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261703142P | 2012-09-19 | 2012-09-19 | |
| US201361777700P | 2013-03-12 | 2013-03-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR092630A1 true AR092630A1 (es) | 2015-04-29 |
Family
ID=49304344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP130103369A AR092630A1 (es) | 2012-09-19 | 2013-09-19 | Metodos y composiciones para prevenir la incorporacion erronea de norleucina en proteinas |
Country Status (21)
| Country | Link |
|---|---|
| US (5) | US20140081003A1 (es) |
| EP (2) | EP3502267B1 (es) |
| JP (3) | JP6479661B2 (es) |
| KR (1) | KR102123134B1 (es) |
| CN (2) | CN104662161A (es) |
| AR (1) | AR092630A1 (es) |
| AU (2) | AU2013318047A1 (es) |
| BR (1) | BR112015005895A2 (es) |
| CA (1) | CA2882463C (es) |
| ES (1) | ES2705493T3 (es) |
| HK (1) | HK1210810A1 (es) |
| HR (1) | HRP20190060T1 (es) |
| IL (2) | IL237310B (es) |
| MX (1) | MX363187B (es) |
| MY (1) | MY180183A (es) |
| PL (1) | PL2898086T3 (es) |
| RU (1) | RU2681928C2 (es) |
| SG (1) | SG11201502076SA (es) |
| SI (1) | SI2898086T1 (es) |
| WO (1) | WO2014047311A1 (es) |
| ZA (1) | ZA201501653B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2496060C (en) * | 2002-09-11 | 2015-08-04 | Genentech, Inc. | Protein purification by ion exchange chromatography |
| KR102123134B1 (ko) | 2012-09-19 | 2020-06-15 | 제넨테크, 인크. | 단백질로의 노르류신 오혼입을 방지하기 위한 방법 및 조성물 |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| KR20250057128A (ko) | 2015-12-30 | 2025-04-28 | 코디악 사이언시스 인코포레이티드 | 항체 및 이의 접합체 |
| MX2020006435A (es) * | 2017-12-19 | 2021-02-09 | Akouos Inc | Administracion de anticuerpos terapeuticos mediada por vector de virus adenoasociado (aav) en el oido interno. |
| MX2020009152A (es) | 2018-03-02 | 2020-11-09 | Kodiak Sciences Inc | Anticuerpos de il-6 y constructos de fusion y conjugados de los mismos. |
| CN114786731A (zh) | 2019-10-10 | 2022-07-22 | 科达制药股份有限公司 | 治疗眼部病症的方法 |
| CR20230228A (es) | 2020-12-01 | 2023-07-18 | Akouos Inc | Construcciones de anticuerpos anti-vegf y métodos relacionados para el tratamiento de los síntomas asociados al schwannoma vestibular |
| WO2024079114A1 (en) * | 2022-10-11 | 2024-04-18 | UCB Biopharma SRL | Process for the production of recombinant proteins |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5599690A (en) | 1988-02-01 | 1997-02-04 | Amgen Inc. | Control of norleucine incorporation into recombinant proteins |
| US5622845A (en) | 1988-02-17 | 1997-04-22 | The Upjohn Company | Fermentation method for producing norleucine |
| ATE152176T1 (de) * | 1988-02-17 | 1997-05-15 | Upjohn Co | Verfahren zum regeln des norleucingehalts in polypeptiden |
| EP0604580A1 (en) | 1991-09-19 | 1994-07-06 | Genentech, Inc. | EXPRESSION IN E. COLI OF ANTIBODY FRAGMENTS HAVING AT LEAST A CYSTEINE PRESENT AS A FREE THIOL, USE FOR THE PRODUCTION OF BIFUNCTIONAL F(ab') 2? ANTIBODIES |
| WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
| US5789199A (en) | 1994-11-03 | 1998-08-04 | Genentech, Inc. | Process for bacterial production of polypeptides |
| US5840523A (en) | 1995-03-01 | 1998-11-24 | Genetech, Inc. | Methods and compositions for secretion of heterologous polypeptides |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| WO1998045331A2 (en) | 1997-04-07 | 1998-10-15 | Genentech, Inc. | Anti-vegf antibodies |
| JP4110641B2 (ja) * | 1998-11-17 | 2008-07-02 | 味の素株式会社 | 発酵法によるｌ−メチオニンの製造法 |
| ES2324645T3 (es) | 2000-11-03 | 2009-08-12 | Genentech, Inc. | Cambios de tasa metabolica en fermentaciones que expresen proteinas recombinantes. |
| DE10247437A1 (de) | 2002-10-11 | 2004-04-29 | Consortium für elektrochemische Industrie GmbH | Feedback-resistente Homoserin-Transsuccinylasen |
| DE10249642A1 (de) | 2002-10-24 | 2004-05-13 | Consortium für elektrochemische Industrie GmbH | Feedback-resistente Homoserin-Transsuccinylasen mit modifiziertem C-Terminus |
| DE10305774A1 (de) | 2003-02-06 | 2004-08-26 | Consortium für elektrochemische Industrie GmbH | Verfahren zur fermentativen Herstellung von L-Methionin |
| US8603781B2 (en) | 2003-09-25 | 2013-12-10 | Monsanto Technology Llc | Prevention of incorporation of non-standard amino acids into protein |
| WO2005111202A1 (en) * | 2004-05-12 | 2005-11-24 | Metabolic Explorer | Recombinant enzyme with altered feedback sensitivity |
| EP1996697A2 (en) * | 2006-03-07 | 2008-12-03 | Novartis AG | Preventing norvaline and norleucine misincorporation in recombinant proteins |
| RS58233B1 (sr) | 2006-11-02 | 2019-03-29 | Genentech Inc | Humanizovana anti-faktor d antitela i njihove upotrebe |
| CR20170001A (es) * | 2008-04-28 | 2017-08-10 | Genentech Inc | Anticuerpos anti factor d humanizados |
| BRPI1012321A8 (pt) * | 2009-06-17 | 2016-09-27 | Abbott Biotherapeutics Corp | Anticorpos anti-vegf e seus usos |
| JP5817529B2 (ja) * | 2009-11-30 | 2015-11-18 | 味の素株式会社 | Ｌ−システイン生産菌及びｌ−システインの製造法 |
| JP2013529203A (ja) * | 2010-05-14 | 2013-07-18 | ジェネンテック， インコーポレイテッド | 治療方法 |
| KR102123134B1 (ko) | 2012-09-19 | 2020-06-15 | 제넨테크, 인크. | 단백질로의 노르류신 오혼입을 방지하기 위한 방법 및 조성물 |
-
2013
- 2013-09-19 KR KR1020157009711A patent/KR102123134B1/ko not_active Expired - Fee Related
- 2013-09-19 SG SG11201502076SA patent/SG11201502076SA/en unknown
- 2013-09-19 PL PL13773482T patent/PL2898086T3/pl unknown
- 2013-09-19 HK HK15111589.7A patent/HK1210810A1/xx unknown
- 2013-09-19 JP JP2015532180A patent/JP6479661B2/ja active Active
- 2013-09-19 CN CN201380048535.XA patent/CN104662161A/zh active Pending
- 2013-09-19 CN CN202011466081.6A patent/CN112575018A/zh active Pending
- 2013-09-19 AU AU2013318047A patent/AU2013318047A1/en not_active Abandoned
- 2013-09-19 HR HRP20190060TT patent/HRP20190060T1/hr unknown
- 2013-09-19 EP EP18194260.8A patent/EP3502267B1/en active Active
- 2013-09-19 AR ARP130103369A patent/AR092630A1/es not_active Application Discontinuation
- 2013-09-19 MY MYPI2015000662A patent/MY180183A/en unknown
- 2013-09-19 EP EP13773482.8A patent/EP2898086B1/en active Active
- 2013-09-19 ES ES13773482T patent/ES2705493T3/es active Active
- 2013-09-19 CA CA2882463A patent/CA2882463C/en active Active
- 2013-09-19 WO PCT/US2013/060653 patent/WO2014047311A1/en not_active Ceased
- 2013-09-19 BR BR112015005895A patent/BR112015005895A2/pt not_active Application Discontinuation
- 2013-09-19 RU RU2015111350A patent/RU2681928C2/ru active
- 2013-09-19 SI SI201331317T patent/SI2898086T1/sl unknown
- 2013-09-19 US US14/031,463 patent/US20140081003A1/en not_active Abandoned
- 2013-09-19 MX MX2015003281A patent/MX363187B/es unknown
-
2015
- 2015-02-19 IL IL237310A patent/IL237310B/en active IP Right Grant
- 2015-03-11 ZA ZA2015/01653A patent/ZA201501653B/en unknown
-
2016
- 2016-03-11 US US15/067,646 patent/US9850514B2/en active Active
-
2017
- 2017-05-08 AU AU2017203049A patent/AU2017203049B2/en not_active Ceased
- 2017-11-17 US US15/816,305 patent/US10179925B2/en active Active
-
2018
- 2018-04-12 US US15/951,895 patent/US10421984B2/en active Active
- 2018-11-29 JP JP2018223132A patent/JP6796631B2/ja active Active
-
2019
- 2019-08-08 US US16/536,149 patent/US11015214B2/en active Active
-
2020
- 2020-02-23 IL IL272866A patent/IL272866B/en active IP Right Grant
- 2020-11-16 JP JP2020190225A patent/JP2021048849A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR092630A1 (es) | Metodos y composiciones para prevenir la incorporacion erronea de norleucina en proteinas | |
| CL2016001553A1 (es) | Medios para cultivo celular | |
| MX2021010518A (es) | Medios y metodos de fermentacion para producir polisacarido en cultivo celular bacteriano. | |
| MX352823B (es) | Formulaciones de proteinas que contienen aminoacidos. | |
| EA201890137A1 (ru) | Среда для культивирования клеток с добавлением таурина и способы применения | |
| MX2019003674A (es) | Enzimas modificadoras de ácido nucleico guiadas por arn y métodos de uso de estas. | |
| CO6440530A2 (es) | Formulaciones de caldo de fermentación | |
| AR084377A1 (es) | Metodos y composiciones relacionados con enzimas de alcohol graso biosintetico | |
| BR112015006426A2 (pt) | composições nutricionais que incluem beta-hidróxi-beta-metilbutirato de cálcio, proteína e baixos níveis de eletrólitos | |
| WO2014172631A3 (en) | Expression of biologically active proteins in a bacterial cell-free synthesis system using cell extracts with elevated levels of exogenous chaperones | |
| EA201591817A1 (ru) | Не содержащая сыворотки среда для культивирования клеток | |
| BR112013020767A2 (pt) | composições compreendendo ácido peróxi alfa-cetocarboxílico e métodos para a produção e o uso do mesmo | |
| BR112015020904A2 (pt) | microrganismos e métodos para produção de butadieno e compostos relacionados por assimilação de formiato | |
| BR112016001778A2 (pt) | Célula transgênica de levedura, composição, e, métodos de produção de 3-hp e de produção de ácido acrílico ou um sal do mesmo | |
| BR112016004510A2 (pt) | composições bioativas deriváveis de concentrados de plaquetas e métodos para preparar e usar as mesmas | |
| BR112016016524A2 (pt) | célula de levedura transformada | |
| BR112016006048A8 (pt) | composições antimicrobianas | |
| EA201490945A1 (ru) | Набор, содержащий заменитель сыворотки и лабильные факторы | |
| AR068419A1 (es) | Cepas de mycoplasma atenuadas vivas | |
| BR112014002173A2 (pt) | proteínas purificadas | |
| BR112014002624A8 (pt) | Microorganismo recombinante e cultura de microorganismo recombinante | |
| BR112014000542A2 (pt) | composições de peroxidase eosinofílica e métodos de uso das mesmas | |
| EA201891335A1 (ru) | Добавление аргинина с целью повышения эффективности ацетогенов, ферментирующих газ | |
| WO2018183848A8 (en) | Media for microorganism culture and related compositions and methods | |
| BR112014011198A2 (pt) | dispositivos e métodos para aumento da viabiliade de bactérias em forma de bastonete |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |