AR098884A1 - NOTCH ACTIVATION CHANGES IN BREAST CANCER - Google Patents
NOTCH ACTIVATION CHANGES IN BREAST CANCERInfo
- Publication number
- AR098884A1 AR098884A1 ARP140104823A ARP140104823A AR098884A1 AR 098884 A1 AR098884 A1 AR 098884A1 AR P140104823 A ARP140104823 A AR P140104823A AR P140104823 A ARP140104823 A AR P140104823A AR 098884 A1 AR098884 A1 AR 098884A1
- Authority
- AR
- Argentina
- Prior art keywords
- breast cancer
- notch activation
- activation changes
- pest domain
- changes
- Prior art date
Links
- 230000004913 activation Effects 0.000 title abstract 2
- 206010006187 Breast cancer Diseases 0.000 title 1
- 208000026310 Breast neoplasm Diseases 0.000 title 1
- 241000607479 Yersinia pestis Species 0.000 abstract 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000005913 Notch signaling pathway Effects 0.000 abstract 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 abstract 1
- 229940121773 Secretase inhibitor Drugs 0.000 abstract 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 1
- 239000004473 Threonine Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 235000013922 glutamic acid Nutrition 0.000 abstract 1
- 239000004220 glutamic acid Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 102000035160 transmembrane proteins Human genes 0.000 abstract 1
- 108091005703 transmembrane proteins Proteins 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Métodos para identificar y tratar pacientes con cáncer que tienen alteraciones de activación en el dominio PEST de Notch1, Notch2 o Notch3 (Proteínas transmembrana), con un inhibidor de la vía de señalización de Notch, tal como el inhibidor de g-secretasa PF-03084014, o una sal de aquel aceptable desde el punto de vista farmacéutico. Dominio PEST (Prolina P, Ácido Glutámico E, Serina S, Treonina T). Uso. Compuesto.Methods for identifying and treating cancer patients who have activation disorders in the PEST domain of Notch1, Notch2 or Notch3 (Transmembrane proteins), with a Notch signaling pathway inhibitor, such as the G-secretase inhibitor PF-03084014 , or a salt thereof pharmaceutically acceptable. PEST domain (Proline P, Glutamic Acid E, Serine S, Threonine T). Use. Compound.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361919431P | 2013-12-20 | 2013-12-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR098884A1 true AR098884A1 (en) | 2016-06-22 |
Family
ID=58698503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP140104823A AR098884A1 (en) | 2013-12-20 | 2014-12-19 | NOTCH ACTIVATION CHANGES IN BREAST CANCER |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR098884A1 (en) |
-
2014
- 2014-12-19 AR ARP140104823A patent/AR098884A1/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |