AR096620A1 - Derivado de aminotriazina y composición farmacéutica que lo comprende - Google Patents
Derivado de aminotriazina y composición farmacéutica que lo comprendeInfo
- Publication number
- AR096620A1 AR096620A1 ARP140102276A ARP140102276A AR096620A1 AR 096620 A1 AR096620 A1 AR 096620A1 AR P140102276 A ARP140102276 A AR P140102276A AR P140102276 A ARP140102276 A AR P140102276A AR 096620 A1 AR096620 A1 AR 096620A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- unsubstituted
- alkyloxy
- independently
- alkyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Compuestos con una actividad antagonista del receptor P2X3 y/o P2X2/3. Reivindicación 1: Un compuesto, caracterizado porque tiene la fórmula (1), en donde Rᵃ y Rᵇ son ambos átomos de hidrógeno o Rᵃ y Rᵇ se toman juntos para formar oxo, tioxo o =N-Rˣ; Rᵈ y Rᵉ son ambos átomos de hidrógeno o Rᵈ y Rᵉ se toman juntos para formar oxo, tioxo o =N-Rʸ; Rˣ y Rʸ son cada uno, de modo independiente, un átomo de hidrógeno, alquilo sustituido o no sustituido, alquenilo sustituido o no sustituido, alquinilo sustituido o no sustituido, cicloalquilo sustituido o no sustituido, cicloalquenilo sustituido o no sustituido, un grupo heterocíclico no aromático sustituido o no sustituido, arilo sustituido o no sustituido o heteroarilo sustituido o no sustituido; R⁴ᵃ es cada uno, de modo independiente, un átomo de hidrógeno o alquilo sustituido o no sustituido; R⁴ᵇ es cada uno, de modo independiente, un átomo de hidrógeno o alquilo sustituido o no sustituido; o R⁴ᵃ y R⁴ᵇ unidos al mismo átomo de carbono se toman juntos para formar oxo o tioxo; n es un número entero de 1 a 4; R² es cicloalquilo sustituido o no sustituido, cicloalquenilo sustituido o no sustituido, un grupo heterocíclico no aromático sustituido o no sustituido, arilo sustituido o no sustituido o heteroarilo sustituido o no sustituido; R⁹ es cada uno, de modo independiente, halógeno, hidroxi, carboxi, ciano, nitro, alquilo sustituido o no sustituido, alquenilo sustituido o no sustituido, alquinilo sustituido o no sustituido, alquiloxi sustituido o no sustituido, alqueniloxi sustituido o no sustituido, alquiniloxi sustituido o no sustituido, alquiltio sustituido o no sustituido, alqueniltio, sustituido o no sustituido, alquiniltio sustituido o no sustituido, acilo sustituido o no sustituido, alquiloxicarbonilo sustituido o no sustituido, alqueniloxicarbonilo sustituido o no sustituido, alquiniloxicarbonilo sustituido o no sustituido, carbamoilo sustituido o no sustituido, amino sustituido o no sustituido, sulfamoilo sustituido o no sustituido, sulfonilo sustituido, sulfinilo sustituido, cicloalquilo sustituido o no sustituido, cicloalquenilo sustituido o no sustituido, un grupo heterocíclico no aromático sustituido o no sustituido, arilo sustituido o no sustituido, heteroarilo sustituido o no sustituido, cicloalquiloxi sustituido o no sustituido, cicloalqueniloxi sustituido o no sustituido, heterocicliloxi no aromático sustituido o no sustituido, ariloxi sustituido o no sustituido o heteroariloxi sustituido o no sustituido; R⁹ es cada uno, de modo independiente, halógeno, hidroxi, carboxi, ciano, nitro, alquilo sustituido o no sustituido, alquenilo sustituido o no sustituido, alquinilo sustituido o no sustituido, alquiloxi sustituido o no sustituido, alqueniloxi sustituido o no sustituido, alquiniloxi sustituido o no sustituido, alquiltio sustituido o no sustituido, alqueniltio sustituido o no sustituido, alquiniltio sustituido o no sustituido, acilo sustituido o no sustituido, alquiloxicarbonilo sustituido o no sustituido, alqueniloxicarbonilo sustituido o no sustituido, alquiniloxicarbonilo sustituido o no sustituido, carbamoilo sustituido o no sustituido, amino sustituido o no sustituido, sulfamoilo sustituido o no sustituido, sulfonil o sustituido, sulfinilo sustituido, cicloalquilo sustituido o no sustituido, cicloalquenilo sustituido o no sustituido, un grupo heterocíclico no aromático sustituido o no sustituido, arilo sustituido o no sustituido, heteroarilo sustituido o no sustituido, cicloalquiloxi sustituido o no sustituido, cicloalqueniloxi sustituido o no sustituido, heterocicliloxi no aromático sustituido o no sustituido, ariloxi sustituido o no sustituido o heteroariloxi sustituido o no sustituido; s y s son cada uno, de modo independiente, un número entero de 0 a 3; R²⁰ᵃ es cada uno, de modo independiente, un átomo de hidrógeno, hidroxi, alquilo sustituido o no sustituido, alquenilo sustituido o no sustituido, alquinilo sustituido o no sustituido o alquiloxi sustituido o no sustituido; R²⁰ᵇ es cada uno, de modo independiente, un átomo de hidrógeno, hidroxi, alquilo sustituido o no sustituido, alquenilo sustituido o no sustituido, alquinilo sustituido o no sustituido o alquiloxi sustituido o no sustituido; o R²⁰ᵃ y R²⁰ᵇ unidos al mismo átomo de carbono o los átomos de carbono diferentes se toman juntos para formar cicloalcano sustituido o no sustituido, cicloalqueno sustituido o no sustituido o un anillo heterocíclico no aromático sustituido o no sustituido; siempre que todos los R²⁰ᵃ y R²⁰ᵇ no sean átomos de hidrógeno al mismo tiempo; u es un número entero de 1 a 4; y R¹³ es un átomo de hidrógeno o alquilo sustituido o no sustituido; siempre que se excluyan los compuestos de fórmula (2) ó (3); o su sal farmacéuticamente aceptable.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013125134 | 2013-06-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR096620A1 true AR096620A1 (es) | 2016-01-20 |
Family
ID=52022364
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP140102276A AR096620A1 (es) | 2013-06-14 | 2014-06-13 | Derivado de aminotriazina y composición farmacéutica que lo comprende |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US9732060B2 (es) |
| EP (1) | EP3009432B1 (es) |
| JP (1) | JP6132371B2 (es) |
| KR (2) | KR20170116177A (es) |
| CN (1) | CN105452234B (es) |
| AR (1) | AR096620A1 (es) |
| AU (1) | AU2014279116B2 (es) |
| BR (1) | BR112015031079B1 (es) |
| CA (1) | CA2915325C (es) |
| DK (1) | DK3009432T3 (es) |
| EA (1) | EA030198B1 (es) |
| ES (1) | ES2675528T3 (es) |
| IL (1) | IL243042A0 (es) |
| MX (1) | MX362995B (es) |
| PH (1) | PH12015502775A1 (es) |
| PL (1) | PL3009432T3 (es) |
| SG (1) | SG11201510179PA (es) |
| TR (1) | TR201809085T4 (es) |
| TW (1) | TWI637949B (es) |
| WO (1) | WO2014200078A1 (es) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2399910E (pt) | 2009-02-13 | 2014-05-02 | Shionogi & Co | Novo derivado de triazina e composição farmacéutica que contém o mesmo |
| PL2604595T3 (pl) | 2010-08-10 | 2016-09-30 | Pochodna triazyny i związek farmaceutyczny, który ją zawiera i wykazuje aktywność przeciwbólową | |
| US9212130B2 (en) * | 2010-08-10 | 2015-12-15 | Shionogi & Co., Ltd. | Heterocyclic derivative and pharmaceutical composition comprising the same |
| TWI637949B (zh) * | 2013-06-14 | 2018-10-11 | 塩野義製藥股份有限公司 | 胺基三衍生物及含有其等之醫藥組合物 |
| JP6422164B2 (ja) | 2013-12-26 | 2018-11-14 | 塩野義製薬株式会社 | 含窒素６員環誘導体およびそれらを含有する医薬組成物 |
| JPWO2016084922A1 (ja) * | 2014-11-28 | 2017-09-07 | 塩野義製薬株式会社 | １，２，４−トリアジン誘導体およびその医薬組成物 |
| ES2905399T3 (es) | 2015-04-24 | 2022-04-08 | Shionogi & Co | Derivados heterocíclicos de seis miembros y composición farmacéutica que los comprende |
| AU2017233841B9 (en) | 2016-03-14 | 2021-09-09 | Afferent Pharmaceuticals Inc. | Pyrimidines and variants thereof, and uses therefor |
| KR102377805B1 (ko) | 2016-03-25 | 2022-03-22 | 애퍼런트 파마슈티컬스 인크. | 피리미딘 및 그의 변이체, 및 그의 용도 |
| CN110072862B (zh) | 2016-10-17 | 2022-05-13 | 盐野义制药株式会社 | 二环性含氮杂环衍生物及含有该衍生物的药物组合物 |
| KR102742881B1 (ko) | 2018-06-29 | 2024-12-16 | 삼성디스플레이 주식회사 | 디스플레이 장치 |
| KR102548987B1 (ko) | 2018-08-09 | 2023-06-29 | 삼성디스플레이 주식회사 | 디스플레이 장치 |
| AU2019353424B2 (en) * | 2018-10-05 | 2022-12-08 | Shionogi & Co., Ltd. | Medicine for treating chronic cough |
| BR112021022099A2 (pt) | 2019-05-31 | 2021-12-28 | Chiesi Farm Spa | Derivados de amino quinazolina como inibidores de p2x3 |
| WO2021054421A1 (ja) | 2019-09-19 | 2021-03-25 | 塩野義製薬株式会社 | １，３，５－トリアジン誘導体またはその溶媒和物の結晶およびその製造方法 |
| HUE069128T2 (hu) | 2019-12-06 | 2025-02-28 | Vertex Pharma | Szubsztituált tetrahidrofurán vegyületek mint nátriumcsatornák modulátorai |
| TW202203930A (zh) * | 2020-04-03 | 2022-02-01 | 日商塩野義製藥股份有限公司 | 睡眠時呼吸中止症候群治療用醫藥 |
| TW202203929A (zh) * | 2020-04-03 | 2022-02-01 | 日商塩野義製藥股份有限公司 | 疼痛治療用醫藥 |
| WO2021230308A1 (ja) | 2020-05-15 | 2021-11-18 | 塩野義製薬株式会社 | 不純物の生成を抑制した医薬組成物 |
| US20230128162A1 (en) | 2021-04-14 | 2023-04-27 | Shionogi & Co., Ltd. | Triazine derivatives having virus replication inhibitory activity and pharmaceutical composition comprising the same |
| EP4349816A4 (en) * | 2021-06-04 | 2025-05-21 | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. | Triazinylmethylcycloalkylcarboxylic acid derivative, and pharmaceutical composition and use thereof |
| AU2022284886A1 (en) | 2021-06-04 | 2023-11-30 | Vertex Pharmaceuticals Incorporated | N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels |
| CN113620888B (zh) * | 2021-09-27 | 2023-06-06 | 成都施贝康生物医药科技有限公司 | 二氢嘧啶类化合物及其制备方法和应用 |
| CN113773300B (zh) * | 2021-09-27 | 2022-10-11 | 成都施贝康生物医药科技有限公司 | 磺酰胺类化合物、其制备方法及用途 |
| CN113801097B (zh) * | 2021-09-27 | 2022-11-22 | 成都施贝康生物医药科技有限公司 | 二氢嘧啶类化合物、其制备方法及用途 |
| KR20240082359A (ko) | 2021-09-28 | 2024-06-10 | 시오노기 앤드 컴파니, 리미티드 | 트라이아진 유도체를 함유하는 의약 조성물 |
| WO2023054292A1 (ja) | 2021-09-28 | 2023-04-06 | 塩野義製薬株式会社 | トリアジン誘導体を含有する医薬組成物 |
| US20240148741A1 (en) | 2021-11-24 | 2024-05-09 | Shionogi & Co., Ltd. | Formulation for oral administration, comprising triazine derivative |
| WO2023095860A1 (ja) * | 2021-11-26 | 2023-06-01 | 塩野義製薬株式会社 | ３ｃｌプロテアーゼ阻害剤及びｃｏｖｉｄ－１９治療用薬剤を組み合わせることを特徴とするｃｏｖｉｄ－１９治療用医薬 |
| US20250099474A1 (en) | 2022-01-19 | 2025-03-27 | Shionogi & Co., Ltd. | Pharmaceutical for treatment of novel coronavirus infection |
| CN115650959B (zh) * | 2022-05-20 | 2023-10-20 | 南京济群医药科技股份有限公司 | 化合物的制备方法或纯化方法 |
| WO2024169781A1 (zh) * | 2023-02-15 | 2024-08-22 | 南京明德新药研发有限公司 | 嘧啶酮衍生物及其在药学上的应用 |
| WO2025255215A1 (en) | 2024-06-05 | 2025-12-11 | Shionogi-Apnimed Sleep Science, Llc | Methods and compositions for treating sleep apnea |
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